Abstract:
:There is a widely held belief that most patients presenting with senile chorea have late-onset Huntington's disease (HD) with an unknown family history. We measured CAG trinucleotide repeat expansion in the HD gene in four patients with a clinical presentation of senile chorea and found that CAG repetition lengths were normal. These findings support senile chorea as being a distinct clinical entity that is nosologically separate from late-onset HD.
journal_name
Neurologyjournal_title
Neurologyauthors
Shinotoh H,Calne DB,Snow B,Hayward M,Kremer B,Theilmann J,Hayden MRdoi
10.1212/wnl.44.11.2183subject
Has Abstractpub_date
1994-11-01 00:00:00pages
2183-4issue
11eissn
0028-3878issn
1526-632Xjournal_volume
44pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract:OBJECTIVE:To evaluate the area of the midbrain and pons on mid-sagittal MRI in patients with progressive supranuclear palsy (PSP), Parkinson disease (PD), and multiple-system atrophy of the Parkinson type (MSA-P), compare these appearances and values with those of normal control subjects, and establish diagnostic MRI c...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000165960.04422.D0
更新日期:2005-06-28 00:00:00
abstract:OBJECTIVE:We aimed to analyze lesion patterns of lacunae-sized infarctions in the perforating arterial territory in terms of shape and to determine whether the particular pattern of conglomerated beads shape affected early neurologic deterioration. METHODS:We consecutively included acute ischemic stroke patients with ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318253d62f
更新日期:2012-05-01 00:00:00
abstract::The authors examined the influence of APOE and human leukocyte antigen-DRB1-DQB1 polymorphisms on the course of multiple sclerosis in 871 patients, 773 with relapsing and 98 with primary progressive disease, and 348 control subjects. The risk of the primary progressive course was increased (odds ratio = 6.81, p = 0.00...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000150579.54878.00
更新日期:2005-02-08 00:00:00
abstract:OBJECTIVE:To identify independent predictors of clinical or cerebral lesion progression in a large sample of adult patients with moyamoya angiopathy (MMA) prior to decisions regarding revascularization surgery. METHODS:Ninety participants (median age, 37.5 years) were assessed at baseline and followed for a median tim...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007819
更新日期:2019-07-23 00:00:00
abstract::We analyzed the frequency of cardiac embolic sources in 62 patients with acute lacunar stroke vs 50 controls. In post hoc analysis, 11 patients with lacunar stroke having neither hypertension nor diabetes mellitus (non-HDM group) had a higher frequency of right-to-left shunt (RLS) (82%) than patients with risk factors...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000253197.83777.c7
更新日期:2007-02-13 00:00:00
abstract::In children, seizures associated with status epilepticus (SE) include a number of types that are age-related. These types of seizures are not associated with SE in older patients. Likewise, etiologies of SE in children are also unique to this patient population, in particular those responsible for SE in the neonate. C...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:
更新日期:1990-05-01 00:00:00
abstract:OBJECTIVE:We determined whether Gram-negative bacterial molecules are associated with Alzheimer disease (AD) neuropathology given that previous studies demonstrate Gram-negative Escherichia coli bacteria can form extracellular amyloid and Gram-negative bacteria have been reported as the predominant bacteria found in no...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003391
更新日期:2016-11-29 00:00:00
abstract::Gamma hydroxybutyrate was administered to adult cats by intravenous infusion at varying dosages while an electroencephalogram (EEG) was recorded from electrodes placed stereotactically in the right and left hippocampus and thalamic intralaminar nucleus and from cortical electrodes. Blood cerebrospinal fluid samples we...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.1.51
更新日期:1976-01-01 00:00:00
abstract:OBJECTIVE:To investigate whether vitamin D, smoking, and anti-Epstein-Barr virus (EBV) antibody concentrations predict long-term cognitive status and neuroaxonal injury in multiple sclerosis (MS). METHODS:This study was conducted among 278 patients with clinically isolated syndrome who participated in the clinical tri...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000009371
更新日期:2020-05-05 00:00:00
abstract::Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels > or = 1.53 microg/mL predicted progression to need for ambulatory assistance during follow-up (s...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/01.wnl.0000238107.31364.21
更新日期:2006-10-10 00:00:00
abstract:OBJECTIVE:The visual system has often been described to be sensitized in migraineurs, with light being perceived as aversive or even painful. One possible explanation for this altered perception is crosslinks between the visual and the trigeminonociceptive system. Visual stimulation in chronic migraineurs on the level ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000005622
更新日期:2018-05-29 00:00:00
abstract:OBJECTIVE:To create and validate a simple, standardized version of the antisaccade (AS) task that requires no specialized equipment for use as a measure of executive function in multicenter clinical studies. METHODS:The bedside AS (BAS) task consisted of 40 pseudorandomized AS trials presented on a laptop computer. BA...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0b013e318258f785
更新日期:2012-06-05 00:00:00
abstract:OBJECTIVE:To investigate the relationship between cerebral amyloid angiopathy (CAA), dementia, and cognitive function in an autopsy sample of 211 Japanese-American men from the population-based Honolulu-Asia Aging Study. METHODS:Starting in 1991, participants were assessed with the Cognitive Abilities Screening Instru...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.11.1629
更新日期:2002-06-11 00:00:00
abstract:BACKGROUND:The neurodegenerative process in Alzheimer's disease (AD) and in the Lewy body variant of AD (LBV) patients is characterized by cholinergic dysfunction and deposition of amyloid beta-peptide (Abeta) 1-40 and 1-42; however, the differential effects of Abeta species on the cholinergic system are not completely...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000073987.79060.4b
更新日期:2003-07-22 00:00:00
abstract:OBJECTIVE:To examine the severity of impairments in the decision-making abilities (understanding, appreciation, reasoning, and choice) and competency to make a decision to use an Alzheimer disease (AD)-slowing medication in patients with AD and the relationships between these impairments, insight, and overall cognition...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000160000.01742.9D
更新日期:2005-05-10 00:00:00
abstract:OBJECTIVES:To compare the degrees to which 8 domains of health are affected across types of cerebrovascular events and to identify factors associated with domain scores in different event types. METHODS:This was an observational cohort study of 2,181 patients with ischemic stroke, intracerebral hemorrhage (ICH), subar...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006626
更新日期:2018-12-04 00:00:00
abstract::Tracheostomy has been employed to release the airway obstruction at the glottic level and to prevent sudden death in patients with multiple system atrophy (MSA). However, sudden death is possible even after tracheostomy. Nocturnal polysomnography showed that the apnea-hypopnea index became higher after tracheostomy, a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000260975.74618.d7
更新日期:2007-05-08 00:00:00
abstract:OBJECTIVE:To evaluate interictal, circulating sphingolipids in women migraineurs. METHODS:In the fasting state, serum samples were obtained pain-free from 88 women with episodic migraine (EM; n=52) and from controls (n=36). Sphingolipids were detected and quantified by high-performance liquid chromatography coupled wi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002004
更新日期:2015-10-06 00:00:00
abstract::Many new treatments under development for Alzheimer disease (AD) will be disease-modifying rather than symptomatic. Clinical evaluation of these treatments will require primary and secondary prevention trials. We describe some of the methodologic challenges in designing primary prevention trials for AD and illustrate ...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.67.9_suppl_3.s2
更新日期:2006-11-14 00:00:00
abstract::A double-blind crossover study with imipramine was conducted in 10 patients with absence and myoclonic-astatic seizures who had not responded to conventional medications. Imipramine produced a significant initial decrease in seizure frequency in 5 of the 10 patients, and in 2 patients the beneficial effect was maintai...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.28.9.953
更新日期:1978-09-01 00:00:00
abstract::Cocaine, especially in its alkaloidal or "crack" form, has been increasingly associated with cerebrovascular disease. Before the crack epidemic, cocaine hydrochloride (HCl) was also implicated as a cause of stroke. However, less is known about the differences in stroke subtypes, age at stroke onset, or presence of und...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.41.8.1173
更新日期:1991-08-01 00:00:00
abstract::Seventy-one neonates were observed for the relationship between phenobarbital plasma concentrations and elimination of seizures. Sixty neonates (85%) had seizures controlled by phenobarbital alone. Effective plasma concentrations were 10.1 to 46.4 mg per liter. Although 36 neonates had seizures controlled by phenobarb...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.32.12.1401
更新日期:1982-12-01 00:00:00
abstract::Lymphocyte subpopulations ("active' T cells, total T cells, and B cells), leukocyte migration, lymphocyte transformation, complements (CH50, C3, and C4), and immune complexes in serum and cerebrospinal fluid were studied in 23 patients with subacute sclerosing panencephalitis. The percentage of active T cells was norm...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.2.177
更新日期:1981-02-01 00:00:00
abstract:BACKGROUND:Pompe disease (acid maltase deficiency, glycogen storage disease type II; OMIM 232300) is an autosomal recessive lysosomal storage disorder characterized by acid alpha-glucosidase deficiency due to mutations in the GAA gene. Progressive skeletal muscle weakness affects motor and respiratory functions and is ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000252798.25690.76
更新日期:2007-01-09 00:00:00
abstract:BACKGROUND:The cytokine interferon beta (IFNbeta) is successfully used in the treatment of multiple sclerosis (MS), although there is a high degree of variability in the response. A common mechanism involved in the modulation of responsiveness to cytokines is represented by regulation of their receptor expression throu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000327340.50284.8d
更新日期:2008-12-09 00:00:00
abstract::Using a crossed-response task, monkeys with neglect induced by frontal lesions appear to have motor rather than sensory neglect. However, the crossed-response task may not reveal sensory neglect (inattention) if no perceptual discrimination is required. We therefore trained two monkeys in a perceptually complex crosse...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.6.1205
更新日期:1995-06-01 00:00:00
abstract::Regional cerebral glucose metabolism was studied in 16 patients with idiopathic torticollis, using positron emission tomography. Analysis of subcortical regions revealed no consistent focal abnormality of cerebral metabolic rate for glucose, but there was a bilateral breakdown of the normal relationships between the t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.5.653
更新日期:1986-05-01 00:00:00
abstract::Management of low-grade gliomas continues to be a challenging task, because CT and MRI do not always differentiate from nontumoral lesions. Furthermore, tumor extent and aggressiveness often remain unclear because of a lack of contrast enhancement. Previous studies indicated that large neutral amino acid tracers accum...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.50.5.1316
更新日期:1998-05-01 00:00:00
abstract::Generic substitution is practiced widely in both hospital and community settings. There have been several reports of reduced serum concentrations and seizure exacerbation following generic substitution of Tegretol. We describe the first 2 cases of carbamazepine toxicity resulting from the substitution of Tegretol with...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.12.2696
更新日期:1993-12-01 00:00:00
abstract:OBJECTIVE:To determine serial MRI and CT abnormalities around calcified cysts due to cysticercosis in previously treated patients during periods of seizure activity. BACKGROUND:Some patients with calcified lesions due to cysticercosis have seizures. How and why seizures occur in this setting are unknown. METHODS:Thre...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.4.777
更新日期:1999-09-11 00:00:00