Subacute sclerosing panencephalitis: clinical and immunologic study of 23 patients.

Abstract:

:Lymphocyte subpopulations ("active' T cells, total T cells, and B cells), leukocyte migration, lymphocyte transformation, complements (CH50, C3, and C4), and immune complexes in serum and cerebrospinal fluid were studied in 23 patients with subacute sclerosing panencephalitis. The percentage of active T cells was normal. The number of patients with positive migration inhibitory response to phytoyhemagglutinin was lower than controls, corresponding to the diminished percentage of total T cells in patients. C1q binding (immune complex formation) was found in the sera of 10 patients.

journal_name

Neurology

journal_title

Neurology

authors

Derakhshan I,Massoud A,Foroozanfar N,Nikbin B,Lotfi J,Shakib N,Ala F

doi

10.1212/wnl.31.2.177

subject

Has Abstract

pub_date

1981-02-01 00:00:00

pages

177-8

issue

2

eissn

0028-3878

issn

1526-632X

journal_volume

31

pub_type

杂志文章
  • Absence of cystatin C mutation in sporadic cerebral amyloid angiopathy-related hemorrhage.

    abstract::In Icelandic pedigrees a cystatin C mutation, glutamine 68 (L68Q), causes autosomal dominant cerebral amyloid angiopathy-related hemorrhage (CAAH). We examined 33 patients with sporadic CAAH for this mutation. None carried L68Q and, including this report, only one of 52 published cases of sporadic CAAH has had the cys...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.54.1.242

    authors: McCarron MO,Nicoll JA,Stewart J,Ironside JW,Mann DM,Love S,Graham DI,Grubb A

    更新日期:2000-01-11 00:00:00

  • The role of small diffusion-weighted imaging lesions in cerebral small vessel disease.

    abstract:OBJECTIVE:To investigate the prevalence of asymptomatic diffusion-weighted imaging-positive (DWI+) lesions in individuals with cerebral small vessel disease (SVD) and identify their role in the origin of SVD markers on MRI. METHODS:We included 503 individuals with SVD from the Radboud University Nijmegen Diffusion Ten...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000008364

    authors: Wiegertjes K,Ter Telgte A,Oliveira PB,van Leijsen EMC,Bergkamp MI,van Uden IWM,Ghafoorian M,van der Holst HM,Norris DG,Platel B,Klijn CJM,Tuladhar AM,de Leeuw FE

    更新日期:2019-10-22 00:00:00

  • MRI in juvenile ALS: a patient report.

    abstract::We describe the MR images of a patient with juvenile ALS. MRI of the brain showed bilateral hyperintensities along the corticospinal tracts extending from the corona radiata to the brainstem on T2-weighted images. These findings should be differentiated from the slight hyperintensities seen in the posterior limbs of t...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.50.6.1879

    authors: Midani H,Truwit CL,Parry GJ

    更新日期:1998-06-01 00:00:00

  • The apolipoprotein epsilon 4 allele in Parkinson's disease with and without dementia.

    abstract::The epsilon 4 isoform of apolipoprotein E (Apo-E) may confer genetic susceptibility for familial and sporadic Alzheimer's disease (AD). Because dementia in AD and Parkinson's disease (PD) share many biologic and clinical features, we determined the Apo-E genotypes for 79 patients with PD, 22 of whom were demented, and...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.44.7.1330

    authors: Marder K,Maestre G,Cote L,Mejia H,Alfaro B,Halim A,Tang M,Tycko B,Mayeux R

    更新日期:1994-07-01 00:00:00

  • Physiologic events initiating REM sleep in patients with the postpolio syndrome.

    abstract:BACKGROUND:We previously studied the occurrence of muscle tone reduction (MTR), sawtooth waves (STW), and REM in sleep, and found a stereotypical sequence of these events in normal subjects. Patients with the postpolio syndrome may have involvement of the reticular formation in the brainstem, an area known to mediate i...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.52.3.516

    authors: Siegel H,McCutchen C,Dalakas MC,Freeman A,Graham B,Alling D,Sato S

    更新日期:1999-02-01 00:00:00

  • Cerebellar learning distinguishes inflammatory neuropathy with and without tremor.

    abstract:OBJECTIVES:This study aims to investigate if patients with inflammatory neuropathies and tremor have evidence of dysfunction in the cerebellum and interactions in sensorimotor cortex compared to nontremulous patients and healthy controls. METHODS:A prospective data collection study investigating patients with inflamma...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e318292a2b8

    authors: Schwingenschuh P,Saifee TA,Katschnig-Winter P,Reilly MM,Lunn MP,Manji H,Aguirregomozcorta M,Schmidt R,Bhatia KP,Rothwell JC,Edwards MJ

    更新日期:2013-05-14 00:00:00

  • Language dominance determined by magnetic source imaging: a comparison with the Wada procedure.

    abstract:OBJECTIVE:To evaluate the validity of data derived from magnetic source imaging (MSI) regarding cerebral dominance for language in patients with intractable seizure disorder. METHOD:The authors performed functional imaging of the receptive language cortex using a whole-head neuromagnetometer in 26 consecutive epilepsy...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.53.5.938

    authors: Breier JI,Simos PG,Zouridakis G,Wheless JW,Willmore LJ,Constantinou JE,Maggio WW,Papanicolaou AC

    更新日期:1999-09-22 00:00:00

  • Effects of weight loss on the course of idiopathic intracranial hypertension in women.

    abstract:OBJECTIVE:To determine the role of weight loss in the treatment of idiopathic intracranial hypertension (IIH) in obese women. METHODS:Chart review of 250 patients with suspected IIH revealed 58 women who met our criteria, did not undergo early surgical intervention, and had adequate documentation of visual status, pap...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.50.4.1094

    authors: Kupersmith MJ,Gamell L,Turbin R,Peck V,Spiegel P,Wall M

    更新日期:1998-04-01 00:00:00

  • Mapping brain recovery after concussion: From acute injury to 1 year after medical clearance.

    abstract:OBJECTIVE:To test the hypothesis that concussion-related brain alterations seen at symptomatic injury and medical clearance to return to play (RTP) will have dissipated by 1 year after RTP. METHODS:For this observational study, 24 athletes with concussion were scanned longitudinally within 1 week after injury, at RTP,...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000008523

    authors: Churchill NW,Hutchison MG,Graham SJ,Schweizer TA

    更新日期:2019-11-19 00:00:00

  • Effects of intermittent levetiracetam dosing in a patient with refractory daily seizures.

    abstract::Some epilepsy patients quickly develop resistance to antiepileptic drugs (AEDs). We report a case of a patient with refractory epilepsy with daily seizures who initially responded to levetiracetam daily therapy, but then returned to baseline seizure frequency. However, when levetiracetam was given once weekly, the pat...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000198500.84481.da

    authors: Friedman D,French JA

    更新日期:2006-02-28 00:00:00

  • Subregional loss of putaminal efferents to the basal ganglia output nuclei may cause parkinsonism in striatonigral degeneration.

    abstract::In this study, we examined the topographic involvement of the putaminal projection neurons and their axons in the globus pallidus and substantia nigra, which we visualized by calcineurin immunostaining, in the basal ganglia of patients with striatonigral degeneration (SND). In all cases examined, there was a marked de...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.47.4.1032

    authors: Goto S,Matsumoto S,Ushio Y,Hirano A

    更新日期:1996-10-01 00:00:00

  • Neutralizing antibodies to interferon beta: assessment of their clinical and radiographic impact: an evidence report: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.

    abstract::The clinical and radiologic impact of developing neutralizing antibodies (NAbs) to interferon beta (IFNbeta) while on this therapy for multiple sclerosis (MS) is assessed. On the basis of Class II and III evidence, it is concluded that treatment of patients with MS with IFNbeta (Avonex, Betaseron, or Rebif) is associa...

    journal_title:Neurology

    pub_type:

    doi:10.1212/01.wnl.0000258545.73854.cf

    authors: Goodin DS,Frohman EM,Hurwitz B,O'Connor PW,Oger JJ,Reder AT,Stevens JC

    更新日期:2007-03-27 00:00:00

  • Cerebral microembolism in symptomatic and asymptomatic high-grade internal carotid artery stenosis.

    abstract::Using transcranial Doppler (TCD) ultrasonography in patients with high-grade (> or = 70%) internal carotid artery (ICA) stenosis, we examined the relation between the rate of TCD-detected silent microembolism of the ipsilateral middle cerebral artery and a history of recent (< 121 days) ischemic symptoms attributable ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.44.4.615

    authors: Siebler M,Kleinschmidt A,Sitzer M,Steinmetz H,Freund HJ

    更新日期:1994-04-01 00:00:00

  • Bacterial meningitis in adults: demonstration of inner ear involvement using high-resolution MRI.

    abstract:OBJECTIVE:To visualize the sites involved in audiovestibular dysfunction during bacterial meningitis in adults and to relate these findings to the extent of hearing impairment and vestibular dysfunction. BACKGROUND:Hearing impairment is among the most frequent complications of bacterial meningitis. METHODS:High-resol...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.52.5.1003

    authors: Dichgans M,Jäger L,Mayer T,Schorn K,Pfister HW

    更新日期:1999-03-23 00:00:00

  • Neutralizing antibodies reduce the efficacy of betaIFN during treatment of multiple sclerosis.

    abstract:OBJECTIVE:To analyze the impact of neutralizing antibodies (NAbs) on the clinical efficacy of IFNbeta. METHODS:This was an open-label study involving 78 patients with multiple sclerosis treated with Betaferon 8 million IU (MIU) subcutaneously (SC) every other day (n = 20), Rebif 22 micro g SC 3 times weekly (n = 25), ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000129265.73259.9e

    authors: Malucchi S,Sala A,Gilli F,Bottero R,Di Sapio A,Capobianco M,Bertolotto A

    更新日期:2004-06-08 00:00:00

  • Methyl bromide intoxication: neurologic features, including simulation of Reye syndrome.

    abstract::Three family members intoxicated with methyl bromide presented with a variety of neuropsychiatric manifestations including coma, severe status epilepticus, hyporeflexia, and acute psychosis. The simulation of Reye syndrome in the child emphasizes the need for careful toxicologic screening of all children presenting wi...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.27.10.959

    authors: Shield LK,Coleman TL,Markesbery WR

    更新日期:1977-10-01 00:00:00

  • Registry studies of long-term multiple sclerosis outcomes: description of key registries.

    abstract:BACKGROUND:Multiple sclerosis (MS) registries can provide valuable insights into the natural history of MS. Key observational findings of the registries include MS patient disability progression rate, predictors of increased disability, and changes in lifespan. MS registries have been established in Canada, the United ...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/WNL.0b013e3182050225

    authors: Hurwitz BJ

    更新日期:2011-01-04 00:00:00

  • Basal ganglia dysmorphism in patients with Aicardi syndrome.

    abstract:OBJECTIVE:Aiming to detect associations between neuroradiologic and EEG evaluations and long-term clinical outcome in order to detect possible prognostic factors, a detailed clinical and neuroimaging characterization of 67 cases of Aicardi syndrome (AIC), collected through a multicenter collaboration, was performed. M...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000011237

    authors: Masnada S,Pichiecchio A,Formica M,Arrigoni F,Borrelli P,Accorsi P,Bonanni P,Borgatti R,Bernardina BD,Danieli A,Darra F,Deconinck N,De Giorgis V,Dulac O,Gataullina S,Giordano L,Guerrini R,La Briola F,Mastrangelo M,Mo

    更新日期:2020-12-04 00:00:00

  • Treatment of amyotrophic lateral sclerosis with the TRH analog DN-1417.

    abstract::Thyrotropin-releasing hormone has been reported to increase strength in patients with amyotrophic lateral sclerosis (ALS). DN-1417 is an analog of thyrotropin-releasing hormone, which has less endocrinologic activity, but more anterior horn cell stimulating effect (with no "autorefractory state"). However, 2 mg DN-141...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.37.4.715

    authors: Hawley RJ,Kratz R,Goodman RR,McCutchen CB,Sirdofsky M,Hanson PA

    更新日期:1987-04-01 00:00:00

  • Spatial-temporal functional mapping of language at the bedside with electrocorticography.

    abstract:OBJECTIVE:To investigate the feasibility and clinical utility of using passive electrocorticography (ECoG) for online spatial-temporal functional mapping (STFM) of language cortex in patients being monitored for epilepsy surgery. METHODS:We developed and tested an online system that exploits ECoG's temporal resolution...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000002525

    authors: Wang Y,Fifer MS,Flinker A,Korzeniewska A,Cervenka MC,Anderson WS,Boatman-Reich DF,Crone NE

    更新日期:2016-03-29 00:00:00

  • Concerns of surrogate decision makers for patients with acute brain injury: A US population survey.

    abstract:OBJECTIVE:To determine whether groups of surrogates for patients with severe acute brain injury (SABI) with poor prognosis can be identified based on their prioritization of goals-of-care (GOC) decisional concerns, an online survey of 1,588 adults recruited via a probability-based panel representative of the US populat...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000009406

    authors: Hwang DY,Knies AK,Mampre D,Kolenikov S,Schalk M,Hammer H,White DB,Holloway RG,Sheth KN,Fraenkel L

    更新日期:2020-05-12 00:00:00

  • Brain metabolite concentration and dementia severity in Alzheimer's disease: a (1)H MRS study.

    abstract:OBJECTIVE:(1)H-MRS studies have shown abnormalities in brain levels of myo-inositol (mI) and N-acetyl aspartate (NAA) in AD, but the relation of these abnormalities with dementia severity was not examined. The authors sought to determine whether altered brain levels of mI and other metabolites occur in mild AD and whet...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.57.4.626

    authors: Huang W,Alexander GE,Chang L,Shetty HU,Krasuski JS,Rapoport SI,Schapiro MB

    更新日期:2001-08-28 00:00:00

  • Familial language network vulnerability in primary progressive aphasia.

    abstract:OBJECTIVE:To investigate evidence of the potential role of early cortical vulnerability in the development of primary progressive aphasia (PPA). METHOD:A woman with a diagnosis of PPA and her 9 adult siblings, 7 with developmental language disabilities, underwent neuropsychological testing, structural MRI, and resting...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000009842

    authors: Weintraub S,Rader B,Coventry C,Sridhar J,Wood J,Guillaume KA,Coppola G,Ramos EM,Bonakdarpour B,Rogalski EJ,Mesulam MM

    更新日期:2020-08-18 00:00:00

  • Exploring rating scale responsiveness: does the total score reflect the sum of its parts?

    abstract::Evaluating rehabilitation requires rating scales that detect change. The authors examined Barthel Index (BI) data from 1,495 patients at a neurorehabilitation unit to determine whether total scale responsiveness accurately reflects item responsiveness. Total score effect sizes were moderate to large (0.47 to 1.09). It...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000116136.22922.d6

    authors: O'Connor RJ,Cano SJ,Thompson AJ,Hobart JC

    更新日期:2004-05-25 00:00:00

  • The incidence and significance of anti-natalizumab antibodies: results from AFFIRM and SENTINEL.

    abstract:OBJECTIVE:To determine the incidence and clinical effects of antibodies that develop during treatment with natalizumab. METHODS:In two randomized, double-blind, placebo-controlled studies (natalizumab safety and efficacy in relapsing remitting multiple sclerosis [MS, AFFIRM] and safety and efficacy of natalizumab in c...

    journal_title:Neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1212/01.wnl.0000277457.17420.b5

    authors: Calabresi PA,Giovannoni G,Confavreux C,Galetta SL,Havrdova E,Hutchinson M,Kappos L,Miller DH,O'Connor PW,Phillips JT,Polman CH,Radue EW,Rudick RA,Stuart WH,Lublin FD,Wajgt A,Weinstock-Guttman B,Wynn DR,Lynn F,Panzar

    更新日期:2007-10-02 00:00:00

  • Nearly ubiquitous tissue distribution of the scrapie agent precursor protein.

    abstract::The "modified host protein" model of scrapie proposes that the transmissible agent is composed of the degradation-resistant protein, Sp33-37, and that clinical and pathologic signs result from neurotoxic accumulations of this protein. Sp33-37 is an abnormal, amyloidogenic isoform of the normally occurring cellular pro...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.42.1.149

    authors: Bendheim PE,Brown HR,Rudelli RD,Scala LJ,Goller NL,Wen GY,Kascsak RJ,Cashman NR,Bolton DC

    更新日期:1992-01-01 00:00:00

  • Racial differences in recurrent ischemic stroke risk and recurrent stroke case fatality.

    abstract:OBJECTIVE:To determine black-white differences in 1-year recurrent stroke and 30-day case fatality after a recurrent stroke in older US adults. METHODS:We conducted a retrospective cohort study using a 5% random sample of Medicare beneficiaries with fee-for-service health insurance coverage who were hospitalized for i...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000006467

    authors: Albright KC,Huang L,Blackburn J,Howard G,Mullen M,Bittner V,Muntner P,Howard V

    更新日期:2018-11-06 00:00:00

  • Computed tomographic angiography for diagnosis of brain death.

    abstract::The authors report two patients with suspected brain death who required confirmatory tests other than clinical examination because of prolonged barbiturate administration for intracranial hypertension. Absence of intracranial blood flow was documented on CT angiography and confirmed by CT perfusion images. Cerebral an...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.62.4.652

    authors: Qureshi AI,Kirmani JF,Xavier AR,Siddiqui AM

    更新日期:2004-02-24 00:00:00

  • A variant of the anti-Purkinje cell antibody in a patient with paraneoplastic cerebellar degeneration.

    abstract::An anti-Purkinje cell antibody was found in the serum and CSF of a man with adenocarcinoma of the lung and paraneoplastic cerebellar degeneration (PCD). This antibody differed from the autoantibodies found in patients with gynecologic cancer and PCD in that it produced a different pattern of Purkinje cell cytoplasmic ...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.38.7.1018

    authors: Anderson NE,Budde-Steffen C,Wiley RG,Thurman L,Rosenblum MK,Nadeau SE,Posner JB

    更新日期:1988-07-01 00:00:00

  • An autosomal dominant disorder with episodic ataxia, vertigo, and tinnitus.

    abstract::The authors report an autosomal dominant episodic ataxia that is clinically distinct from the other episodic ataxias. Vestibular ataxia, vertigo, tinnitus, and interictal myokymia are prominent; attacks are diminished by acetazolamide. Linkage analyses of markers flanking the EA1 and EA2 loci demonstrate genetic exclu...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.57.8.1499

    authors: Steckley JL,Ebers GC,Cader MZ,McLachlan RS

    更新日期:2001-10-23 00:00:00