Delivery of active hexosaminidase across the blood-brain barrier in rats.

abstract：OBJECTIVE:To examine the association between socioeconomic status (SES) and disability outcomes and progression in multiple sclerosis (MS). METHODS:Health administrative and MS clinical data were linked for 2 cohorts of patients with MS in British Columbia (Canada) and South East Wales (UK). SES was measured at MS sym...

journal_title：Neurology

authors： Harding KE,Wardle M,Carruthers R,Robertson N,Zhu F,Kingwell E,Tremlett H

更新日期：2019-03-26 00:00:00

abstract：OBJECTIVE:To explore the inflammatory processes in the pathogenesis of psychiatric symptoms and the prognostic value of psychiatric comorbidities in multiple sclerosis (MS). METHODS:Four hundred five patients with relapsing-remitting (RR) MS underwent psychiatric evaluation by means of Beck Depression Inventory II (BD...

journal_title：Neurology

authors： Rossi S,Studer V,Motta C,Polidoro S,Perugini J,Macchiarulo G,Giovannetti AM,Pareja-Gutierrez L,Calò A,Colonna I,Furlan R,Martino G,Centonze D

更新日期：2017-09-26 00:00:00

abstract：OBJECTIVE:To compare characteristics between Black and White patients with amyotrophic lateral sclerosis (ALS) in order to identify disparities and phenotypic variability. METHODS:We performed database review for patients seen between 1997 and 2020 at the Emory ALS Center in Atlanta, Georgia. Patients with ALS were in...

journal_title：Neurology

authors： Brand D,Polak M,Glass JD,Fournier CN

更新日期：2020-12-28 00:00:00

abstract：OBJECTIVES:SCN1A mutations were recently reported in several patients with severe myoclonic epilepsy in infancy (SMEI). The authors analyzed SCN1A mutations in 93 patients with SMEI and made genotype-phenotype correlation to clarify the role of this gene in the etiology of SMEI. METHODS:All patients fulfilled the crit...

journal_title：Neurology

authors： Nabbout R,Gennaro E,Dalla Bernardina B,Dulac O,Madia F,Bertini E,Capovilla G,Chiron C,Cristofori G,Elia M,Fontana E,Gaggero R,Granata T,Guerrini R,Loi M,La Selva L,Lispi ML,Matricardi A,Romeo A,Tzolas V,Valseriati

更新日期：2003-06-24 00:00:00

abstract：OBJECTIVES:More than 30 different rare mutations, including copy number variants (CNVs), in the amyloid precursor protein gene (APP) cause early-onset familial Alzheimer disease (EOFAD), whereas the contribution of common APP variants to disease risk remains controversial. In this study we systematically assessed the r...

journal_title：Neurology

authors： Hooli BV,Mohapatra G,Mattheisen M,Parrado AR,Roehr JT,Shen Y,Gusella JF,Moir R,Saunders AJ,Lange C,Tanzi RE,Bertram L

更新日期：2012-04-17 00:00:00

abstract：OBJECTIVE:We sought to examine brain white matter abnormalities based on MRI in adults with Lesch-Nyhan disease (LND) or an attenuated variant (LNV) of this rare, X-linked neurodevelopmental disorder of purine metabolism. METHODS:In this observational study, we compared 21 adults with LND, 17 with LNV, and 33 age-, se...

journal_title：Neurology

authors： Schretlen DJ,Varvaris M,Vannorsdall TD,Gordon B,Harris JC,Jinnah HA

更新日期：2015-01-13 00:00:00

abstract：OBJECTIVES:We used functional MRI (fMRI), transcranial Doppler ultrasound, and visual evoked potentials (VEPs) to determine the nature of blood flow responses to functional brain activity and carbon dioxide (CO2) inhalation in patients with cerebral amyloid angiopathy (CAA), and their association with markers of CAA se...

journal_title：Neurology

authors： Peca S,McCreary CR,Donaldson E,Kumarpillai G,Shobha N,Sanchez K,Charlton A,Steinback CD,Beaudin AE,Flück D,Pillay N,Fick GH,Poulin MJ,Frayne R,Goodyear BG,Smith EE

更新日期：2013-11-05 00:00:00

abstract：:We report imaging and clinical findings of leukoencephalopathy occurring after levamisole. The lesions were hypoattenuating on CT and appeared as multifocal oval or elliptical foci in the white matter or along the subependymal veins on MRI. Most lesions resolve after prompt withdrawal of levamisole. Detailed history t...

journal_title：Neurology

authors： Liu HM,Hsieh WJ,Yang CC,Wu VC,Wu KD

更新日期：2006-09-26 00:00:00

abstract：:Endovascular therapy for acute ischemic stroke continues to evolve to improve both efficacy and safety. In the late 1990 s, intra-arterial chemical thrombolysis with prourokinase was shown to be effective in achieving partial recanalization and improving clinical outcome, in comparison with intra-arterial heparin admi...

journal_title：Neurology

authors： Novakovic RL,Toth G,Narayanan S,Zaidat OO

更新日期：2012-09-25 00:00:00

abstract：:All Olmsted County, Minnesota, residents who experienced brain injury from 1935 through 1979 were identified and their medical records reviewed for survival and neurologic outcome. Minimum inclusion criteria included loss of consciousness or post-traumatic amnesia or neurologic evidence of brain injury or skull fractu...

journal_title：Neurology

authors： Wiederholt WC,Melton LJ 3rd,Annegers JF,Grabow JD,Laws ER Jr,Ilstrup DM

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:To determine whether comorbidity is associated with clinical (relapses, disability worsening) and MRI outcomes in multiple sclerosis (MS) by conducting a secondary analysis of the CombiRx clinical trial. METHODS:CombiRx compared interferon beta-1a, glatiramer acetate, and the combination of these agents. For...

journal_title：Neurology

authors： Salter A,Kowalec K,Fitzgerald KC,Cutter G,Marrie RA

更新日期：2020-08-04 00:00:00

abstract：BACKGROUND:Basic issues regarding factors influencing progressive supranuclear palsy (PSP) patient caregiver burden remain unresolved, including whether and how disease severity and duration influence caregiver burden. OBJECTIVE:To examine the relation between PSP patient caregiver burden and disease severity, describ...

journal_title：Neurology

authors： Uttl B,Santacruz P,Litvan I,Grafman J

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Although hospital-outcome relationships have been explored for a variety of procedures and interventions, little is known about the association between annual stroke admission volumes and stroke mortality. Our aim was to determine whether facility type and hospital volume was associated with stroke mortality...

journal_title：Neurology

authors： Saposnik G,Baibergenova A,O'Donnell M,Hill MD,Kapral MK,Hachinski V,Stroke Outcome Research Canada (SORCan) Working Group.

更新日期：2007-09-11 00:00:00

abstract：:A 61-year-old woman presented with two paraneoplastic neurologic disorders--Lambert-Eaton myasthenic syndrome (LEMS) and subacute cerebellar degeneration (SCD)--that antedated the diagnosis of small-cell carcinoma of the lung by 15 months. Plasmapheresis initiated before the identification of the tumor had a beneficia...

journal_title：Neurology

authors： Blumenfeld AM,Recht LD,Chad DA,DeGirolami U,Griffin T,Jaeckle KA

更新日期：1991-10-01 00:00:00

abstract：:About one-third of patients with acoustic tumor (AT) initially seek medical attention for nonaudiologic complaints. The nonspecific early symptoms of AT require the inclusion of AT in many neurologic differential diagnoses. Advances in electrophysiologic and radiographic tests have allowed earlier diagnosis of AT at a...

journal_title：Neurology

authors： Hart RG,Gardner DP,Howieson J

更新日期：1983-02-01 00:00:00

abstract：:A 52-year-old steelworker displayed a consistent defect in leftward voluntary gaze across the midline. Both fast (saccadic) and slow (pursuit) eye movements were affected. Neuro-ophthalmologic evaluation revealed no additional neurologic or ophthalmologic deficit. Pupilary miosis occurred during leftward gaze attempt,...

journal_title：Neurology

authors： Troost BT,Troost EG

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND:Cerebral microbleeds are known to be indicative of bleeding-prone microangiopathy and may predict incident intracerebral hemorrhage (ICH). In this study, we investigated whether microbleeds are associated with the incidence of warfarin-related ICH. METHODS:Twenty-four patients with ICH while on outpatient t...

journal_title：Neurology

authors： Lee SH,Ryu WS,Roh JK

更新日期：2009-01-13 00:00:00

abstract：:Clinicians have long suspected an association of classic amyotrophic lateral sclerosis (ALS) with Parkinson's disease (PD), dementia, or both. If proven, this would raise the possibility of a shared genetic susceptibility to the three disorders. To investigate this hypothesis, we compared 151 newly diagnosed ALS patie...

journal_title：Neurology

authors： Majoor-Krakauer D,Ottman R,Johnson WG,Rowland LP

更新日期：1994-10-01 00:00:00

abstract：:Single motor unit firing rates were measured from the first dorsal interosseous muscle (FDI) of normal subjects and patients with partial denervation of that muscle. Motor unit discharges were recorded at various levels of voluntary, stationary, isometric contraction of the FDI. The mean increase in firing rate associ...

journal_title：Neurology

authors： Miller RG,Sherratt M

更新日期：1978-12-01 00:00:00

abstract：:We studied the effect of CSF drainage on cerebral blood flow (CBF) in normal pressure hydrocephalus (NPH) and non-NPH dementia using the 133Xenon inhalation technique. Dementia patients had lower CBF than matched elderly normals. Flow values for NPH and non-NPH patients did not differ before or after CSF drainage. CBF...

journal_title：Neurology

authors： Kushner M,Younkin D,Weinberger J,Hurtig H,Goldberg H,Reivich M

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVE:To compare the accuracy of Alberta Stroke Program Early Computed Tomography Score (ASPECTS) and CT perfusion to detect established infarction in acute anterior circulation stroke. METHODS:We performed an observational study in 59 acute anterior circulation ischemic stroke patients who underwent brain noncont...

journal_title：Neurology

authors： Demeestere J,Garcia-Esperon C,Garcia-Bermejo P,Ombelet F,McElduff P,Bivard A,Parsons M,Levi C

更新日期：2017-06-13 00:00:00

abstract：:The authors studied immunoglobulin (Ig) G subclasses in the CSF and sera of patients with relapsing neuromyelitis optica (RNMO) and typical multiple sclerosis (MS). Although the total IgG concentrations were elevated in the CSF of patients with RNMO and MS, IgG1% and IgG1 index were significantly elevated only in pati...

journal_title：Neurology

authors： Nakashima I,Fujihara K,Fujimori J,Narikawa K,Misu T,Itoyama Y

更新日期：2004-01-13 00:00:00

abstract：:Current concepts suggest that avoidance of pulsatile stimulation of dopamine receptors in Parkinson's disease (PD) can prevent the onset of dyskinesia. In MPTP-treated primates, repeated administration of levodopa or other short-acting dopamine agonist drugs leads to the onset of marked involuntary movements. In contr...

journal_title：Neurology

authors： Jenner P

更新日期：2004-01-13 00:00:00

abstract：BACKGROUND:The APOE epsilon4 allele has emerged as a major genetic factor for Alzheimer disease (AD), and its presence has been associated with an increase in beta-amyloid senile plaques (SPs) and neuritic plaques (NPs). Whether it affects neurofibrillary tangle (NFT) accumulation or cholinergic losses in AD remains co...

journal_title：Neurology

authors： Tiraboschi P,Hansen LA,Masliah E,Alford M,Thal LJ,Corey-Bloom J

更新日期：2004-06-08 00:00:00

abstract：:The authors found serum immunoglobulin M (IgM) autoantibody in a patient with typical acute cerebellar ataxia (ACA) and identified the antigen molecule as triosephosphate isomerase (TPI). TPI antigenicity to the patient's antibody was the highest in the cerebellar tissue. Eight of 23 patients with ACA had increased Ig...

journal_title：Neurology

authors： Uchibori A,Sakuta M,Kusunoki S,Chiba A

更新日期：2005-10-11 00:00:00

abstract：:Erythrocyte calcium transport as a function of free [Ca++] was examined using inside-out vesicles from eight pairs of patients with Duchenne dystrophy and age- and sex-matched controls. The Km for Ca++ of the transport protein and the Vmax were higher in the Duchenne vesicles in seven of the eight pairs. The mean Km a...

journal_title：Neurology

authors： Mollman JE,Cardenas JC,Pleasure DE

更新日期：1980-11-01 00:00:00

abstract：:We describe a 78-year-old man with right hemiballism as the presenting symptom of a metastatic occult adenocarcinoma of the lung. CT demonstrated two contrast-enhancing lesions: one in the left subthalamic region and the other in the left parietal region. Metastatic tumor was confirmed at autopsy. ...

journal_title：Neurology

authors： Glass JP,Jankovic J,Borit A

更新日期：1984-02-01 00:00:00

abstract：:The authors describe a patient with bilateral papilledema, visual field abnormalities, poorly reactive pupils, meningeal enhancement on cranial MRI, and diffuse brain parenchymal hypervascularity. The opening pressure at the time of lumbar puncture was normal, and results of other CSF studies were normal. All abnormal...

journal_title：Neurology

authors： O'Halloran HS,Berger JR,Baker RS,Lee WB,Pearson PA,Ryan S

更新日期：1999-12-10 00:00:00

abstract：:The effect of imipramine on the absorption of a single dose of levodopa was studied in male volunteers. By delaying gastric emptying and retarding delivery to intestinal absorptive sites, imipramine interfered with the absorption of levodopa. This action caused by the anticholinergic effect of imipramine. The retardat...

journal_title：Neurology

authors： Morgan JP,Rivera-Calimlim L,Messiha F,Sundaresan PR,Trabert N

更新日期：1975-11-01 00:00:00

abstract：OBJECTIVES:To describe the clinical, CSF, and radiologic findings and long-term follow-up in a cohort of patients with acute disseminated encephalomyelitis (ADEM), and to determine possible prognostic factors for progression to MS. METHODS:Forty adults (28 women, mean age 33.5 years) diagnosed with ADEM were analyzed....

journal_title：Neurology

authors： Schwarz S,Mohr A,Knauth M,Wildemann B,Storch-Hagenlocher B

更新日期：2001-05-22 00:00:00