A randomized trial of 3,4-diaminopyridine in Lambert-Eaton myasthenic syndrome.

abstract：:Neurologists are prescribing intravenous immunoglobulin (IVIg) with increasing frequency to treat many neurologic conditions that have a proven or presumed autoimmune or inflammatory pathogenesis. Although IVIg is not FDA approved for any neurologic condition, physicians can safely prescribe it for several disorders w...

journal_title：Neurology

authors： Donofrio PD,Busis NA

更新日期：2002-12-24 00:00:00

abstract：:Study of diagnostic practice is necessary to optimize neurologists' clinical performance and ensure patient safety. To our knowledge, this report is the first set of systematic observations of diagnostic practices of community neurologists in their clinics. The study consisted of six 2-week periods of in situ observat...

journal_title：Neurology

authors： Dhand A,Engstrom J,Dhaliwal G

更新日期：2013-10-15 00:00:00

abstract：OBJECTIVE:To report the safety and long-term efficacy of ventro-oral thalamotomy for 171 consecutive patients with task-specific focal hand dystonia. METHODS:Between October 2003 and February 2017, 171 consecutive patients with task-specific focal hand dystonia underwent unilateral ventro-oral thalamotomy. Etiologies ...

journal_title：Neurology

authors： Horisawa S,Ochiai T,Goto S,Nakajima T,Takeda N,Fukui A,Hanada T,Kawamata T,Taira T

更新日期：2019-01-22 00:00:00

abstract：:We present a new benign eating disorder associated with lesions involving parts of the right anterior cerebral hemisphere. This "gourmand" syndrome describes a preoccupation with food and a preference for fine eating. Two exemplary case reports illustrate this new syndrome. Analysis of the clinical and anatomical data...

journal_title：Neurology

authors： Regard M,Landis T

更新日期：1997-05-01 00:00:00

abstract：:Cognitive impairment is a frequent manifestation of advanced human immunodeficiency virus (HIV) infection. The response to antiretroviral medication is often partial and poorly sustained. Recent studies suggest that free radical production within the CNS and neuronal apoptosis may play important roles in the pathogene...

journal_title：Neurology

authors：

更新日期：1998-03-01 00:00:00

abstract：:The incidence of MS was assessed in a nationwide cohort study of 31,990 employees of Danish utility companies between 1900 and 1993. Overall, 32 cases of MS were diagnosed, as compared with 23.7 expected from national incidence rates, to yield a standardized incidence ratio of 1.35 (95% confidence interval, 0.92 to 1....

journal_title：Neurology

authors： Johansen C,Koch-Henriksen N,Rasmussen S,Olsen JH

更新日期：1999-04-12 00:00:00

abstract：:The authors describe diffusion-weighted imaging (DWI) and magnetic resonance spectroscopy (MRS) changes in the hippocampus within 48 hours of acute symptomatic seizures or status epilepticus in 12 patients. DWI showed increased signal and a decreased apparent diffusion coefficient (ADC) in all patients, with correspon...

journal_title：Neurology

authors： Parmar H,Lim SH,Tan NC,Lim CC

更新日期：2006-06-13 00:00:00

abstract：OBJECTIVE:Evidence of a relation between use of lipid lowering drugs and cognitive outcomes is mixed. This study aimed to test the association between use of statins and incidence of dementia and cognitive impairment without dementia (CIND) over 5 years of follow-up. METHODS:Data were from a population-based cohort st...

journal_title：Neurology

authors： Cramer C,Haan MN,Galea S,Langa KM,Kalbfleisch JD

更新日期：2008-07-29 00:00:00

abstract：:Fatal familial insomnia (FFI), a condition characterized by inability to sleep, dysautonomia, motor disturbances, and selective thalamic atrophy is a prion disease linked to a GAC----AAC mutation at codon 178 of the prion gene. These data were obtained from one kindred. We now report a second kindred affected by FFI a...

journal_title：Neurology

authors： Medori R,Montagna P,Tritschler HJ,LeBlanc A,Cortelli P,Tinuper P,Lugaresi E,Gambetti P

更新日期：1992-03-01 00:00:00

abstract：:We tested serum specimens from patients with HAM/TSP and asymptomatic HTLV-I carriers from endemic areas of Japan, Jamaica, Colombia, and Chile for neutralizing antibodies against HTLV-I. The data suggest a trend for neutralizing activity to be found more frequently in the sera from HAM/TSP patients than in sera from ...

journal_title：Neurology

authors： Minagawa H,Yoshida T,Itoyama Y,Mora CA,Albert P,Mori R

更新日期：1992-11-01 00:00:00

abstract：:Patients with myotonic dystrophy often develop respiratory failure caused by alveolar hypoventilation. Abnormalities in the ventilatory response to hypoxia and hypercapnia may explain this phenomenon. Accordingly, hypoxic and hypercapnic responses were measured in seven patients with myotonic dystrophy who had only mi...

journal_title：Neurology

authors： Carroll JE,Zwillich CW,Weil JV

更新日期：1977-12-01 00:00:00

abstract：:The authors report an autosomal dominant episodic ataxia that is clinically distinct from the other episodic ataxias. Vestibular ataxia, vertigo, tinnitus, and interictal myokymia are prominent; attacks are diminished by acetazolamide. Linkage analyses of markers flanking the EA1 and EA2 loci demonstrate genetic exclu...

journal_title：Neurology

authors： Steckley JL,Ebers GC,Cader MZ,McLachlan RS

更新日期：2001-10-23 00:00:00

abstract：:To determine the extent that different dopamine (DA) neuronal markers provide similar estimates of striatal (caudate and putamen) DA nerve terminal loss in idiopathic Parkinson's disease (PD), we compared, in postmortem striatum of 12 patients with PD and 10 matched controls, levels of five different DA neuronal marke...

journal_title：Neurology

authors： Wilson JM,Levey AI,Rajput A,Ang L,Guttman M,Shannak K,Niznik HB,Hornykiewicz O,Pifl C,Kish SJ

更新日期：1996-09-01 00:00:00

abstract：:Gilles de la Tourette's syndrome (TS) is a familial disorder that is often exacerbated by stress or fatigue. Here we present a family of a TS proband that has several members with obsessive-compulsive symptoms, a bleeding disorder, and an unusual sensitivity to heat. The proband, who is affected by all of these traits...

journal_title：Neurology

authors： Lombroso PJ,Mack G,Scahill L,King RA,Leckman JF

更新日期：1991-12-01 00:00:00

abstract：OBJECTIVE:To determine the relationship between hippocampal, amygdalar, and entorhinal cortex atrophy and duration of epilepsy, presence of secondary generalized seizures, and prolonged childhood febrile convulsions in patients with pharmacologically intractable temporal lobe epilepsy (TLE). METHODS:Volumetric MRI of ...

journal_title：Neurology

authors： Bernasconi N,Natsume J,Bernasconi A

更新日期：2005-07-26 00:00:00

abstract：OBJECTIVE:To assess the association of early morning serum cortisol with cognitive performance and brain structural integrity in community-dwelling young and middle-aged adults without dementia. METHODS:We evaluated dementia-free Framingham Heart Study (generation 3) participants (mean age 48.5 years, 46.8% men) who u...

journal_title：Neurology

authors： Echouffo-Tcheugui JB,Conner SC,Himali JJ,Maillard P,DeCarli CS,Beiser AS,Vasan RS,Seshadri S

更新日期：2018-11-20 00:00:00

abstract：:Migraine does not increase the risk for complications of pregnancy for the mother or for the fetus: the incidences of toxemia, miscarriages, abnormal labour, congenital anomalies, and stillbirths are comparable to those of the general population. Several retrospective studies have shown a tendency for migraine to impr...

journal_title：Neurology

authors： Aubé M

更新日期：1999-01-01 00:00:00

abstract：:"Healthy citizens are the greatest asset any country can have."-Sir Winston Churchill. ...

journal_title：Neurology

authors： Sharma M

更新日期：2014-01-28 00:00:00

abstract：:In a cohort of 337 patients with subarachnoid hemorrhage (SAH), we investigated the relationship between blood glucose levels, baseline characteristics, and outcome by means of Student's t-test and multivariate logistic regression. The mean glucose levels on admission and from day 1 to 10 were significantly higher in ...

journal_title：Neurology

authors： Dorhout Mees SM,van Dijk GW,Algra A,Kempink DR,Rinkel GJ

更新日期：2003-10-28 00:00:00

abstract：:The aim of this randomized, double-blind, placebo-controlled cross-over study was to test whether valproic acid relieves painful polyneuropathy. Thirty-one patients completed two treatment phases of 4 weeks' duration with valproic acid (1,500 mg daily) and placebo. There was no significant difference between valproic ...

journal_title：Neurology

authors： Otto M,Bach FW,Jensen TS,Sindrup SH

更新日期：2004-01-27 00:00:00

abstract：:We compared 42 myasthenia gravis (MG) patients with thymoma with 42 generalized MG patients without thymoma using a modified Osserman classification. The mean Osserman grades at diagnosis, 6 months, and 5 and 10 years post-thymectomy did not differ between groups. Our results indicate that thymoma is not a negative de...

journal_title：Neurology

authors： Bril V,Kojic J,Dhanani A

更新日期：1998-10-01 00:00:00

abstract：:We investigated the modulatory effects of human interferon beta (IFN-beta) and gamma (IFN-gamma) on expression of class I and II major histocompatibility complex (MHC) antigens and intercellular adhesion molecule-1 (ICAM-1) in fetal human astrocytes in culture using flow cytometry and immunocytochemistry. Under the ba...

journal_title：Neurology

authors： Satoh J,Paty DW,Kim SU

更新日期：1995-02-01 00:00:00

abstract：:Among 50 patients with phenytoin intoxication, 14 had seizures during the episode. Seizures in 9 of these 14 patients probably resulted from poor seizure control despite high phenytoin levels, but in 5 cases, attacks were attributed to phenytoin toxicity. The only factor that seemed to correlate with seizures was a se...

journal_title：Neurology

authors： Stilman N,Masdeu JC

更新日期：1985-12-01 00:00:00

abstract：:We followed 21 patients with sensory neuronopathy without evidence of cancer for up to 23 years. All were seronegative for type 1 antineuronal nuclear antibodies (ANNA-1, also called "anti-Hu"). We additionally studied 67 seropositive patients with sensory neuropathy or a related neurologic syndrome. Ninety-one percen...

journal_title：Neurology

authors： Chalk CH,Lennon VA,Stevens JC,Windebank AJ

更新日期：1993-11-01 00:00:00

abstract：:The authors describe a patient with sporadic distal myopathy associated with reduced caveolin-3 in muscle fibers in which the muscle atrophy was restricted to the small muscles of the hands and feet. Gene analysis disclosed a heterozygous 80 G-->A substitution in the caveolin-3 gene that was identical to that of repor...

journal_title：Neurology

authors： Tateyama M,Aoki M,Nishino I,Hayashi YK,Sekiguchi S,Shiga Y,Takahashi T,Onodera Y,Haginoya K,Kobayashi K,Iinuma K,Nonaka I,Arahata K,Itoyama Y

更新日期：2002-01-22 00:00:00

abstract：:We conducted a case-control study of the possible association of occupations with likely exposure to electromagnetic fields and Alzheimer's disease (AD) with patients from the Alzheimer Disease Treatment and Diagnostic Center, Rancho Los Amigos Medical Center, Downey, CA. Patients with definite or probable AD were the...

journal_title：Neurology

authors： Sobel E,Dunn M,Davanipour Z,Qian Z,Chui HC

更新日期：1996-12-01 00:00:00

abstract：:(-)Deprenyl, a specific monoamine oxidase subtype B inhibitor (MAOI-B), has been reported to be a safe and valuable adjunct to conventional treatment of parkinsonism. A double-blind, clinical comparison of (-)deprenyl with placebo was undertaken in 11 parkinsonian patients; the efficacy of 10 mg daily was studied over...

journal_title：Neurology

authors： Eisler T,Teräväinen H,Nelson R,Krebs H,Weise V,Lake CR,Ebert MH,Whetzel N,Murphy DL,Kopin IJ,Calne DB

更新日期：1981-01-01 00:00:00

abstract：:This nested case-control study assessed the putative protective effect of human herpesvirus-8 (HHV-8) against HIV-1-related dementia (dementia). The HHV-8 seropositivity of 210 male age- and HIV disease stage-matched cases and controls was compared. The overall HHV-8 seropositivity of 66% was similar among demented HI...

journal_title：Neurology

authors： Polk S,Muñoz A,Sacktor NC,Jenkins FJ,Cohen B,Miller EN,Jacobson LP

更新日期：2002-09-24 00:00:00

abstract：OBJECTIVE:We sought to determine the range and extent of neurologic complications due to pandemic influenza A (H1N1) 2009 infection (pH1N1'09) in children hospitalized with influenza. METHODS:Active hospital-based surveillance in 6 Australian tertiary pediatric referral centers between June 1 and September 30, 2009, f...

journal_title：Neurology

authors： Khandaker G,Zurynski Y,Buttery J,Marshall H,Richmond PC,Dale RC,Royle J,Gold M,Snelling T,Whitehead B,Jones C,Heron L,McCaskill M,Macartney K,Elliott EJ,Booy R

更新日期：2012-10-02 00:00:00

abstract：OBJECTIVE:To address the role of cell death regulatory genes of the bcl-2 and caspase families in the neuropathology of human epilepsy using tissue extracted from patients undergoing temporal lobectomy for intractable seizures. METHODS:Using Western blotting and immunohistochemistry, the authors investigated the expre...

journal_title：Neurology

authors： Henshall DC,Clark RS,Adelson PD,Chen M,Watkins SC,Simon RP

更新日期：2000-07-25 00:00:00