Apraxia during Wada testing.


:Apraxia is the loss of the ability to perform learned skilled movements correctly. In right-handers, apraxia and aphasia are most frequently associated with left-hemisphere lesions. When they are dissociated, however, aphasia is more common in the absence of apraxia than vice versa. There are two hypotheses that can account for this discrepancy: (1) in right-handers, praxis is more likely than language to be mediated by the right hemisphere, or (2) the left-hemisphere network that mediates language is either more widely distributed than the network that mediates praxis or is more likely to be in the middle cerebral artery distribution. We studied apraxia in a group of right-handers undergoing selective hemispheric anesthesia, or Wada testing. All nine subjects had language lateralized to the left hemisphere, and seven of the nine had praxis lateralized to the left hemisphere. Two of the subjects had praxis bilaterally represented. Although our data suggest that speech and praxis functions tend to be lateralized to the left hemisphere in most right-handers, praxis appears to be more distributed between the hemispheres than speech-language functions. Furthermore, an analysis of the types of errors made during praxis testing suggests differential roles of the hemispheres in praxis functions.






Foundas AL,Henchey R,Gilmore RL,Fennell EB,Heilman KM




Has Abstract


1995-07-01 00:00:00












  • Myasthenia gravis activities of daily living profile.

    abstract::The authors have developed an MG activities of daily living (ADL) profile (MG-ADL)-a simple eight-question survey of MG symptoms. In 254 consecutive encounters with established MG patients, the authors compared scores from the MG-ADL to the quantitative MG score (QMG)-a standardized, reliable scale used in clinical tr...


    pub_type: 杂志文章


    authors: Wolfe GI,Herbelin L,Nations SP,Foster B,Bryan WW,Barohn RJ

    更新日期:1999-04-22 00:00:00

  • Interaction between HLA-DR2 and abnormal brain MRI in optic neuritis and early MS. Optic Neuritis Study Group.

    abstract::The association of the human leukocyte antigen (HLA)-DR2 allele with brain MRI signal abnormalities and with the development of MS was assessed in 178 patients enrolled in the Optic Neuritis Treatment Trial. HLA haplotype DR2 was present in 85 (48%) of the 178 patients. Its presence was associated with increased odds ...


    pub_type: 杂志文章


    authors: Hauser SL,Oksenberg JR,Lincoln R,Garovoy J,Beck RW,Cole SR,Moke PS,Kip KE,Gal RL,Long DT

    更新日期:2000-05-09 00:00:00

  • Partial epilepsy presenting as focal paroxysmal pain.

    abstract::A 3-year old, previously well child developed paroxysms of left thigh pain. Evaluation was unremarkable except for interictal and postictal EEG epileptiform activity in the right parietal and posterior temporal regions. The painful spells were controlled with anticonvulsant medication. Episodes of paroxysmal, unexplai...


    pub_type: 杂志文章


    authors: Trevathan E,Cascino GD

    更新日期:1988-02-01 00:00:00

  • Spasmodic dysphonia associated with a left ventrolateral putaminal lesion.

    abstract::A 34-year-old man presented with a 30-year history of spasmodic dysphonia. He developed a speech disturbance 1 month after a closed head injury due to a fall. Sighing, coughing, and crying were normal. He had a tremor of the right hand when he drew a vertical line. His out-stretched right hand had a minimal dystonic p...


    pub_type: 杂志文章


    authors: Lee MS,Lee SB,Kim WC

    更新日期:1996-09-01 00:00:00

  • Phenotypic expression of X-linked dystonia-parkinsonism (lubag) in two women.

    abstract::Lubag (X-linked dystonia-parkinsonism) has been considered a sex-linked recessive trait and has been mapped to the pericentromeric region of the X chromosome. We studied a 54-year-old man with lubag and two of his female first cousins. Genetic typing was carried out using X chromosome markers. Fluorodopa PET was perfo...


    pub_type: 杂志文章


    authors: Waters CH,Takahashi H,Wilhelmsen KC,Shubin R,Snow BJ,Nygaard TG,Moskowitz CB,Fahn S,Calne DB

    更新日期:1993-08-01 00:00:00

  • A 1-year controlled trial of acetyl-l-carnitine in early-onset AD.

    abstract:OBJECTIVE:To determine the efficacy of acetyl-l-carnitine (ALCAR) on the rate of decline in early-onset AD patients. METHODS:A 1-year, multicenter, double-blind, placebo-controlled, randomized trial was conducted. Subjects were 45 to 65 years old, with a diagnosis of probable AD according to National Institute of Neur...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Thal LJ,Calvani M,Amato A,Carta A

    更新日期:2000-09-26 00:00:00

  • Cough, exertional, and sexual headaches: an analysis of 72 benign and symptomatic cases.

    abstract::We analyzed our experience with cough, exertional, and vascular sexual headaches, evaluated the interrelationships among them, and examined the possible symptomatic cases. Seventy-two patients consulted us because of headaches precipitated by coughing (n = 30), physical exercise (n = 28), or sexual excitement (n = 14)...


    pub_type: 杂志文章,评审


    authors: Pascual J,Iglesias F,Oterino A,Vázquez-Barquero A,Berciano J

    更新日期:1996-06-01 00:00:00

  • Tapping linked to function and structure in premanifest and symptomatic Huntington disease.

    abstract:OBJECTIVE:Motor signs are functionally disabling features of Huntington disease. Characteristic motor signs define disease manifestation. Their severity and onset are assessed by the Total Motor Score of the Unified Huntington's Disease Rating Scale, a categorical scale limited by interrater variability and insensitivi...


    pub_type: 杂志文章,多中心研究


    authors: Bechtel N,Scahill RI,Rosas HD,Acharya T,van den Bogaard SJ,Jauffret C,Say MJ,Sturrock A,Johnson H,Onorato CE,Salat DH,Durr A,Leavitt BR,Roos RA,Landwehrmeyer GB,Langbehn DR,Stout JC,Tabrizi SJ,Reilmann R

    更新日期:2010-12-14 00:00:00

  • Value of Hu antibody determinations in the follow-up of paraneoplastic neurologic syndromes.

    abstract::The long-term evolution of Hu antibody (Hu-Ab) titers in patients with paraneoplastic neurologic syndromes (PNSs) is not known. Described is the evolution of Hu-Ab titers in 35 patients with PNS with a median follow-up of 32 months (range 6 to 108 months). No correlation was observed between Hu-Ab titers and neurologi...


    pub_type: 杂志文章,评审


    authors: Lladó A,Mannucci P,Carpentier AF,Paris S,Blanco Y,Saiz A,Delattre JY,Graus F

    更新日期:2004-11-23 00:00:00

  • Improvement of motor function in early Parkinson disease by safinamide.

    abstract::A median safinamide (SAF) dose of 70 mg/day (range 40 to 90 mg/day) increased the percentage of parkinsonian patients improving their motor scores by > or =30% from baseline (responders) after 3 months from 21.4% (placebo) to 37.5% (p < 0.05, calculated by logistic regression analysis). In a subgroup of 101 patients u...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Stocchi F,Arnold G,Onofrj M,Kwiecinski H,Szczudlik A,Thomas A,Bonuccelli U,Van Dijk A,Cattaneo C,Sala P,Fariello RG,Safinamide Parkinson's Study Group.

    更新日期:2004-08-24 00:00:00

  • Serum-mediated Schwann cell cytotoxicity in the Guillain-Barré syndrome.

    abstract::To study the anti-Schwann cell activity of serum from patients with Guillain-Barré syndrome (GBS), we used a 51Cr-release cytotoxicity assay. Specific release of 51Cr mediated by GBS serum did not differ from that with normals or disease controls. Heating sera from GBS patients or controls at 56 or 50 degrees C for 30...


    pub_type: 杂志文章


    authors: Lisak RP,Kuchmy D,Armati-Gulson PJ,Brown MJ,Sumner AJ

    更新日期:1984-09-01 00:00:00

  • Multiple sclerosis: magnetic resonance imaging, evoked responses, and spinal fluid electrophoresis.

    abstract::Magnetic resonance images (MRI), evoked responses (ER), and CSF findings were compared in 39 patients with possible, probable, or definite MS. MRI disclosed multiple lesions (72%) more often than ERs (55%) in the total group of patients. In possible MS, MRI showed multiple lesions in 71%, and ER abnormalities were fou...


    pub_type: 杂志文章


    authors: Farlow MR,Markand ON,Edwards MK,Stevens JC,Kolar OJ

    更新日期:1986-06-01 00:00:00

  • 3-O-methyldopa and motor fluctuations in Parkinson's disease.

    abstract::High plasma levels of 3-O-methyldopa (OMD) were found in parkinsonian patients chronically treated with levodopa, particularly in those with on-off phenomenon. However, no relation could be established between circulating levels of the levodopa metabolite and the presence of motor response fluctuations at any stage of...


    pub_type: 杂志文章


    authors: Fabbrini G,Juncos JL,Mouradian MM,Serrati C,Chase TN

    更新日期:1987-05-01 00:00:00

  • Intravenous phenytoin in acute treatment of seizures.

    abstract::Large doses of phenytoin were administered on 159 occasions to 139 adult patients. Most patients had had more than three seizures or were in status epilepticus. Based on response to treatment, patients could be divided into two groups. Those with excellent response (recurrent seizures, 10%; mortality, 1%) included kno...


    pub_type: 杂志文章


    authors: Cranford RE,Leppik IE,Patrick B,Anderson CB,Kostick B

    更新日期:1979-11-01 00:00:00

  • Fulminant encephalopathy with basal ganglia hyperintensities in HIV-infected drug users.

    abstract:OBJECTIVE:To define a clinical syndrome associated with active drug abuse in HIV-infected individuals. METHODS:We performed a retrospective review to identify individuals treated at the Johns Hopkins Hospital from 1993 to 2008 who were HIV-infected and were actively abusing drugs and had bilateral basal ganglia lesion...


    pub_type: 杂志文章


    authors: Newsome SD,Johnson E,Pardo C,McArthur JC,Nath A

    更新日期:2011-03-01 00:00:00

  • Postmenopausal hormone therapy and Alzheimer disease: A prospective cohort study.

    abstract:OBJECTIVE:To explore the association between postmenopausal hormone therapy (HT) and Alzheimer disease (AD). METHODS:Twenty-year follow-up data from the Kuopio Osteoporosis Risk Factor and Prevention study cohort were used. Self-administered questionnaires were sent to all women aged 47-56 years, residing in Kuopio Pr...


    pub_type: 杂志文章


    authors: Imtiaz B,Tuppurainen M,Rikkonen T,Kivipelto M,Soininen H,Kröger H,Tolppanen AM

    更新日期:2017-03-14 00:00:00

  • Guillain-Barré syndrome after epidural anesthesia: direct nerve root damage may trigger disease.

    abstract::Guillain-Barré syndrome (GBS) appeared in four patients 1 to 2 weeks after epidural anesthesia. In all patients, clinical diagnosis was confirmed by CSF findings and nerve conduction velocity studies. Although epidural anesthesia has not been listed as an antecedent event in GBS, evidence for the relationship has been...


    pub_type: 杂志文章


    authors: Steiner I,Argov Z,Cahan C,Abramsky O

    更新日期:1985-10-01 00:00:00

  • Monoamine metabolites in the CSF of epileptic patients.

    abstract::To assess the possible role of amine neurotransmitters in human epilepsy, we measured metabolites of serotonin (5-hydroxyindoleacetic acid [5-HIAA]), dopamine (homovanillic acid [HVA]), and norepinephrine (3-methoxy-4-hydroxyphenylethylene glycol [MHPG]) in the lumbar cerebrospinal fluid (CSF) of patients with partial...


    pub_type: 杂志文章


    authors: Laxer KD,Sourkes TL,Fang TY,Young SN,Gauthier SG,Missala K

    更新日期:1979-08-01 00:00:00

  • Factors influencing osmotic fragility of red blood cells in Duchenne muscular dystrophy.

    abstract::Factors affecting osmotic fragility were studied in red blood cells of patients with Duchenne muscular dystrophy. The mean osmotic fragility (MOF), operationally defined as the NaCl concentration for 50% hemolysis, was found to be higher by 3.63 +/- 0.51 mM in Duchenne cells than in normal cells having an MOF of 60.1 ...


    pub_type: 杂志文章


    authors: Kim HD,Luthra MG,Watts RP,Stern LZ

    更新日期:1980-07-01 00:00:00

  • 3-Methylglutaconic aciduria type I redefined: a syndrome with late-onset leukoencephalopathy.

    abstract:OBJECTIVE:3-Methylglutaconic aciduria type I is a rare inborn error of leucine catabolism. It is thought to present in childhood with nonspecific symptoms; it was even speculated to be a nondisease. The natural course of disease is unknown. METHODS:This is a study on 10 patients with 3-methylglutaconic aciduria type I...


    pub_type: 杂志文章


    authors: Wortmann SB,Kremer BH,Graham A,Willemsen MA,Loupatty FJ,Hogg SL,Engelke UF,Kluijtmans LA,Wanders RJ,Illsinger S,Wilcken B,Cruysberg JR,Das AM,Morava E,Wevers RA

    更新日期:2010-09-21 00:00:00

  • Prevalence of medically diagnosed dementia in a defined United States population: Rochester, Minnesota, January 1, 1975.

    abstract::Using the centralized diagnostic data resource for the population of Rochester, Minnesota, we determined the prevalence of medically diagnosed dementia for this community. There were 289 individuals with dementia who were residing in Rochester on January 1, 1975: 208 women and 81 men. The overall age- and sex-adjusted...


    pub_type: 杂志文章


    authors: Kokmen E,Beard CM,Offord KP,Kurland LT

    更新日期:1989-06-01 00:00:00

  • The functional anatomy of gaze-evoked tinnitus and sustained lateral gaze.

    abstract:OBJECTIVE:To identify neural sites associated with gaze-evoked tinnitus (GET), an unusual condition that may follow cerebellar-pontine angle surgery. METHODS:The authors examined eight patients with GET and used PET to map the neural sites activated by lateral gaze in them and seven age- and sex-matched control subjec...


    pub_type: 杂志文章


    authors: Lockwood AH,Wack DS,Burkard RF,Coad ML,Reyes SA,Arnold SA,Salvi RJ

    更新日期:2001-02-27 00:00:00

  • Insulin increases CSF Abeta42 levels in normal older adults.

    abstract:BACKGROUND:Abnormal insulin metabolism may contribute to the clinical symptoms and pathophysiology of AD. In vitro studies show that insulin enhances the release of beta-amyloid protein (Abeta) or inhibits its degradation, either of which might increase amyloid burden. METHODS:On separate mornings, 16 healthy older ad...


    pub_type: 临床试验,杂志文章


    authors: Watson GS,Peskind ER,Asthana S,Purganan K,Wait C,Chapman D,Schwartz MW,Plymate S,Craft S

    更新日期:2003-06-24 00:00:00

  • APOE epsilon variation in multiple sclerosis susceptibility and disease severity: some answers.

    abstract:BACKGROUND:Previous studies have examined the role of APOE variation in multiple sclerosis (MS), but have lacked the statistical power to detect modest genetic influences on risk and disease severity. The meta- and pooled analyses presented here utilize the largest collection, to date, of MS cases, controls, and famili...


    pub_type: 杂志文章,meta分析


    authors: Burwick RM,Ramsay PP,Haines JL,Hauser SL,Oksenberg JR,Pericak-Vance MA,Schmidt S,Compston A,Sawcer S,Cittadella R,Savettieri G,Quattrone A,Polman CH,Uitdehaag BM,Zwemmer JN,Hawkins CP,Ollier WE,Weatherby S,Enzinger C

    更新日期:2006-05-09 00:00:00

  • Correlates of posttraumatic epilepsy 35 years following combat brain injury.

    abstract:BACKGROUND:The Vietnam Head Injury Study (VHIS) is a prospective, longitudinal follow-up of 1,221 Vietnam War veterans with mostly penetrating head injuries (PHIs). The high prevalence (45%-53%) of posttraumatic epilepsy (PTE) in this unique cohort makes it valuable for study. METHODS:A standardized multidisciplinary ...


    pub_type: 杂志文章


    authors: Raymont V,Salazar AM,Lipsky R,Goldman D,Tasick G,Grafman J

    更新日期:2010-07-20 00:00:00

  • Structural brain imaging and multivariate analysis enable virtual lumbar punctures.

    abstract::Functional brain imaging has been a standard tool in the basic and clinical neurosciences for at least 2 decades, and structural brain imaging can claim an even longer track record of successful use for diagnosis of neurodegenerative disease. It is instructive to recall the ways in which brain imaging has been used to...


    pub_type: 评论,社论


    authors: Habeck C,Whitwell JL

    更新日期:2013-01-08 00:00:00

  • Cardiac injury associated with neurogenic pulmonary edema following subarachnoid hemorrhage.

    abstract:OBJECTIVE:To describe the clinical features of cardiac injury associated with neurogenic pulmonary edema (NPE) in patients with acute subarachnoid hemorrhage (SAH). BACKGROUND:NPE is generally viewed as a form of noncardiogenic pulmonary edema related to massive sympathetic discharge. METHODS:Case series. RESULTS:We...


    pub_type: 杂志文章


    authors: Mayer SA,Fink ME,Homma S,Sherman D,LiMandri G,Lennihan L,Solomon RA,Klebanoff LM,Beckford A,Raps EC

    更新日期:1994-05-01 00:00:00

  • Central nervous system involvement in dengue: a study in fatal cases from a dengue endemic area.

    abstract:OBJECTIVE:This study aimed to determine the frequency of CNS infection by dengue virus (DENV) in individuals with fatal outcomes. METHODS:Samples of 150 individuals suspect of an infection disease and with fatal outcomes were investigated for evidence of the presence of DENV. The sampling was made up of 150 CSF, 120 t...


    pub_type: 杂志文章


    authors: Araújo FM,Araújo MS,Nogueira RM,Brilhante RS,Oliveira DN,Rocha MF,Cordeiro RA,Araújo RM,Sidrim JJ

    更新日期:2012-03-06 00:00:00

  • Localizing value of torsional nystagmus in small midbrain lesions.

    abstract:BACKGROUND:The topodiagnostic value and specificity of nystagmus in patients with mesencephalic lesions and its relation to tonic torsional deficits and vertical saccade deficits is controversial and anecdotal. METHODS:The authors examined 11 patients with vascular MRI-identified mesencephalic lesions and clinical evi...


    pub_type: 临床试验,杂志文章


    authors: Helmchen C,Rambold H,Kempermann U,Büttner-Ennever JA,Büttner U

    更新日期:2002-12-24 00:00:00

  • Psychological stress as risk factor for exacerbations in multiple sclerosis.

    abstract::We prospectively evaluated the relationship between a common psychological stressor and relapses in multiple sclerosis (MS) in a group of 32 MS patients exposed to the threat of missile attacks during the Persian Gulf War of 1991. The number of relapses during the war and the following 2 months was significantly lower...


    pub_type: 杂志文章


    authors: Nisipeanu P,Korczyn AD

    更新日期:1993-07-01 00:00:00