Abstract:
:We carried out an open study of the effects of large doses (12 to 16 gm per day) of oral choline on medically intractable human complex partial seizures (CPS). Marked increases of plasma choline concentration (75 to 300%) in three subjects were associated with (1) shorter duration of CPS, (2) less postseizure fatigue, and (3) slight increase of seizure frequency. Both the patients and their families considered the patients much improved. No differences in any of these evaluations were noted in a fourth subject who had less of an increase (21%) of plasma choline content. The results suggest that oral choline therapy may be a useful adjunct in the treatment of intractable CPS. A blinded prospective study will be necessary to assess this possibility.
journal_name
Neurologyjournal_title
Neurologyauthors
McNamara JO,Carwile S,Hope V,Luther J,Miller Pdoi
10.1212/wnl.30.12.1334subject
Has Abstractpub_date
1980-12-01 00:00:00pages
1334-6issue
12eissn
0028-3878issn
1526-632Xjournal_volume
30pub_type
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