Arterial thrombosis induced by IVIg and its treatment with tPA.


:IV immunoglobulin therapy can lead to vascular events through increased serum viscosity and possibly other mechanisms. The authors describe the successful use of tissue plasminogen activator in three of four patients who developed cerebral and peripheral arterial thrombosis after treatment with IV immunoglobulin.






Okuda D,Flaster M,Frey J,Sivakumar K




Has Abstract


2003-06-10 00:00:00












  • Increasing comorbidity and health services utilization in older adults with prior stroke.

    abstract:OBJECTIVE:To characterize comorbid chronic conditions, describe health services use, and estimate health care costs among community-dwelling older adults with prior stroke. METHODS:This is a retrospective cohort study using administrative data from Ontario, Canada. We identified all community-dwelling individuals aged...


    pub_type: 杂志文章


    authors: Gruneir A,Griffith LE,Fisher K,Panjwani D,Gandhi S,Sheng L,Patterson C,Gafni A,Ploeg J,Markle-Reid M

    更新日期:2016-11-15 00:00:00

  • Diagnostic criteria for dystonia in DYT1 families.

    abstract::Family studies of primary torsion dystonia have used the diagnostic categories of definite, probable, and possible dystonia for gene mapping and identification, but the validity of this hierarchical classification is not known. The authors assessed 147 DYT1 GAG deletion carriers and 113 blood-related noncarriers from ...


    pub_type: 临床试验,杂志文章


    authors: Bressman SB,Raymond D,Wendt K,Saunders-Pullman R,De Leon D,Fahn S,Ozelius L,Risch N

    更新日期:2002-12-10 00:00:00

  • Reasons for exclusion from thrombolytic therapy following acute ischemic stroke.

    abstract::Despite evidence for the efficacy of thrombolytic therapy in acute ischemic stroke, only 1 to 7% of patients receive this therapy. The authors sought to determine the reasons for exclusion from tissue plasminogen activator (tPA) in an acute setting and found avoidable causes in 18% of patients. Improvements in intraho...


    pub_type: 杂志文章


    authors: Cocho D,Belvís R,Martí-Fàbregas J,Molina-Porcel L,Díaz-Manera J,Aleu A,Pagonabarraga J,García-Bargo D,Mauri A,Martí-Vilalta JL

    更新日期:2005-02-22 00:00:00

  • Multisystem triglyceride storage disease is due to a specific defect in the degradation of endocellularly synthesized triglycerides.

    abstract::We studied two unrelated patients with autosomal recessive multisystem triglyceride storage disease. Cultured fibroblasts accumulated 10 times more triglyceride than controls under glycerol or palmitate feeding. Mutant fibroblasts could not degrade accumulated triglycerides of endogenous origin, but normally degraded ...


    pub_type: 杂志文章


    authors: Di Donato S,Garavaglia B,Strisciuglio P,Borrone C,Andria G

    更新日期:1988-07-01 00:00:00

  • Comprehensive analysis of the predictors of neurobehavioral symptom reporting in veterans.

    abstract:OBJECTIVE:This study assessed the strength of military-related concussion-, psychological-, and behavioral-related measures to predict neurobehavioral symptom (NBS) reporting in order to help clarify the extent to which persistent NBS reflect lingering effects of concussion vs other psychological/behavioral factors amo...


    pub_type: 杂志文章


    authors: Andrews RJ,Fonda JR,Levin LK,McGlinchey RE,Milberg WP

    更新日期:2018-08-21 00:00:00

  • Local alterations of hemostatic-fibrinolytic mechanisms in reforming subdural hematomas.

    abstract::Multiple chemical and coagulation determinations were undertaken on the subdural hematoma fluid from the reformed effusions of two patients. It was found that plasma or blood repeatedly reentered the subdural cavity. Coagulation studies compared the in vitro effects of subdural fluid with those of cerebrospinal fluid,...


    pub_type: 杂志文章


    authors: Labadie EL,Glover D

    更新日期:1975-07-01 00:00:00

  • MRI correlates of neurofibrillary tangle pathology at autopsy: a voxel-based morphometry study.

    abstract:BACKGROUND:Neurofibrillary tangles (NFTs), composed of hyperphosphorylated tau proteins, are one of the pathologic hallmarks of Alzheimer disease (AD). We aimed to determine whether patterns of gray matter atrophy from antemortem MRI correlate with Braak staging of NFT pathology. METHODS:Eighty-three subjects with Bra...


    pub_type: 杂志文章


    authors: Whitwell JL,Josephs KA,Murray ME,Kantarci K,Przybelski SA,Weigand SD,Vemuri P,Senjem ML,Parisi JE,Knopman DS,Boeve BF,Petersen RC,Dickson DW,Jack CR Jr

    更新日期:2008-09-02 00:00:00

  • Mechanisms of action of anticonvulsant agents.

    abstract::Systematic screening of many compounds in animal models led to identification of the established antiepileptic drugs (AEDs). By contrast, the newer AEDs were specifically designed to enhance an inhibitory process or to inhibit a specific excitatory pathway. However, it was later discovered that some of the designed dr...


    pub_type: 杂志文章,评审


    authors: Moshé SL

    更新日期:2000-01-01 00:00:00

  • Serum trihexyphenidyl levels in the treatment of torsion dystonia.

    abstract::Using a radioreceptor technique, we assayed serum trihexyphenidyl levels in patients with dystonia being treated chronically with high dosage. We found a significant correlation between total daily dose and the daily lowest (trough) serum levels. There was no relationship between serum levels and therapeutic response ...


    pub_type: 杂志文章


    authors: Burke RE,Fahn S

    更新日期:1985-07-01 00:00:00

  • Spontaneous thrombosis of a giant cerebral aneurysm in five days. Report of a case.

    abstract::This single case report describes a large (giant) left internal carotid aneurysm that showed a very marked decrease in the size of its lumen on reevaluation 5 days after the initial arteriogram. A review of the literature found only 5 cases of spontaneous thrombosis documented by arteriography and only one involved a ...


    pub_type: 杂志文章


    authors: Carlson DH,Thomson D

    更新日期:1976-04-01 00:00:00

  • Incidence and prevalence of intracranial vascular malformations in Olmsted County, Minnesota, 1965 to 1992.

    abstract::We used the Mayo Clinic medical records linkage system to detect all cases of intracranial vascular malformation (IVM) among residents of Olmsted County, Minnesota from 1965 to 1992 and found 48 IVMs over the 27-year period, including four patients with IVM detected at autopsy, without prior symptoms. Twenty-nine of 4...


    pub_type: 杂志文章


    authors: Brown RD Jr,Wiebers DO,Torner JC,O'Fallon WM

    更新日期:1996-04-01 00:00:00

  • Subregional loss of putaminal efferents to the basal ganglia output nuclei may cause parkinsonism in striatonigral degeneration.

    abstract::In this study, we examined the topographic involvement of the putaminal projection neurons and their axons in the globus pallidus and substantia nigra, which we visualized by calcineurin immunostaining, in the basal ganglia of patients with striatonigral degeneration (SND). In all cases examined, there was a marked de...


    pub_type: 杂志文章


    authors: Goto S,Matsumoto S,Ushio Y,Hirano A

    更新日期:1996-10-01 00:00:00

  • Treatment of pseudobulbar affect in ALS with dextromethorphan/quinidine: a randomized trial.

    abstract:BACKGROUND:Patients with ALS commonly exhibit pseudobulbar affect. METHODS:The authors conducted a multicenter, randomized, double-blind, controlled, parallel, three-arm study to test a defined combination of dextromethorphan hydrobromide (DM) and quinidine sulfate (Q) (AVP-923) for the treatment of pseudobulbar affec...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Brooks BR,Thisted RA,Appel SH,Bradley WG,Olney RK,Berg JE,Pope LE,Smith RA,AVP-923 ALS Study Group.

    更新日期:2004-10-26 00:00:00

  • Survival in Alzheimer disease: a multiethnic, population-based study of incident cases.

    abstract:OBJECTIVE:To describe factors associated with survival in Alzheimer disease (AD) in a multiethnic, population-based longitudinal study. METHODS:AD cases were identified in the Washington Heights Inwood Columbia Aging Project, a longitudinal, community-based study of cognitive aging in Northern Manhattan. The sample co...


    pub_type: 杂志文章


    authors: Helzner EP,Scarmeas N,Cosentino S,Tang MX,Schupf N,Stern Y

    更新日期:2008-11-04 00:00:00

  • The clinical spectrum of cerebral amyloid angiopathy: presentations without lobar hemorrhage.

    abstract::Cerebral amyloid angiopathy is a common cause of spontaneous lobar hemorrhage in elderly patients. We discuss seven patients with amyloid angiopathy presenting without major lobar hemorrhage. The patients' presentations fell into two groups: recurrent transient neurologic symptoms and rapidly progressive dementia. The...


    pub_type: 杂志文章


    authors: Greenberg SM,Vonsattel JP,Stakes JW,Gruber M,Finklestein SP

    更新日期:1993-10-01 00:00:00

  • TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers.

    abstract:OBJECTIVES:To determine whether TMEM106B single nucleotide polymorphisms (SNPs) are associated with frontotemporal lobar degeneration (FTLD) in patients with and without mutations in progranulin (GRN) and to determine whether TMEM106B modulates GRN expression. METHODS:We performed a case-control study of 3 SNPs in TME...


    pub_type: 杂志文章


    authors: Finch N,Carrasquillo MM,Baker M,Rutherford NJ,Coppola G,Dejesus-Hernandez M,Crook R,Hunter T,Ghidoni R,Benussi L,Crook J,Finger E,Hantanpaa KJ,Karydas AM,Sengdy P,Gonzalez J,Seeley WW,Johnson N,Beach TG,Mesulam M,

    更新日期:2011-02-01 00:00:00

  • Decreased striatal monoaminergic terminals in Huntington disease.

    abstract:OBJECTIVE:To evaluate the integrity of the dorsal striatal dopaminergic innervation in rigid and choreic Huntington disease (HD). BACKGROUND:Some patients with HD have an akinetic-rigid phenotype. It has been suggested that nigrostriatal in addition to striatal pathology is present in this subgroup. The authors sought...


    pub_type: 杂志文章


    authors: Bohnen NI,Koeppe RA,Meyer P,Ficaro E,Wernette K,Kilbourn MR,Kuhl DE,Frey KA,Albin RL

    更新日期:2000-05-09 00:00:00

  • Current state of educational compensation in academic neurology: Results of a US national survey.

    abstract::In the current medical climate, medical education is at risk of being de-emphasized, leading to less financial support and compensation for faculty. A rise in compensation plans that reward clinical or research productivity fails to incentivize and threatens to erode the educational missions of our academic institutio...


    pub_type: 杂志文章


    authors: Weber D,Sarva H,Weaver J,Wang F,Chou J,Cornes S,Nickels K,Safdieh JE,Poncelet A,Stern BJ

    更新日期:2019-07-02 00:00:00

  • Magnetic resonance imaging of the head in the diagnosis of multiple sclerosis: a prospective 2-year follow-up with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT.

    abstract::We previously compared the diagnostic capabilities of MRI of the head with CT, evoked potentials, and CSF oligoclonal banding (OB) analysis in a prospective evaluation of 200 patients with suspected multiple sclerosis (MS). To examine the ability of MRI and other paraclinical tests to predict the diagnosis of clinical...


    pub_type: 杂志文章


    authors: Lee KH,Hashimoto SA,Hooge JP,Kastrukoff LF,Oger JJ,Li DK,Paty DW

    更新日期:1991-05-01 00:00:00

  • Osteopenia and osteoporosis in idiopathic benign positional vertigo.

    abstract:OBJECTIVE:Causes of benign positional vertigo (BPV) are mostly unknown. The aim of this study was to elucidate an association of osteoporosis with idiopathic BPV. METHODS:Two hundred nine consecutive patients with a confirmed diagnosis of idiopathic BPV underwent bone mineral densitometry of anterior-posterior lumbar ...


    pub_type: 杂志文章


    authors: Jeong SH,Choi SH,Kim JY,Koo JW,Kim HJ,Kim JS

    更新日期:2009-03-24 00:00:00

  • Daily energy expenditure in free-living non-institutionalized Alzheimer's patients: a doubly labeled water study.

    abstract::Weight loss is common in Alzheimer's disease (AD), but its pathogenesis is poorly understood. It is unclear whether an elevated daily energy expenditure contributes to the weight loss. We tested the hypothesis that daily energy expenditure is higher in AD patients compared to healthy elderly. Thirty AD (73 +/- 8 years...


    pub_type: 杂志文章


    authors: Poehlman ET,Toth MJ,Goran MI,Carpenter WH,Newhouse P,Rosen CJ

    更新日期:1997-04-01 00:00:00

  • Demyelinating neuropathy due to primary IgM kappa B cell lymphoma of peripheral nerve.

    abstract::A 53-year-old man presented with a painful, demyelinating sensorimotor peripheral neuropathy with lymphomatous infiltration on sural nerve biopsy, but no evidence of systemic lymphoma. The neuropathy responded to cytotoxic therapy. Seven years later he developed generalized lymphadenopathy due to B cell lymphoplasmacy...


    pub_type: 杂志文章


    authors: Ince PG,Shaw PJ,Fawcett PR,Bates D

    更新日期:1987-07-01 00:00:00

  • Donepezil and flight simulator performance: effects on retention of complex skills.

    abstract::We report a randomized, double-blind, parallel group, placebo-controlled study to test the effects of the acetylcholinesterase inhibitor, donepezil (5 mg/d for 30 days), on aircraft pilot performance in 18 licensed pilots with mean age of 52 years. After 30 days of treatment, the donepezil group showed greater ability...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Yesavage JA,Mumenthaler MS,Taylor JL,Friedman L,O'Hara R,Sheikh J,Tinklenberg J,Whitehouse PJ

    更新日期:2002-07-09 00:00:00

  • Sex differences in Alzheimer risk: Brain imaging of endocrine vs chronologic aging.

    abstract:OBJECTIVE:This observational multimodality brain imaging study investigates emergence of endophenotypes of late-onset Alzheimer disease (AD) risk during endocrine transition states in a cohort of clinically and cognitively normal women and age-matched men. METHODS:Forty-two 40- to 60-year-old cognitively normal women ...


    pub_type: 杂志文章


    authors: Mosconi L,Berti V,Quinn C,McHugh P,Petrongolo G,Varsavsky I,Osorio RS,Pupi A,Vallabhajosula S,Isaacson RS,de Leon MJ,Brinton RD

    更新日期:2017-09-26 00:00:00

  • Amino-terminal deletion of 53% of dystrophin results in an intermediate Duchenne-Becker muscular dystrophy phenotype.

    abstract::We report a Japanese boy with muscular dystrophy whose clinical symptoms were intermediate between those usually considered typical of Duchenne and Becker muscular dystrophies. The patient had a large inframe deletion extending from exons 3 to 41 of the dystrophin gene, which would be expected to cause the production ...


    pub_type: 杂志文章


    authors: Takeshima Y,Nishio H,Narita N,Wada H,Ishikawa Y,Ishikawa Y,Minami R,Nakamura H,Matsuo M

    更新日期:1994-09-01 00:00:00

  • Aldehyde dehydrogenase variation enhances effect of pesticides associated with Parkinson disease.

    abstract:OBJECTIVE:The objective of this study was to determine whether environmental and genetic alterations of neuronal aldehyde dehydrogenase (ALDH) enzymes were associated with increased Parkinson disease (PD) risk in an epidemiologic study. METHODS:A novel ex vivo assay was developed to identify pesticides that can inhibi...


    pub_type: 杂志文章


    authors: Fitzmaurice AG,Rhodes SL,Cockburn M,Ritz B,Bronstein JM

    更新日期:2014-02-04 00:00:00

  • MS, MRI, and the 2010 McDonald criteria: a Canadian expert commentary.

    abstract::Since the first development of diagnostic criteria for multiple sclerosis (MS), there have been regular revisions of disease definitions and diagnostic thresholds aimed at improving specificity while maintaining sensitivity. The central requirements for diagnosis of MS are dissemination in space (DIS) and disseminatio...


    pub_type: 杂志文章


    authors: Selchen D,Bhan V,Blevins G,Devonshire V,Duquette P,Grand'Maison F,Kremenchutzky M,Lapierre Y,Li D,von Riedemann SJ,Freedman M

    更新日期:2012-12-04 00:00:00

  • Study of hypothalamic metabolism in cluster headache by proton MR spectroscopy.

    abstract::The authors used 1H-MRS to investigate hypothalamic metabolism in 26 patients with cluster headache (CH) and 12 healthy subjects. Hypothalamic N-acetylaspartate/creatine was reduced in patients with CH vs controls (p < 0.01). Dividing the patients into episodic CH outside- and in-cluster periods and chronic CH, the hy...


    pub_type: 杂志文章


    authors: Lodi R,Pierangeli G,Tonon C,Cevoli S,Testa C,Bivona G,Magnifico F,Cortelli P,Montagna P,Barbiroli B

    更新日期:2006-04-25 00:00:00

  • Detection and cellular localization of enterovirus RNA sequences in spinal cord of patients with ALS.

    abstract:OBJECTIVE:To investigate the possible association of persistent enterovirus (EV) infection with the development of ALS. BACKGROUND:Although ALS is a clinically well-defined motor neuron disease, little is known about the etiology and pathogenesis of the sporadic cases. Among the different causes that have been hypothe...


    pub_type: 杂志文章


    authors: Berger MM,Kopp N,Vital C,Redl B,Aymard M,Lina B

    更新日期:2000-01-11 00:00:00

  • Concerns of surrogate decision makers for patients with acute brain injury: A US population survey.

    abstract:OBJECTIVE:To determine whether groups of surrogates for patients with severe acute brain injury (SABI) with poor prognosis can be identified based on their prioritization of goals-of-care (GOC) decisional concerns, an online survey of 1,588 adults recruited via a probability-based panel representative of the US populat...


    pub_type: 杂志文章


    authors: Hwang DY,Knies AK,Mampre D,Kolenikov S,Schalk M,Hammer H,White DB,Holloway RG,Sheth KN,Fraenkel L

    更新日期:2020-05-12 00:00:00