Study of the afferent pathways from the rectum with a new distention control device.


:Quantitative studies of the afferent pathways from hollow viscera have been limited by the lack of an easily controlled, reproducible visceral stimulus. We adapted a slow distention device to allow for rapid distention to study the afferent pathways from the rectum. The device produced a pressure increase of 10 mm Hg in 42 msec and of 20 mm Hg in 60 msec. We recorded cerebral evoked potentials (EPs) after rectal balloon distention in 17 healthy subjects. Several averages of 25 to 50 rectal distentions at 0.17-Hz frequency were recorded. The responses consisted of multiple peaks within 200 msec after stimulation. The mean latency of the initial positive peak was 44 msec, suggesting that a myelinated pathway was stimulated with mechanical rectal distention. Our device produced reliable and repeatable EPs that were independent of balloon characteristics or rectal pressures. EP recording after rectal stimulation may become a useful technique for the physiologic investigation of disorders such as fecal incontinence, constipation, irritable bowel syndrome, and chronic intestinal pseudo-obstruction.






Loening-Baucke V,Anderson RH,Yamada T,Zhu YX




Has Abstract


1995-08-01 00:00:00












  • Evidence for a genetic predisposition for status epilepticus.

    abstract::The role of genetic factors in determining risk for status epilepticus (SE) was examined in twins identified using the population-based Virginia Twin Registry. Concordance rates for SE were 0.38 for monozygotic (MZ) and 0.00 for dizygotic (DZ) twins, with the rate in MZs being significantly increased over DZs. The pre...


    pub_type: 杂志文章


    authors: Corey LA,Pellock JM,Boggs JG,Miller LL,DeLorenzo RJ

    更新日期:1998-02-01 00:00:00

  • Effects of intermittent levetiracetam dosing in a patient with refractory daily seizures.

    abstract::Some epilepsy patients quickly develop resistance to antiepileptic drugs (AEDs). We report a case of a patient with refractory epilepsy with daily seizures who initially responded to levetiracetam daily therapy, but then returned to baseline seizure frequency. However, when levetiracetam was given once weekly, the pat...


    pub_type: 杂志文章


    authors: Friedman D,French JA

    更新日期:2006-02-28 00:00:00

  • Amygdala and hippocampal volumes in children with Down syndrome: a high-resolution MRI study.

    abstract::The objective of this study was to use high-resolution MRI techniques to determine whether children with Down syndrome exhibit decreases in hippocampal and amygdala volumes similar to those demonstrated in recent studies of adults with this condition. When corrected for overall brain volumes, amygdala volumes did not ...


    pub_type: 杂志文章


    authors: Pinter JD,Brown WE,Eliez S,Schmitt JE,Capone GT,Reiss AL

    更新日期:2001-04-10 00:00:00

  • Prospective natural history study of C9orf72 ALS clinical characteristics and biomarkers.

    abstract:OBJECTIVE:To define the natural history of the C9orf72 amyotrophic lateral sclerosis (C9ALS) patient population, develop disease biomarkers, and characterize patient pathologies. METHODS:We prospectively collected clinical and demographic data from 116 symptomatic C9ALS and 12 non-amyotrophic lateral sclerosis (ALS) f...


    pub_type: 杂志文章


    authors: Cammack AJ,Atassi N,Hyman T,van den Berg LH,Harms M,Baloh RH,Brown RH,van Es MA,Veldink JH,de Vries BS,Rothstein JD,Drain C,Jockel-Balsarotti J,Malcolm A,Boodram S,Salter A,Wightman N,Yu H,Sherman AV,Esparza TJ,Mc

    更新日期:2019-10-22 00:00:00

  • Hughlings Jackson's clinical research: evidence from contemporary documents.

    abstract::Because Hughlings Jackson directed that his personal documents be destroyed upon his death, none of his own clinical records are known. However, we have discovered several pages of notes in the Royal London Hospital Archive written in 1893 by Jackson to his House Physician at Queen Square concerning his proposals for ...


    pub_type: 传,历史文章,杂志文章


    authors: Swash M,Evans J

    更新日期:2006-08-22 00:00:00

  • Brain atrophy and lesion load in a large population of patients with multiple sclerosis.

    abstract:OBJECTIVE:To measure white matter (WM) and gray matter (GM) atrophy and lesion load in a large population of patients with multiple sclerosis (MS) using a fully automated, operator-independent, multiparametric segmentation method. METHODS:The study population consisted of 597 patients with MS and 104 control subjects....


    pub_type: 杂志文章


    authors: Tedeschi G,Lavorgna L,Russo P,Prinster A,Dinacci D,Savettieri G,Quattrone A,Livrea P,Messina C,Reggio A,Bresciamorra V,Orefice G,Paciello M,Brunetti A,Coniglio G,Bonavita S,Di Costanzo A,Bellacosa A,Valentino P,Quar

    更新日期:2005-07-26 00:00:00

  • Coexistence of Lambert-Eaton myasthenic syndrome and subacute cerebellar degeneration: differential effects of treatment.

    abstract::A 61-year-old woman presented with two paraneoplastic neurologic disorders--Lambert-Eaton myasthenic syndrome (LEMS) and subacute cerebellar degeneration (SCD)--that antedated the diagnosis of small-cell carcinoma of the lung by 15 months. Plasmapheresis initiated before the identification of the tumor had a beneficia...


    pub_type: 杂志文章


    authors: Blumenfeld AM,Recht LD,Chad DA,DeGirolami U,Griffin T,Jaeckle KA

    更新日期:1991-10-01 00:00:00

  • Recent advances in the treatment of orthostatic hypotension.

    abstract::Orthostatic hypotension is a fall in blood pressure on standing that causes symptoms of dizziness, visual changes, and discomfort in the head and neck. The goal of treatment is the improvement of the patient's functional capacity, rather than a target blood pressure. For treatment to be successful, it must be individu...


    pub_type: 杂志文章,评审


    authors: Robertson D,Davis TL

    更新日期:1995-04-01 00:00:00

  • Pontine anosognosia for hemiplegia.

    abstract::Four patients had anosognosia for hemiplegia (AHP) as a manifestation of pontine infarction in the mediolateral region. Patients with AHP syndrome had no mental and neuropsychologic disturbances, and all had involvement of the medial or lateral part of the pons (medial or lateral pontine reticular nuclei). Brainstem l...


    pub_type: 杂志文章


    authors: Evyapan D,Kumral E

    更新日期:1999-08-11 00:00:00

  • Spinal muscular atrophy is not the result of mutations at the beta-hexosaminidase or GM2-activator locus.

    abstract::The disease locus for the clinically heterogeneous childhood spinal muscular atrophies (SMA) maps to the chromosome 5 subregion, 5q11.2-13.3. The beta-subunit of beta-D-N-acetylhexosaminidase (hexosaminidase) (EC (Hex B) maps to the same region, and the protein required for substrate recognition by this enzy...


    pub_type: 杂志文章


    authors: Kleyn PW,Brzustowicz LM,Wilhelmsen KC,Freimer NB,Miller JM,Munsat TL,Gilliam TC

    更新日期:1991-09-01 00:00:00

  • Focused ultrasound thalamotomy in Parkinson disease: Nonmotor outcomes and quality of life.

    abstract:OBJECTIVE:To examine nonmotor outcomes and correlates of quality of life (QoL) 3 and 12 months after unilateral focused ultrasound thalamotomy in tremor-dominant Parkinson disease (TDPD). METHODS:Twenty-seven patients with TDPD in a double-blind, sham-controlled, randomized clinical trial underwent comprehensive neuro...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Sperling SA,Shah BB,Barrett MJ,Bond AE,Huss DS,Gonzalez Mejia JA,Elias WJ

    更新日期:2018-10-02 00:00:00

  • Familial frontotemporal dementia with ubiquitin-positive, tau-negative inclusions.

    abstract:OBJECTIVE:To describe the clinical features, neuropathology, and genetic studies in a family with autosomal dominant frontotemporal dementia (FTD). BACKGROUND:Clinical Pick's disease, or FTD with parkinsonism, has been described in several families linked to chromosome 17 (FTDP-17). Most of these have shown tau protei...


    pub_type: 杂志文章


    authors: Kertesz A,Kawarai T,Rogaeva E,St George-Hyslop P,Poorkaj P,Bird TD,Munoz DG

    更新日期:2000-02-22 00:00:00

  • NT-proBNP, blood pressure, and cognitive decline in the oldest old: The Leiden 85-plus Study.

    abstract:OBJECTIVE:To study the relation between N-terminal pro-brain natriuretic peptide (NT-proBNP) levels, used as a marker of heart failure in clinical practice, blood pressure (BP), and cognitive decline in the oldest old. METHODS:In 560 participants of the Leiden 85-plus Study, we measured NT-proBNP levels and BP at age ...


    pub_type: 杂志文章


    authors: van Vliet P,Sabayan B,Wijsman LW,Poortvliet RK,Mooijaart SP,de Ruijter W,Gussekloo J,de Craen AJ,Westendorp RG

    更新日期:2014-09-23 00:00:00

  • Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 200-, 400-, and 600-mg daily dosages. Topiramate YD Study Group.

    abstract::We conducted a randomized double-blind comparison of three doses of the novel antiepileptic drug (AED) topiramate (200, 400, and 600 mg/day) and placebo as adjunctive therapy in patients with refractory partial onset epilepsy receiving one or two other AEDs at therapeutic concentrations. A total of 181 patients comple...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Faught E,Wilder BJ,Ramsay RE,Reife RA,Kramer LD,Pledger GW,Karim RM

    更新日期:1996-06-01 00:00:00

  • Associations with autoimmune disorders and HLA class I and II antigens in inclusion body myositis.

    abstract::Whether autoimmune mechanisms play a role in the pathogenesis of inclusion body myositis (IBM) is unknown. Human leukocyte antigen (HLA) analysis in 52 patients, including 17 with autoimmune disorders (AIDs), showed that patients were more likely to have antigens from the autoimmune-prone HLA-B8-DR3 ancestral haplotyp...


    pub_type: 杂志文章


    authors: Badrising UA,Schreuder GM,Giphart MJ,Geleijns K,Verschuuren JJ,Wintzen AR,Maat-Schieman ML,van Doorn P,van Engelen BG,Faber CG,Hoogendijk JE,de Jager AE,Koehler PJ,de Visser M,van Duinen SG,Dutch IBM Study Group.

    更新日期:2004-12-28 00:00:00

  • Alexander disease: ventricular garlands and abnormalities of the medulla and spinal cord.

    abstract:BACKGROUND:Alexander disease is most commonly associated with macrocephaly and, on MRI, a leukoencephalopathy with frontal preponderance. The disease is caused by mutation of the GFAP gene. Clinical and MRI phenotypic variation have been increasingly recognized. METHODS:The authors studied seven patients with Alexande...


    pub_type: 杂志文章


    authors: van der Knaap MS,Ramesh V,Schiffmann R,Blaser S,Kyllerman M,Gholkar A,Ellison DW,van der Voorn JP,van Dooren SJ,Jakobs C,Barkhof F,Salomons GS

    更新日期:2006-02-28 00:00:00

  • How did stroke become of interest to neurologists?: a slow 19th century saga.

    abstract::It was not until the first half of the 19th century that the vascular nature of strokes was readily recognized and accepted. Brain "softenings" were distinguished from hemorrhagic "apoplexy," but stroke etiology remained unstudied. The terms artherosclerosis, thrombosis, embolism, and lacune were introduced to indicat...


    pub_type: 历史文章,杂志文章


    authors: Paciaroni M,Bogousslavsky J

    更新日期:2009-09-01 00:00:00

  • Prion disease incidence in the United States: 2003-2015.

    abstract:OBJECTIVE:To report the incidence of prion disease in the United States. METHODS:Prion disease decedents were retrospectively identified from the US national multiple cause-of-death data for 2003-2015 and matched with decedents in the National Prion Disease Pathology Surveillance Center (NPDPSC) database through compa...


    pub_type: 杂志文章


    authors: Maddox RA,Person MK,Blevins JE,Abrams JY,Appleby BS,Schonberger LB,Belay ED

    更新日期:2020-01-14 00:00:00

  • Serial study of gadolinium-DTPA MRI enhancement in multiple sclerosis.

    abstract::We performed serial baseline and gadolinium (Gd)-DTPA-enhanced MRI in 4 patients with definite multiple sclerosis. Studies were performed every month for a total of 4 scans. We obtained short TR/short TE sequences at 10 and 60 minutes after Gd-DTPA injection. All patients had multiple hyperintense lesions seen on base...


    pub_type: 杂志文章


    authors: Bastianello S,Pozzilli C,Bernardi S,Bozzao L,Fantozzi LM,Buttinelli C,Fieschi C

    更新日期:1990-04-01 00:00:00

  • The cerebrospinal fluid production rate is reduced in dementia of the Alzheimer's type.

    abstract:OBJECTIVE:To evaluate the production rate of CSF in patients with differing disease states. METHODS:The authors measured the production rate of CSF in three groups of patients: five patients with PD below age 60 (aged 51 +/- 4 years, mean +/- SD), nine with PD over age 60 (aged 69 +/- 6 years, mean +/- SD), and seven ...


    pub_type: 杂志文章


    authors: Silverberg GD,Heit G,Huhn S,Jaffe RA,Chang SD,Bronte-Stewart H,Rubenstein E,Possin K,Saul TA

    更新日期:2001-11-27 00:00:00

  • Pituitary enlargement in patients with intracranial hypotension syndrome.

    abstract::Article abstract-The authors analyzed whether the pituitary gland enlarges in intracranial hypotension syndrome by studying 11 consecutive patients. Initial MRI scans showed pituitary gland enlargement with a convex superior margin. Follow-up MRI studies revealed that the size of the gland invariably diminished in all...


    pub_type: 杂志文章


    authors: Alvarez-Linera J,Escribano J,Benito-León J,Porta-Etessam J,Rovira A

    更新日期:2000-12-26 00:00:00

  • Automated CT perfusion imaging for acute ischemic stroke: Pearls and pitfalls for real-world use.

    abstract::Recent positive trials have thrust acute cerebral perfusion imaging into the routine evaluation of acute ischemic stroke. Updated guidelines state that in patients with anterior circulation large vessel occlusions presenting beyond 6 hours from time last known well, advanced imaging selection including perfusion-based...


    pub_type: 杂志文章,评审


    authors: Vagal A,Wintermark M,Nael K,Bivard A,Parsons M,Grossman AW,Khatri P

    更新日期:2019-11-12 00:00:00

  • The effects of acute and chronic ethanol administration on twitch and tetanic force production by rat gastrocnemius muscle in situ.

    abstract::The effects of acute ethanol injection on force production were measured in normal and chronic alcoholic rats. Acutely injected normal rats, acutely injected chronic alcoholic rats, and noninjected chronic alcoholic rats were compared with control groups: normal nonalcoholic rats and a dietetically deprived control gr...


    pub_type: 杂志文章


    authors: Martyn DA,Munsat TL

    更新日期:1980-02-01 00:00:00

  • Prevalence and size of directly detected patent foramen ovale in migraine with aura.

    abstract:BACKGROUND:Transcranial contrast Doppler studies have shown an increased prevalence of right-to-left shunts in patients with migraine with aura compared with controls. The anatomy and size of these right-to-left shunts have never been directly assessed. METHODS:In a cross-sectional case-control study, the authors perf...


    pub_type: 杂志文章


    authors: Schwerzmann M,Nedeltchev K,Lagger F,Mattle HP,Windecker S,Meier B,Seiler C

    更新日期:2005-11-08 00:00:00

  • Cognitive deficits of pure subcortical vascular dementia vs. Alzheimer disease: PiB-PET-based study.

    abstract:OBJECTIVES:Despite many neuropsychological studies to differentiate subcortical vascular dementia (SVaD) from Alzheimer disease (AD), previous studies did not eliminate confounding effects of mixed Alzheimer and vascular pathology. We aimed to investigate neuropsychological differences between patients with Pittsburgh ...


    pub_type: 杂志文章


    authors: Yoon CW,Shin JS,Kim HJ,Cho H,Noh Y,Kim GH,Chin JH,Oh SJ,Kim JS,Choe YS,Lee KH,Lee JH,Seo SW,Na DL

    更新日期:2013-02-05 00:00:00

  • Developmental venous anomaly in adult patients with diffuse glioma: A clinically relevant coexistence?

    abstract:OBJECTIVE:To determine the prevalence of developmental venous anomaly in adult patients with diffuse glioma. METHODS:We performed a retrospective cohort study (2010-2016) of consecutive adult patients harboring a supratentorial diffuse glioma in 2 centers: Sainte-Anne Hospital (experimental and control sets) and Pitié...


    pub_type: 杂志文章,多中心研究


    authors: Roux A,Edjlali M,Porelli S,Tauziede-Espariat A,Zanello M,Dezamis E,Zah-Bi G,Sanson M,Puget S,Capelle L,Varlet P,Oppenheim C,Pallud J

    更新日期:2019-01-01 00:00:00

  • Multiple sclerosis and age at exposure to childhood diseases and animals: cases and their friends.

    abstract::Eighty-eight multiple sclerosis case-friend pairs were interviewed by telephone to elicit information about early-life exposures. Available mothers were also interviewed. Risk factors included childhood diseases, exposures to animals, and residence. We found a positive association between MS and having measles at a la...


    pub_type: 杂志文章


    authors: Sullivan CB,Visscher BR,Detels R

    更新日期:1984-09-01 00:00:00

  • Correlation of enzyme-inducing anticonvulsant use with outcome of patients with glioblastoma.

    abstract:BACKGROUND:Clinical trials involving patients with glioblastoma (GBM) distinguish cohorts who are treated with enzyme-inducing anticonvulsants (EIAC). Such anticonvulsants induce hepatic P450 microsomal enzymes, which accelerate the metabolism of certain chemotherapy and molecular targeted agents. However, the resultan...


    pub_type: 杂志文章


    authors: Jaeckle KA,Ballman K,Furth A,Buckner JC

    更新日期:2009-10-13 00:00:00

  • Long-term therapy with high doses of subcutaneous immunoglobulin in multifocal motor neuropathy.

    abstract:BACKGROUND:In multifocal motor neuropathy (MMN), high dose of IV immunoglobulin (IVIg) is the only established treatment. Subcutaneous self-infusion with immunoglobulin G (IgG) (SCIG) increases patient autonomy and treatment flexibility, and might be associated with fewer side effects due to lower peak IgG levels. In a...


    pub_type: 临床试验,杂志文章


    authors: Harbo T,Andersen H,Jakobsen J

    更新日期:2010-10-12 00:00:00

  • Diagnosis of cryptococcal meningitis by cytologic methods: an old technique revisited.

    abstract::In six patients with cryptococcal meningitis, diagnosis was made by routine cytologic examination of cerebrospinal fluid (CSF). A seventh patient had a false-positive cryptococcal antigen titer, and no organism was seen on SCF examination. The patient had herpes simplex encephalitis on brain biopsy. Cytologic examinat...


    pub_type: 杂志文章


    authors: Bernad PG,Szyfelbein WM,Weiss HD,Richardson EP Jr

    更新日期:1980-01-01 00:00:00