Depression in patients with early versus late onset of Parkinson's disease.


:We examined correlates of depression in patients whose onset of Parkinson's disease (PD) began before age 55 (early-onset group) compared with patients whose onset was after age 55 (late-onset group). The early-onset group showed a significantly higher frequency of depression than the late-onset group. When both groups were matched for duration of the disease, the early-onset group still showed a significantly higher frequency of depression, whereas tremor, akinesia, and rigidity were significantly more severe in the late-onset group. A stepwise regression analysis showed that in the early-onset group, depression scores were significantly correlated with scores of cognitive impairment and duration of the disease, while in the late-onset group, depression scores were significantly correlated with impairments in activities of daily living. These data suggest that depression in patients with early-onset PD may have a different etiology than in patients with late-onset PD.






Starkstein SE,Berthier ML,Bolduc PL,Preziosi TJ,Robinson RG




Has Abstract


1989-11-01 00:00:00












  • Subdural empyema in bacterial meningitis.

    abstract:OBJECTIVE:To evaluate the occurrence, treatment, and outcome of subdural empyema complicating community-acquired bacterial meningitis in adults. METHODS:Case series from a prospective nationwide cohort study from Dutch hospitals from 2006 to 2011. RESULTS:Subdural empyema was diagnosed in 28 of 1,034 episodes (2.7%),...


    pub_type: 杂志文章


    authors: Jim KK,Brouwer MC,van der Ende A,van de Beek D

    更新日期:2012-11-20 00:00:00

  • Practice guideline update summary: Pharmacologic treatment for pediatric migraine prevention: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Headache Society.

    abstract:OBJECTIVE:To provide updated evidence-based recommendations for migraine prevention using pharmacologic treatment with or without cognitive behavioral therapy in the pediatric population. METHODS:The authors systematically reviewed literature from January 2003 to August 2017 and developed practice recommendations usin...


    pub_type: 杂志文章,评审


    authors: Oskoui M,Pringsheim T,Billinghurst L,Potrebic S,Gersz EM,Gloss D,Holler-Managan Y,Leininger E,Licking N,Mack K,Powers SW,Sowell M,Victorio MC,Yonker M,Zanitsch H,Hershey AD

    更新日期:2019-09-10 00:00:00

  • Role for the microtubule-associated protein tau variant p.A152T in risk of α-synucleinopathies.

    abstract:OBJECTIVE:To assess the importance of MAPT variant p.A152T in the risk of synucleinopathies. METHODS:In this case-control study, we screened a large global series of patients and controls, and assessed associations between p.A152T and disease risk. We included 3,229 patients with clinical Parkinson disease (PD), 442 w...


    pub_type: 杂志文章


    authors: Labbé C,Ogaki K,Lorenzo-Betancor O,Soto-Ortolaza AI,Walton RL,Rayaprolu S,Fujioka S,Murray ME,Heckman MG,Puschmann A,McCarthy A,Lynch T,Siuda J,Opala G,Rudzinska M,Krygowska-Wajs A,Barcikowska M,Czyzewski K,Sanotsky Y

    更新日期:2015-11-10 00:00:00

  • Pigment variant of lipofuscinosis.

    abstract::A woman had a progressive neurologic syndrome beginning at age 3 and lasting for three decades. Clinical manifestations included severe mental deterioration, spastic paralysis, myoclonus, and tremors. A postmortem examination showed ubiquitous infiltration of neurons by lipofuscin and deposits of pigment in the globus...


    pub_type: 杂志文章


    authors: Jervis GA,Pullarkat RK

    更新日期:1978-05-01 00:00:00

  • The impact of neuropathic pain on health-related quality of life: review and implications.

    abstract::A number of high-quality studies have recently been published that examine the association between neuropathic pain and health-related quality of life (HRQoL). The current review identified 52 such studies in patients with six neuropathic pain conditions associated with lesions of either the peripheral (postsurgical n...


    pub_type: 杂志文章,meta分析,评审


    authors: Jensen MP,Chodroff MJ,Dworkin RH

    更新日期:2007-04-10 00:00:00

  • From benign fasciculations and cramps to motor neuron disease.

    abstract::Fasciculations and cramps may occur in motor neuron disease or as part of a more benign syndrome. A man with apparently benign fasciculations and cramps for 4 years developed progressive muscle weakness and wasting. Such a previously undocumented evolution of benign fasciculations and cramps to motor neuron disease ma...


    pub_type: 杂志文章


    authors: Fleet WS,Watson RT

    更新日期:1986-07-01 00:00:00

  • Why do frontal lobe symptoms predominate in vascular dementia with lacunes?

    abstract::We studied 30 necropsy cases of vascular dementia with a lacunar state. Manifestations included dementia, lack of volition, emotional lability, small-stepped gait, dysarthria, urinary incontinence, grasp reflex, pyramidal signs, paraplegia in flexion, and akinetic mutism. Pathologically, there was diffuse incomplete s...


    pub_type: 杂志文章


    authors: Ishii N,Nishihara Y,Imamura T

    更新日期:1986-03-01 00:00:00

  • Depiction of the neuroscientific principles of human motion 2 millennia ago by Lucretius.

    abstract::Titus Lucretius Carus was an ancient Roman philosopher of the Epicurean school whose epic poem On the Nature of Things described numerous aspects of the natural world. In fact, much contemporary scientific understanding is consistent with or inspired by his work. Among Lucretius's contributions to neurology were his d...


    pub_type: 传,历史文章,杂志文章


    authors: Hyam JA,Paterson DJ,Aziz TZ,Green AL

    更新日期:2011-09-06 00:00:00

  • Neuroanatomy of the self: evidence from patients with frontotemporal dementia.

    abstract:OBJECTIVE:To evaluate the frequency and types of change in "self" seen in frontotemporal dementia (FTD) and to determine the relative involvement of the nondominant and dominant frontal and temporal brain regions in FTD patients with or without changes in a sense of self using neuropsychology tests and neuroimaging. B...


    pub_type: 杂志文章


    authors: Miller BL,Seeley WW,Mychack P,Rosen HJ,Mena I,Boone K

    更新日期:2001-09-11 00:00:00

  • Increasing comorbidity and health services utilization in older adults with prior stroke.

    abstract:OBJECTIVE:To characterize comorbid chronic conditions, describe health services use, and estimate health care costs among community-dwelling older adults with prior stroke. METHODS:This is a retrospective cohort study using administrative data from Ontario, Canada. We identified all community-dwelling individuals aged...


    pub_type: 杂志文章


    authors: Gruneir A,Griffith LE,Fisher K,Panjwani D,Gandhi S,Sheng L,Patterson C,Gafni A,Ploeg J,Markle-Reid M

    更新日期:2016-11-15 00:00:00

  • Electrographic seizures in pediatric ICU patients: cohort study of risk factors and mortality.

    abstract:OBJECTIVES:We aimed to determine the incidence of electrographic seizures in children in the pediatric intensive care unit who underwent EEG monitoring, risk factors for electrographic seizures, and whether electrographic seizures were associated with increased odds of mortality. METHODS:Eleven sites in North America ...


    pub_type: 杂志文章,多中心研究


    authors: Abend NS,Arndt DH,Carpenter JL,Chapman KE,Cornett KM,Gallentine WB,Giza CC,Goldstein JL,Hahn CD,Lerner JT,Loddenkemper T,Matsumoto JH,McBain K,Nash KB,Payne E,Sánchez SM,Fernández IS,Shults J,Williams K,Yang A,Dlu

    更新日期:2013-07-23 00:00:00

  • Can allodynic migraine patients be identified interictally using a questionnaire?

    abstract:OBJECTIVE:The gradual development of cutaneous allodynia during the course of a migraine attack is commonly detected by quantitative sensory testing (QST) in migraineurs seeking secondary and tertiary medical help. In this study, the authors developed a questionnaire that tested the recollection of the patients on thei...


    pub_type: 杂志文章


    authors: Jakubowski M,Silberstein S,Ashkenazi A,Burstein R

    更新日期:2005-11-08 00:00:00

  • Orthostatic hypotension as a risk factor for symptomatic occlusive cerebrovascular disease.

    abstract::Thirteen patients presented with brief, repetitive, stereotyped transient ischemic attacks, large artery atherostenoses or occlusions with impaired collateral flow to a cortical perfusion borderzone, and orthostatic hypotension (OH). OH was caused by diabetes mellitus, aging, and treatments for ischemic heart disease ...


    pub_type: 杂志文章


    authors: Dobkin BH

    更新日期:1989-01-01 00:00:00

  • Assessment of motor function after stereotactic pallidotomy.

    abstract::Despite a paucity of controlled data, stereotactic pallidotomy is increasingly used for the treatment of advanced Parkinson's disease (PD). To study the efficacy of the procedure on the cardinal PD features of rigidity, tremor, bradykinesia, and postural instability, we blindly rated randomized videos of 34 patients r...


    pub_type: 杂志文章


    authors: Ondo WG,Jankovic J,Lai EC,Sankhla C,Khan M,Ben-Arie L,Schwartz K,Grossman RG,Krauss JK

    更新日期:1998-01-01 00:00:00

  • Familial typical migraine: linkage to chromosome 19p13 and evidence for genetic heterogeneity.

    abstract::Migraine is a frequent familial disorder that, in common with most multifactorial disorders, has an unknown etiology. The authors identified several families with multiple individuals affected by typical migraine using a single set of diagnostic criteria and studied these families for cosegregation between the disorde...


    pub_type: 杂志文章


    authors: Nyholt DR,Lea RA,Goadsby PJ,Brimage PJ,Griffiths LR

    更新日期:1998-05-01 00:00:00

  • Pemoline-induced chorea.

    abstract::Acute chorea in a child followed ingestion of pemoline mesylate. In guinea pigs, in an experimental model of chorea, chronic administration of pemoline induced behavioral supersensitivity to other dopaminergic agonists. Pemoline is similar to both d-amphetamine and methylphenidate in altering central dopaminergic sens...


    pub_type: 杂志文章


    authors: Nausieda PA,Koller WC,Weiner WJ,Klawans HL

    更新日期:1981-03-01 00:00:00

  • Novel missense mutation in the early growth response 2 gene associated with Dejerine-Sottas syndrome phenotype.

    abstract:BACKGROUND:Mutations in the early growth response 2 (EGR2) gene have recently been found in patients with congenital hypomyelinating neuropathy and Charcot-Marie-Tooth type 1 (CMT1) disease. OBJECTIVE:To determine the frequency of EGR2 mutations in patients with a diagnosis of CMT1, Dejerine-Sottas syndrome (DSS), or ...


    pub_type: 杂志文章


    authors: Timmerman V,De Jonghe P,Ceuterick C,De Vriendt E,Löfgren A,Nelis E,Warner LE,Lupski JR,Martin JJ,Van Broeckhoven C

    更新日期:1999-06-10 00:00:00

  • Silent stroke in the NINCDS Stroke Data Bank.

    abstract::Previous brain infarctions seen on CT are common in the absence of history of stroke. Eleven percent of patients (135/1,203) without stroke history had ischemic lesions on their first CT, unrelated to the presenting stroke. Stroke Data Bank files were reviewed to determine whether the occurrence, location, and CT char...


    pub_type: 杂志文章


    authors: Chodosh EH,Foulkes MA,Kase CS,Wolf PA,Mohr JP,Hier DB,Price TR,Furtado JG Jr

    更新日期:1988-11-01 00:00:00

  • Cranial dystonia: double-blind crossover study of anticholinergics.

    abstract::In patients with cranial dystonia, we compared the effects of central anticholinergic, peripheral anticholinergic, and placebo treatments in a double-blind crossover study. One of the nine patients who completed the study improved markedly with central anticholinergic therapy. The three treatments were indistinguishab...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Nutt JG,Hammerstad JP,deGarmo P,Carter J

    更新日期:1984-02-01 00:00:00

  • Case-control study of late onset "probable Alzheimer's disease".

    abstract::A case-control study was conducted on 64 cases of "probable Alzheimer's disease" with late onset of illness (after age 70 years) and 64 controls matched by age (+/- 3 years), race, and sex. Information was obtained on birth order, lifetime medical and surgical history, personal characteristics, exposure to toxins and ...


    pub_type: 杂志文章


    authors: Chandra V,Philipose V,Bell PA,Lazaroff A,Schoenberg BS

    更新日期:1987-08-01 00:00:00

  • Erenumab in chronic migraine: Patient-reported outcomes in a randomized double-blind study.

    abstract:OBJECTIVE:To determine the effect of erenumab, a human monoclonal antibody targeting the calcitonin gene-related peptide receptor, on health-related quality of life (HRQoL), headache impact, and disability in patients with chronic migraine (CM). METHODS:In this double-blind, placebo-controlled study, 667 adults with C...


    pub_type: 杂志文章,随机对照试验


    authors: Lipton RB,Tepper SJ,Reuter U,Silberstein S,Stewart WF,Nilsen J,Leonardi DK,Desai P,Cheng S,Mikol DD,Lenz R

    更新日期:2019-05-07 00:00:00

  • Autopsy validation of 123I-FP-CIT dopaminergic neuroimaging for the diagnosis of DLB.

    abstract:OBJECTIVE:To conduct a validation study of 123I-N-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) nortropane (123I-FP-CIT) SPECT dopaminergic imaging in the clinical diagnosis of dementia with Lewy bodies (DLB) with autopsy as the gold standard. METHODS:Patients >60 years of age with dementia who had undergone 123I-FP-...


    pub_type: 杂志文章


    authors: Thomas AJ,Attems J,Colloby SJ,O'Brien JT,McKeith I,Walker R,Lee L,Burn D,Lett DJ,Walker Z

    更新日期:2017-01-17 00:00:00

  • Primary medullary hypertensive hemorrhage.

    abstract::A 33-year-old man with untreated hypertension had sudden onset of signs and symptoms suggestive of a dorsal lateral medullary syndrome. He died after 27 days. Postmortem studies revealed intramedullary hemorrhage with extension into the fourth ventricle and hypertensive cardiovascular disease. ...


    pub_type: 杂志文章


    authors: Neumann PE,Mehler MF,Horoupian DS

    更新日期:1985-06-01 00:00:00

  • Insights into the natural history of spontaneous intracranial hypotension from infusion testing.

    abstract:OBJECTIVE:To assess the pathophysiologic changes in patients with spontaneous intracranial hypotension (SIH) based on measures of CSF dynamics, and on the duration of symptoms, in a retrospective case-controlled study. METHODS:We included consecutive patients investigated for SIH at our department from January 2012 to...


    pub_type: 杂志文章


    authors: Häni L,Fung C,Jesse CM,Ulrich CT,Miesbach T,Cipriani DR,Dobrocky T,Z'Graggen WJ,Raabe A,Piechowiak EI,Beck J

    更新日期:2020-07-21 00:00:00

  • Cerebral atrophy and functional deficits in alcoholics without clinically apparent liver disease.

    abstract::Ninety-seven chronic alcoholics, both impaired and unimpaired, without clinically evident liver disease, showed significantly more cerebral atrophy on computed tomography than age-matched neurologic controls. Age was the variable most highly correlated with cerebral atrophy measurements, and it accounted for most of t...


    pub_type: 杂志文章


    authors: Carlen PL,Wilkinson DA,Wortzman G,Holgate R,Cordingley J,Lee MA,Huszar L,Moddel G,Singh R,Kiraly L,Rankin JG

    更新日期:1981-04-01 00:00:00

  • Clinical and laboratory assessment of distal peripheral nerves in Gulf War veterans and spouses.

    abstract:BACKGROUND:The prevalence of symptoms suggesting distal symmetric polyneuropathy (DSP) was reported to be higher among deployed veterans (DV) to the Persian Gulf in 1990-1991 than to control non-deployed veterans (NDV). The authors therefore compared the prevalence of DSP by direct examination of DV and their spouses t...


    pub_type: 历史文章,杂志文章,多中心研究


    authors: Davis LE,Eisen SA,Murphy FM,Alpern R,Parks BJ,Blanchard M,Reda DJ,King MK,Mithen FA,Kang HK

    更新日期:2004-09-28 00:00:00

  • Unrecognized preclinical Alzheimer disease confounds rs-fcMRI studies of normal aging.

    abstract:OBJECTIVE:To determine whether, and to what degree, preclinical Alzheimer disease (AD) confounds studies of healthy aging where "healthy" is based on cognitive normality alone. METHODS:We examined the effects of preclinical AD in cognitively normal older individuals using resting-state functional connectivity MRI. We ...


    pub_type: 杂志文章


    authors: Brier MR,Thomas JB,Snyder AZ,Wang L,Fagan AM,Benzinger T,Morris JC,Ances BM

    更新日期:2014-10-28 00:00:00

  • Severe dysarthria with right hemisphere stroke.

    abstract::Ten patients are presented with severe dysarthria from a right hemisphere stroke, 4 with autopsies, emphasizing that this lesion alone is compatible with severely slurred speech. Most had oropharyngeal weakness; the accompanying hemiparesis was of variable severity. Superficial or deep infarctions were responsible, th...


    pub_type: 杂志文章


    authors: Ropper AH

    更新日期:1987-06-01 00:00:00

  • Hereditary dystonia-parkinsonism syndrome of juvenile onset.

    abstract::We studied a family with an extrapyramidal disorder characterized by childhood onset of lower-limb and axial dystonia, followed by parkinsonism. Dramatic response to levodopa therapy and minimal progression in adult life was seen. The family included five generations of affected members of both sexes in an autosomal d...


    pub_type: 杂志文章


    authors: Nygaard TG,Duvoisin RC

    更新日期:1986-11-01 00:00:00

  • Medial temporal lobe atrophy on MRI scans and the diagnosis of Alzheimer disease.

    abstract:BACKGROUND:Despite convenience, accessibility, and strong correlation to severity of Alzheimer disease (AD) pathology, medial temporal lobe atrophy (MTA) has not been used as a criterion in the diagnosis of prodromal and probable AD. METHODS:Using a newly validated visual rating system, mean MTA scores of three bilate...


    pub_type: 杂志文章


    authors: Duara R,Loewenstein DA,Potter E,Appel J,Greig MT,Urs R,Shen Q,Raj A,Small B,Barker W,Schofield E,Wu Y,Potter H

    更新日期:2008-12-09 00:00:00