A novel laminin alpha2 isoform in severe laminin alpha2 deficient congenital muscular dystrophy.

abstract：BACKGROUND:Silas Weir Mitchell (1829 to 1914), one of the most important neurologists in American Medicine, was known for his seminal work on the phantom limb syndrome, causalgia, and nerve injuries. He was also a prolific writer of novels and short stories. The neurologic content of this fiction has not been studied. ...

journal_title：Neurology

authors： Louis ED,Horn S,Roth LA

更新日期：2006-02-14 00:00:00

abstract：:Juvenile-onset dystonia that improves after levodopa may occur in both dopa-responsive dystonia (DRD) and juvenile parkinsonism (JP), clinically similar conditions with different prognoses and management goals. The authors show normal striatal uptake of the dopamine transporter ligand FP-CIT with SPECT in a clinically...

journal_title：Neurology

authors： O'Sullivan JD,Costa DC,Gacinovic S,Lees AJ

更新日期：2001-01-23 00:00:00

abstract：:We studied the cerebral effects of oxygen-derived free radicals generated from the xanthine oxidase/hypoxanthine/ADP-Fe3+ system. Xanthine oxidase/hypoxanthine/ADP-Fe3+ solution (0.1 ml) was infused into caudate putamen, and brain was frozen rapidly in situ. Brain water and sodium content increased concomitant with de...

journal_title：Neurology

authors： Chan PH,Schmidley JW,Fishman RA,Longar SM

更新日期：1984-03-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that accelerated peripheral blood mononuclear cell recovery after alemtuzumab treatment of multiple sclerosis is associated with recurrent disease activity and to investigate the claim that CD4 counts greater than 388.5 × 10(6) cells/mL at 12 months can be used to identify patients who ...

journal_title：Neurology

authors： Kousin-Ezewu O,Azzopardi L,Parker RA,Tuohy O,Compston A,Coles A,Jones J

更新日期：2014-06-17 00:00:00

abstract：OBJECTIVE:To describe the clinical features, MRI findings, and pathogenesis of strokes producing internuclear ophthalmoplegia (INO) as an isolated or predominant clinical manifestation. METHODS:Thirty patients presenting with INO without (n = 12) or with (n = 18) minimal other neurologic signs were studied. MRI and an...

journal_title：Neurology

authors： Kim JS

更新日期：2004-05-11 00:00:00

abstract：:As the substantia nigra degenerates in Parkinson's disease (PD), the nigrostriatal pathway is disrupted, reducing striatal dopamine and producing PD symptoms. Although dopamine does not readily cross the blood-brain barrier, its precursor, levodopa, does. Levodopa is absorbed in the small bowel and is rapidly cataboli...

journal_title：Neurology

authors： Koller WC,Rueda MG

更新日期：1998-06-01 00:00:00

abstract：:A double-blind crossover study with imipramine was conducted in 10 patients with absence and myoclonic-astatic seizures who had not responded to conventional medications. Imipramine produced a significant initial decrease in seizure frequency in 5 of the 10 patients, and in 2 patients the beneficial effect was maintai...

journal_title：Neurology

authors： Fromm GH,Wessel HB,Glass JD,Alvin JD,Van Horn G

更新日期：1978-09-01 00:00:00

abstract：:Seventy-one neonates were observed for the relationship between phenobarbital plasma concentrations and elimination of seizures. Sixty neonates (85%) had seizures controlled by phenobarbital alone. Effective plasma concentrations were 10.1 to 46.4 mg per liter. Although 36 neonates had seizures controlled by phenobarb...

journal_title：Neurology

authors： Gal P,Toback J,Boer HR,Erkan NV,Wells TJ

更新日期：1982-12-01 00:00:00

abstract：BACKGROUND:Several lines of evidence suggest that inflammatory mechanisms contribute to AD. OBJECTIVE:To examine whether several markers of inflammation are associated with cognitive decline in African-American and white well-functioning elders. METHODS:The authors studied 3,031 African-American and white men and wom...

journal_title：Neurology

authors： Yaffe K,Lindquist K,Penninx BW,Simonsick EM,Pahor M,Kritchevsky S,Launer L,Kuller L,Rubin S,Harris T

更新日期：2003-07-08 00:00:00

abstract：BACKGROUND:Differentiating idiopathic late-onset cerebellar ataxia (ILOCA) from ataxia due to the cerebellar subtype of multiple-system atrophy (MSA-C) can be difficult in the early stages of the disease METHODS:The authors analyzed the levels of various CSF biomarkers in 27 patients with MSA-C and 18 patients with IL...

journal_title：Neurology

authors： Abdo WF,van de Warrenburg BP,Munneke M,van Geel WJ,Bloem BR,Kremer HP,Verbeek MM

更新日期：2006-08-08 00:00:00

abstract：:We describe the clinical, pathologic, and ultrastructural findings in a case of juvenile onset neuronal ceroid-lipofuscinosis without visual symptoms or retinal abnormalities. The histochemical and ultrastructural characteristics of the neuronal lipopigment were similar to those in typical cases of neuronal ceroid-lip...

journal_title：Neurology

authors： Greenwood RS,Nelson JS

更新日期：1978-07-01 00:00:00

abstract：OBJECTIVE:To assess the recovery process in patients after an acute optic neuritis (ON) attack, comparing static and dynamic visual functions. METHODS:In this prospective controlled study, 21 patients with unilateral, first-ever ON were followed over the course of 1 year. Standard visual tests, visual evoked potential...

journal_title：Neurology

authors： Raz N,Dotan S,Benoliel T,Chokron S,Ben-Hur T,Levin N

更新日期：2011-06-14 00:00:00

abstract：:The association between multiple sclerosis (MS) and alleles of the HLA class II genes indicates that at least one MS susceptibility gene is linked to the HLA class II region. However, the actual locus responsible has not been precisely identified. The recent cloning of new genes involved in antigen processing that map...

journal_title：Neurology

authors： Liblau R,van Endert PM,Sandberg-Wollheim M,Patel SD,Lopez MT,Land S,Fugger L,McDevitt HO

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND:There is a paucity of therapies for gait impairment in Parkinson disease (PD). Open-label studies have suggested improved gait after treatment with methylphenidate (MPD). OBJECTIVE:To evaluate the efficacy of MPD for the treatment of gait impairment in PD. METHODS:Twenty-seven subjects with PD and moderate...

journal_title：Neurology

authors： Espay AJ,Dwivedi AK,Payne M,Gaines L,Vaughan JE,Maddux BN,Slevin JT,Gartner M,Sahay A,Revilla FJ,Duker AP,Shukla R

更新日期：2011-04-05 00:00:00

abstract：OBJECTIVE:To assess whether lifetime physical activity during work and leisure time is associated with an increased risk of developing ALS and to determine the association between physical activity and duration or age at onset of disease. METHODS:Patients referred to our clinic during the 1-year period 2001 to 2002 wh...

journal_title：Neurology

authors： Veldink JH,Kalmijn S,Groeneveld GJ,Titulaer MJ,Wokke JH,van den Berg LH

更新日期：2005-01-25 00:00:00

abstract：:A 42-year-old man had progressive distal weakness and muscle atrophy, stocking-type sensory loss, upper motor-neuron and visual pathway lesions, and dysautonomia. Electrodiagnostic tests revealed a generalized sensorimotor peripheral neuropathy that largely involved axons. Low recumbent and upright norepinephrine leve...

journal_title：Neurology

authors： Rechthand E,Reife R,Kaplan JG

更新日期：1983-11-01 00:00:00

abstract：BACKGROUND:The authors previously reported on the development of thyroid dysfunction and autoimmunity during 1-year treatment of patients with MS with interferon-beta 1b (IFN beta-1b). OBJECTIVE:To evaluate the evolution of incident thyroid disease and the possible development of more thyroid disease during longer ter...

journal_title：Neurology

authors： Monzani F,Caraccio N,Casolaro A,Lombardo F,Moscato G,Murri L,Ferrannini E,Meucci G

更新日期：2000-08-22 00:00:00

abstract：OBJECTIVES:Neurocysticercosis (NCYST) is the most frequent CNS parasitic disease worldwide, affecting more than 50 million people. However, some of its clinical findings, such as cognitive impairment and dementia, remain poorly characterized, with no controlled studies conducted so far. We investigated the frequency an...

journal_title：Neurology

authors： Ciampi de Andrade D,Rodrigues CL,Abraham R,Castro LH,Livramento JA,Machado LR,Leite CC,Caramelli P

更新日期：2010-04-20 00:00:00

abstract：OBJECTIVE:To comprehensively assess neurobiological effects of the protective APOE2 allele in the aged brain using a cross-sectional multimodal neuroimaging approach. METHODS:Multimodal neuroimaging data were obtained from a total of 572 older individuals without dementia (cognitively normal and mild cognitive impairm...

journal_title：Neurology

authors： Grothe MJ,Villeneuve S,Dyrba M,Bartrés-Faz D,Wirth M,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2017-02-07 00:00:00

abstract：:The incidence of MS in the Orkney Islands has been updated from 1941 to September 21, 1983. Since 1965, MS incidence rates have fallen significantly when compared with those for 1941 to 1964. Alterations in age-specific prevalence, mean duration of illness, and mean age of the MS population are consistent with the dec...

journal_title：Neurology

authors： Cook SD,Cromarty JI,Tapp W,Poskanzer D,Walker JD,Dowling PC

更新日期：1985-04-01 00:00:00

abstract：:We studied the eye movements and visual perception in a man with extensive bilateral occipital lesions acquired at birth. He had 3/500 acuity, limited visual fields, and extrafoveal fixation attributable to an intact left superior visual cortex. Analysis of digitized electro-oculography and magnetic search coil data s...

journal_title：Neurology

authors： Rizzo M,Hurtig R

更新日期：1989-03-01 00:00:00

abstract：:The authors report an autosomal dominant episodic ataxia that is clinically distinct from the other episodic ataxias. Vestibular ataxia, vertigo, tinnitus, and interictal myokymia are prominent; attacks are diminished by acetazolamide. Linkage analyses of markers flanking the EA1 and EA2 loci demonstrate genetic exclu...

journal_title：Neurology

authors： Steckley JL,Ebers GC,Cader MZ,McLachlan RS

更新日期：2001-10-23 00:00:00

abstract：:This study investigates a canine model of experimental brain tumor. Particularly addressed was the usefulness of gadolinium contrast-enhanced MRI for differentiating brain tumor tissue from cerebral edema. Cultured canine glioma cells were injected into the left hemispheres of six adult mongrel dogs. All dogs develope...

journal_title：Neurology

authors： Whelan HT,Clanton JA,Moore PM,Tolner DJ,Kessler RM,Whetsell WO Jr

更新日期：1987-07-01 00:00:00

abstract：BACKGROUND:Microvascular brain injury, typically measured by extent of white matter hyperintensity (WMH) on MRI, is an important contributor to cognitive impairment in the elderly. Recent studies suggest a role for circulating beta-amyloid peptide in microvascular dysfunction and white matter disease. METHODS:The auth...

journal_title：Neurology

authors： Gurol ME,Irizarry MC,Smith EE,Raju S,Diaz-Arrastia R,Bottiglieri T,Rosand J,Growdon JH,Greenberg SM

更新日期：2006-01-10 00:00:00

abstract：OBJECTIVE:To characterize disease severity and distribution of disability in pediatric-onset multiple sclerosis (POMS) and to develop an optimized modeling scale for measuring disability, we performed a multicenter retrospective analysis of disability scores in 873 persons with POMS over time and compared this to previ...

journal_title：Neurology

authors： Santoro JD,Waltz M,Aaen G,Belman A,Benson L,Gorman M,Goyal MS,Graves JS,Harris Y,Krupp L,Lotze T,Mar S,Moodley M,Ness J,Rensel M,Rodriguez M,Schreiner T,Tillema JM,Waubant E,Weinstock-Guttman B,Hurtubise BF,Roal

更新日期：2020-09-29 00:00:00

abstract：:The term "Wernicke's area" is most often used as an anatomical label for the gyri forming the lower posterior left sylvian fissure. Although traditionally this region was held to support language comprehension, modern imaging and neuropsychological studies converge on the conclusion that this region plays a much large...

journal_title：Neurology

authors： Binder JR

更新日期：2015-12-15 00:00:00

abstract：OBJECTIVES:To examine the illusional sensation of movement evoked by vibration of an immobilized arm. METHODS:Patients with idiopathic focal dystonia were compared with those with idiopathic PD and with patients with dystonia secondary to PD. A 100-Hz transcutaneous vibratory stimulus was applied to the biceps brachii...

journal_title：Neurology

authors： Rome S,Grünewald RA

更新日期：1999-11-10 00:00:00

abstract：:The authors investigated whether repetitive transcranial magnetic stimulation (rTMS) at 1 Hz (12 minutes; 90% of motor threshold) to the primary motor cortex (M1) leads to changes in diffusion-weighted imaging (DWI). After the rTMS train, there was a temporary small restriction in diffusion within the targeted left M1...

journal_title：Neurology

authors： Mottaghy FM,Gangitano M,Horkan C,Chen Y,Pascual-Leone A,Schlaug G

更新日期：2003-05-13 00:00:00

abstract：OBJECTIVE:To study the accuracy of the ABCD2 score in predicting early stroke risk following TIA and to model post-test probability of stroke for varying cutoff scores and baseline stroke risk. METHODS:Medline, PubMed, Embase, conference proceedings, and manuscript references up to October 2010 were searched for studi...

journal_title：Neurology

authors： Sanders LM,Srikanth VK,Blacker DJ,Jolley DJ,Cooper KA,Phan TG

更新日期：2012-09-04 00:00:00

abstract：:In the current medical climate, medical education is at risk of being de-emphasized, leading to less financial support and compensation for faculty. A rise in compensation plans that reward clinical or research productivity fails to incentivize and threatens to erode the educational missions of our academic institutio...

journal_title：Neurology

authors： Weber D,Sarva H,Weaver J,Wang F,Chou J,Cornes S,Nickels K,Safdieh JE,Poncelet A,Stern BJ

更新日期：2019-07-02 00:00:00