Subacute sclerosing panencephalitis: clinical and immunologic study of 23 patients.


:Lymphocyte subpopulations ("active' T cells, total T cells, and B cells), leukocyte migration, lymphocyte transformation, complements (CH50, C3, and C4), and immune complexes in serum and cerebrospinal fluid were studied in 23 patients with subacute sclerosing panencephalitis. The percentage of active T cells was normal. The number of patients with positive migration inhibitory response to phytoyhemagglutinin was lower than controls, corresponding to the diminished percentage of total T cells in patients. C1q binding (immune complex formation) was found in the sera of 10 patients.






Derakhshan I,Massoud A,Foroozanfar N,Nikbin B,Lotfi J,Shakib N,Ala F




Has Abstract


1981-02-01 00:00:00












  • Association of amyloid-β CSF/PET discordance and tau load 5 years later.

    abstract:OBJECTIVE:To investigate the association between discordant β-amyloid (Aβ) PET and CSF biomarkers at baseline and the emergence of tau pathology 5 years later. METHODS:We included 730 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants without dementia (282 cognitively normal, 448 mild cognitive impairment...


    pub_type: 杂志文章


    authors: Reimand J,Collij L,Scheltens P,Bouwman F,Ossenkoppele R,Alzheimer's Disease Neuroimaging Initiative.

    更新日期:2020-11-10 00:00:00

  • Pituitary enlargement in patients with intracranial hypotension syndrome.

    abstract::Article abstract-The authors analyzed whether the pituitary gland enlarges in intracranial hypotension syndrome by studying 11 consecutive patients. Initial MRI scans showed pituitary gland enlargement with a convex superior margin. Follow-up MRI studies revealed that the size of the gland invariably diminished in all...


    pub_type: 杂志文章


    authors: Alvarez-Linera J,Escribano J,Benito-León J,Porta-Etessam J,Rovira A

    更新日期:2000-12-26 00:00:00

  • APOE ε4 worsens hippocampal CA1 apical neuropil atrophy and episodic memory.

    abstract:OBJECTIVES:Using high-resolution structural MRI, we endeavored to study the relationships among APOE ε4, hippocampal subfield and stratal anatomy, and episodic memory. METHODS:Using a cross-sectional design, we studied 11 patients with Alzheimer disease dementia, 14 patients with amnestic mild cognitive impairment, an...


    pub_type: 杂志文章


    authors: Kerchner GA,Berdnik D,Shen JC,Bernstein JD,Fenesy MC,Deutsch GK,Wyss-Coray T,Rutt BK

    更新日期:2014-02-25 00:00:00

  • Patterns of progression in patients with recurrent glioblastoma treated with bevacizumab.

    abstract:OBJECTIVE:We evaluated patterns of tumor progression in patients with recurrent glioblastoma who were treated with bevacizumab (BEV) alone or in combination with irinotecan (CPT-11) while participating in the BRAIN study. METHODS:An independent neuroradiologist reviewed MRI scans at baseline and progression in patient...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Pope WB,Xia Q,Paton VE,Das A,Hambleton J,Kim HJ,Huo J,Brown MS,Goldin J,Cloughesy T

    更新日期:2011-02-01 00:00:00

  • Phenotypic heterogeneity of spinal muscular atrophy mapping to chromosome 5q11.2-13.3 (SMA 5q).

    abstract::We made phenotypic analysis of 14 families with spinal muscular atrophy (SMA) linking to chromosome 5q11.2-13.3 (SMA 5q), and 2 that may not map to this locus, to assess clinical symptoms among SMA families known to result from mutation at the identical gene/locus. Although the current number of families is still smal...


    pub_type: 杂志文章


    authors: Munsat TL,Skerry L,Korf B,Pober B,Schapira Y,Gascon GG,al-Rajeh SM,Dubowitz V,Davies K,Brzustowicz LM

    更新日期:1990-12-01 00:00:00

  • Sign language aphasia due to left occipital lesion in a deaf signer.

    abstract::Localization of sign language production and comprehension in deaf people has been described as similar to that of spoken language aphasia. However, sign language employs a visuospatial modality through visual information. We present the first report of a deaf signer who showed substantial sign language aphasia with s...


    pub_type: 杂志文章


    authors: Saito K,Otsuki M,Ueno S

    更新日期:2007-10-02 00:00:00

  • Neurofilament light chain level is a weak risk factor for the development of MS.

    abstract:OBJECTIVE:To determine the prognostic value of selected biomarkers in clinically isolated syndromes (CIS) for conversion to multiple sclerosis (MS) and disability accrual. METHODS:Data were acquired from 2 CIS cohorts. The screening phase evaluated patients developing clinically definite MS (CIS-CDMS) and patients who...


    pub_type: 杂志文章


    authors: Arrambide G,Espejo C,Eixarch H,Villar LM,Alvarez-Cermeño JC,Picón C,Kuhle J,Disanto G,Kappos L,Sastre-Garriga J,Pareto D,Simon E,Comabella M,Río J,Nos C,Tur C,Castilló J,Vidal-Jordana A,Galán I,Arévalo MJ,Auger C

    更新日期:2016-09-13 00:00:00

  • Cutaneous innervation in sensory neuropathies: evaluation by skin biopsy.

    abstract:OBJECTIVE:To use punch skin biopsies to evaluate the loss of intra-epidermal nerve fibers in sensory neuropathies. BACKGROUND:Previous assessments of epidermal nerve fibers have been constrained by relatively insensitive staining techniques and variability in quantification. METHODS:Punch skin biopsies were performed...


    pub_type: 杂志文章


    authors: McCarthy BG,Hsieh ST,Stocks A,Hauer P,Macko C,Cornblath DR,Griffin JW,McArthur JC

    更新日期:1995-10-01 00:00:00

  • Internal carotid artery stent placement without emboli protection: results and long-term outcome.

    abstract::Patients with symptomatic > or = 60% (n = 134), asymptomatic > or = 80% (n = 143), and asymptomatic progressive > or = 60% (n = 25) internal carotid artery stenosis underwent stenting and were followed clinically and by Doppler-assisted duplex imaging for 27.1 +/- 15.6 months. Stroke and death from stroke occurred wit...


    pub_type: 临床试验,杂志文章


    authors: Bibl D,Lampl C,Biberhofer I,Kerschner K,Kypta A,Bergmann J,Kaindlstorfer A,Röper C,Yazdi K,Engleder C,Hofmann R,Deibl M,Leisch F,Ransmayr G

    更新日期:2005-07-12 00:00:00

  • The role of small diffusion-weighted imaging lesions in cerebral small vessel disease.

    abstract:OBJECTIVE:To investigate the prevalence of asymptomatic diffusion-weighted imaging-positive (DWI+) lesions in individuals with cerebral small vessel disease (SVD) and identify their role in the origin of SVD markers on MRI. METHODS:We included 503 individuals with SVD from the Radboud University Nijmegen Diffusion Ten...


    pub_type: 杂志文章


    authors: Wiegertjes K,Ter Telgte A,Oliveira PB,van Leijsen EMC,Bergkamp MI,van Uden IWM,Ghafoorian M,van der Holst HM,Norris DG,Platel B,Klijn CJM,Tuladhar AM,de Leeuw FE

    更新日期:2019-10-22 00:00:00

  • Retrievable stents, "stentrievers," for endovascular acute ischemic stroke therapy.

    abstract::Endovascular therapy for acute ischemic stroke continues to evolve to improve both efficacy and safety. In the late 1990 s, intra-arterial chemical thrombolysis with prourokinase was shown to be effective in achieving partial recanalization and improving clinical outcome, in comparison with intra-arterial heparin admi...


    pub_type: 杂志文章,评审


    authors: Novakovic RL,Toth G,Narayanan S,Zaidat OO

    更新日期:2012-09-25 00:00:00

  • Migraine association and linkage studies of an endothelial nitric oxide synthase (NOS3) gene polymorphism.

    abstract::Migraine shows strong familial aggregation. However, the number of genes involved in the disorder is unknown and not identified. Nitric oxide is involved in the central processing of pain stimuli and plays an important role in the regulation of basal or stimulated vasodilation. Nitric oxide synthase, which controls th...


    pub_type: 杂志文章


    authors: Griffiths LR,Nyholt DR,Curtain RP,Goadsby PJ,Brimage PJ

    更新日期:1997-08-01 00:00:00

  • Oral sumatriptan for the long-term treatment of migraine: clinical findings.

    abstract::This double-blind, placebo-controlled, crossover study of the acute treatment of migraine investigated the efficacy and tolerability of oral sumatriptan 100 mg (Imitrex) administered for up to nine attacks compared with placebo administered for up to three attacks. Patients were randomized to receive oral sumatriptan ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rederich G,Rapoport A,Cutler N,Hazelrigg R,Jamerson B

    更新日期:1995-08-01 00:00:00

  • Isoniazid for tremor in multiple sclerosis: a controlled trial.

    abstract::We evaluated the effects of isoniazid on tremor in 13 patients with MS. Patients were evaluated before treatment, after 1 month of therapy (1,000 mg daily), and 1 month after the last dose. Ten patients improved on at least one of three methods of evaluation. Transient side effects were common, possibly because there ...


    pub_type: 临床试验,杂志文章


    authors: Duquette P,Pleines J,du Souich P

    更新日期:1985-12-01 00:00:00

  • Sensory neuronopathy and Sjögren's syndrome: clinical and immunologic study of two patients.

    abstract::In two patients, a sensory neuronopathy was the initial presentation of Sjögren's syndrome. There was no systemic or peripheral nerve vasculitis. Immunochemical studies failed to demonstrate specific antibodies against the nervous system. These features suggest that the damage to the sensory neurons might not be media...


    pub_type: 杂志文章


    authors: Graus F,Pou A,Kanterewicz E,Anderson NE

    更新日期:1988-10-01 00:00:00

  • Erythrocyte thiolmethyltransferase: another failed marker for Alzheimer's and Parkinson's diseases.

    abstract::There are reports that patients with Parkinson's disease (PD) and Alzheimer's disease (AD) have reduced levels of thiolmethyltransferase (TMT) in erythrocyte membranes. TMT methylates thiols and thiocarbamates, thereby reducing their toxicity. We examined TMT levels in erythrocytes from patients with PD and AD and fro...


    pub_type: 杂志文章


    authors: Hurwitz A,Hubble JP,Glatt SL,Koller WC,Pollack J

    更新日期:1995-10-01 00:00:00

  • Search patterns using the line bisection test for neglect.

    abstract:BACKGROUND/OBJECTIVE:Neglect has been attributed to sensory-attentional, motor-intentional, and representational disorders. Although patients with neglect may have defective visual exploration, the nature of this exploration deficit has not been entirely elucidated. The purpose of this study is to learn how, compared w...


    pub_type: 杂志文章


    authors: Kim M,Anderson JM,Heilman KM

    更新日期:1997-10-01 00:00:00

  • Quantitative MRI in temporal lobe epilepsy: evidence for fornix atrophy.

    abstract:OBJECTIVE:To investigate whether the fornix and mamillary bodies, being part of the limbic system, are abnormal in patients with mesial temporal lobe epilepsy (MTLE). BACKGROUND:The limbic system comprises the hippocampal formation, fornix, mamillary bodies, thalamus, and other integrated structures. This system is im...


    pub_type: 杂志文章


    authors: Kuzniecky R,Bilir E,Gilliam F,Faught E,Martin R,Hugg J

    更新日期:1999-08-11 00:00:00

  • Pediatric cavernous sinus thrombosis: A case series and review of the literature.

    abstract:OBJECTIVE:To describe clinical characteristics, imaging findings, morbidity, and mortality in a single-center cohort of 12 pediatric cavernous sinus thrombosis cases and to review all cases available in recent English literature. METHODS:Clinical data and radiographic studies on 12 cases from our institution were anal...


    pub_type: 杂志文章,评审


    authors: Smith DM,Vossough A,Vorona GA,Beslow LA,Ichord RN,Licht DJ

    更新日期:2015-09-01 00:00:00

  • The impact of neuropathic pain on health-related quality of life: review and implications.

    abstract::A number of high-quality studies have recently been published that examine the association between neuropathic pain and health-related quality of life (HRQoL). The current review identified 52 such studies in patients with six neuropathic pain conditions associated with lesions of either the peripheral (postsurgical n...


    pub_type: 杂志文章,meta分析,评审


    authors: Jensen MP,Chodroff MJ,Dworkin RH

    更新日期:2007-04-10 00:00:00

  • Calcification of the basal ganglia as a cause of levodopa-resistant parkinsonism.

    abstract::We present a patient with levodopa-resistant parkinsonism due to basal ganglia calcification related to surgically-induced hypoparathyroidism. The calcification was seen on computerized axial tomography but not on skull x-rays. Such calcification should be looked for in all cases of levodopa-resistant parkinsonism, si...


    pub_type: 杂志文章


    authors: Klawans HL,Lupton M,Simon L

    更新日期:1976-03-01 00:00:00

  • Evaluation of essential tremor with multi-voxel magnetic resonance spectroscopy.

    abstract::The pathologic substrate of essential tremor (ET) remains unknown. The authors studied 10 patients with ET and 10 volunteers using a multislice MR spectroscopy imaging sequence. Left and right cerebellar hemisphere NAA/CR and NAA/Cho ratios were significantly smaller in the ET patients than healthy subjects. The autho...


    pub_type: 杂志文章


    authors: Pagan FL,Butman JA,Dambrosia JM,Hallett M

    更新日期:2003-04-22 00:00:00

  • Mitochondrial DNA haplogroups and mutations in children with acquired central demyelination.

    abstract:OBJECTIVE:We investigated mitochondrial DNA (mtDNA) variants in children with a first episode of acquired demyelinating syndromes (PD-ADS) of the CNS and their relationship to disease phenotype, including subsequent diagnosis of multiple sclerosis (MS). METHODS:This exploratory analysis included the initial 213 childr...


    pub_type: 杂志文章


    authors: Venkateswaran S,Zheng K,Sacchetti M,Gagne D,Arnold DL,Sadovnick AD,Scherer SW,Banwell B,Bar-Or A,Simon DK,Canadian Pediatric Demyelinating Disease Network.

    更新日期:2011-03-01 00:00:00

  • Not paralysis, but dystonia causes stridor in multiple system atrophy.

    abstract::Electromyography (EMG) was performed in 10 patients with multiple system atrophy, laryngeal or pharyngeal symptoms, or both. In patients with stridor, EMG during quiet breathing revealed persistent tonic activity in both abductor and adductor vocal cord muscles. In patients with dysphagia, the cricopharyngeal muscle s...


    pub_type: 杂志文章


    authors: Merlo IM,Occhini A,Pacchetti C,Alfonsi E

    更新日期:2002-02-26 00:00:00

  • Parkinson's disease in a nationwide twin cohort.

    abstract::The Finnish Twin Cohort includes all Finnish same-sexed twins born before 1958 and alive in 1967; the number of individuals alive in 1975 was 33,247. We performed a search for cases with Parkinson's disease among this cohort by linking the Twin Cohort Register with the Finnish Hospital Discharge Register and the Finni...


    pub_type: 杂志文章


    authors: Marttila RJ,Kaprio J,Koskenvuo M,Rinne UK

    更新日期:1988-08-01 00:00:00

  • Conglomerated beads shape of lacunar infarcts on diffusion-weighted MRI: what does it suggest?

    abstract:OBJECTIVE:We aimed to analyze lesion patterns of lacunae-sized infarctions in the perforating arterial territory in terms of shape and to determine whether the particular pattern of conglomerated beads shape affected early neurologic deterioration. METHODS:We consecutively included acute ischemic stroke patients with ...


    pub_type: 杂志文章


    authors: Ryu DW,Shon YM,Kim BS,Cho AH

    更新日期:2012-05-01 00:00:00

  • The predictive value of CSF oligoclonal banding for MS 5 years after optic neuritis. Optic Neuritis Study Group.

    abstract::The predictive value of CSF oligoclonal banding for the development of clinically definite MS (CDMS) within 5 years after optic neuritis was assessed in 76 patients enrolled in the Optic Neuritis Treatment Trial. The presence of oligoclonal bands was associated with the development of CDMS (p = 0.02). However, the res...


    pub_type: 杂志文章


    authors: Cole SR,Beck RW,Moke PS,Kaufman DI,Tourtellotte WW

    更新日期:1998-09-01 00:00:00

  • A randomized crossover study of bee sting therapy for multiple sclerosis.

    abstract:BACKGROUND:Bee sting therapy is increasingly used to treat patients with multiple sclerosis (MS) in the belief that it can stabilize or ameliorate the disease. However, there are no clinical studies to justify its use. METHODS:In a randomized, crossover study, we assigned 26 patients with relapsing-remitting or relaps...


    pub_type: 杂志文章,随机对照试验


    authors: Wesselius T,Heersema DJ,Mostert JP,Heerings M,Admiraal-Behloul F,Talebian A,van Buchem MA,De Keyser J

    更新日期:2005-12-13 00:00:00

  • Intrathecal administration of natural human interferon alpha in amyotrophic lateral sclerosis.

    abstract::Ten patients with amyotrophic lateral sclerosis were given intrathecal injections of natural interferon alpha, 1 million units weekly for 7 to 24 weeks. Six patients completed the trial. Four voluntarily withdrew after 7 to 13 injections. The slopes of deterioration for 40 quantitative tests of neuromuscular function ...


    pub_type: 临床试验,杂志文章


    authors: Mora JS,Munsat TL,Kao KP,Finison LJ,Hedlund W,Bradley GA,Scheife R,Georgiades JA

    更新日期:1986-08-01 00:00:00

  • Why do seizures in generalized epilepsy often occur in the morning?

    abstract:OBJECTIVE:We used transcranial magnetic stimulation to investigate the effect of diurnal variability on cortical excitability in patients with epilepsy. METHODS:Thirty drug-naive patients with epilepsy (20 idiopathic generalized epilepsy [IGE], including 10 juvenile myoclonic epilepsy [JME], and 10 focal epilepsy) and...


    pub_type: 杂志文章


    authors: Badawy RA,Macdonell RA,Jackson GD,Berkovic SF

    更新日期:2009-07-21 00:00:00