Abstract:
:The development of reliable preclinical detection procedures for idiopathic Parkinson's disease may be the fundamental advance required for the establishment of the cause, the natural history, and ultimately, the prevention of this neurodegenerative disorder. The usefulness of these preclinical markers in efforts to better understand the etiology and development of this disorder will relate to whether they are direct measures of dopamine production or indirect measures such as metabolic changes or comorbidity, whether they can be used in the first or later decades of life, whether they are invasive, and whether they are expensive and sophisticated or simple and cheap. An overview of the criteria for evaluation of the utility of specific markers, as well as an assessment of the importance of early markers in future research, is presented.
journal_name
Neurologyjournal_title
Neurologyauthors
Ellenberg JHdoi
10.1212/wnl.41.5_suppl_2.14subject
Has Abstractpub_date
1991-05-01 00:00:00pages
14-20issue
5 Suppl 2eissn
0028-3878issn
1526-632Xjournal_volume
41pub_type
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