Abstract:
:We studied the effects of 3-methoxy, 4-hydroxy-phenylalanine (3-OM-dopa) on monoamine turnover, L-3-4-dihydroxy-phenylalanine (L-dopa) reversal of catecholamine depletion induced by alpha-methyl-paratyrosine (alpha-MT), and the passage of L-dopa across the blood-brain barrier of the rat brain. 3-OM-dopa did not affect monoamine turnover but interfered with restoration of dopamine levels by L-dopa. In addition, systemic 3-OM-dopa decreased brain uptake of 14C-L-dopa. High 3-OM-dopa blood levels may interfere with the therapeutic response to L-dopa in parkinsonism.
journal_name
Neurologyjournal_title
Neurologyauthors
Gervas JJ,Muradás V,Bazán E,Aguado EG,de Yébenes JGdoi
10.1212/wnl.33.3.278subject
Has Abstractpub_date
1983-03-01 00:00:00pages
278-82issue
3eissn
0028-3878issn
1526-632Xjournal_volume
33pub_type
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