Abstract:
:This nested case-control study assessed the putative protective effect of human herpesvirus-8 (HHV-8) against HIV-1-related dementia (dementia). The HHV-8 seropositivity of 210 male age- and HIV disease stage-matched cases and controls was compared. The overall HHV-8 seropositivity of 66% was similar among demented HIV-infected cases and nondemented HIV-infected controls.
journal_name
Neurologyjournal_title
Neurologyauthors
Polk S,Muñoz A,Sacktor NC,Jenkins FJ,Cohen B,Miller EN,Jacobson LPdoi
10.1212/wnl.59.6.950subject
Has Abstractpub_date
2002-09-24 00:00:00pages
950-3issue
6eissn
0028-3878issn
1526-632Xjournal_volume
59pub_type
杂志文章,多中心研究相关文献
NEUROLOGY文献大全abstract::Myoclonus--dystonia is a genetically heterogeneous autosomal dominant disorder caused by a mutation in the D2 dopamine receptor on chromosome 11 and a locus on chromosome 7q21-q31. The authors tested linkage to the chromosome 7q candidate region in four families with either myoclonic dystonia (n = 3) or essential myoc...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.9.1213
更新日期:2001-05-08 00:00:00
abstract:OBJECTIVE:To determine if abnormalities exist in postural control in autism and if they are related to age. METHODS:Dynamic posturography was performed in 79 autistic individuals without mental retardation and 61 healthy volunteers between ages 5 and 52 years. Both the sensory organization and the movement coordinatio...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000145771.98657.62
更新日期:2004-12-14 00:00:00
abstract:OBJECTIVES:The Stroke-Thrombolytic Predictive Instrument (Stroke-TPI) predicts the probability of good and bad outcomes with and without recombinant tissue plasminogen activator (rtPA). We sought to rebuild and externally validate a simpler Stroke-TPI to support implementation in routine clinical care. METHODS:Using t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001925
更新日期:2015-09-15 00:00:00
abstract::Regional levels of brain monoamines and their metabolites were examined in a rat model of reversible and diffuse forebrain ischemia with and without reperfusion. During ischemia, blood flow decreased by 87 to 95%, but recovered to control values during recirculation. Norepinephrine and serotonin decreased in the cereb...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.7.971
更新日期:1986-07-01 00:00:00
abstract:BACKGROUND:The clinical characteristics of Tourette syndrome (TS) present challenges for the systematic determination of whether individuals are affected and severity. Vocal and motor tics wax and wane, decrease over time, and may be voluntarily suppressible, and therefore may be absent at interview. Current instrument...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.9.2108
更新日期:1999-12-10 00:00:00
abstract:OBJECTIVE:To determine the role of oxidative stress in mediating HIV dementia and to identify novel therapeutic compounds that may block this oxidative stress. METHODS:Brain tissue from patients with HIV encephalitis and macaques with simian immune deficiency virus encephalitis was immunostained for lipid peroxidation...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000042048.85204.3d
更新日期:2003-01-28 00:00:00
abstract:OBJECTIVE:To describe the results of a multicenter study that validated two new patient-reported measures of neurologic impairment and disability for use in MS clinical research. BACKGROUND:Self-reported data can provide a cost-effective means to assess patient functioning, and can be useful for screening patients who...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/wnl.52.1.63
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:Aiming to detect associations between neuroradiologic and EEG evaluations and long-term clinical outcome in order to detect possible prognostic factors, a detailed clinical and neuroimaging characterization of 67 cases of Aicardi syndrome (AIC), collected through a multicenter collaboration, was performed. M...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000011237
更新日期:2020-12-04 00:00:00
abstract:BACKGROUND:After 1 to 4 years, seizure-free children with epilepsy are encouraged to stop daily antiepileptic drug (AED) treatment. Approximately 70% are successful. The authors examined how often intractable epilepsy follows discontinuation of AED treatment in a population-based cohort of children with epilepsy. METH...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000154517.82748.A7
更新日期:2005-03-22 00:00:00
abstract:OBJECTIVE:To assess the association of early morning serum cortisol with cognitive performance and brain structural integrity in community-dwelling young and middle-aged adults without dementia. METHODS:We evaluated dementia-free Framingham Heart Study (generation 3) participants (mean age 48.5 years, 46.8% men) who u...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006549
更新日期:2018-11-20 00:00:00
abstract:OBJECTIVE:To evaluate if mental fatigue is a symptom that appears independently from other clinical features in patients with Parkinson disease (PD), and to study if fatigue is persistent over time in these patients. METHODS:In 1993, 233 patients with PD were included in a community-based study of fatigue and followed...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000144277.06917.cc
更新日期:2004-11-23 00:00:00
abstract:OBJECTIVE:To investigate the lateralization and localization of ictal EEG in focal epilepsy. METHODS:A total of 486 ictal EEG of 72 patients with focal epilepsy arising from the mesial temporal, neocortical temporal, mesial frontal, dorsolateral frontal, parietal, and occipital regions were analyzed. RESULTS:Surface ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.11.2022
更新日期:2001-12-11 00:00:00
abstract::Lymphocyte subpopulations ("active' T cells, total T cells, and B cells), leukocyte migration, lymphocyte transformation, complements (CH50, C3, and C4), and immune complexes in serum and cerebrospinal fluid were studied in 23 patients with subacute sclerosing panencephalitis. The percentage of active T cells was norm...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.2.177
更新日期:1981-02-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate the association between spinal cord injury (SCI) and type 2 diabetes in a large representative sample and to determine whether an association exists irrespective of known risk factors for type 2 diabetes. METHODS:Data were obtained on 60,678 respondents to the Stat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000436074.98534.6e
更新日期:2013-11-19 00:00:00
abstract::Postprandial hypotension occurs commonly in patients with autonomic failure and may be due to attenuation of the normal sympathetic nervous system activation in response to meal ingestion. In a randomized, double-blind, placebo-controlled study, we investigated the therapeutic effect of the norepinephrine precursor 3,...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.47.6.1414
更新日期:1996-12-01 00:00:00
abstract:OBJECTIVE:To quantify disease progression in individuals with Duchenne muscular dystrophy (DMD) using magnetic resonance biomarkers of leg muscles. METHODS:MRI and magnetic resonance spectroscopy (MRS) biomarkers were acquired from 104 participants with DMD and 51 healthy controls using a prospective observational stu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000009244
更新日期:2020-04-14 00:00:00
abstract::We studied four patients with neurologic disorders of the lumbosacral plexus. Except for location of symptoms, the disorder confirmed to criteria established for the clinical diagnosis of brachial plexus neuritis. Acute onset of pain in one or both legs was followed by weakness, loss of stretch reflexes, and sometimes...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.4.470
更新日期:1981-04-01 00:00:00
abstract::The effects of acute ethanol injection on force production were measured in normal and chronic alcoholic rats. Acutely injected normal rats, acutely injected chronic alcoholic rats, and noninjected chronic alcoholic rats were compared with control groups: normal nonalcoholic rats and a dietetically deprived control gr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.2.139
更新日期:1980-02-01 00:00:00
abstract::Tolcapone is a potent, reversible inhibitor of catechol O-methyltransferase (COMT) intended for use as an adjunct to levodopa therapy for Parkinson's disease (PD). Findings from the first pharmacokinetics/pharmacodynamics and tolerability studies of tolcapone in volunteers are reviewed. Following linear and dose-propo...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.50.5_suppl_5.s31
更新日期:1998-05-01 00:00:00
abstract::We report a family with Machado-Joseph disease (MJD) that was previously diagnosed with dentatorubral-pallidoluysian atrophy (DRPLA), on the basis of the neuropathologic findings. Because the clinical and pathologic reevaluation strongly suggested a diagnosis of MJD, we conducted a genetic study in the family. Two pat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.4.1154
更新日期:1996-04-01 00:00:00
abstract:OBJECTIVE:To describe two symptomatic dysferlin gene mutation carriers. METHODS:One patient had limb girdle weakness. His brother was diagnosed with limb girdle muscular dystrophy 2B with two mutations in the dysferlin gene (D625Y and E1734G). The second patient had distal weakness. He had two sons with Miyoshi myopat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000256768.79353.60
更新日期:2007-04-17 00:00:00
abstract::The Finnish Twin Cohort includes all Finnish same-sexed twins born before 1958 and alive in 1967; the number of individuals alive in 1975 was 33,247. We performed a search for cases with Parkinson's disease among this cohort by linking the Twin Cohort Register with the Finnish Hospital Discharge Register and the Finni...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.8.1217
更新日期:1988-08-01 00:00:00
abstract:OBJECTIVE:Physician prediction of outcome in critically ill neurologic patients impacts treatment decisions and goals of care. In this observational study, we prospectively compared predictions by neurointensivists to patient outcomes at 6 months. METHODS:Consecutive neurologic patients requiring mechanical ventilatio...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181d8197f
更新日期:2010-04-06 00:00:00
abstract:BACKGROUND AND PURPOSE:Resistance to insulin-mediated glucose uptake by peripheral tissues is a cardinal defect in type 2 diabetes mellitus. Insulin resistance is also common among nondiabetic individuals, and may be an important risk factor for stroke in both populations. The authors review the definition, epidemiolog...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.59.6.809
更新日期:2002-09-24 00:00:00
abstract:OBJECTIVE:To revise the 1999 Airlie House consensus guidelines for the design and implementation of preclinical therapeutic studies and clinical trials in amyotrophic lateral sclerosis (ALS). METHODS:A consensus committee comprising 140 key members of the international ALS community (ALS researchers, clinicians, patie...
journal_title:Neurology
pub_type: 共识发展会议,杂志文章
doi:10.1212/WNL.0000000000007242
更新日期:2019-04-02 00:00:00
abstract::Conditioning stimuli to the coronal gyrus or periventricular gray matter inhibit the activity of spinal trigeminal neurons. Valproate decreased the corticofugal inhibition of the spinal trigeminal nucleus, as did ethosuximide, trimethadione, and imipramine. Valproate and ethosuximide also decreased the periventricular...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.2.126
更新日期:1980-02-01 00:00:00
abstract::Four men with evidence of hemiatrophy resulting from early-life hemispheral injury developed unilateral hemiparkinsonism on the side of the hemiatrophy. The parkinsonism began in the fourth decade and has remained unilateral for 5 to 35 years. In all four patients, the parkinsonism was slowly progressive, but the clin...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.5.625
更新日期:1981-05-01 00:00:00
abstract:OBJECTIVE:We endeavored to develop an unruptured intracranial aneurysm (UIA) treatment score (UIATS) model that includes and quantifies key factors involved in clinical decision-making in the management of UIAs and to assess agreement for this model among specialists in UIA management and research. METHODS:An internat...
journal_title:Neurology
pub_type: 共识发展会议,杂志文章
doi:10.1212/WNL.0000000000001891
更新日期:2015-09-08 00:00:00
abstract:OBJECTIVE:To define potential pathogenic mitochondrial DNA (mtDNA) point mutations in a patient with myoclonus epilepsy with ragged-red fibers (MERRF) syndrome. BACKGROUND:MERRF syndrome is typically associated with point mutations in the mtDNA tRNALys gene. METHODS:We performed morphologic, biochemical, and genetic ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.2.377
更新日期:1999-01-15 00:00:00
abstract:BACKGROUND:Because of the relatively poor results of frontal lobe epilepsy (FLE) surgery, identification of prognostic factors for surgical outcome is of great importance. METHODS:To identify predictive factors for FLE surgery, we analyzed the data of 61 patients (mean age at surgery 19.2) who had undergone presurgica...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.54.7.1470
更新日期:2000-04-11 00:00:00