Season of birth and risk of brain tumors in adults.


BACKGROUND:Recent studies demonstrated an excess of winter births in children with brain tumors and in adults with various neurologic or psychiatric diseases relative to the general population. OBJECTIVE:To investigate a possible association between month of birth and risk of brain tumors in adults using data from a large, hospital-based case-control study. METHODS:Cases were patients with incident glioma (n = 489) or meningioma (n = 197) diagnosed at hospitals in Boston, MA, Phoenix, AZ, and Pittsburgh, PA. Controls (n = 799) were patients hospitalized for a variety of nonmalignant conditions and frequency matched to cases by hospital, age, sex, race/ethnicity, and distance of residence from hospital. Odds ratios (ORs) were calculated using multivariate unconditional logistic regression allowing for cyclic variation in risk with month of birth. RESULTS:A relationship between month of birth and risk of adult glioma and meningioma was found, best described by a 12-month periodic function with peaks in February and January and troughs in August and July. The association between month of birth and risk of glioma differed significantly by handedness, with left-handed and ambidextrous subjects born during late fall through early spring being at particularly high risk of adult glioma as compared with those born at other times of the year. CONCLUSION:These findings suggest the importance of seasonally varying exposures during the pre- or postnatal period in the development of brain tumors in adults.






Brenner AV,Linet MS,Shapiro WR,Selker RG,Fine HA,Black PM,Inskip PD




Has Abstract


2004-07-27 00:00:00














  • Primary intramedullary spinal cord lymphoma.

    abstract:OBJECTIVE:Among the rare causes of myelopathies is primary intramedullary spinal cord lymphoma (PISCL). As PISCL is often underrecognized, delaying appropriate treatment, we sought to describe its presentation, imaging characteristics, and outcomes. METHODS:Mayo Clinic medical records, lymphoma database, and autopsies...


    pub_type: 杂志文章


    authors: Flanagan EP,O'Neill BP,Porter AB,Lanzino G,Haberman TM,Keegan BM

    更新日期:2011-08-23 00:00:00

  • ALS phenotype is influenced by age, sex, and genetics: A population-based study.

    abstract:OBJECTIVE:To assess the determinants of amyotrophic lateral sclerosis (ALS) phenotypes in a population-based cohort. METHODS:The study population included 2,839 patients with ALS diagnosed in Piemonte, Italy (1995-2015). Patients were classified according to motor (classic, bulbar, flail arm, flail leg, predominantly ...


    pub_type: 杂志文章


    authors: Chiò A,Moglia C,Canosa A,Manera U,D'Ovidio F,Vasta R,Grassano M,Brunetti M,Barberis M,Corrado L,D'Alfonso S,Iazzolino B,Peotta L,Sarnelli MF,Solara V,Zucchetti JP,De Marchi F,Mazzini L,Mora G,Calvo A

    更新日期:2020-02-25 00:00:00

  • Extended use of glatiramer acetate (Copaxone) is well tolerated and maintains its clinical effect on multiple sclerosis relapse rate and degree of disability. Copolymer 1 Multiple Sclerosis Study Group.

    abstract::When 251 relapsing-remitting patients with multiple sclerosis were randomized to receive daily subcutaneous injections of glatiramer acetate, previously called copolymer 1 (Copaxone; n = 125) or placebo (n = 126) for 24 months, there were no laboratory abnormalities associated with glatiramer acetate treatment and it ...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Johnson KP,Brooks BR,Cohen JA,Ford CC,Goldstein J,Lisak RP,Myers LW,Panitch HS,Rose JW,Schiffer RB,Vollmer T,Weiner LP,Wolinsky JS

    更新日期:1998-03-01 00:00:00

  • Subacute sclerosing panencephalitis: measles virus matrix protein nucleic acid sequences detected by in situ hybridization.

    abstract::Subacute sclerosing panencephalitis (SSPE) is characterized by a hyperimmune state toward the polypeptides of measles virus except the matrix (M) protein. Using cloned (3H)-labeled complementary DNA probes for in situ hybridization, we found the M protein and nucleocapsid (NP) protein nucleotide sequences in glial cel...


    pub_type: 杂志文章


    authors: Shapshak P,Tourtellotte WW,Nakamura S,Graves MC,Darvish M,Hoffman D,Walsh MJ,Fareed GC,Schmid P,Heinzmann C

    更新日期:1985-11-01 00:00:00

  • Common peroneal neuropathy: A study of selective motor and sensory involvement.

    abstract::We performed a prospective clinical and electrophysiologic study of common peroneal (CP) neuropathy to evaluate the extent of involvement of the muscles and cutaneous areas supplied by this nerve. In 22 patients, seven had more weakness clinically in muscles innervated by the deep peroneal nerve than in those innervat...


    pub_type: 杂志文章


    authors: Sourkes M,Stewart JD

    更新日期:1991-07-01 00:00:00

  • Defining the Lowest Threshold for Amyloid-PET to Predict Future Cognitive Decline and Amyloid Accumulation.

    abstract:INTRODUCTION:As clinical trials move toward earlier intervention, we sought to redefine the β-amyloid (Aβ)-PET threshold based on the lowest point in a baseline distribution that robustly predicts future Aβ accumulation and cognitive decline in 3 independent samples of clinically normal individuals. METHODS:Sequential...


    pub_type: 杂志文章


    authors: Farrell ME,Jiang S,Schultz AP,Properzi MJ,Price JC,Becker JA,Jacobs HIL,Hanseeuw BJ,Rentz DM,Villemagne VL,Papp KV,Mormino EC,Betensky RA,Johnson KA,Sperling RA,Buckley RF,Alzheimer's Disease Neuroimaging Initiative and t

    更新日期:2021-01-26 00:00:00

  • Plasma exchange for acute attacks of CNS demyelination: Predictors of improvement at 6 months.

    abstract:BACKGROUND:Plasma exchange (PE) is used to treat severe episodes of CNS demyelination unresponsive to corticosteroids. Predictors of long-term response are not well known. METHODS:We retrospectively reviewed the medical records of 41 patients consecutively treated by PE between January 1995 and July 2007. The primary ...


    pub_type: 杂志文章


    authors: Llufriu S,Castillo J,Blanco Y,Ramió-Torrentà L,Río J,Vallès M,Lozano M,Castellà MD,Calabia J,Horga A,Graus F,Montalban X,Saiz A

    更新日期:2009-09-22 00:00:00

  • Fulminant amebic meningoencephalitis due to Acanthamoeba.

    abstract::A 57-year-old chronically immunosuppressed woman with systemic lupus erythematosus developed fulminant meningoencephalitis due to Acanthamoeba castellanii. Amebic trophozoites were also found in the lungs, suggesting a primary pulmonary focus of infection. This case illustrates that Acanthamoeba can cause a fulminant,...


    pub_type: 杂志文章


    authors: Grunnet ML,Cannon GH,Kushner JP

    更新日期:1981-02-01 00:00:00

  • Epileptic skew deviation.

    abstract::We describe a 43-year-old neurologically intact patient who reported episodes of diplopia and oscillopsia associated with a right-beating nystagmus and a skew deviation. These symptoms and signs were related to a left posterior epileptic EEG discharge. We suggest that these ocular motor signs derived from an ictal act...


    pub_type: 杂志文章


    authors: Galimberti CA,Versino M,Sartori I,Manni R,Martelli A,Tartara A

    更新日期:1998-05-01 00:00:00

  • Double-blind comparison of pramipexole and bromocriptine treatment with placebo in advanced Parkinson's disease. International Pramipexole-Bromocriptine Study Group.

    abstract::Pramipexole is a new, selective, nonergoline dopamine agonist that acts on D2 and preferentially on D3 dopamine receptors. Phase II and III clinical trials have shown this drug to be useful in treating both early and advanced Parkinson's disease (PD) patients. A double-blind, randomized, multicenter study was performe...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Guttman M

    更新日期:1997-10-01 00:00:00

  • Exacerbation of Gilles de la Tourette's syndrome associated with thermal stress: a family study.

    abstract::Gilles de la Tourette's syndrome (TS) is a familial disorder that is often exacerbated by stress or fatigue. Here we present a family of a TS proband that has several members with obsessive-compulsive symptoms, a bleeding disorder, and an unusual sensitivity to heat. The proband, who is affected by all of these traits...


    pub_type: 杂志文章


    authors: Lombroso PJ,Mack G,Scahill L,King RA,Leckman JF

    更新日期:1991-12-01 00:00:00

  • Impact of multiple sclerosis relapses on progression diminishes with time.

    abstract:OBJECTIVE:The relationship between relapses and long-term disability in multiple sclerosis (MS) remains to be fully elucidated. Current literature is conflicting and focused on early relapses. We investigated the effects of relapses at different stages on disability progression. METHODS:We conducted a retrospective re...


    pub_type: 杂志文章


    authors: Tremlett H,Yousefi M,Devonshire V,Rieckmann P,Zhao Y,UBC Neurologists.

    更新日期:2009-11-17 00:00:00

  • Recurrent stroke and cardiac risks after first ischemic stroke: the Northern Manhattan Study.

    abstract:BACKGROUND:Few population-based studies with long-term follow-up have compared risk of recurrent stroke and cardiac events after first ischemic stroke. The relative risk of these two outcomes may inform treatment decisions. METHODS:In the population-based Northern Manhattan Study, first ischemic stroke patients age 40...


    pub_type: 杂志文章


    authors: Dhamoon MS,Sciacca RR,Rundek T,Sacco RL,Elkind MS

    更新日期:2006-03-14 00:00:00

  • Neuroleptic malignant syndrome: a unique association with a tricyclic antidepressant.

    abstract::We report the lst case of neuroleptic malignant syndrome occurring in a patient receiving desipramine, a tricyclic antidepressant, with no exposure to neuroleptics. Our case suggests that this syndrome may be caused by a central imbalance between norepinephrine and dopamine, and not by dopamine depletion alone. ...


    pub_type: 杂志文章


    authors: Baca L,Martinelli L

    更新日期:1990-11-01 00:00:00

  • Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease.

    abstract:OBJECTIVE:Diverse autolysosomal proteins were quantified in neurally derived blood exosomes from patients with Alzheimer disease (AD) and controls to investigate disordered neuronal autophagy. METHODS:Blood exosomes obtained once from patients with AD (n = 26) or frontotemporal dementia (n = 16), other patients with A...


    pub_type: 杂志文章


    authors: Goetzl EJ,Boxer A,Schwartz JB,Abner EL,Petersen RC,Miller BL,Kapogiannis D

    更新日期:2015-07-07 00:00:00

  • Autonomic hyperreflexia in pure progressive autonomic failure: a case report.

    abstract::A 60-year-old woman suffered from recurrent episodes of fever, hypertension, facial flushing, vomiting, stridor, slowly progressive symptoms of hypohidrosis, and orthostatic hypotension. The episodes were synchronous with elevated catecholamine concentration in plasma and urine. This is an example of paroxysmal autono...


    pub_type: 杂志文章


    authors: Mitsui T,Kawai H,Taguchi E,Miyamoto H,Saito S

    更新日期:1993-09-01 00:00:00

  • Advances in intravenous thrombolytic therapy for treatment of acute stroke.

    abstract::Intravenous tissue plasminogen activator (tPA) is an effective therapy for treatment of acute ischemic stroke when administered within 3 hours of symptom onset. Three large randomized clinical trials that have attempted to extend the time window for tPA treatment beyond 3 hours have failed to demonstrate convincing ev...


    pub_type: 杂志文章,评审


    authors: Albers GW

    更新日期:2001-01-01 00:00:00

  • TNF-alpha expression in painful and nonpainful neuropathies.

    abstract:OBJECTIVE:To determine whether the cytokine tumor necrosis factor alpha (TNF-alpha) acts as a pain mediator in neuropathic pain in humans. BACKGROUND:In animal models, inflammatory cytokines such as TNF-alpha have been shown to facilitate neuropathic pain. METHODS:The expression of TNF-alpha was analyzed immunohistoc...


    pub_type: 杂志文章


    authors: Empl M,Renaud S,Erne B,Fuhr P,Straube A,Schaeren-Wiemers N,Steck AJ

    更新日期:2001-05-22 00:00:00

  • Tetanus vaccination and risk of multiple sclerosis: a systematic review.

    abstract:OBJECTIVE:To conduct a systematic review on the association between tetanus vaccination and the risk of multiple sclerosis (MS). METHODS:The authors searched the databases Medline, LILACS, EMBASE, and Science Citation Index including the period 1966 to September 1, 2005. Eligible studies had to meet the following incl...


    pub_type: 杂志文章,评审


    authors: Hernán MA,Alonso A,Hernández-Díaz S

    更新日期:2006-07-25 00:00:00

  • Acrylamide induces early morphologic reorganization of the neuronal cell body.

    abstract::Rats were intoxicated with acrylamide monomer at 50 mg per kilogram per day; lumbar dorsal root ganglia and distal sural and tibial nerves were studied morphologically. At the sixth day of intoxication, large and small neuronal cell bodies showed a spectrum of remodeling changes that included nuclear eccentricity, cyt...


    pub_type: 杂志文章


    authors: Sterman AB

    更新日期:1982-09-01 00:00:00

  • Botulinum toxin for simple motor tics: a randomized, double-blind, controlled clinical trial.

    abstract:OBJECTIVE:To determine the effect of injections of botulinum toxin on simple motor tics. BACKGROUND:Case series with unblinded assessments have reported improvement in tic frequency and associated urge with botulinum toxin. METHODS:Patients with suitable simple motor tics were randomized to receive botulinum toxin an...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Marras C,Andrews D,Sime E,Lang AE

    更新日期:2001-03-13 00:00:00

  • Prevalence of headaches in a Chinese elderly population in Kinmen: age and gender effect and cross-cultural comparisons.

    abstract:OBJECTIVE:To investigate the prevalence of headaches in a Chinese elderly population. BACKGROUND:There are few headache surveys in the elderly. Previous studies have shown a low headache prevalence in Chinese. METHODS: TARGET POPULATION:eligible registered residents > or = 65 years old (N = 2,003) in two townships o...


    pub_type: 杂志文章


    authors: Wang SJ,Liu HC,Fuh JL,Liu CY,Lin KP,Chen HM,Lin CH,Wang PN,Hsu LC,Wang HC,Lin KN

    更新日期:1997-07-01 00:00:00

  • Sorivudine: a promising drug for the treatment of varicella-zoster virus infection.

    abstract::Sorivudine provides a unique nucleoside analog with significantly enhanced both in vitro and in vitro activity and enhanced oral bioavailability. Early indications from controlled studies indicate that sorivudine therapy is superior to acyclovir for the treatment of localized zoster in individuals with HIV infection a...


    pub_type: 杂志文章,评审


    authors: Whitley RJ

    更新日期:1995-12-01 00:00:00

  • In vivo studies on striatal dopamine D1 and D2 site binding in L-dopa-treated Parkinson's disease patients with and without dyskinesias.

    abstract::Dyskinesias are usually seen in Parkinson's disease (PD) patients after several years of L-dopa therapy. Their presence has been attributed to supersensitivity of striatal D1 and D2 receptors. We have used PET to assess striatal D2 receptor binding in untreated PD patients and striatal D1 and D2 binding in L-dopa-trea...


    pub_type: 杂志文章


    authors: Turjanski N,Lees AJ,Brooks DJ

    更新日期:1997-09-01 00:00:00

  • Pathogenesis of pseudotumor cerebri syndromes.

    abstract::Intracranial hypertension in the absence of an intracranial mass lesion or hydrocephalus can be caused by an alteration of one or more of the four determinants of cerebrospinal fluid (CSF) pressure: (1) intrasagittal sinus pressure, (2) resistance of arachnoid villi to the egress of CSF, (3) rate of production of CSF,...


    pub_type: 杂志文章


    authors: Donaldson JO

    更新日期:1981-07-01 00:00:00

  • Botulinum toxin for blepharospasm: single-fiber EMG studies.

    abstract::In four patients who received periocular injections of botulinum toxin for blepharospasm, abnormal neuromuscular transmission was demonstrated by single-fiber EMG in arm muscles. The time course with which the abnormalities developed and cleared, as well as the inverse relationship between the neuromuscular jitter and...


    pub_type: 杂志文章


    authors: Sanders DB,Massey EW,Buckley EG

    更新日期:1986-04-01 00:00:00

  • Circulating cortisol and cognitive and structural brain measures: The Framingham Heart Study.

    abstract:OBJECTIVE:To assess the association of early morning serum cortisol with cognitive performance and brain structural integrity in community-dwelling young and middle-aged adults without dementia. METHODS:We evaluated dementia-free Framingham Heart Study (generation 3) participants (mean age 48.5 years, 46.8% men) who u...


    pub_type: 杂志文章


    authors: Echouffo-Tcheugui JB,Conner SC,Himali JJ,Maillard P,DeCarli CS,Beiser AS,Vasan RS,Seshadri S

    更新日期:2018-11-20 00:00:00

  • Recognizing and preventing epilepsy-related mortality: A call for action.

    abstract::Epilepsy is associated with a high rate of premature mortality from direct and indirect effects of seizures, epilepsy, and antiseizure therapies. Sudden unexpected death in epilepsy (SUDEP) is the second leading neurologic cause of total lost potential life-years after stroke, yet SUDEP may account for less than half ...


    pub_type: 杂志文章,评审


    authors: Devinsky O,Spruill T,Thurman D,Friedman D

    更新日期:2016-02-23 00:00:00

  • Body mass index and the risk of Parkinson disease.

    abstract:OBJECTIVE:To examine the association between body mass index (BMI) and the risk of Parkinson disease (PD). METHODS:Study cohorts included 22,367 Finnish men and 23,439 women 25 to 59 years of age without a history of PD at baseline. Hazards ratios (HRs) of incident PD were estimated for different levels of BMI. RESUL...


    pub_type: 杂志文章


    authors: Hu G,Jousilahti P,Nissinen A,Antikainen R,Kivipelto M,Tuomilehto J

    更新日期:2006-12-12 00:00:00

  • Dysarthria and broader motor speech deficits in Dravet syndrome.

    abstract:OBJECTIVE:To analyze the oral motor, speech, and language phenotype in 20 children and adults with Dravet syndrome (DS) associated with mutations in SCN1A. METHODS:Fifteen verbal and 5 minimally verbal DS patients with SCN1A mutations (aged 15 months-28 years) underwent a tailored assessment battery. RESULTS:Speech w...


    pub_type: 杂志文章


    authors: Turner SJ,Brown A,Arpone M,Anderson V,Morgan AT,Scheffer IE

    更新日期:2017-02-21 00:00:00