Abstract:
:We developed a rating scale for tic disorders that uses only objective criteria and accommodates the variety of tic manifestations. Using short videotaped recordings with the examiner out of the taping room, we measured five tic variables: number of body areas affected, frequency of motor tics and vocalizations, and severity of motor tics and vocalizations. The rating scale fulfilled tests for inter-rater reliability and temporal stability, and correlated well with scales used to assess global changes over prolonged periods. It objectively detected improvement in tics with neuroleptics, the one pharmacotherapy accepted to abate tics in most patients.
journal_name
Neurologyjournal_title
Neurologyauthors
Goetz CG,Tanner CM,Wilson RS,Shannon KMdoi
10.1212/wnl.37.9.1542subject
Has Abstractpub_date
1987-09-01 00:00:00pages
1542-4issue
9eissn
0028-3878issn
1526-632Xjournal_volume
37pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract:OBJECTIVE:To use a combined neurogenetic-neuroimaging approach to examine the functional consequences of preclinical dopaminergic nigrostriatal dysfunction in the human motor system. Specifically, we examined how a single heterozygous mutation in different genes associated with recessively inherited Parkinson disease a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000338699.56379.11
更新日期:2009-03-24 00:00:00
abstract:OBJECTIVE:In the North Dublin Population Stroke Study, we investigated the risk of recurrent stroke within the 14-day time window recommended for endarterectomy. METHODS:In a population-based prospective cohort study, all ischemic stroke patients were identified over 1 year and categorized into those with (CS-positive...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0b013e31822b00cf
更新日期:2011-08-23 00:00:00
abstract::The clinical and genetic findings are described for 16 patients from a large Italian family with a variant form of hereditary spastic paraplegia and congenital arachnoid cysts inherited as an autosomal dominant trait. A molecular study has revealed a novel missense mutation, T614I, in exon 17 of SPG4, which may play a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000125324.32082.d9
更新日期:2004-05-25 00:00:00
abstract::The relevance of neutralizing antibodies (NAb) to interferon-beta (IFNbeta) for patients with MS treated with IFNbeta injections has been controversial. Published data from several double-blind, randomized clinical trials demonstrate that disease activity in IFNbeta-treated patients with MS is similar to placebo-treat...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000092363.40248.0e
更新日期:2003-11-11 00:00:00
abstract::Localization of sign language production and comprehension in deaf people has been described as similar to that of spoken language aphasia. However, sign language employs a visuospatial modality through visual information. We present the first report of a deaf signer who showed substantial sign language aphasia with s...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000277455.08067.9c
更新日期:2007-10-02 00:00:00
abstract:OBJECTIVE:To determine the potential of detection in CSF of specific Borrelia burgdorferi antigen, OspA, as a marker of infection in neurologic Lyme disease and compare this with the detection of antibody. DESIGN:CSF from 83 neurologic patients in an area highly endemic for Lyme disease was examined prospectively for ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.11.2010
更新日期:1995-11-01 00:00:00
abstract::Interferon beta (IFN-beta) has been shown in several clinical trials to have efficacy in MS. Its mechanism of action, however, remains unclear. In this review, several biological activities of IFN-beta are highlighted, including its inhibitory effects on proliferation of leukocytes and antigen presentation. Furthermor...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.51.3.682
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:To investigate the lateralization and localization of ictal EEG in focal epilepsy. METHODS:A total of 486 ictal EEG of 72 patients with focal epilepsy arising from the mesial temporal, neocortical temporal, mesial frontal, dorsolateral frontal, parietal, and occipital regions were analyzed. RESULTS:Surface ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.11.2022
更新日期:2001-12-11 00:00:00
abstract::We report on the prevalence of dementia in Canadians age 85 years and older. The purpose of this study was to determine whether the prevalence of dementia continued to increase in the very old, and to define the types of dementia and their relative proportions in this age group. We collected data as part of the Canadi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.9.1593
更新日期:1994-09-01 00:00:00
abstract::We studied clinical characteristics and coexisting causes of stroke in 305 patients admitted to a population-based primary care center with an initial ischemic stroke and a potential cardiac source of embolism (PCSE). Using systematic standardized cardiac, arterial, and cerebral investigations and the logistics of the...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.6.855
更新日期:1991-06-01 00:00:00
abstract:OBJECTIVE:This study was conducted to determine the relationship of frontal lobe cortical thickness and basal ganglia volumes to measures of cognition in adults with sickle cell anemia (SCA). METHODS:Participants included 120 adults with SCA with no history of neurologic dysfunction and 33 healthy controls (HCs). Part...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000000188
更新日期:2014-03-11 00:00:00
abstract:OBJECTIVE:To investigate whether plasma interleukin-6 (IL-6) is cross-sectionally related to poorer cognitive function and whether a baseline plasma IL-6 measurement can predict risk for decline in cognitive function in longitudinal follow-up of a population-based sample of nondisabled elderly people. METHODS:A prospe...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/wnl.59.3.371
更新日期:2002-08-13 00:00:00
abstract::In an attempt to determine the opinions and practices of neurologists regarding the use of antithrombotic drugs in the treatment of acute ischemic stroke, we conducted a survey of 349 randomly selected neurologists from throughout the United States. Responses were received from 247 (71%), and 219 identified themselves...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.12.1631
更新日期:1989-12-01 00:00:00
abstract::To examine animal exposure in ALS patients, a case-control study was undertaken on 40 ALS patients and 40 closely matched controls. Exposure to pets of any kind and to small dogs in the period from birth until 10 years before onset of ALS symptoms was significantly increased. Affected men showed a trend toward increas...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.5.717
更新日期:1985-05-01 00:00:00
abstract:BACKGROUND:No data exist on whether the syndrome of amnestic mild cognitive impairment occurs in the oldest old, or if the relationships for functional status and neuropsychometric performance based on clinical diagnosis hold true in this age group. DESIGN/METHODS:The authors performed comprehensive neurologic evaluat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.60.3.477
更新日期:2003-02-11 00:00:00
abstract::We performed a retrospective study on a series of 119 of our patients who have Friedreich's disease to assess the predictive value of age at onset, gender, and left ventricular hypertrophy in regard to disease progression. Outcome variables were survival, time to loss of independent gait, and time to confinement in a ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.5.1260
更新日期:1996-11-01 00:00:00
abstract::IgM anti-GM1 antibodies occur with increased frequency in the serum of patients with multifocal motor neuropathy (MMN). We tested the ability of serum IgM from patients with MMN to bind to GM1 ganglioside covalently bound to secondary amino groups on ELISA plates (Co-GM1). The Co-GM1 technique detected high titer (> 1...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.5.1289
更新日期:1997-11-01 00:00:00
abstract::Traditional side-by-side visual interpretation of ictal and interictal single-photon emission computed tomography (SPECT) scans can be difficult in identifying the surgical focus, particularly in patients with extratemporal or otherwise unlocalized intractable epilepsy. Computer-aided subtraction ictal SPECT co-regist...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.2.445
更新日期:1998-02-01 00:00:00
abstract:OBJECTIVE:To evaluate patients with early HIV-cognitive motor complex (HIV-CMC) for possible regional cerebral blood flow (rCBF) abnormalities on perfusion MRI (pMRI). BACKGROUND:Nuclear medicine techniques have demonstrated global and focal cerebral perfusion abnormalities in patients with HIV dementia. Ultrafast pMR...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.2.389
更新日期:2000-01-25 00:00:00
abstract::We detected large numbers of HLA-DR-positive reactive microglia (macrophages), along with Lewy bodies and free melanin, in the substantia nigra of all cases studied with Parkinson's disease (5) and parkinsonism with dementia (PD) (5). We found similar, but less extensive, pathology in the substantia nigra of six of ni...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.8.1285
更新日期:1988-08-01 00:00:00
abstract:OBJECTIVE:To update the 1997 American Academy of Neurology (AAN) practice parameter regarding sports concussion, focusing on 4 questions: 1) What factors increase/decrease concussion risk? 2) What diagnostic tools identify those with concussion and those at increased risk for severe/prolonged early impairments, neurolo...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0b013e31828d57dd
更新日期:2013-06-11 00:00:00
abstract:OBJECTIVE:To investigate the feasibility and clinical utility of using passive electrocorticography (ECoG) for online spatial-temporal functional mapping (STFM) of language cortex in patients being monitored for epilepsy surgery. METHODS:We developed and tested an online system that exploits ECoG's temporal resolution...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002525
更新日期:2016-03-29 00:00:00
abstract::Clinical presentation of carotid artery dissection (CAD) is variable, including acute or subacute headache, cervical pain, or focal neurologic deficit that occurs spontaneously, after a high-speed neck manipulation, or trauma. Isolated lower cranial nerve palsy in carotid dissection is uncommon. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31828727e8
更新日期:2013-03-12 00:00:00
abstract::To evaluate when it is possible to discontinue anticonvulsant treatment in children with cryptogenic partial epilepsy, the authors studied 89 epileptic children divided into two groups: Group A, 45 children whose therapy was discontinued after 1 year from the last seizure; and Group B, 44 children whose therapy was st...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.9.1393
更新日期:2000-11-14 00:00:00
abstract:OBJECTIVE:To determine the current best practice for treatment of infantile spasms in children. METHODS:Database searches of MEDLINE from 1966 and EMBASE from 1980 and searches of reference lists of retrieved articles were performed. Inclusion criteria were the documented presence of infantile spasms and hypsarrhythmi...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000127773.72699.c8
更新日期:2004-05-25 00:00:00
abstract:OBJECTIVE:To determine the prevalence and incidence of epilepsy among U.S. Medicare beneficiaries aged 65 years old and over, and to compare rates across demographic groups. METHODS:We performed a retrospective analysis of Medicare administrative claims for 2001-2005, defining prevalent cases as persons with ≥1 claim ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182477edc
更新日期:2012-02-14 00:00:00
abstract::Generic substitution is practiced widely in both hospital and community settings. There have been several reports of reduced serum concentrations and seizure exacerbation following generic substitution of Tegretol. We describe the first 2 cases of carbamazepine toxicity resulting from the substitution of Tegretol with...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.12.2696
更新日期:1993-12-01 00:00:00
abstract::We investigated levodopa intravenous infusion rates, plasma concentrations, and clinical responses in 23 parkinsonian patients with a fluctuating response to the drug. There was a linear relationship between rate of levodopa infusion and plasma concentration when carbidopa was coadministered. Minimum-therapeutically e...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.6.739
更新日期:1986-06-01 00:00:00
abstract:OBJECTIVE:To conduct a validation study of 123I-N-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) nortropane (123I-FP-CIT) SPECT dopaminergic imaging in the clinical diagnosis of dementia with Lewy bodies (DLB) with autopsy as the gold standard. METHODS:Patients >60 years of age with dementia who had undergone 123I-FP-...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003512
更新日期:2017-01-17 00:00:00
abstract::The effects of acute ethanol injection on force production were measured in normal and chronic alcoholic rats. Acutely injected normal rats, acutely injected chronic alcoholic rats, and noninjected chronic alcoholic rats were compared with control groups: normal nonalcoholic rats and a dietetically deprived control gr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.2.139
更新日期:1980-02-01 00:00:00