Abstract:
:Seven hours after 39 migraineurs and 37 controls consumed an amino acid drink that contained or omitted l-tryptophan (thereby reducing brain serotonin synthesis), motion sickness was provoked by the visual illusion of movement. Tryptophan depletion boosted dizziness, nausea, and the illusion of movement in controls to levels that approached those of migraineurs. Thus, reduced brain serotonin activity may promote vestibuloocular disturbances during motion sickness and attacks of migraine.
journal_name
Neurologyjournal_title
Neurologyauthors
Drummond PDdoi
10.1212/01.wnl.0000172339.15577.a6subject
Has Abstractpub_date
2005-08-23 00:00:00pages
620-2issue
4eissn
0028-3878issn
1526-632Xpii
65/4/620journal_volume
65pub_type
杂志文章,随机对照试验相关文献
NEUROLOGY文献大全abstract:OBJECTIVE:The aim of this prospective study was to survey our patients about their experience with our clinic's telemedicine program to better understand telemedicine's utility for families, and to improve patient satisfaction and ultimately patient care. METHODS:This was a prospective survey study of patients and the...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000005482
更新日期:2018-05-08 00:00:00
abstract:OBJECTIVE:To investigate whether sex and race differences exist in dementia diagnosis risk associated with traumatic brain injury (TBI) among older veterans. METHODS:Using Fine-Gray regression models, we investigated incident dementia diagnosis risk with TBI exposure by sex and race. RESULTS:After the exclusion of ba...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000010617
更新日期:2020-09-29 00:00:00
abstract:OBJECTIVE:The present retrospective cohort study compares the long-term functional outcome, improvement or deterioration, of patients considered in a vegetative state (VS) or a minimally conscious state (MCS) 1 year after coma onset, then yearly for up to 5 years. METHODS:We reviewed the clinical courses of 12 patient...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181e8e8df
更新日期:2010-07-20 00:00:00
abstract:OBJECTIVE:To examine subjective versus objective memory change after anterior temporal lobectomy (ATL). METHODS:A prospective, controlled study. Controls included 39 unoperated patients with intractable temporal lobe epilepsy (TLE) who were administered a series of cognitive and health-related quality of life measures...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.7.1511
更新日期:1999-10-22 00:00:00
abstract::PET-demonstrated decreases in [11C]flumazenil binding occur in anterior mesial temporal structures on the side of epileptogenesis in unilateral mesial temporal lobe epilepsy. We performed quantitative autoradiography on anterior mesial and lateral temporal specimens from 11 subjects with unilateral mesial temporal lob...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.5.934
更新日期:1995-05-01 00:00:00
abstract::A 3-year 8-month-old girl died after 14 months of illness characterized by episodes of intermittent ataxia associated with oculomotor palsy, hypotonia, mental confusion, and disturbances of consciousness. In the last 4 months of life, there were signs of liver dysfunction. Pyruvate dehydrogenase and alpha-ketoglutarat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.12.1578
更新日期:1979-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the usefulness of ocular motor information in the early diagnosis of corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP). METHODS:Seven PSP patients, six CBD patients, and three atypical CBD patients were followed longitudinally with repeated electrooculographic (EOG) recordi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.5.1029
更新日期:2000-03-14 00:00:00
abstract::Pramipexole is a new, selective, nonergoline dopamine agonist that acts on D2 and preferentially on D3 dopamine receptors. Phase II and III clinical trials have shown this drug to be useful in treating both early and advanced Parkinson's disease (PD) patients. A double-blind, randomized, multicenter study was performe...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/wnl.49.4.1060
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND:In cerebral small vessel disease, the core MRI findings include white matter lesions (WML) and lacunar infarcts. While the clinical significance of WML is better understood, the contribution of lacunes to the rate of cognitive decline has not been established. This study investigated whether incident lacunes...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0b013e31821d752f
更新日期:2011-05-31 00:00:00
abstract:OBJECTIVES:Many patients with traumatic brain injury (TBI) report chronic fatigue, and previous studies showed a potential relationship between sleepiness and fatigue in these patients. Our study first looked at the impact of objective and subjective sleepiness on fatigue in patients with TBI. We then investigated how ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000334753.49193.48
更新日期:2008-11-11 00:00:00
abstract::This nested case-control study assessed the putative protective effect of human herpesvirus-8 (HHV-8) against HIV-1-related dementia (dementia). The HHV-8 seropositivity of 210 male age- and HIV disease stage-matched cases and controls was compared. The overall HHV-8 seropositivity of 66% was similar among demented HI...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/wnl.59.6.950
更新日期:2002-09-24 00:00:00
abstract::We investigated the prevalence of Parkinson's disease and other types of parkinsonism in a Sicilian population using a door-to-door two-phase approach. This design called for the administration of a brief screening instrument to all subjects who, on November 1, 1987, were residents of Terrasini (Palermo Province), San...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.10.1901
更新日期:1992-10-01 00:00:00
abstract::The endogenous auditory P300 event-related potential (P3) has been used to differentiate functional and organic cognitive disorders in adults. We found that children with organic cognitive impairments (as determined by the Halstead-Reitan [HR] test) had greater P3 latencies than children with normal HR evaluations. Th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.3.323
更新日期:1985-03-01 00:00:00
abstract:OBJECTIVE:There is a high risk of readmission within 30 days of index acute ischemic stroke (AIS), but effect of readmission to a different hospital is not known. We performed a retrospective cohort study to assess our hypothesis that 30-day readmission outcomes after AIS are worse for those readmitted to another hospi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008446
更新日期:2019-11-12 00:00:00
abstract:OBJECTIVE:To assess cerebrovascular reactivity in response to a visual task in participants with cerebral amyloid angiopathy (CAA), Alzheimer disease (AD), and mild cognitive impairment (MCI) using fMRI. METHODS:This prospective cohort study included 40 patients with CAA, 22 with AD, 27 with MCI, and 25 healthy contro...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000010201
更新日期:2020-09-08 00:00:00
abstract:OBJECTIVES:To study the effects of head injury on disease progression and on neuropathologic outcomes in amyotrophic lateral sclerosis (ALS). METHODS:Patients with ALS were surveyed to obtain head injury history, and medical records were reviewed. Linear regression was performed to determine if head injury was a predi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001522
更新日期:2015-04-28 00:00:00
abstract:OBJECTIVE:To evaluate if mental fatigue is a symptom that appears independently from other clinical features in patients with Parkinson disease (PD), and to study if fatigue is persistent over time in these patients. METHODS:In 1993, 233 patients with PD were included in a community-based study of fatigue and followed...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000144277.06917.cc
更新日期:2004-11-23 00:00:00
abstract::A patient with glioblastoma of the rostral brainstem and hypothalamus exhibited bilateral internuclear ophthalmoplegia and vertical nystagmus; he suffered episodes of cataplexy, narcolepsy, and sleep paralysis. A peculiar fluctuation of posture and tone ("limp man syndrome") proved to be a manifestation of continuous ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.10.1115
更新日期:1980-10-01 00:00:00
abstract:OBJECTIVE:To determine the accuracy of the clinical history performed by epileptologists in the identification of seizures in patients with suspected temporal lobe epilepsy. METHODS:The clinical and EEG telemetry (EEGT) monitoring data of 88 patients with suspected refractory temporal lobe seizures referred for evalua...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/01.wnl.0000090566.40544.04
更新日期:2003-12-23 00:00:00
abstract::In the current medical climate, medical education is at risk of being de-emphasized, leading to less financial support and compensation for faculty. A rise in compensation plans that reward clinical or research productivity fails to incentivize and threatens to erode the educational missions of our academic institutio...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007664
更新日期:2019-07-02 00:00:00
abstract:OBJECTIVE:We aimed to assess the innervation density of dermal nerves in human skin biopsies by bright-field immunohistochemistry. METHODS:The size of dermal area where nerve length was quantified was validated in 30 skin biopsy sections (5 controls and 5 patients with small-fiber neuropathy [SFN]). It was obtained di...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318225ab51
更新日期:2011-07-19 00:00:00
abstract::We compared 42 myasthenia gravis (MG) patients with thymoma with 42 generalized MG patients without thymoma using a modified Osserman classification. The mean Osserman grades at diagnosis, 6 months, and 5 and 10 years post-thymectomy did not differ between groups. Our results indicate that thymoma is not a negative de...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.51.4.1198
更新日期:1998-10-01 00:00:00
abstract::Impairment of object-bound movements of the hand performed under visual guidance ("optic ataxia") was a prominent sign in a patient with bilateral circumscribed infarctions in the posterior watershed territory. The sign was interpreted as resulting from defective integration of panoramic visual information with propri...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.2.170
更新日期:1979-02-01 00:00:00
abstract::There is a widely held belief that most patients presenting with senile chorea have late-onset Huntington's disease (HD) with an unknown family history. We measured CAG trinucleotide repeat expansion in the HD gene in four patients with a clinical presentation of senile chorea and found that CAG repetition lengths wer...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.11.2183
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:The 1875 publications of Erb and Westphal brought widespread attention to the percussion of muscle stretch reflexes. Although the maneuver may have been observed before 1875, there is little concrete evidence of this. OBJECTIVES:To bring to light an early report of percussion eliciting the muscle stretch re...
journal_title:Neurology
pub_type: 传,历史文章,杂志文章
doi:10.1212/01.wnl.0000305968.03898.fe
更新日期:2008-03-18 00:00:00
abstract::In an attempt to determine the opinions and practices of neurologists regarding the use of antithrombotic drugs in the treatment of acute ischemic stroke, we conducted a survey of 349 randomly selected neurologists from throughout the United States. Responses were received from 247 (71%), and 219 identified themselves...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.12.1631
更新日期:1989-12-01 00:00:00
abstract:OBJECTIVE:To analyze the spectrum and mechanisms of cutaneous adverse events (AEs) in patients with multiple sclerosis treated with daclizumab high-yield process (DAC-HYP). METHODS:A total of 31 participants in an institutional review board-approved open-label phase I study of DAC-HYP (NCT01143441) were prospectively ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002417
更新日期:2016-03-01 00:00:00
abstract::We detected large numbers of HLA-DR-positive reactive microglia (macrophages), along with Lewy bodies and free melanin, in the substantia nigra of all cases studied with Parkinson's disease (5) and parkinsonism with dementia (PD) (5). We found similar, but less extensive, pathology in the substantia nigra of six of ni...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.8.1285
更新日期:1988-08-01 00:00:00
abstract::Spontaneous arm levitation (SAL) is well-recognized in cortical-basal ganglionic degeneration, but not in other neurodegenerative diseases. We report six cases of progressive supranuclear palsy (PSP) with SAL. Pathologic examination in four revealed the classic features of PSP with additional areas of focal cortical d...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.4.879
更新日期:1999-03-10 00:00:00
abstract::In two patients, a sensory neuronopathy was the initial presentation of Sjögren's syndrome. There was no systemic or peripheral nerve vasculitis. Immunochemical studies failed to demonstrate specific antibodies against the nervous system. These features suggest that the damage to the sensory neurons might not be media...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.10.1637
更新日期:1988-10-01 00:00:00