Abstract:
:Fatal familial insomnia (FFI), a condition characterized by inability to sleep, dysautonomia, motor disturbances, and selective thalamic atrophy is a prion disease linked to a GAC----AAC mutation at codon 178 of the prion gene. These data were obtained from one kindred. We now report a second kindred affected by FFI and carrying the same mutation. The finding of the same disease phenotype and genotype in a second family further validates FFI as a distinct disease entity and a phenotype of the GAC----AAC mutation at codon 178 of the prion gene.
journal_name
Neurologyjournal_title
Neurologyauthors
Medori R,Montagna P,Tritschler HJ,LeBlanc A,Cortelli P,Tinuper P,Lugaresi E,Gambetti Pdoi
10.1212/wnl.42.3.669subject
Has Abstractpub_date
1992-03-01 00:00:00pages
669-70issue
3 Pt 1eissn
0028-3878issn
1526-632Xjournal_volume
42pub_type
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