Prion protein codon 129 polymorphism and risk of Alzheimer disease.

Abstract:

:The authors investigated the PRNP Met129Val polymorphism in 1,393 subjects including 482 patients with Alzheimer disease (AD) and two independent control groups. In patients, PRNP Met homozygosity conferred increasing risk with decreasing age at onset (onset: 61 to 70 years, n = 151, p = 0.02, odds ratio [OR] = 1.72, 95% CI = 1.2 to 2.53; onset: < or =60 years, n = 138, p = 0.013, OR = 1.92, 95% CI = 1.31 to 2.87), whereas no association was obtained in patients with onset at older than 70 years. The results suggest involvement of the prion protein in the pathogenesis of early-onset AD.

journal_name

Neurology

journal_title

Neurology

authors

Riemenschneider M,Klopp N,Xiang W,Wagenpfeil S,Vollmert C,Müller U,Förstl H,Illig T,Kretzschmar H,Kurz A

doi

10.1212/01.wnl.0000130198.72589.69

subject

Has Abstract

pub_date

2004-07-27 00:00:00

pages

364-6

issue

2

eissn

0028-3878

issn

1526-632X

pii

63/2/364

journal_volume

63

pub_type

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