Levodopa pharmacokinetics and pharmacodynamics in fluctuating parkinsonian patients.

abstract：OBJECTIVE:To describe factors associated with survival in Alzheimer disease (AD) in a multiethnic, population-based longitudinal study. METHODS:AD cases were identified in the Washington Heights Inwood Columbia Aging Project, a longitudinal, community-based study of cognitive aging in Northern Manhattan. The sample co...

journal_title：Neurology

authors： Helzner EP,Scarmeas N,Cosentino S,Tang MX,Schupf N,Stern Y

更新日期：2008-11-04 00:00:00

abstract：:A patient with PD who exhibited disabling tremor and prominent dyskinesia underwent deep brain stimulation (DBS) of the left thalamic ventral intermediate nucleus. The electrode migrated and was replaced but with suboptimal clinical response. Two years later, postmortem analysis found the second electrode tip had ente...

journal_title：Neurology

authors： Henderson JM,O'Sullivan DJ,Pell M,Fung VS,Hely MA,Morris JG,Halliday GM

更新日期：2001-06-12 00:00:00

abstract：OBJECTIVE:The 36-item Short Form Health Survey Questionnaire (SF-36) is a widely used generic health status measure. Recently it has been adapted to produce a disease-specific measure for MS-the 54-item Multiple Sclerosis Quality of Life Scale (MSQOL-54)-composed of five unchanged SF-36 scales; three altered SF-36 scal...

journal_title：Neurology

authors： Freeman JA,Hobart JC,Thompson AJ

更新日期：2001-07-10 00:00:00

abstract：OBJECTIVE:To examine whether the incidence, comorbidity, and mortality of first-time ischemic stroke changed in Denmark between 1996 and 2016 overall and according to age and sex using a nationwide cohort design. METHODS:In this cohort study, 224,617 individuals ≥18 years of age admitted with first-time ischemic strok...

journal_title：Neurology

authors： Yafasova A,Fosbøl EL,Christiansen MN,Vinding NE,Andersson C,Kruuse C,Johnsen SP,Gislason GH,Torp-Pedersen C,Køber L,Butt JH

更新日期：2020-10-27 00:00:00

abstract：BACKGROUND:Although gray matter (GM) atrophy is recognized as a common feature of multiple sclerosis (MS), conflicting results have been obtained in patients with clinically isolated syndromes (CIS). Methodologic and clinical constraints may take account for literature discrepancies. METHODS:A total of 105 patients pr...

journal_title：Neurology

authors： Calabrese M,Rinaldi F,Mattisi I,Bernardi V,Favaretto A,Perini P,Gallo P

更新日期：2011-07-19 00:00:00

abstract：OBJECTIVE:In this study, we aimed to investigate the effect of hypoglycemia on cardiovascular outcomes in a sample of patients with chronic kidney disease (CKD). METHODS:Information about study participants was extracted from the National Health Insurance Research Database of Taiwan for the years 1998 through 2008. We...

journal_title：Neurology

authors： Yu TM,Lin CL,Chang SN,Sung FC,Kao CH

更新日期：2014-08-19 00:00:00

abstract：:We reviewed the records of all patients with optic neuritis (ON) in Olmsted County, Minnesota, identified through the comprehensive records-linkage system at the Mayo Clinic, and identified 156 ON patients from 1935 to 1991 who had onset of the disease while residing in Olmsted County (incidence cases). Poisson regres...

journal_title：Neurology

authors： Rodriguez M,Siva A,Cross SA,O'Brien PC,Kurland LT

更新日期：1995-02-01 00:00:00

abstract：:Information on 1,343 hospitalized patients in the Cornell Neurology Database with final diagnoses of transient ischemic attacks (TIA), reversible ischemic neurologic deficits (RIND), or ischemic stroke was examined in order to determine the duration of ischemic deficits. Episodes resolved within the first 24 hours (cl...

journal_title：Neurology

authors： Levy DE

更新日期：1988-05-01 00:00:00

abstract：:The triad of normal-pressure hydrocephalus, parkinsonism, and primary empty sella appeared in a 70-year-old woman. There was dramatic resolution of the extrapyramidal signs and symptoms on treatment with levodopa-carbidopa and ventriculojugular shunt. The syndrome may be the result of several mechanisms, but an altera...

journal_title：Neurology

authors： Spagna VA,Maeder MC,Johnson JC,Mazzaferri EL

更新日期：1978-11-01 00:00:00

abstract：:Dyskinesias are usually seen in Parkinson's disease (PD) patients after several years of L-dopa therapy. Their presence has been attributed to supersensitivity of striatal D1 and D2 receptors. We have used PET to assess striatal D2 receptor binding in untreated PD patients and striatal D1 and D2 binding in L-dopa-trea...

journal_title：Neurology

authors： Turjanski N,Lees AJ,Brooks DJ

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:To investigate the prevalence and nature of cognitive changes associated with sporadic amyotrophic lateral sclerosis (ALS) using a large scale study. METHODS:Consecutive patients with sporadic ALS (n = 279) underwent comprehensive neurologic evaluation and neuropsychological testing. Testing data from normal...

journal_title：Neurology

authors： Ringholz GM,Appel SH,Bradshaw M,Cooke NA,Mosnik DM,Schulz PE

更新日期：2005-08-23 00:00:00

abstract：BACKGROUND:The annual relapse rate has been commonly used as a primary efficacy endpoint in phase III multiple sclerosis (MS) clinical trials. The aim of this study was to determine the relative contribution of different possible prognostic factors available at baseline to the on-study relapse rate in MS. METHODS:A to...

journal_title：Neurology

authors： Held U,Heigenhauser L,Shang C,Kappos L,Polman C,Sylvia Lawry Centre for MS Research.

更新日期：2005-12-13 00:00:00

abstract：:MRI and CSF investigations revealed meningeal involvement in a 29-year-old patient with biopsy-confirmed Wegener's granulomatosis. The intracranial manifestation of Wegener's granulomatosis was supported by the detection of pathologic circulating antineutrophil cytoplasm (c-ANCA) in the CSF. We monitored disease activ...

journal_title：Neurology

authors： Spranger M,Schwab S,Meinck HM,Tischendorf M,Sis J,Breitbart A,Andrassy K

更新日期：1997-01-01 00:00:00

abstract：:We assessed the severity and temporal profile of distant neuromuscular effects from a single dose (280 units) of botulinum neurotoxin injected into neck muscles for torticollis. We performed single-fiber EMG studies on the biceps brachii of six patients to measure jitter (20 pairs) and fiber density on the initial tre...

journal_title：Neurology

authors： Olney RK,Aminoff MJ,Gelb DJ,Lowenstein DH

更新日期：1988-11-01 00:00:00

abstract：:We investigated 185 families with ALS for evidence of anticipation and mitochondrial inheritance. Although initial analysis demonstrated significant anticipation of age at death between generations in patients with familial ALS, further analysis demonstrated features of regression to the mean, suggesting that the perc...

journal_title：Neurology

authors： Bradley M,Bradley L,de Belleroche J,Orrell RW

更新日期：2005-05-10 00:00:00

abstract：:CSF lymphocyte subpopulations of eight patients with neurosarcoidosis were examined. CSF or CT was abnormal in all. The CSF T4/T8 (helper/suppressor) ratio was elevated at 6.8 and 7.6 in two patients; in one, there were only CSF T4 cells. The ratio was normal in five patients. ...

journal_title：Neurology

authors： Stern BJ,Griffin DE,Luke RA,Krumholz A,Johns CJ

更新日期：1987-05-01 00:00:00

abstract：OBJECTIVES:The authors report the results of a prospective, placebo-controlled, randomized study to evaluate the effectiveness of 3,4-diaminopyridine (DAP) in patients with Lambert-Eaton myasthenic syndrome (LEMS) and to determine the acute and long-term side effects of DAP. METHODS:Twenty-six patients with LEMS compl...

journal_title：Neurology

authors： Sanders DB,Massey JM,Sanders LL,Edwards LJ

更新日期：2000-02-08 00:00:00

abstract：OBJECTIVE:To conduct a comprehensive analysis of circulating metabolites and incident stroke in large prospective population-based settings. METHODS:We investigated the association of metabolites with risk of stroke in seven prospective cohort studies including 1,791 incident stroke events among 38,797 participants in...

journal_title：Neurology

authors： Vojinovic D,Kalaoja M,Trompet S,Fischer K,Shipley MJ,Li S,Havulinna AS,Perola M,Salomaa V,Yang Q,Sattar N,Jousilahti P,Amin N,Satizabal CL,Taba N,Sabayan B,Vasan RS,Ikram MA,Stott DJ,Ala-Korpela M,Jukema JW,Sesh

更新日期：2020-12-02 00:00:00

abstract：BACKGROUND:Although about 7 million people in the US population use marijuana at least weekly, there is a paucity of scientific data on persistent neurocognitive effects of marijuana use. OBJECTIVE:To determine if neurocognitive deficits persist in 28-day abstinent heavy marijuana users and if these deficits are dose-...

journal_title：Neurology

authors： Bolla KI,Brown K,Eldreth D,Tate K,Cadet JL

更新日期：2002-11-12 00:00:00

abstract：BACKGROUND:Recent studies demonstrated an excess of winter births in children with brain tumors and in adults with various neurologic or psychiatric diseases relative to the general population. OBJECTIVE:To investigate a possible association between month of birth and risk of brain tumors in adults using data from a l...

journal_title：Neurology

authors： Brenner AV,Linet MS,Shapiro WR,Selker RG,Fine HA,Black PM,Inskip PD

更新日期：2004-07-27 00:00:00

abstract：OBJECTIVE:To assess the available evidence for the diagnostic accuracy of CSF testing for protein 14-3-3 in patients with suspected sporadic Creutzfeldt-Jakob disease (sCJD). METHODS:The authors performed a systematic review of the available literature from 1995 to January 1, 2011, to identify articles involving patie...

journal_title：Neurology

authors： Muayqil T,Gronseth G,Camicioli R

更新日期：2012-10-02 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of onabotulinumtoxinA 100 U in noncatheterizing patients with multiple sclerosis (MS) with urinary incontinence (UI) due to neurogenic detrusor overactivity (NDO). METHODS:In this randomized, double-blind phase III study, patients received onabotulinumtoxinA 100 U (n = 66)...

journal_title：Neurology

authors： Tullman M,Chartier-Kastler E,Kohan A,Keppenne V,Brucker BM,Egerdie B,Mandle M,Nicandro JP,Jenkins B,Denys P

更新日期：2018-08-14 00:00:00

abstract：:We developed a scheme using routinely available data to estimate the risk of human immunodeficiency virus (HIV) dementia in HIV-infected persons over time. We performed a longitudinal review of medical records from more than 100 medical facilities in 11 U.S. cities. A total of 19,462 HIV-infected persons without histo...

journal_title：Neurology

authors： Qureshi AI,Hanson DL,Jones JL,Janssen RS

更新日期：1998-02-01 00:00:00

abstract：:Gilles de la Tourette's syndrome (TS) is a familial disorder that is often exacerbated by stress or fatigue. Here we present a family of a TS proband that has several members with obsessive-compulsive symptoms, a bleeding disorder, and an unusual sensitivity to heat. The proband, who is affected by all of these traits...

journal_title：Neurology

authors： Lombroso PJ,Mack G,Scahill L,King RA,Leckman JF

更新日期：1991-12-01 00:00:00

abstract：:The Finnish Twin Cohort includes all Finnish same-sexed twins born before 1958 and alive in 1967; the number of individuals alive in 1975 was 33,247. We performed a search for cases with Parkinson's disease among this cohort by linking the Twin Cohort Register with the Finnish Hospital Discharge Register and the Finni...

journal_title：Neurology

authors： Marttila RJ,Kaprio J,Koskenvuo M,Rinne UK

更新日期：1988-08-01 00:00:00

abstract：OBJECTIVES:Laminin alpha2 deficiency presents at birth with muscle weakness, hypotonia, and usually asymptomatic white matter signal on MRI. Few patients with laminin alpha2 deficiency have been described with seizures and structural brain abnormalities. The reason for the variation in the severity of the clinical phen...

journal_title：Neurology

authors： Pegoraro E,Fanin M,Trevisan CP,Angelini C,Hoffman EP

更新日期：2000-10-24 00:00:00

abstract：OBJECTIVE:To evaluate levels of neurofilament light (NFL) and glial fibrillary acidic protein (GFAP) in CSF from patients with multiple sclerosis (MS) in relation to clinical progress of the disease. METHODS:CSF levels of NFL and GFAP were determined by sensitive ELISAs in 99 patients with different subtypes of MS, cl...

journal_title：Neurology

authors： Norgren N,Sundström P,Svenningsson A,Rosengren L,Stigbrand T,Gunnarsson M

更新日期：2004-11-09 00:00:00

abstract：:We conducted a retrospective study to determine the frequency of depression, hallucinations, and delusions in patients with diffuse Lewy body disease (DLBD) and to compare these findings with those in Alzheimer's disease (AD) and Parkinson's disease (PD). One hundred twelve subjects were included in the study. Of thes...

journal_title：Neurology

authors： Klatka LA,Louis ED,Schiffer RB

更新日期：1996-11-01 00:00:00

abstract：:Pathologic changes and distribution of lesions of the spinal cord were studied in 16 patients who suffered from "anoxic" episodes. The lesions were symmetrical and limited to the gray matter. The vulnerability of the spinal cord was most marked in the lumbosacral region, although almost every nucleus throughout the sp...

journal_title：Neurology

authors： Azzarelli B,Roessmann U

更新日期：1977-11-01 00:00:00

abstract：OBJECTIVE:To investigate whether baseline concentrations of plasma total tau (t-tau) and neurofilament light (NfL) chain proteins are associated with annual percent change (APC) of the basal forebrain cholinergic system (BFCS) in cognitively intact older adults at risk for Alzheimer disease (AD). METHODS:This was a la...

journal_title：Neurology

authors： Cavedo E,Lista S,Houot M,Vergallo A,Grothe MJ,Teipel S,Zetterberg H,Blennow K,Habert MO,Potier MC,Dubois B,Hampel H,INSIGHT-preAD Study Group.,Alzheimer Precision Medicine Initiative

更新日期：2020-01-07 00:00:00