Cognition in multiple sclerosis: State of the field and priorities for the future.

abstract：:This multicenter, double-blind, crossover study compared Tegretol-XR and Tegretol tablets with respect to trough plasma carbamazepine (CBZ) concentrations, seizure control, tolerability, and safety. We randomized 96 patients with epilepsy to 56-day monotherapy with their usual daily CBZ dose administered as (1) Tegret...

journal_title：Neurology

authors：

更新日期：1995-09-01 00:00:00

abstract：:In muscles with sustained voluntary contraction, EMG activity is transiently inhibited after transcranial magnetic stimulation. We recorded this postexcitatory silent period (SP) at 1.5 times individual stimulus threshold level from the first dorsal interosseus muscle in 65 neurologic patients aged 11 to 80 years. Whe...

journal_title：Neurology

authors： Haug BA,Kukowski B

更新日期：1994-05-01 00:00:00

abstract：:We studied the effects of low-frequency transcranial magnetic stimulation (TMS) on motor cortex excitability in humans. TMS at 0.1 Hz for 1 hour did not change cortical excitability. Stimulation at 0.9 Hz for 15 minutes (810 pulses), similar to the parameters used to induce long-term depression (LTD) in cortical slice...

journal_title：Neurology

authors： Chen R,Classen J,Gerloff C,Celnik P,Wassermann EM,Hallett M,Cohen LG

更新日期：1997-05-01 00:00:00

abstract：:We studied the effects of botulinum toxin A in 12 patients with spasticity and in eight patients with rigidity. The study design was a double-blind, placebo-controlled crossover trial with botulinum toxin A versus saline. Using the Ashworth Scale for spasticity and the Unified Parkinson's Disease Rating Scale for rigi...

journal_title：Neurology

authors： Grazko MA,Polo KB,Jabbari B

更新日期：1995-04-01 00:00:00

abstract：:The authors investigated the PRNP Met129Val polymorphism in 1,393 subjects including 482 patients with Alzheimer disease (AD) and two independent control groups. In patients, PRNP Met homozygosity conferred increasing risk with decreasing age at onset (onset: 61 to 70 years, n = 151, p = 0.02, odds ratio [OR] = 1.72, ...

journal_title：Neurology

authors： Riemenschneider M,Klopp N,Xiang W,Wagenpfeil S,Vollmert C,Müller U,Förstl H,Illig T,Kretzschmar H,Kurz A

更新日期：2004-07-27 00:00:00

abstract：OBJECTIVE:To study the relation between N-terminal pro-brain natriuretic peptide (NT-proBNP) levels, used as a marker of heart failure in clinical practice, blood pressure (BP), and cognitive decline in the oldest old. METHODS:In 560 participants of the Leiden 85-plus Study, we measured NT-proBNP levels and BP at age ...

journal_title：Neurology

authors： van Vliet P,Sabayan B,Wijsman LW,Poortvliet RK,Mooijaart SP,de Ruijter W,Gussekloo J,de Craen AJ,Westendorp RG

更新日期：2014-09-23 00:00:00

abstract：BACKGROUND:Two recent studies suggest that the risk of ALS is increased among Gulf War veterans. It is not known whether military service outside of the Gulf War is associated with increased risk of ALS. METHODS:The authors prospectively assessed the relation between service in the military and ALS mortality among par...

journal_title：Neurology

authors： Weisskopf MG,O'Reilly EJ,McCullough ML,Calle EE,Thun MJ,Cudkowicz M,Ascherio A

更新日期：2005-01-11 00:00:00

abstract：:This study examined the frequency of epilepsy in a consecutive series of patients who received a definitive diagnosis of psychogenic nonepileptic seizures (PNES) after completing inpatient video-EEG (VEEG) monitoring. Of the 1,590 patients receiving definitive diagnosis, 514 (32.3%) were diagnosed with PNES. Twenty-ni...

journal_title：Neurology

authors： Martin R,Burneo JG,Prasad A,Powell T,Faught E,Knowlton R,Mendez M,Kuzniecky R

更新日期：2003-12-23 00:00:00

abstract：OBJECTIVES:There is currently much interest in biomarkers of disease activity in frontotemporal lobar degeneration (FTLD). We assessed MRI and behavioral measures of progression in a longitudinal FTLD cohort. METHODS:Thirty-two patients with FTLD (11 behavioral variant frontotemporal dementia [bvFTD], 11 semantic deme...

journal_title：Neurology

authors： Gordon E,Rohrer JD,Kim LG,Omar R,Rossor MN,Fox NC,Warren JD

更新日期：2010-02-23 00:00:00

abstract：:We present an 11-year-old girl in whom high field strength MRI performed 2 1/2 years and 6 months before her death showed prominent hypointensity in the globus pallidus and substantia nigra consistent with iron deposition. This finding suggested Hallervorden-Spatz disease, which was confirmed at autopsy. ...

journal_title：Neurology

authors： Schaffert DA,Johnsen SD,Johnson PC,Drayer BP

更新日期：1989-03-01 00:00:00

abstract：:We compared MRI and CT in a study of 175 patients; 87 infarcts within a week, 40 from 1 to 40 weeks, 25 a year after onset, and 23 hemorrhages, 18 within 2 weeks and 5 in 4 to 8 weeks. Fifty-nine infarcts and eight hemorrhages had sequential scanning. MRI is more sensitive than CT in the early detection of cerebral in...

journal_title：Neurology

authors： Kertesz A,Black SE,Nicholson L,Carr T

更新日期：1987-10-01 00:00:00

abstract：:A woman with typical features of myoclonic epilepsy with ragged red fibers (MERRF) had a novel heteroplasmic mutation (G611A) in the mitochondrial DNA tRNA phenylalanine gene. The mutation was heteroplasmic (91%) in muscle but undetectable in accessible tissues from the patient and her maternal relatives. Single-fiber...

journal_title：Neurology

authors： Mancuso M,Filosto M,Mootha VK,Rocchi A,Pistolesi S,Murri L,DiMauro S,Siciliano G

更新日期：2004-06-08 00:00:00

abstract：:This study investigates the histories and the clinical course of 111 patients who had nonlesional temporal lobe epilepsy. We compared 61 patients with unilateral hippocampal sclerosis (UHS group) and 50 patients with minimal change (MRI negative group) assessed on the basis of MRI. In agreement with previous reports, ...

journal_title：Neurology

authors： Kanemoto K,Takeuchi J,Kawasaki J,Kawai I

更新日期：1996-11-01 00:00:00

abstract：:Previous studies reported that a 2- to 3-week course of IV cyclophosphamide plus adrenocorticotropic hormone (ACTH) induction can temporarily halt progressive MS for a period of 12 months in the majority of patients treated, after which reprogression occurs. The Northeast Cooperative Multiple Sclerosis Treatment Group...

journal_title：Neurology

authors： Weiner HL,Mackin GA,Orav EJ,Hafler DA,Dawson DM,LaPierre Y,Herndon R,Lehrich JR,Hauser SL,Turel A

更新日期：1993-05-01 00:00:00

abstract：:Nerve root stimulation may be employed in patients with motor neuron disease (MND) to rule out motor neuropathy with conduction block. The diagnostic utility of these studies is unknown, in part because the range of amplitude changes across nerve root segments in patients with active neuronal degeneration has not been...

journal_title：Neurology

authors： Raynor EM,Shefner JM,Ross MH,Logigian EL,Hinchey JA

更新日期：1998-06-01 00:00:00

abstract：:The electronic medical record (EMR) is changing the landscape of medical practice in the modern age. Increasing emphasis on quality metric reporting, data-driven documentation, and timely coding and billing are pressuring institutions across the country to adopt the latest EMR technology. The impact of these systems o...

journal_title：Neurology

authors： Strowd RE 3rd

更新日期：2014-09-23 00:00:00

abstract：:Cerebral amyloid angiopathy is a common cause of spontaneous lobar hemorrhage in elderly patients. We discuss seven patients with amyloid angiopathy presenting without major lobar hemorrhage. The patients' presentations fell into two groups: recurrent transient neurologic symptoms and rapidly progressive dementia. The...

journal_title：Neurology

authors： Greenberg SM,Vonsattel JP,Stakes JW,Gruber M,Finklestein SP

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:Sleep-disordered breathing (SDB) and respiratory failure (RF) are complications of acid maltase deficiency (AMD), a rare hereditary myopathy. OBJECTIVE:To define the relationship between lung and respiratory muscle function, to establish incidence and patterns of SDB, and to determine daytime predictors of ...

journal_title：Neurology

authors： Mellies U,Ragette R,Schwake C,Baethmann M,Voit T,Teschler H

更新日期：2001-10-09 00:00:00

abstract：:Mammalian spinal cord neurons were grown in dissociated cell culture and used to study the effects of the anticonvulsant barbiturates phenobarbital and mephobarbital, and the anesthetic barbiturates pentobarbital, secobarbital, and 1,3-dimethyl-butylethyl barbituric acid on amino acid responses and neuronal membrane p...

journal_title：Neurology

authors： Macdonald RL,Barker JL

更新日期：1979-04-01 00:00:00

abstract：:Clinical presentation of carotid artery dissection (CAD) is variable, including acute or subacute headache, cervical pain, or focal neurologic deficit that occurs spontaneously, after a high-speed neck manipulation, or trauma. Isolated lower cranial nerve palsy in carotid dissection is uncommon. ...

journal_title：Neurology

authors： Pongmoragot J,Bharatha A,Saposnik G

更新日期：2013-03-12 00:00:00

abstract：:Mutations in POMT1 have been identified in Walker-Warburg syndrome and in patients with limb-girdle muscular dystrophy and mental retardation (LGMD2K). The authors report new POMT1 mutations in three unrelated children with severe motor impairment, leg hypertrophy, and mental retardation but without brain and ocular m...

journal_title：Neurology

authors： D'Amico A,Tessa A,Bruno C,Petrini S,Biancheri R,Pane M,Pedemonte M,Ricci E,Falace A,Rossi A,Mercuri E,Santorelli FM,Bertini E

更新日期：2006-05-23 00:00:00

abstract：OBJECTIVE:To investigate the involvement of the epidermal small sensory fibers in the neurodegenerative process in amyotrophic lateral sclerosis (ALS). METHODS:In the present study, skin biopsies of 28 patients with ALS were obtained at an average of 34 months after disease onset by history. Protein gene product 9.5 (...

journal_title：Neurology

authors： Weis J,Katona I,Müller-Newen G,Sommer C,Necula G,Hendrich C,Ludolph AC,Sperfeld AD

更新日期：2011-06-07 00:00:00

abstract：:It is generally believed that a diet high in carbohydrate improves exercise tolerance in patients with carnitine palmitoyltransferase II (CPT II) deficiency, but it has never been systematically investigated. The authors investigated the effect of a high- vs low-carbohydrate diet on exercise tolerance in four patients...

journal_title：Neurology

authors： Ørngreen MC,Ejstrup R,Vissing J

更新日期：2003-08-26 00:00:00

abstract：:The apolipoprotein E gene has been associated with various types of dementia. We studied the connection between the APOE gene and the risk and onset of disease in 34 patients with clinically diagnosed frontal lobe dementia (FLD) derived from a population-based study in the Netherlands. A significant increased risk of ...

journal_title：Neurology

authors： Stevens M,van Duijn CM,de Knijff P,van Broeckhoven C,Heutink P,Oostra BA,Niermeijer MF,van Swieten JC

更新日期：1997-06-01 00:00:00

abstract：:We investigated levodopa intravenous infusion rates, plasma concentrations, and clinical responses in 23 parkinsonian patients with a fluctuating response to the drug. There was a linear relationship between rate of levodopa infusion and plasma concentration when carbidopa was coadministered. Minimum-therapeutically e...

journal_title：Neurology

authors： Nutt JG,Woodward WR

更新日期：1986-06-01 00:00:00

abstract：:Using a 1.5-tesla GE Signa MR scanner, we imaged the brains of 14 right-handed Tourette's syndrome (TS) patients (11 men, three women), aged 18 to 49 years, who had minimal lifetime neuroleptic exposure. We also studied an equal number of normal controls individually matched for age, sex, and handedness and group-matc...

journal_title：Neurology

authors： Peterson B,Riddle MA,Cohen DJ,Katz LD,Smith JC,Hardin MT,Leckman JF

更新日期：1993-05-01 00:00:00

abstract：OBJECTIVE:To investigate whether arginine methylation is altered in patients with amyotrophic lateral sclerosis (ALS) and how it affects disease severity, progression, and prognosis. METHODS:We compared the immunoreactivity of protein arginine methyltransferase 1 (PRMT1) and its products, asymmetric dimethylated prote...

journal_title：Neurology

authors： Ikenaka K,Atsuta N,Maeda Y,Hotta Y,Nakamura R,Kawai K,Yokoi D,Hirakawa A,Taniguchi A,Morita M,Mizoguchi K,Mochizuki H,Kimura K,Katsuno M,Sobue G

更新日期：2019-04-16 00:00:00

abstract：OBJECTIVE:To determine if abnormalities exist in postural control in autism and if they are related to age. METHODS:Dynamic posturography was performed in 79 autistic individuals without mental retardation and 61 healthy volunteers between ages 5 and 52 years. Both the sensory organization and the movement coordinatio...

journal_title：Neurology

authors： Minshew NJ,Sung K,Jones BL,Furman JM

更新日期：2004-12-14 00:00:00

abstract：:Creatine monohydrate has been shown to increase strength in studies of young healthy subjects and in a few studies with patients. Creatine monohydrate (10 g daily for 5 days to 5 g daily for 5 days) was administered to patients with neuromuscular disease in a pilot study (Study 1; n = 81), followed by a single-blinded...

journal_title：Neurology

authors： Tarnopolsky M,Martin J

更新日期：1999-03-10 00:00:00

abstract：:In multifocal motor neuropathy (MMN), little is known of the long-term effect of human immunoglobulin (HIG) infusions as a maintenance therapy. We report a patient who improved after an initial HIG infusion of 2 g/kg and continued to improve both clinically and electrophysiologically during maintenance HIG treatment c...

journal_title：Neurology

authors： Van den Berg LH,Franssen H,Wokke JH

更新日期：1995-05-01 00:00:00