Root stimulation studies in the evaluation of patients with motor neuron disease.


:Nerve root stimulation may be employed in patients with motor neuron disease (MND) to rule out motor neuropathy with conduction block. The diagnostic utility of these studies is unknown, in part because the range of amplitude changes across nerve root segments in patients with active neuronal degeneration has not been well studied. We reviewed root stimulation studies in 32 patients (59 nerves) with MND and found segmental amplitude reduction from 0 to 45%, a range similar to values reported for normal subjects; there was no suggestion of conduction block based on our usual criteria.






Raynor EM,Shefner JM,Ross MH,Logigian EL,Hinchey JA




Has Abstract


1998-06-01 00:00:00












  • Efficacy of phenobarbital monotherapy in treatment of neonatal seizures -- relationship to blood levels.

    abstract::Seventy-one neonates were observed for the relationship between phenobarbital plasma concentrations and elimination of seizures. Sixty neonates (85%) had seizures controlled by phenobarbital alone. Effective plasma concentrations were 10.1 to 46.4 mg per liter. Although 36 neonates had seizures controlled by phenobarb...


    pub_type: 杂志文章


    authors: Gal P,Toback J,Boer HR,Erkan NV,Wells TJ

    更新日期:1982-12-01 00:00:00

  • Calcification of the basal ganglia as a cause of levodopa-resistant parkinsonism.

    abstract::We present a patient with levodopa-resistant parkinsonism due to basal ganglia calcification related to surgically-induced hypoparathyroidism. The calcification was seen on computerized axial tomography but not on skull x-rays. Such calcification should be looked for in all cases of levodopa-resistant parkinsonism, si...


    pub_type: 杂志文章


    authors: Klawans HL,Lupton M,Simon L

    更新日期:1976-03-01 00:00:00

  • Anticipation of age at onset in multiple sclerosis: a Sardinian cohort study.

    abstract:BACKGROUND:To assess the temporal trend in multiple sclerosis (MS) onset during the last 50 years in Sardinia, Italy. METHODS:The authors used a cohort study to assess age at onset in 1,513 MS patients at the MS clinic in Cagliari, all born and living in Sardinia. They also assessed age at onset in 41 pairs of familia...


    pub_type: 杂志文章


    authors: Cocco E,Sardu C,Lai M,Spinicci G,Contu P,Marrosu MG

    更新日期:2004-05-25 00:00:00

  • Poor school and cognitive functioning with silent cerebral infarcts and sickle cell disease.

    abstract::The authors evaluated education attainment and neuropsychological deficits in children with sickle cell disease (SCD) and silent cerebral infarcts. Children with silent infarcts had twice the rate of school difficulties as children without infarcts. Eighty percent of silent infarct cases had clinically significant cog...


    pub_type: 杂志文章


    authors: Schatz J,Brown RT,Pascual JM,Hsu L,DeBaun MR

    更新日期:2001-04-24 00:00:00

  • Normal CAG repeat length in the Huntington's disease gene in senile chorea.

    abstract::There is a widely held belief that most patients presenting with senile chorea have late-onset Huntington's disease (HD) with an unknown family history. We measured CAG trinucleotide repeat expansion in the HD gene in four patients with a clinical presentation of senile chorea and found that CAG repetition lengths wer...


    pub_type: 杂志文章


    authors: Shinotoh H,Calne DB,Snow B,Hayward M,Kremer B,Theilmann J,Hayden MR

    更新日期:1994-11-01 00:00:00

  • Reactivity of T cells from seronegative patients with myasthenia gravis to T cell epitopes of the human acetylcholine receptor.

    abstract::Seronegative (SN) patients with myasthenia gravis (MG) have clinical and electrophysiologic features similar to those of seropositive (SP) patients, and they respond to the same therapeutic measures. However, because SN patients lack detectable (by standard radioimmunoassays) serum antibodies to acetylcholine receptor...


    pub_type: 杂志文章


    authors: Karni A,Zisman E,Katz-Levy Y,Paas-Rozner M,Dayan M,Brautbar C,Abramsky O,Sela M,Mozes E

    更新日期:1997-06-01 00:00:00

  • Incidence and prevalence of epilepsy among older U.S. Medicare beneficiaries.

    abstract:OBJECTIVE:To determine the prevalence and incidence of epilepsy among U.S. Medicare beneficiaries aged 65 years old and over, and to compare rates across demographic groups. METHODS:We performed a retrospective analysis of Medicare administrative claims for 2001-2005, defining prevalent cases as persons with ≥1 claim ...


    pub_type: 杂志文章


    authors: Faught E,Richman J,Martin R,Funkhouser E,Foushee R,Kratt P,Kim Y,Clements K,Cohen N,Adoboe D,Knowlton R,Pisu M

    更新日期:2012-02-14 00:00:00

  • Psychogenic seizures: ictal characteristics and diagnostic pitfalls.

    abstract::We analyzed ictal features of psychogenic seizures using video-EEG recordings in 47 patients and reviewed the medical records to determine if patients received antiepileptic drug therapy and whether they were treated pharmacologically for status epilepticus. Unresponsive behavior in the absence of motor manifestations...


    pub_type: 杂志文章


    authors: Leis AA,Ross MA,Summers AK

    更新日期:1992-01-01 00:00:00

  • A pedigree with protanopia and bulbospinal muscular atrophy.

    abstract::We have studied one family of a pedigree in which bulbospinal muscular atrophy and protanopia were segregated. Genotypes for these disorders were obtained on three generations, and the maximum likelihood estimate of recombination fraction was 0.4 with the lod score method. The results indicated that the two loci are n...


    pub_type: 杂志文章


    authors: Mukai E,Yasuma T

    更新日期:1987-06-01 00:00:00

  • Controlled-release carbidopa/levodopa (Sinemet 50/200 CR4): clinical and pharmacokinetic studies.

    abstract::Several controlled-release carbidopa/levodopa preparations have been formulated to achieve a more stable and extended antiparkinsonian action. The most effective is Sinemet CR (Sinemet CR4), with an erodible polymer matrix that retards release of levodopa. In 19 parkinsonians with prominent dose-by-dose fluctuations, ...


    pub_type: 临床试验,杂志文章


    authors: LeWitt PA,Nelson MV,Berchou RC,Galloway MP,Kesaree N,Kareti D,Schlick P

    更新日期:1989-11-01 00:00:00

  • A direct comparison of PET activation and electrocortical stimulation mapping for language localization.

    abstract::Mapping eloquent language cortex in presurgical patients typically is accomplished using highly invasive direct cortical stimulation techniques. Functional imaging during language activation using positron emission tomography (PET) is a promising, noninvasive alternative that requires validation. In seven patients und...


    pub_type: 杂志文章


    authors: Bookheimer SY,Zeffiro TA,Blaxton T,Malow BA,Gaillard WD,Sato S,Kufta C,Fedio P,Theodore WH

    更新日期:1997-04-01 00:00:00

  • Effect of mitoxantrone on MRI in progressive MS: results of the MIMS trial.

    abstract:OBJECTIVE:To evaluate the effects of mitoxantrone (Mx) in progressive multiple sclerosis (MS) on MRI. METHODS:A total of 194 patients with worsening relapsing-remitting or secondary progressive MS were treated with Mx 12 mg/m2 (n = 34), Mx 5 mg/m2 (n = 40), or placebo (n = 36) at 3-month intervals IV over a 2-year per...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Krapf H,Morrissey SP,Zenker O,Zwingers T,Gonsette R,Hartung HP,MIMS Study Group.

    更新日期:2005-09-13 00:00:00

  • Increased risk of familial late-onset Alzheimer's disease in women.

    abstract::The role of gender in the pathogenesis of Alzheimer's disease (AD) is an important issue that remains controversial. We compared men and women in late-onset familial AD kindreds for the risk of developing AD by studying 26 well-characterized familial AD kindreds from the Oregon Alzheimer Disease Center and, for confir...


    pub_type: 杂志文章


    authors: Payami H,Montee K,Grimslid H,Shattuc S,Kaye J

    更新日期:1996-01-01 00:00:00

  • Cerebral ischemia and deterioration with lower blood pressure target in intracerebral hemorrhage.

    abstract:OBJECTIVE:To determine the incidence and predictors of acute cerebral ischemia and neurologic deterioration in intracerebral hemorrhage (ICH) patients after an institutional protocol change in systolic blood pressure (SBP) target from <160 to <140 mm Hg. METHODS:We retrospectively compared persons admitted with primar...


    pub_type: 杂志文章


    authors: Buletko AB,Thacker T,Cho SM,Mathew J,Thompson NR,Organek N,Frontera JA,Uchino K

    更新日期:2018-09-11 00:00:00

  • Cerebral atrophy and functional deficits in alcoholics without clinically apparent liver disease.

    abstract::Ninety-seven chronic alcoholics, both impaired and unimpaired, without clinically evident liver disease, showed significantly more cerebral atrophy on computed tomography than age-matched neurologic controls. Age was the variable most highly correlated with cerebral atrophy measurements, and it accounted for most of t...


    pub_type: 杂志文章


    authors: Carlen PL,Wilkinson DA,Wortzman G,Holgate R,Cordingley J,Lee MA,Huszar L,Moddel G,Singh R,Kiraly L,Rankin JG

    更新日期:1981-04-01 00:00:00

  • Human herpesvirus 8 DNA in CNS lymphomas from patients with and without AIDS.

    abstract:BACKGROUND AND OBJECTIVE:Human herpesvirus 8 (HHV-8) has been found in association with Kaposi's sarcomas in human immunodeficiency virus (HIV)-positive and -negative patients, primary effusion lymphomas (PELs), multicentric Castleman's disease, and multiple myeloma. The PELs share several features with acquired immuno...


    pub_type: 杂志文章


    authors: Corboy JR,Garl PJ,Kleinschmidt-DeMasters BK

    更新日期:1998-02-01 00:00:00

  • Sensory syndromes in parietal stroke.

    abstract::We studied 20 patients with an acute parietal stroke with hemisensory disturbances but no visual field deficit and no or only slight motor weakness, without thalamic involvement on CT or MRI and found three main sensory syndromes. (1) The pseudothalamic sensory syndrome consists of a faciobrachiocrural impairment of e...


    pub_type: 杂志文章


    authors: Bassetti C,Bogousslavsky J,Regli F

    更新日期:1993-10-01 00:00:00

  • Brain atrophy and lesion load in a large population of patients with multiple sclerosis.

    abstract:OBJECTIVE:To measure white matter (WM) and gray matter (GM) atrophy and lesion load in a large population of patients with multiple sclerosis (MS) using a fully automated, operator-independent, multiparametric segmentation method. METHODS:The study population consisted of 597 patients with MS and 104 control subjects....


    pub_type: 杂志文章


    authors: Tedeschi G,Lavorgna L,Russo P,Prinster A,Dinacci D,Savettieri G,Quattrone A,Livrea P,Messina C,Reggio A,Bresciamorra V,Orefice G,Paciello M,Brunetti A,Coniglio G,Bonavita S,Di Costanzo A,Bellacosa A,Valentino P,Quar

    更新日期:2005-07-26 00:00:00

  • Hypothetical explanation of selective saccadic palsy caused by pontine lesion.

    abstract::Recent clinical neuropathologic reports are inconsistent with previous models of how pontine neural circuits generate saccadic eye movements. We present a hypothetical explanation of these and other clinical and experimental findings based on a new model that accurately predicts the eye signs in pontine lesions. ...


    pub_type: 杂志文章


    authors: Kaneko CR

    更新日期:1989-07-01 00:00:00

  • Initial CSF total tau correlates with 1-year outcome in patients with traumatic brain injury.

    abstract:OBJECTIVE:We investigated if tau, microtubular binding protein, in serum and ventricular CSF (vCSF) in patients with severe traumatic brain injury (TBI) during the initial posttraumatic days correlated to 1-year outcome. METHODS:Patients with severe TBI (n = 39, Glasgow Coma Scale score


    pub_type: 杂志文章


    authors: Ost M,Nylén K,Csajbok L,Ohrfelt AO,Tullberg M,Wikkelsö C,Nellgård P,Rosengren L,Blennow K,Nellgård B

    更新日期:2006-11-14 00:00:00

  • Measurement of tissue oxygen consumption in patients with mitochondrial myopathy by noninvasive tissue oximetry.

    abstract::We measured oxygen consumption in the exercising lower limb by using noninvasive tissue oximetry with the near-infrared spectra of hemoglobin in the quadriceps muscle during bicycle ergometer exercise in four normal controls and three patients with chronic progressive external ophthalmoplegia (CPEO) as well as one pat...


    pub_type: 杂志文章


    authors: Abe K,Matsuo Y,Kadekawa J,Inoue S,Yanagihara T

    更新日期:1997-09-01 00:00:00

  • Pilot age and expertise predict flight simulator performance: a 3-year longitudinal study.

    abstract:BACKGROUND:Expert knowledge may compensate for age-related declines in basic cognitive and sensory-motor abilities in some skill domains. We investigated the influence of age and aviation expertise (indexed by Federal Aviation Administration pilot ratings) on longitudinal flight simulator performance. METHODS:Over a 3...


    pub_type: 杂志文章


    authors: Taylor JL,Kennedy Q,Noda A,Yesavage JA

    更新日期:2007-02-27 00:00:00

  • Combined (1)H MR spectroscopy and diffusion-weighted MRI improves the prediction of stroke outcome.

    abstract:BACKGROUND:The prognostic value of the biochemical changes seen with proton MR spectroscopy (1H MRS) in ischemic stroke was examined. Acute diffusion-weighted imaging (DWI) was used to identify regions of ischemia for 1H MRS voxel localization. METHODS:Nineteen patients had 36 1H MRS studies, 13 patients acutely (mean...


    pub_type: 临床试验,杂志文章


    authors: Parsons MW,Li T,Barber PA,Yang Q,Darby DG,Desmond PM,Gerraty RP,Tress BM,Davis SM

    更新日期:2000-08-22 00:00:00

  • Serum levels of alpha-tocopherol (vitamin E) in Parkinson's disease.

    abstract::To elucidate the possible role of vitamin E in the pathogenesis of Parkinson's disease (PD), we compared serum levels of alpha-tocopherol (vitamin E), measured by high-performance liquid chromatography, and the vitamin E/cholesterol ratio of 42 Parkinson's disease (PD) patients using their spouses as the control group...


    pub_type: 杂志文章


    authors: Férnandez-Calle P,Molina JA,Jiménez-Jiménez FJ,Vázquez A,Pondal M,García-Ruiz PJ,Urra DG,Domingo J,Codoceo R

    更新日期:1992-05-01 00:00:00

  • Branched-chain amino acids and amyotrophic lateral sclerosis: a treatment failure? The Italian ALS Study Group.

    abstract::We initiated a double-blind, placebo-controlled trial to test the efficacy and safety of branched-chain amino acids (BCAA) (L-leucine 12 g, L-isoleucine 6 g, and L-valine 6 g daily) in amyotrophic lateral sclerosis (ALS) patients. There was an excess mortality in subjects randomized to active treatment (24 BCAA, 13 pl...


    pub_type: 临床试验,杂志文章,随机对照试验



    更新日期:1993-12-01 00:00:00

  • The psychosocial consequences of pediatric multiple sclerosis.

    abstract::Although psychological distress and cognitive dysfunction are well documented in adults with multiple sclerosis (MS), they are poorly understood in children with the disease. Psychosocial difficulty experienced by children and adolescents with MS involves factors common to all chronic illnesses in children, as well as...


    pub_type: 杂志文章,评审


    authors: MacAllister WS,Boyd JR,Holland NJ,Milazzo MC,Krupp LB,International Pediatric MS Study Group.

    更新日期:2007-04-17 00:00:00

  • Familial aggregation of amyotrophic lateral sclerosis, dementia, and Parkinson's disease: evidence of shared genetic susceptibility.

    abstract::Clinicians have long suspected an association of classic amyotrophic lateral sclerosis (ALS) with Parkinson's disease (PD), dementia, or both. If proven, this would raise the possibility of a shared genetic susceptibility to the three disorders. To investigate this hypothesis, we compared 151 newly diagnosed ALS patie...


    pub_type: 杂志文章


    authors: Majoor-Krakauer D,Ottman R,Johnson WG,Rowland LP

    更新日期:1994-10-01 00:00:00

  • Hemifacial spasm due to contralateral acoustic neuroma: case report.

    abstract::A patient with a large acoustic neuroma had contralateral hemifacial spasm. On CT, the brainstem was markedly displaced and distorted by the tumor. After total removal of the tumor the hemifacial spasm was temporarily worse, but disappeared 14 days after the operation. ...


    pub_type: 杂志文章


    authors: Nishi T,Matsukado Y,Nagahiro S,Fukushima M,Koga K

    更新日期:1987-02-01 00:00:00

  • Long-term association between seizure outcome and depression after resective epilepsy surgery.

    abstract:OBJECTIVE:This study explored the association between long-term epilepsy surgery outcome and changes in depressive symptoms. METHODS:Adults were enrolled between 1996 and 2001 in a multicenter prospective study to evaluate outcomes of resective epilepsy surgery. The extent of depressive symptoms and depression case st...


    pub_type: 杂志文章,多中心研究


    authors: Hamid H,Liu H,Cong X,Devinsky O,Berg AT,Vickrey BG,Sperling MR,Shinnar S,Langfitt JT,Walczak TS,Barr WB,Dziura J,Bazil CW,Spencer SS

    更新日期:2011-11-29 00:00:00

  • Prevalence and size of directly detected patent foramen ovale in migraine with aura.

    abstract:BACKGROUND:Transcranial contrast Doppler studies have shown an increased prevalence of right-to-left shunts in patients with migraine with aura compared with controls. The anatomy and size of these right-to-left shunts have never been directly assessed. METHODS:In a cross-sectional case-control study, the authors perf...


    pub_type: 杂志文章


    authors: Schwerzmann M,Nedeltchev K,Lagger F,Mattle HP,Windecker S,Meier B,Seiler C

    更新日期:2005-11-08 00:00:00