Treatment of pseudobulbar affect in ALS with dextromethorphan/quinidine: a randomized trial.

abstract：:We describe a familial disorder consisting of sleep apnea, anosmia, colorblindness, partial complex seizures, and cognitive dysfunction. The phenotypic expression of the syndrome suggests an autosomal dominant inheritance with incomplete penetrance. ...

journal_title：Neurology

authors： Manon-Espaillat R,Gothe B,Adams N,Newman C,Ruff R

更新日期：1988-02-01 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH) exerts many effects upon spinal cord function in animals, and may also play a role in human spinal cord function. We have used the technique of quantitative autoradiography to anatomically localize specific receptors for TRH within human spinal cord. Highest concentrations of TRH re...

journal_title：Neurology

authors： Manaker S,Winokur A,Rhodes CH,Rainbow TC

更新日期：1985-03-01 00:00:00

abstract：:We studied the efficacy, pharmacokinetics, and brain entry of lorazepam in the treatment of status epilepticus (SE) using a rat model of secondarily generalized convulsive SE. Lorazepam entered the bloodstream rapidly following intraperitoneal injection. Brain concentrations peaked 10 minutes after peak serum levels w...

journal_title：Neurology

authors： Walton NY,Treiman DM

更新日期：1990-06-01 00:00:00

abstract：OBJECTIVE:To report on the long-term outcomes of deep brain stimulation (DBS) of the thalamic ventral intermediate nucleus (VIM) in Parkinson disease (PD), essential tremor (ET), and dystonic tremor. METHODS:One hundred fifty-nine patients with PD, ET, and dystonia underwent VIM DBS due to refractory tremor at the Gre...

journal_title：Neurology

authors： Cury RG,Fraix V,Castrioto A,Pérez Fernández MA,Krack P,Chabardes S,Seigneuret E,Alho EJL,Benabid AL,Moro E

更新日期：2017-09-26 00:00:00

abstract：:Although psychological distress and cognitive dysfunction are well documented in adults with multiple sclerosis (MS), they are poorly understood in children with the disease. Psychosocial difficulty experienced by children and adolescents with MS involves factors common to all chronic illnesses in children, as well as...

journal_title：Neurology

authors： MacAllister WS,Boyd JR,Holland NJ,Milazzo MC,Krupp LB,International Pediatric MS Study Group.

更新日期：2007-04-17 00:00:00

abstract：OBJECTIVE:To describe neural autoantibody profiles and outcomes in patients with neurologic autoimmunity associated with immune checkpoint inhibitor (ICI) cancer immunotherapy. METHODS:In this retrospective descriptive study, 63 patients with ICI-related neurologic autoimmunity were included: 39 seen at the Mayo Clini...

journal_title：Neurology

authors： Sechi E,Markovic SN,McKeon A,Dubey D,Liewluck T,Lennon VA,Lopez-Chiriboga AS,Klein CJ,Mauermann M,Pittock SJ,Flanagan EP,Zekeridou A

更新日期：2020-10-27 00:00:00

abstract：:Patients with symptomatic > or = 60% (n = 134), asymptomatic > or = 80% (n = 143), and asymptomatic progressive > or = 60% (n = 25) internal carotid artery stenosis underwent stenting and were followed clinically and by Doppler-assisted duplex imaging for 27.1 +/- 15.6 months. Stroke and death from stroke occurred wit...

journal_title：Neurology

authors： Bibl D,Lampl C,Biberhofer I,Kerschner K,Kypta A,Bergmann J,Kaindlstorfer A,Röper C,Yazdi K,Engleder C,Hofmann R,Deibl M,Leisch F,Ransmayr G

更新日期：2005-07-12 00:00:00

abstract：OBJECTIVE:To present the current terminology and natural history of neurofibromatosis 1 (NF1) cutaneous neurofibromas (cNF). METHODS:NF1 experts from various research and clinical backgrounds reviewed the terms currently in use for cNF as well as the clinical, histologic, and radiographic features of these tumors usin...

journal_title：Neurology

authors： Ortonne N,Wolkenstein P,Blakeley JO,Korf B,Plotkin SR,Riccardi VM,Miller DC,Huson S,Peltonen J,Rosenberg A,Carroll SL,Verma SK,Mautner V,Upadhyaya M,Stemmer-Rachamimov A

更新日期：2018-07-10 00:00:00

abstract：:About one-third of patients with acoustic tumor (AT) initially seek medical attention for nonaudiologic complaints. The nonspecific early symptoms of AT require the inclusion of AT in many neurologic differential diagnoses. Advances in electrophysiologic and radiographic tests have allowed earlier diagnosis of AT at a...

journal_title：Neurology

authors： Hart RG,Gardner DP,Howieson J

更新日期：1983-02-01 00:00:00

abstract：:Plasma levels of six short-chain fatty acids (SCFA) were measured in 23 Reye's syndrome patients. In sequential measurements, only propionic acid correlated closely with neurologic severity. Although admission SCFA levels were slightly elevated, there were no significant differences between patients grouped by severit...

journal_title：Neurology

authors： McArthur B,Sarnaik AP,Mitchell RA

更新日期：1984-06-01 00:00:00

abstract：:Eighty-eight multiple sclerosis case-friend pairs were interviewed by telephone to elicit information about early-life exposures. Available mothers were also interviewed. Risk factors included childhood diseases, exposures to animals, and residence. We found a positive association between MS and having measles at a la...

journal_title：Neurology

authors： Sullivan CB,Visscher BR,Detels R

更新日期：1984-09-01 00:00:00

abstract：OBJECTIVE:The MS Functional Composite (MSFC), a recently developed outcome measure for clinical trials, was applied to 240 patients with MS to explore its utility in different subgroups of MS and for comparison with the Expanded Disability Status Scale (EDSS). METHOD:Three clinical dimensions were examined: arm/hand f...

journal_title：Neurology

authors： Kalkers NF,de Groot V,Lazeron RH,Killestein J,Adèr HJ,Barkhof F,Lankhorst GJ,Polman CH

更新日期：2000-03-28 00:00:00

abstract：:People with AD have deficient contrast sensitivity and impaired face discrimination. The authors presented photographs of unfamiliar faces of three different sizes to enhance the low, middle, or high facial frequency information (cycles per face). Patients with AD demonstrated normal discrimination of small faces only...

journal_title：Neurology

authors： Cronin-Golomb A,Cronin-Golomb M,Dunne TE,Brown AC,Jain K,Cipolloni PB,Auerbach SH

更新日期：2000-06-27 00:00:00

abstract：:We investigated levodopa intravenous infusion rates, plasma concentrations, and clinical responses in 23 parkinsonian patients with a fluctuating response to the drug. There was a linear relationship between rate of levodopa infusion and plasma concentration when carbidopa was coadministered. Minimum-therapeutically e...

journal_title：Neurology

authors： Nutt JG,Woodward WR

更新日期：1986-06-01 00:00:00

abstract：:In the same family, the generalized or infantile form of acid maltase deficiency (glycogenosis type II, Pompe disease) and the muscular or adult-onset form affected different individuals. Autosomal-recessive inheritance for the two clinical forms was demonstrated in this family by assay of acid alpha-glucosidase in mu...

journal_title：Neurology

authors： Loonen MC,Busch HF,Koster JF,Martin JJ,Niermeijer MF,Schram AW,Brouwer-Kelder B,Mekes W,Slee RG,Tager JM

更新日期：1981-10-01 00:00:00

abstract：:Motor axons supplying lumbrical muscles are less severely affected than axons supplying thenar muscles in the carpal tunnel syndrome; sometimes lumbrical motor fibers are less affected than digit 2 sensory fibers. This pattern is consistent with compression of both the anterior and posterior aspects of the median nerv...

journal_title：Neurology

authors： Logigian EL,Busis NA,Berger AR,Bruyninckx F,Khalil N,Shahani BT,Young RR

更新日期：1987-09-01 00:00:00

abstract：:Spontaneous circadian fluctuations of motor symptoms in Parkinson's disease (PD) often occur, with dysfunction typically less severe in the early morning than in the afternoon. In 23 PD patients with or without a history of circadian motor fluctuations, we studied contrast sensitivity (CS), a non-motor function, consi...

journal_title：Neurology

authors： Struck LK,Rodnitzky RL,Dobson JK

更新日期：1990-03-01 00:00:00

abstract：:Cognitive decline is recognized as a prevalent and debilitating symptom of multiple sclerosis (MS), especially deficits in episodic memory and processing speed. The field aims to (1) incorporate cognitive assessment into standard clinical care and clinical trials, (2) utilize state-of-the-art neuroimaging to more thor...

journal_title：Neurology

authors： Sumowski JF,Benedict R,Enzinger C,Filippi M,Geurts JJ,Hamalainen P,Hulst H,Inglese M,Leavitt VM,Rocca MA,Rosti-Otajarvi EM,Rao S

更新日期：2018-02-06 00:00:00

abstract：:Two women with myasthenia gravis became apneic immediately after IV injection of iodinated contrast material for CT. Aggravation of myasthenia continued for days after this initial reaction. ...

journal_title：Neurology

authors： Chagnac Y,Hadani M,Goldhammer Y

更新日期：1985-08-01 00:00:00

abstract：:Nodoparanodopathy is a recent concept in the field of peripheral neuropathy, corresponding to peripheral nerve disorders stemming from an autoimmune attack directed and limited to the nodal region. This concept was identified using modern techniques of electrophysiology, immunology, and pathology (including electron m...

journal_title：Neurology

authors： Mathis S,Le Masson G,Vallat JM

更新日期：2019-10-29 00:00:00

abstract：OBJECTIVE:Asians who carry the HLA-B*1502 allele have an elevated risk of developing Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) when treated with the antiepileptic drugs (AEDs) carbamazepine (CBZ) and phenytoin (PHT). With a focus on Singapore, this analysis identifies circumstances in which ge...

journal_title：Neurology

authors： Dong D,Sung C,Finkelstein EA

更新日期：2012-09-18 00:00:00

abstract：:Dopa-responsive dystonia (DRD) is an autosomal dominant disorder typically presenting as dystonia with diurnal variability. Described is an 8-year-old boy who had had waddling gait, generalized hypotonia, and proximal weakness since early childhood. He responded well to low-dose L-dopa. He had a point mutation of the ...

journal_title：Neurology

authors： Kong CK,Ko CH,Tong SF,Lam CW

更新日期：2001-09-25 00:00:00

abstract：:Migraine and the MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) syndrome have some clinical features in common. First, cerebral infarctions, most often in the posterior cerebral regions, which are a main symptom of MELAS, may complicate migraine. Second, migrainous headache w...

journal_title：Neurology

authors： Klopstock T,May A,Seibel P,Papagiannuli E,Diener HC,Reichmann H

更新日期：1996-06-01 00:00:00

abstract：:We compared 42 myasthenia gravis (MG) patients with thymoma with 42 generalized MG patients without thymoma using a modified Osserman classification. The mean Osserman grades at diagnosis, 6 months, and 5 and 10 years post-thymectomy did not differ between groups. Our results indicate that thymoma is not a negative de...

journal_title：Neurology

authors： Bril V,Kojic J,Dhanani A

更新日期：1998-10-01 00:00:00

abstract：:No uniformly accepted hypothesis explains the genesis and rupture of intracranial aneurysms. We followed 5,184 men and women prospectively for 26 years; 36 cases of aneurysmal subarachnoid hemorrhage (SAH) accounted for 62% of all intracranial hemorrhages. Blood pressure before SAH was higher in these patients than in...

journal_title：Neurology

authors： Sacco RL,Wolf PA,Bharucha NE,Meeks SL,Kannel WB,Charette LJ,McNamara PM,Palmer EP,D'Agostino R

更新日期：1984-07-01 00:00:00

abstract：BACKGROUND:Few population-based studies with long-term follow-up have compared risk of recurrent stroke and cardiac events after first ischemic stroke. The relative risk of these two outcomes may inform treatment decisions. METHODS:In the population-based Northern Manhattan Study, first ischemic stroke patients age 40...

journal_title：Neurology

authors： Dhamoon MS,Sciacca RR,Rundek T,Sacco RL,Elkind MS

更新日期：2006-03-14 00:00:00

abstract：BACKGROUND:According to the International Classification of Headache Disorders (ICHD)-2, primary daily headaches unremitting from onset are classified as new daily-persistent headache (NDPH) only if migraine features are absent. When migraine features are present, classification is problematic. METHODS:We developed a ...

journal_title：Neurology

authors： Robbins MS,Grosberg BM,Napchan U,Crystal SC,Lipton RB

更新日期：2010-04-27 00:00:00

abstract：BACKGROUND:Although gray matter (GM) atrophy is recognized as a common feature of multiple sclerosis (MS), conflicting results have been obtained in patients with clinically isolated syndromes (CIS). Methodologic and clinical constraints may take account for literature discrepancies. METHODS:A total of 105 patients pr...

journal_title：Neurology

authors： Calabrese M,Rinaldi F,Mattisi I,Bernardi V,Favaretto A,Perini P,Gallo P

更新日期：2011-07-19 00:00:00

abstract：:We studied 20 patients with an acute parietal stroke with hemisensory disturbances but no visual field deficit and no or only slight motor weakness, without thalamic involvement on CT or MRI and found three main sensory syndromes. (1) The pseudothalamic sensory syndrome consists of a faciobrachiocrural impairment of e...

journal_title：Neurology

authors： Bassetti C,Bogousslavsky J,Regli F

更新日期：1993-10-01 00:00:00

abstract：:To learn if limb-kinetic apraxia (LKA) is associated with Parkinson disease (PD), participants with PD (on medications) and control subjects performed finger tapping (FT), measuring movement speed, and performed coin rotation (CR), measuring precise coordinated but independent finger movements and speed. There were no...

journal_title：Neurology

authors： Quencer K,Okun MS,Crucian G,Fernandez HH,Skidmore F,Heilman KM

更新日期：2007-01-09 00:00:00