Oral sumatriptan for the long-term treatment of migraine: clinical findings.

abstract：:In Swiss mice, muscimol (3 mg per kilogram, intraperitoneally) caused myoclonic jerks of the hindquarters. These jerks were strong, repetitive, more or less regular, and of high frequency (peak response, 76 per minute). Pretreatment with sodium gamma-hydroxybutyrate (50 to 200 mg per kilogram) caused a dose-dependent ...

journal_title：Neurology

authors： Menon MK

更新日期：1982-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Human herpesvirus 8 (HHV-8) has been found in association with Kaposi's sarcomas in human immunodeficiency virus (HIV)-positive and -negative patients, primary effusion lymphomas (PELs), multicentric Castleman's disease, and multiple myeloma. The PELs share several features with acquired immuno...

journal_title：Neurology

authors： Corboy JR,Garl PJ,Kleinschmidt-DeMasters BK

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVE:To study the prognostic significance of multiple novel biomarkers in combination after ischemic stroke. METHODS:We derived data from the China Antihypertensive Trial in Acute Ischemic Stroke, and 12 informative biomarkers were measured. The primary outcome was the combination of death and major disability (m...

journal_title：Neurology

authors： Zhong C,Zhu Z,Wang A,Xu T,Bu X,Peng H,Yang J,Han L,Chen J,Xu T,Peng Y,Wang J,Li Q,Ju Z,Geng D,He J,Zhang Y

更新日期：2019-01-22 00:00:00

abstract：:We investigated the possible role of potassium deficiency, a recognized cause of myopathy, in the pathogenesis of experimental acute alcoholic myopathy (EAM) in the rat. Alcohol-treated animals receiving the same dietary potassium as controls developed mild hypokalemia; however, muscle potassium was preserved or eleva...

journal_title：Neurology

authors： Haller RG,Carter NW,Ferguson E,Knochel JP

更新日期：1984-04-01 00:00:00

abstract：BACKGROUND:Structural abnormalities were detected in bilateral primary sensorimotor areas in writer's cramp. Evidence in other primary dystonia, including blepharospasm and cervical dystonia, suggest that structural abnormalities may be observed in other brain areas such as the cerebellum in writer's cramp. OBJECTIVE:...

journal_title：Neurology

authors： Delmaire C,Vidailhet M,Elbaz A,Bourdain F,Bleton JP,Sangla S,Meunier S,Terrier A,Lehéricy S

更新日期：2007-07-24 00:00:00

abstract：OBJECTIVES:To estimate patient-acceptable symptom state (PASS) cut points for myasthenia gravis (MG) health scales. METHODS:We conducted an electronic survey that included the Myasthenia Gravis Impairment Index (MGII), EuroQol 5-Dimension (EQ5D), and a simple PASS question. PASS-anchored thresholds were estimated for ...

journal_title：Neurology

authors： Mendoza M,Tran C,Bril V,Katzberg HD,Barnett C

更新日期：2020-09-22 00:00:00

abstract：:The ability of two noninvasive diagnostic methods--oculoplethysmography-carotid phonoangiography (OPG/CPA) and directional Doppler ultrasonography--to detect extracranial cerebrovascular disease was examined in 400 consecutive studies. Cerebral arteriography was performed in 74 patients. Transient ischemic attack was ...

journal_title：Neurology

authors： Ginsberg MD,Greenwood SA,Goldberg HI

更新日期：1979-05-01 00:00:00

abstract：:We studied lymphocyte subsets and major histocompatibility complex (MHC) class II antigens in frozen brain tissues from three patients with subacute sclerosing panencephalitis (SSPE) using immunocytochemical techniques. Perivascular cuffs consisted predominantly of T cells and MHC class II-positive cells. In the paren...

journal_title：Neurology

authors： Nagano I,Nakamura S,Yoshioka M,Kogure K

更新日期：1991-10-01 00:00:00

abstract：:The antimigraine efficacy of many drugs may be mediated less through their primary modes of action than through the common pathway of serotonergic transmission stabilization. Migraine treatment may be symptomatic, acute/abortive, or prophylactic. Because oral drug absorption is impaired during attacks, parenteral agen...

journal_title：Neurology

authors： Raskin NH

更新日期：1993-06-01 00:00:00

abstract：:Migration from an area where MS is common to an area where it is rare (and vice versa) affects the risk of MS, provided migration occurs in childhood. A childhood infection might explain this effect. Therefore, the age pattern of infectious diseases in different regions was examined. A higher proportion of children sh...

journal_title：Neurology

authors： Alter M,Zhang ZX,Davanipour Z,Sobel E,Zibulewski J,Schwartz G,Friday G

更新日期：1986-10-01 00:00:00

abstract：:We studied the effect of deep brain stimulation (DBS) of the ventral intermediate thalamic nucleus on voice symptoms in seven patients with essential tremor. All had undergone DBS for management of hand tremor. Five of the patients had received unilateral implants; two were treated bilaterally. Each reported improveme...

journal_title：Neurology

authors： Carpenter MA,Pahwa R,Miyawaki KL,Wilkinson SB,Searl JP,Koller WC

更新日期：1998-03-01 00:00:00

abstract：:A decade of empirical work in brain imaging, genomics, and other areas of research has yielded new knowledge about the frequency of incidental findings, investigator responsibility, and risks and benefits of disclosure. Straightforward guidance for handling such findings of possible clinical significance, however, has...

journal_title：Neurology

authors： Illes J,Kirschen MP,Edwards E,Bandettini P,Cho MK,Ford PJ,Glover GH,Kulynych J,Macklin R,Michael DB,Wolf SM,Grabowski T,Seto B

更新日期：2008-01-29 00:00:00

abstract：:Stuttering is an action-induced speech disorder with involuntary, audible, or silent repetitions or prolongations in the utterance of short speech elements (sounds, syllables) and words. Symptomatic treatment programs frequently have initial success; persistent benefit is variable and many patients remain disabled. St...

journal_title：Neurology

authors： Brin MF,Stewart C,Blitzer A,Diamond B

更新日期：1994-12-01 00:00:00

abstract：OBJECTIVE:To determine whether comorbidity is associated with clinical (relapses, disability worsening) and MRI outcomes in multiple sclerosis (MS) by conducting a secondary analysis of the CombiRx clinical trial. METHODS:CombiRx compared interferon beta-1a, glatiramer acetate, and the combination of these agents. For...

journal_title：Neurology

authors： Salter A,Kowalec K,Fitzgerald KC,Cutter G,Marrie RA

更新日期：2020-08-04 00:00:00

abstract：:We measured the cerebral metabolic rate for glucose (CMRglc) with positron emission tomography and [18F]2-fluoro-2-deoxy-D-glucose in a 47-year-old man with trisomy 21 Down's syndrome (DS) and autopsy-confirmed Alzheimer's disease. Dementia was evident from a confirmed history of cognitive decline, memory loss, and pe...

journal_title：Neurology

authors： Schapiro MB,Ball MJ,Grady CL,Haxby JV,Kaye JA,Rapoport SI

更新日期：1988-06-01 00:00:00

abstract：OBJECTIVE:Carotid endarterectomy (CEA) is frequently performed based solely on noninvasive vascular imaging (NVI) results (duplex ultrasound, DU; magnetic resonance angiography, MRA; CT angiography, CTA). The authors determined how often intra-arterial contrast angiography (ANGIO) alters a CEA decision as compared to N...

journal_title：Neurology

authors： Johnston DC,Goldstein LB

更新日期：2001-04-24 00:00:00

abstract：OBJECTIVES:To investigate the relationship between markers of vitamin B(12) status and brain volume loss per year over a 5-year period in an elderly population. METHODS:A prospective study of 107 community-dwelling volunteers aged 61 to 87 years without cognitive impairment at enrollment. Volunteers were assessed year...

journal_title：Neurology

authors： Vogiatzoglou A,Refsum H,Johnston C,Smith SM,Bradley KM,de Jager C,Budge MM,Smith AD

更新日期：2008-09-09 00:00:00

abstract：OBJECTIVE:To study the impact of negative expectation related to receiving a placebo (the "lessebo effect") on efficacy outcome measures of symptomatic treatments in Parkinson disease (PD). METHODS:We conducted meta-analyses of double-blind randomized controlled trials (RCTs) of dopamine agonists in PD and compared th...

journal_title：Neurology

authors： Mestre TA,Shah P,Marras C,Tomlinson G,Lang AE

更新日期：2014-04-22 00:00:00

abstract：OBJECTIVE:To determine the association between traumatic brain injury (TBI) and any clinically diagnosed α-synucleinopathy including Parkinson disease (PD), dementia with Lewy bodies (DLB), PD dementia (PDD), and multiple system atrophy (MSA). METHODS:Using the medical records-linkage system of the Rochester Epidemiol...

journal_title：Neurology

authors： Hasan S,Mielke MM,Turcano P,Ahlskog JE,Bower JH,Savica R

更新日期：2020-02-25 00:00:00

abstract：:Mutations in NOTCH3 are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a hereditary angiopathy causing stroke and vascular dementia. All CADASIL mutations identified so far result in the loss or gain of one cysteine residue within epidermal growth fac...

journal_title：Neurology

authors： Dichgans M,Herzog J,Gasser T

更新日期：2001-11-13 00:00:00

abstract：OBJECTIVE:Prospective memory (PM) describes the ability to fulfill previously planned intentions and is highly dependent on executive functions. Previous studies have shown deficits in executive functions in patients with juvenile myoclonic epilepsy (JME) and in their unaffected siblings. JME has a strong genetic predi...

journal_title：Neurology

authors： Wandschneider B,Kopp UA,Kliegel M,Stephani U,Kurlemann G,Janz D,Schmitz B

更新日期：2010-12-14 00:00:00

abstract：:Spinal muscular atrophy (SMA) is the most common fatal neuromuscular disease of infancy. SMA type I is the most severe and mortality is usually due to respiratory failure. In type II the disability is of later onset and less severe, and prognosis has improved primarily due to supportive care. Type III is the mildest f...

journal_title：Neurology

authors： Hirtz D,Iannaccone S,Heemskerk J,Gwinn-Hardy K,Moxley R 3rd,Rowland LP

更新日期：2005-11-08 00:00:00

abstract：:We report the cases of three siblings homozygous for a mutated transthyretin (TTR) gene that causes type I familial amyloidotic polyneuropathy (FAP), in whom we made the diagnosis by identifying both the mutated TTR gene and a variant TTR in their sera. Their serum levels for the variant TTR are twice those of patient...

journal_title：Neurology

authors： Yoshinaga T,Nakazato M,Ikeda S,Ohnishi A

更新日期：1992-10-01 00:00:00

abstract：:INeuro@neurolist.mcg. edu: An e-mail discussion list for neurologists Neuro@neurolist.mcg.edu (Neurolist) is a discussion list for neurologists. This Internet tool, established in 1994, allows the worldwide community of neurologists to communicate quickly and efficiently using e-mail, web browsers, and newsreaders. Ne...

journal_title：Neurology

authors： Rivner MH

更新日期：1999-06-10 00:00:00

abstract：:We detected 29 conduction blocks in 12 patients with hereditary neuropathy and liability to pressure palsies. The blocks occurred at entrapment sites, most often the ulnar nerve at the elbow. Some had lasted for several years. This kind of block seems to be characteristic of the neuropathy, and may be related to the l...

journal_title：Neurology

authors： Magistris MR,Roth G

更新日期：1985-11-01 00:00:00

abstract：:Apraxia is the loss of the ability to perform learned skilled movements correctly. In right-handers, apraxia and aphasia are most frequently associated with left-hemisphere lesions. When they are dissociated, however, aphasia is more common in the absence of apraxia than vice versa. There are two hypotheses that can a...

journal_title：Neurology

authors： Foundas AL,Henchey R,Gilmore RL,Fennell EB,Heilman KM

更新日期：1995-07-01 00:00:00

abstract：OBJECTIVES:Based on the hippocampus disconnection hypothesis in Alzheimer disease (AD), which postulates that uncoupling from cortical inputs contributes to disinhibition-like changes in hippocampus activity, we suggested that in patients with AD, the more the intrinsic functional connectivity between hippocampus and p...

journal_title：Neurology

authors： Tahmasian M,Pasquini L,Scherr M,Meng C,Förster S,Mulej Bratec S,Shi K,Yakushev I,Schwaiger M,Grimmer T,Diehl-Schmid J,Riedl V,Sorg C,Drzezga A

更新日期：2015-05-12 00:00:00

abstract：:It is not known whether the antiepileptic drug (AED) levetiracetam can be used safely in human pregnancy. As part of a study to determine the risks of major congenital malformations (MCMs) for infants exposed to AEDs in utero, we identified all cases exposed to levetiracetam. Three of 117 exposed pregnancies had an MC...

journal_title：Neurology

authors： Hunt S,Craig J,Russell A,Guthrie E,Parsons L,Robertson I,Waddell R,Irwin B,Morrison PJ,Morrow J

更新日期：2006-11-28 00:00:00

abstract：:MRI and CSF investigations revealed meningeal involvement in a 29-year-old patient with biopsy-confirmed Wegener's granulomatosis. The intracranial manifestation of Wegener's granulomatosis was supported by the detection of pathologic circulating antineutrophil cytoplasm (c-ANCA) in the CSF. We monitored disease activ...

journal_title：Neurology

authors： Spranger M,Schwab S,Meinck HM,Tischendorf M,Sis J,Breitbart A,Andrassy K

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:To describe and analyze etiologies, clinical presentations, therapeutic management, and outcomes of patients with acute encephalitis and identify outcome predictors. METHODS:We conducted a retrospective review of patients diagnosed with acute encephalitis at Mayo Clinic Rochester between January 2000 and Dec...

journal_title：Neurology

authors： Singh TD,Fugate JE,Rabinstein AA

更新日期：2015-01-27 00:00:00