Study of the afferent pathways from the rectum with a new distention control device.


:Quantitative studies of the afferent pathways from hollow viscera have been limited by the lack of an easily controlled, reproducible visceral stimulus. We adapted a slow distention device to allow for rapid distention to study the afferent pathways from the rectum. The device produced a pressure increase of 10 mm Hg in 42 msec and of 20 mm Hg in 60 msec. We recorded cerebral evoked potentials (EPs) after rectal balloon distention in 17 healthy subjects. Several averages of 25 to 50 rectal distentions at 0.17-Hz frequency were recorded. The responses consisted of multiple peaks within 200 msec after stimulation. The mean latency of the initial positive peak was 44 msec, suggesting that a myelinated pathway was stimulated with mechanical rectal distention. Our device produced reliable and repeatable EPs that were independent of balloon characteristics or rectal pressures. EP recording after rectal stimulation may become a useful technique for the physiologic investigation of disorders such as fecal incontinence, constipation, irritable bowel syndrome, and chronic intestinal pseudo-obstruction.






Loening-Baucke V,Anderson RH,Yamada T,Zhu YX




Has Abstract


1995-08-01 00:00:00












  • Headache types and panic disorder: directionality and specificity.

    abstract:OBJECTIVE:To examine the relationship of migraine and other severe headaches with panic disorder. METHODS:Representative samples of persons with migraine, non-migrainous severe headaches, and controls with no history of severe headaches, identified by a telephone survey, were interviewed in person, using a standardize...


    pub_type: 杂志文章


    authors: Breslau N,Schultz LR,Stewart WF,Lipton R,Welch KM

    更新日期:2001-02-13 00:00:00

  • Endothelial progenitor cells correlate with lesion volume and growth in acute stroke.

    abstract:OBJECTIVES:Circulating endothelial progenitor cells (EPC) are markers of vascular injury and their numbers decrease in acute stroke. However, the relation of EPC levels to stroke severity has not been quantified. MRI measurements of lesion volume provide an objective method for stroke severity assessment and outcome pr...


    pub_type: 杂志文章


    authors: Bogoslovsky T,Chaudhry A,Latour L,Maric D,Luby M,Spatz M,Frank J,Warach S

    更新日期:2010-12-07 00:00:00

  • Neural stem/progenitors and glioma stem-like cells have differential sensitivity to chemotherapy.

    abstract:OBJECTIVES:New data suggest that glioma stem-like cells (GSCs) and neural stem/progenitor cells (NSCs) may share common origins. GSCs drive tumor proliferation and appear to be resistant to classic chemotherapy, while the effects of chemotherapy on NSCs are not well studied. As the role of NSCs in learning and memory i...


    pub_type: 杂志文章


    authors: Gong X,Schwartz PH,Linskey ME,Bota DA

    更新日期:2011-03-29 00:00:00

  • Current treatment pathways in ALS: a European perspective.

    abstract::This article presents the findings relating to the European subgroup of 91 patients in an international survey of the current diagnosis and treatment of patients with amyotrophic lateral sclerosis (ALS). The mean time between first symptoms and first consultation with a physician was 4.9 months, and mean delay in seei...


    pub_type: 杂志文章


    authors: Dengler R

    更新日期:1999-01-01 00:00:00

  • Weekly alcohol consumption, cigarette smoking, and the risk of ischemic stroke: results of a case-control study at three urban medical centers in Chicago, Illinois.

    abstract::To assess the role of current weekly alcohol consumption as a risk factor for cerebral infarction, we administered a pretested questionnaire to 205 middle-aged and elderly acute ischemic stroke patients and 410 outpatient controls matched by age, sex, race, and method of hospital payment. The frequency of hypertension...


    pub_type: 杂志文章


    authors: Gorelick PB,Rodin MB,Langenberg P,Hier DB,Costigan J

    更新日期:1989-03-01 00:00:00

  • A new explanation for recessive myotonia congenita: exon deletions and duplications in CLCN1.

    abstract:OBJECTIVE:To assess whether exon deletions or duplications in CLCN1 are associated with recessive myotonia congenita (MC). METHODS:We performed detailed clinical and electrophysiologic characterization in 60 patients with phenotypes consistent with MC. DNA sequencing of CLCN1 followed by multiplex ligation-dependent p...


    pub_type: 杂志文章


    authors: Raja Rayan DL,Haworth A,Sud R,Matthews E,Fialho D,Burge J,Portaro S,Schorge S,Tuin K,Lunt P,McEntagart M,Toscano A,Davis MB,Hanna MG

    更新日期:2012-06-12 00:00:00

  • EEG in cough syncope.

    abstract::In 17 patients with cough syncope, electroencephalograms showed normal interictal recordings in 12 patients, minimally abnormal recordings in 4, and a moderately abnormal recording in 1. Fourteen episodes of cough syncope (six patients) were recorded, with the EEGs showing diffuse theta and delta slowing during the ep...


    pub_type: 杂志文章


    authors: DeMaria AA Jr,Westmoreland BF,Sharbrough FW

    更新日期:1984-03-01 00:00:00

  • Patterns of progression in patients with recurrent glioblastoma treated with bevacizumab.

    abstract:OBJECTIVE:We evaluated patterns of tumor progression in patients with recurrent glioblastoma who were treated with bevacizumab (BEV) alone or in combination with irinotecan (CPT-11) while participating in the BRAIN study. METHODS:An independent neuroradiologist reviewed MRI scans at baseline and progression in patient...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Pope WB,Xia Q,Paton VE,Das A,Hambleton J,Kim HJ,Huo J,Brown MS,Goldin J,Cloughesy T

    更新日期:2011-02-01 00:00:00

  • Expanding the clinical spectrum of POMT1 phenotype.

    abstract::Mutations in POMT1 have been identified in Walker-Warburg syndrome and in patients with limb-girdle muscular dystrophy and mental retardation (LGMD2K). The authors report new POMT1 mutations in three unrelated children with severe motor impairment, leg hypertrophy, and mental retardation but without brain and ocular m...


    pub_type: 杂志文章


    authors: D'Amico A,Tessa A,Bruno C,Petrini S,Biancheri R,Pane M,Pedemonte M,Ricci E,Falace A,Rossi A,Mercuri E,Santorelli FM,Bertini E

    更新日期:2006-05-23 00:00:00

  • Natural history of nonketotic hyperglycinemia in 65 patients.

    abstract:BACKGROUND:Glycine encephalopathy, also known as nonketotic hyperglycinemia (NKH), is an autosomal recessive disorder caused by a defect in the glycine cleavage system. NKH is classically associated with neonatal apnea, lethargy, hypotonia, and seizures, followed by severe psychomotor retardation in those who survive. ...


    pub_type: 杂志文章


    authors: Hoover-Fong JE,Shah S,Van Hove JL,Applegarth D,Toone J,Hamosh A

    更新日期:2004-11-23 00:00:00

  • Serum levels of alpha-tocopherol (vitamin E) in Parkinson's disease.

    abstract::To elucidate the possible role of vitamin E in the pathogenesis of Parkinson's disease (PD), we compared serum levels of alpha-tocopherol (vitamin E), measured by high-performance liquid chromatography, and the vitamin E/cholesterol ratio of 42 Parkinson's disease (PD) patients using their spouses as the control group...


    pub_type: 杂志文章


    authors: Férnandez-Calle P,Molina JA,Jiménez-Jiménez FJ,Vázquez A,Pondal M,García-Ruiz PJ,Urra DG,Domingo J,Codoceo R

    更新日期:1992-05-01 00:00:00

  • Cervical epidural abscess.

    abstract::We present 3 new cases of cervical epidural abscess (CEA), a rare condition, along with a review of 12 other case reports. The average patient age was 45 years; just over half were male. The abscesses usually involved the mid to lower cervical region and extended an average of three to four segments. Neck stiffness wa...


    pub_type: 杂志文章,评审


    authors: Lasker BR,Harter DH

    更新日期:1987-11-01 00:00:00

  • Familial frontotemporal dementia with ubiquitin-positive, tau-negative inclusions.

    abstract:OBJECTIVE:To describe the clinical features, neuropathology, and genetic studies in a family with autosomal dominant frontotemporal dementia (FTD). BACKGROUND:Clinical Pick's disease, or FTD with parkinsonism, has been described in several families linked to chromosome 17 (FTDP-17). Most of these have shown tau protei...


    pub_type: 杂志文章


    authors: Kertesz A,Kawarai T,Rogaeva E,St George-Hyslop P,Poorkaj P,Bird TD,Munoz DG

    更新日期:2000-02-22 00:00:00

  • Prospective study of new-onset seizures presenting as status epilepticus in childhood.

    abstract:OBJECTIVE:To characterize children with new-onset seizures presenting as status epilepticus at a tertiary care children's hospital. METHODS:Prospectively collected data were reviewed from a database derived from a mandated critical care pathway. A total of 1,382 patients presented with new-onset seizures between 2001 ...


    pub_type: 杂志文章


    authors: Singh RK,Stephens S,Berl MM,Chang T,Brown K,Vezina LG,Gaillard WD

    更新日期:2010-02-23 00:00:00

  • Serum trihexyphenidyl levels in the treatment of torsion dystonia.

    abstract::Using a radioreceptor technique, we assayed serum trihexyphenidyl levels in patients with dystonia being treated chronically with high dosage. We found a significant correlation between total daily dose and the daily lowest (trough) serum levels. There was no relationship between serum levels and therapeutic response ...


    pub_type: 杂志文章


    authors: Burke RE,Fahn S

    更新日期:1985-07-01 00:00:00

  • Age-associated leukoaraiosis and cortical cholinergic deafferentation.

    abstract:OBJECTIVE:To investigate the relationship between age-associated MRI leukoaraiosis or white matter hyperintensities (WMH) and cortical acetylcholinesterase (AChE) activity. BACKGROUND:One possible mechanism of cognitive decline in elderly individuals with leukoaraiosis is disruption of cholinergic fibers by strategica...


    pub_type: 杂志文章


    authors: Bohnen NI,Müller ML,Kuwabara H,Constantine GM,Studenski SA

    更新日期:2009-04-21 00:00:00

  • Nonsteroidal anti-inflammatory drugs are associated with increased neuritic plaques.

    abstract:OBJECTIVES:Observational and experimental studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs) may protect against Alzheimer disease (AD); however, clinical trials and other observational studies, including the Adult Changes in Thought (ACT) study, show no protection or promotion of AD. The objective of t...


    pub_type: 杂志文章


    authors: Sonnen JA,Larson EB,Walker RL,Haneuse S,Crane PK,Gray SL,Breitner JC,Montine TJ

    更新日期:2010-09-28 00:00:00

  • Search for cytomegalovirus and herpes simplex virus genetic information in multiple sclerosis.

    abstract::Human cytomegalovirus and herpes simplex virus DNA probes were labeled in vitro and hybridized to the DNA extracted from brains of patients with multiple sclerosis (MS) to detect the presence of genetic information related to these viruses. We were unable to detect any virus-related genetic information complementary t...


    pub_type: 杂志文章


    authors: Aulakh GS,Albrecht P,Tourtellotte WW

    更新日期:1980-05-01 00:00:00

  • Parental sex effect in familial amyotrophic lateral sclerosis.

    abstract::Since a parental sex effect has been reported in Huntington's disease, we looked to see whether a similar effect is apparent in adult (autosomal dominant) familial ALS. We analyzed the data for 145 patients, with an onset age range of 20 to 68 years and a known affected parent (AP), from 52 families described in the l...


    pub_type: 杂志文章,评审


    authors: Leone M

    更新日期:1991-08-01 00:00:00

  • Search for autonomously proliferating spinal fluid lymphocytes in patients with multiple sclerosis.

    abstract::Recently published reports have suggested that multiple sclerosis (MS) may be associated with human retrovirus infection. Indeed, an autonomously proliferating T-cell clone was isolated from the CSF of an MS patient, an observation interpreted as indicating an infection with human T lymphotropic virus I (HTLV I). In v...


    pub_type: 杂志文章


    authors: Birnbaum G,Aubitz S,Kotilinek L

    更新日期:1988-01-01 00:00:00

  • Summary of evidence-based guideline: complementary and alternative medicine in multiple sclerosis: report of the guideline development subcommittee of the American Academy of Neurology.

    abstract:OBJECTIVE:To develop evidence-based recommendations for complementary and alternative medicine (CAM) in multiple sclerosis (MS). METHODS:We searched the literature (1970-March 2011; March 2011-September 2013 MEDLINE search), classified articles, and linked recommendations to evidence. RESULTS AND RECOMMENDATIONS:Clin...


    pub_type: 杂志文章,meta分析


    authors: Yadav V,Bever C Jr,Bowen J,Bowling A,Weinstock-Guttman B,Cameron M,Bourdette D,Gronseth GS,Narayanaswami P

    更新日期:2014-03-25 00:00:00

  • Hemispatial and directional performance biases in motor neglect.

    abstract::Motivationally responsive motor deficits may occur in isolation or as part of more general neglect syndromes. We describe three patients with two discrete syndromes of isolated motor neglect, differentiated primarily by their performance in motor tasks enacted within or toward the contralesional hemispace. The lesions...


    pub_type: 杂志文章


    authors: Simon ES,Hegarty AM,Mehler MF

    更新日期:1995-03-01 00:00:00

  • Ophthalmologic features of Parkinson's disease.

    abstract::Patients with Parkinson's disease (PD) commonly complain of impaired visual function and difficulty reading, despite normal visual acuity. Although previous studies have evaluated contrast sensitivity, color vision, visuospatial processing, visual hallucinations, and ocular movements, none has systematically evaluated...


    pub_type: 杂志文章


    authors: Biousse V,Skibell BC,Watts RL,Loupe DN,Drews-Botsch C,Newman NJ

    更新日期:2004-01-27 00:00:00

  • Motor fibers in the sural nerve of humans.

    abstract::Although motor fibers in the sural nerve were already described in three individuals, this nerve is considered purely sensory. We investigated the occurrence of motor fibers in 331 sural nerves of 207 individuals. We found motor fibers in 15 nerves (4.5%) or in 13 individuals (6.2%). The identification of motor fibers...


    pub_type: 杂志文章


    authors: Amoiridis G,Schöls L,Ameridis N,Przuntek H

    更新日期:1997-12-01 00:00:00

  • Lambert-Eaton myasthenic syndrome: electrodiagnostic findings and response to treatment.

    abstract::The authors reviewed the incidence of cancer, repetitive nerve stimulation findings, and response to treatment in 73 patients with Lambert-Eaton myasthenic syndrome. Thirty-one patients (42%) had lung cancer, 29 small cell. Doubling of the compound motor action potential amplitude in three tested distal muscles was se...


    pub_type: 杂志文章


    authors: Tim RW,Massey JM,Sanders DB

    更新日期:2000-06-13 00:00:00

  • Movement disorders in alcoholism: a review.

    abstract::A wide variety of movement disorders are associated with alcohol abuse. Some idiopathic movement disorders are markedly improved by small amounts of alcohol and this response occasionally may lead to alcoholism. Alcohol abuse alone or combined with hepatic encephalopathy can cause various types of tremor, asterixis, a...


    pub_type: 杂志文章,评审


    authors: Neiman J,Lang AE,Fornazzari L,Carlen PL

    更新日期:1990-05-01 00:00:00

  • Charcot-Marie-Tooth disease type 2 with restless legs syndrome.

    abstract::In a series of 44 consecutive patients with Charcot-Marie-Tooth disease (CMT), we found restless legs syndrome (RLS) in 10 of 27 CMT type 2 (CMT2) patients (37%) and in none of 17 CMT type 1 patients (p = 0.004). In the CMT2 patients, RLS was associated with positive sensory symptoms (10/10 versus 10/17; p = 0.026). T...


    pub_type: 杂志文章


    authors: Gemignani F,Marbini A,Di Giovanni G,Salih S,Terzano MG

    更新日期:1999-03-23 00:00:00

  • Disconnection as a mechanism for social cognition impairment in multiple sclerosis.

    abstract:OBJECTIVE:To assess the contribution of microstructural normal-appearing white matter (NAWM) damage to social cognition impairment, specifically in the theory of mind (ToM), in multiple sclerosis (MS). METHODS:We enrolled consecutively 60 patients with MS and 60 healthy controls (HC) matched on age, sex, and education...


    pub_type: 杂志文章


    authors: Batista S,Alves C,d'Almeida OC,Afonso A,Félix-Morais R,Pereira J,Macário C,Sousa L,Castelo-Branco M,Santana I,Cunha L

    更新日期:2017-07-04 00:00:00

  • Corticospinal excitability in human sleep as assessed by transcranial magnetic stimulation.

    abstract::The excitability of the corticospinal system was studied in 23 healthy subjects in sleep stages NREM2, NREM4, REM, and wakefulness using transcranial magnetic stimulation. Assessment of motor thresholds, stimulus-response curves, and latencies of motor evoked potentials shows activation of the fast-conducting corticos...


    pub_type: 临床试验,杂志文章


    authors: Grosse P,Khatami R,Salih F,Kühn A,Meyer BU

    更新日期:2002-12-24 00:00:00

  • Double-blind, randomized, placebo-controlled study of oral, high-dose methylprednisolone in attacks of MS.

    abstract:OBJECTIVE:There is only limited evidence from adequately controlled clinical trials to support high-dose methylprednisolone therapy for attacks of multiple sclerosis (MS) and none supporting oral administration. We assessed the effect of oral high-dose methylprednisolone therapy in attacks of MS. METHODS:Twenty-five p...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sellebjerg F,Frederiksen JL,Nielsen PM,Olesen J

    更新日期:1998-08-01 00:00:00