Regional cerebral glucose metabolism in dementia with Lewy bodies and Alzheimer's disease.


OBJECTIVE:To delineate the features of regional cerebral metabolic rate of glucose (CMRglc) in dementia with Lewy bodies (DLB). METHODS:We compared absolute CMRglc in 12 patients with a clinical diagnosis of DLB, 12 patients with a clinical diagnosis of Alzheimer's disease (AD), and 12 normal volunteers (NC), using 18F-fluorodeoxyglucose (FDG) and PET. The three groups were matched for age and sex, and there were no differences in disease duration or severity of cognitive disturbances between the DLB and AD groups. RESULTS:CMRglc was significantly lower in patients with DLB than in that of NC in most parts of the brain, except the sensorimotor cortices, basal ganglia, thalamus, and pons. Between the DLB and AD groups, there were significant regional CMRglc differences in the medial and lateral occipital lobes. In DLB and AD, the CMRglc reduction patterns were similar, though the global metabolic reduction was larger in DLB, and the occipital CMRglc reduction in DLB could differentiate DLB from AD. The relative occipital CMRglc (normalized to the sensorimotor CMRglc) was a useful measure for the differential diagnosis of DLB from AD. The sensitivity and the specificity were 92% when using the minimal value of the normalized occipital CMRglc in the NC group as the cut-off point. CONCLUSION:These different regional CMRglc reductions substantiate the pathologic, neurochemical, and clinical differences between DLB and AD.






Ishii K,Imamura T,Sasaki M,Yamaji S,Sakamoto S,Kitagaki H,Hashimoto M,Hirono N,Shimomura T,Mori E




Has Abstract


1998-07-01 00:00:00












  • Magnetic resonance brain tumor imaging in canine glioma.

    abstract::This study investigates a canine model of experimental brain tumor. Particularly addressed was the usefulness of gadolinium contrast-enhanced MRI for differentiating brain tumor tissue from cerebral edema. Cultured canine glioma cells were injected into the left hemispheres of six adult mongrel dogs. All dogs develope...


    pub_type: 杂志文章


    authors: Whelan HT,Clanton JA,Moore PM,Tolner DJ,Kessler RM,Whetsell WO Jr

    更新日期:1987-07-01 00:00:00

  • Neurologic improvement after peripheral blood stem cell transplantation in POEMS syndrome.

    abstract:BACKGROUND:Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is a rare multisystem disorder associated with plasma cell dyscrasia. There is increasing evidence that high-dose chemotherapy with autologous peripheral blood stem cell transplantation (Auto-PBSCT) is an efficacious t...


    pub_type: 杂志文章


    authors: Kuwabara S,Misawa S,Kanai K,Suzuki Y,Kikkawa Y,Sawai S,Hattori T,Nishimura M,Nakaseko C

    更新日期:2008-11-18 00:00:00

  • Novel missense mutation in the early growth response 2 gene associated with Dejerine-Sottas syndrome phenotype.

    abstract:BACKGROUND:Mutations in the early growth response 2 (EGR2) gene have recently been found in patients with congenital hypomyelinating neuropathy and Charcot-Marie-Tooth type 1 (CMT1) disease. OBJECTIVE:To determine the frequency of EGR2 mutations in patients with a diagnosis of CMT1, Dejerine-Sottas syndrome (DSS), or ...


    pub_type: 杂志文章


    authors: Timmerman V,De Jonghe P,Ceuterick C,De Vriendt E,Löfgren A,Nelis E,Warner LE,Lupski JR,Martin JJ,Van Broeckhoven C

    更新日期:1999-06-10 00:00:00

  • Headache types and panic disorder: directionality and specificity.

    abstract:OBJECTIVE:To examine the relationship of migraine and other severe headaches with panic disorder. METHODS:Representative samples of persons with migraine, non-migrainous severe headaches, and controls with no history of severe headaches, identified by a telephone survey, were interviewed in person, using a standardize...


    pub_type: 杂志文章


    authors: Breslau N,Schultz LR,Stewart WF,Lipton R,Welch KM

    更新日期:2001-02-13 00:00:00

  • Safety and efficacy of omaveloxolone in patients with mitochondrial myopathy: MOTOR trial.

    abstract:OBJECTIVE:To investigate the safety and efficacy of escalating doses of the semi-synthetic triterpenoid omaveloxolone in patients with mitochondrial myopathy. METHODS:In cohorts of 8-13, 53 participants were randomized double-blind to 12 weeks of treatment with omaveloxolone 5, 10, 20, 40, 80, or 160 mg, or placebo. O...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Madsen KL,Buch AE,Cohen BH,Falk MJ,Goldsberry A,Goldstein A,Karaa A,Koenig MK,Muraresku CC,Meyer C,O'Grady M,Scaglia F,Shieh PB,Vockley J,Zolkipli-Cunningham Z,Haller RG,Vissing J

    更新日期:2020-02-18 00:00:00

  • A clinical staging classification for type C Niemann-Pick disease.

    abstract::Analysis of the temporal sequence of neurologic events, neurophysiologic abnormalities, and longevity in 36 Niemann-Pick type C patients revealed two clinical subgroups with five stages of severity within each group. Patients with a preschool onset (group I; n = 18) had a higher mortality than did patients with a scho...


    pub_type: 杂志文章


    authors: Higgins JJ,Patterson MC,Dambrosia JM,Pikus AT,Pentchev PG,Sato S,Brady RO,Barton NW

    更新日期:1992-12-01 00:00:00

  • Competency to consent to medical treatment in cognitively impaired patients with Parkinson's disease.

    abstract:OBJECTIVES:To investigate capacity to consent to medical treatment (competency) in cognitively impaired patients with PD. BACKGROUND:Although competency has been studied empirically in patients with cortical dementia (AD), no empirical studies have examined competency in patients with PD or other subcortical neurodege...


    pub_type: 杂志文章


    authors: Dymek MP,Atchison P,Harrell L,Marson DC

    更新日期:2001-01-09 00:00:00

  • Creutzfeldt-Jakob disease associated with a deletion of two repeats in the prion protein gene.

    abstract::A two-octapeptide repeat deletion of the prion protein gene has been recently observed in a patient with a 2-year history of dementia and a clinical diagnosis of possible Creutzfeldt-Jakob disease (CJD). The authors report a similar deletion in a patient with a definitive diagnosis of CJD. Since the two-repeat deletio...


    pub_type: 杂志文章


    authors: Capellari S,Parchi P,Wolff BD,Campbell J,Atkinson R,Posey DM,Petersen RB,Gambetti P

    更新日期:2002-11-26 00:00:00

  • Subregional loss of putaminal efferents to the basal ganglia output nuclei may cause parkinsonism in striatonigral degeneration.

    abstract::In this study, we examined the topographic involvement of the putaminal projection neurons and their axons in the globus pallidus and substantia nigra, which we visualized by calcineurin immunostaining, in the basal ganglia of patients with striatonigral degeneration (SND). In all cases examined, there was a marked de...


    pub_type: 杂志文章


    authors: Goto S,Matsumoto S,Ushio Y,Hirano A

    更新日期:1996-10-01 00:00:00

  • Head impulse test in unilateral vestibular loss: vestibulo-ocular reflex and catch-up saccades.

    abstract:BACKGROUND:Quantitative head impulse test (HIT) measures the gain of the angular vestibulo-ocular reflex (VOR) during head rotation as the ratio of eye to head acceleration. Bedside HIT identifies subsequent catch-up saccades after the head rotation as indirect signs of VOR deficit. OBJECTIVE:To determine the VOR defi...


    pub_type: 杂志文章


    authors: Weber KP,Aw ST,Todd MJ,McGarvie LA,Curthoys IS,Halmagyi GM

    更新日期:2008-02-05 00:00:00

  • Practice parameter: risk of driving and Alzheimer's disease (an evidence-based review): report of the quality standards subcommittee of the American Academy of Neurology.

    abstract::Studies of automobile accident frequency among drivers with AD have yielded conflicting results about the risk of accidents. To develop a practice parameter regarding driving and AD the authors performed a systematic review of the literature. The authors identified well-designed, controlled studies of driving and AD u...


    pub_type: 杂志文章,评审


    authors: Dubinsky RM,Stein AC,Lyons K

    更新日期:2000-06-27 00:00:00

  • Prehospital selection of thrombectomy candidates beyond large vessel occlusion: M-DIRECT scale.

    abstract:OBJECTIVE:Current prehospital scales used to detect large vessel occlusion reveal very low endovascular thrombectomy (EVT) rates among selected patients. We developed a novel prehospital scale, the Madrid-Direct Referral to Endovascular Center (M-DIRECT), to identify EVT candidates for direct transfer to EVT-capable ce...


    pub_type: 杂志文章


    authors: Rodríguez-Pardo J,Riera-López N,Fuentes B,Alonso de Leciñana M,Secades-García S,Álvarez-Fraga J,Busca-Ostolaza P,Carneado-Ruiz J,Díaz-Guzmán J,Egido-Herrero J,Gil-Núñez A,Masjuan-Vallejo J,Real-Martínez V,Vivancos-Mora J,Díez

    更新日期:2020-02-25 00:00:00

  • A family with hereditary ataxia: HLA typing.

    abstract::In a previously unreported family with olivopontocerebellar atrophy, the kindred contained over 600 individuals in five generations. Of 83 offsping of affected individuals who over over 38.8 years of age (the mean age of the onset of disease in this family), 47 had ataxia; there was autosomal dominant transmission. Cl...


    pub_type: 杂志文章


    authors: Nino HE,Noreen HJ,Dubey DP,Resch JA,Namboodiri K,Elston RC,Yunis EJ

    更新日期:1980-01-01 00:00:00

  • Sixty hertz pallidal deep brain stimulation for primary torsion dystonia.

    abstract:OBJECTIVE:To evaluate the safety and efficacy of 60 Hz deep brain stimulation (DBS) of the globus pallidus internus (GPi) in 15 consecutive patients with primary dystonia. METHODS:We conducted a retrospective analysis of clinic charts relative to 15 consecutive patients with medically refractory primary dystonia who u...


    pub_type: 杂志文章


    authors: Alterman RL,Miravite J,Weisz D,Shils JL,Bressman SB,Tagliati M

    更新日期:2007-08-14 00:00:00

  • Regional and progressive thinning of the cortical ribbon in Huntington's disease.

    abstract:BACKGROUND:Huntington's disease (HD) is a fatal and progressive neurodegenerative disease that is accompanied by involuntary movements, cognitive dysfunction, and psychiatric symptoms. Although progressive striatal degeneration is known to occur, little is known about how the disease affects the cortex, including which...


    pub_type: 杂志文章


    authors: Rosas HD,Liu AK,Hersch S,Glessner M,Ferrante RJ,Salat DH,van der Kouwe A,Jenkins BG,Dale AM,Fischl B

    更新日期:2002-03-12 00:00:00

  • Sex, race, and risk of dementia diagnosis after traumatic brain injury among older veterans.

    abstract:OBJECTIVE:To investigate whether sex and race differences exist in dementia diagnosis risk associated with traumatic brain injury (TBI) among older veterans. METHODS:Using Fine-Gray regression models, we investigated incident dementia diagnosis risk with TBI exposure by sex and race. RESULTS:After the exclusion of ba...


    pub_type: 杂志文章


    authors: Kornblith E,Peltz CB,Xia F,Plassman B,Novakovic-Apopain T,Yaffe K

    更新日期:2020-09-29 00:00:00

  • Specific antagonism of GABA-mediated postsynaptic inhibition in cultured mammalian spinal cord neurons: a common mode of convulsant action.

    abstract::Mammalian spinal neurons grown in tissue culture were used to study the effects of the four convulsants-penicillin, pentylenetetrazol, picrotoxin, and bicuculline-on these neurons' responses to amino acids. Bath application of all four convulsants produced paroxysmal depolarizing events in the neurons; iontophoresis o...


    pub_type: 杂志文章


    authors: Macdonald RL,Barker JL

    更新日期:1978-04-01 00:00:00

  • Hemifacial spasm due to contralateral acoustic neuroma: case report.

    abstract::A patient with a large acoustic neuroma had contralateral hemifacial spasm. On CT, the brainstem was markedly displaced and distorted by the tumor. After total removal of the tumor the hemifacial spasm was temporarily worse, but disappeared 14 days after the operation. ...


    pub_type: 杂志文章


    authors: Nishi T,Matsukado Y,Nagahiro S,Fukushima M,Koga K

    更新日期:1987-02-01 00:00:00

  • Cerebrospinal fluid pressure in normal obese subjects and patients with pseudotumor cerebri.

    abstract::Cerebrospinal fluid (CSF) pressure was measured in four groups of patients: 116 with acute pseudotumor cerebri, 18 with chronic pseudotumor cerebri, 41 obese and 15 nonobese normal patients undergoing spinal anesthesia. Spinal fluid pressure between 200 and 250 mm H2O was found in members of each group. This suggests ...


    pub_type: 杂志文章


    authors: Corbett JJ,Mehta MP

    更新日期:1983-10-01 00:00:00

  • Effect of L-carnitine treatment for valproate-induced hepatotoxicity.

    abstract::The authors analyzed the association of L-carnitine treatment with hepatic survival in 92 patients with severe, symptomatic, valproate-induced hepatotoxicity. Forty-eight percent of the 42 patients treated with L-carnitine survived, but only 10% of the 50 patients treated solely with aggressive supportive care survive...


    pub_type: 杂志文章


    authors: Bohan TP,Helton E,McDonald I,König S,Gazitt S,Sugimoto T,Scheffner D,Cusmano L,Li S,Koch G

    更新日期:2001-05-22 00:00:00

  • West Nile virus infection presenting as acute flaccid paralysis in an HIV-infected patient: a case report and review of the literature.

    abstract::We describe a case of West Nile virus (WNV) infection in an HIV-infected patient who presented with an isolated flaccid monoparesis of the right upper extremity. To our knowledge, this is the first reported case of flaccid paralysis caused by WNV infection in an HIV-infected patient. We then review the medical literat...


    pub_type: 杂志文章,评审


    authors: Torno M,Vollmer M,Beck CK

    更新日期:2007-02-13 00:00:00

  • Peri-ictal SPECT and surgical treatment for intractable epilepsy related to schizencephaly.

    abstract::The authors evaluated four patients with schizencephaly who underwent subtraction ictal SPECT coregistered to MRI (SISCOM) prior to epilepsy surgery. Three patients had a SISCOM alteration that was concordant with the epileptic brain tissue. Two of these patients were rendered seizure-free and one individual experienc...


    pub_type: 杂志文章


    authors: Cascino GD,Buchhalter JR,Sirven JI,So EL,Drazkowski JF,Zimmerman RS,Raffel C

    更新日期:2004-12-28 00:00:00

  • Dialysis encephalopathy: a possible seizure disorder.

    abstract::Dialysis encephalopathy is a progressive, fatal condition that occurs in patients receiving hemodialysis. It is characterized by abnormalities in speech, myoclonic jerks, and striking changes on the electroencephalogram. We observed dramatic reversal of the clinical symptoms and electroencephalographic abnormalities i...


    pub_type: 杂志文章


    authors: Nadel AM,Wilson WP

    更新日期:1976-12-01 00:00:00

  • Bevacizumab for recurrent ependymoma.

    abstract:BACKGROUND:Ependymoma is a rare type of glioma, representing 5% of all CNS malignancies. Radiotherapy (RT) is commonly administered, but there is no standard chemotherapy. At recurrence, ependymoma is notoriously refractory to therapy and the prognosis is poor. In recurrent glioblastoma, encouraging responses with beva...


    pub_type: 杂志文章


    authors: Green RM,Cloughesy TF,Stupp R,DeAngelis LM,Woyshner EA,Ney DE,Lassman AB

    更新日期:2009-11-17 00:00:00

  • Clinical-pathologic study of depressive symptoms and cognitive decline in old age.

    abstract:OBJECTIVE:To clarify the relationship between depressive symptoms and the clinical and neuropathologic manifestations of dementia. METHODS:In a clinical-pathologic cohort study, 1,764 older persons without cognitive impairment at enrollment completed annual clinical evaluations for a mean of 7.8 years. The evaluations...


    pub_type: 杂志文章


    authors: Wilson RS,Capuano AW,Boyle PA,Hoganson GM,Hizel LP,Shah RC,Nag S,Schneider JA,Arnold SE,Bennett DA

    更新日期:2014-08-19 00:00:00

  • Reactivity of T cells from seronegative patients with myasthenia gravis to T cell epitopes of the human acetylcholine receptor.

    abstract::Seronegative (SN) patients with myasthenia gravis (MG) have clinical and electrophysiologic features similar to those of seropositive (SP) patients, and they respond to the same therapeutic measures. However, because SN patients lack detectable (by standard radioimmunoassays) serum antibodies to acetylcholine receptor...


    pub_type: 杂志文章


    authors: Karni A,Zisman E,Katz-Levy Y,Paas-Rozner M,Dayan M,Brautbar C,Abramsky O,Sela M,Mozes E

    更新日期:1997-06-01 00:00:00

  • Vagus nerve stimulation therapy: a research update.

    abstract::Over the past 5 years, and especially within the last year, there has been a rapid expansion of vagus nerve stimulation (VNS)-related preclinical research, as well as clinical studies in indications other than epilepsy. The research advances in understanding VNS are occurring in the midst of a blossoming of other form...


    pub_type: 杂志文章,评审


    authors: George MS,Nahas Z,Bohning DE,Kozel FA,Anderson B,Chae JH,Lomarev M,Denslow S,Li X,Mu C

    更新日期:2002-09-24 00:00:00

  • Cognitive profiles differ in autopsy-confirmed frontotemporal dementia and AD.

    abstract:BACKGROUND:Frontotemporal dementia (FTD) is currently distinguished from AD primarily on the basis of behavioral features because studies of cognition have shown negligible or inconsistent differences. However, the poor discriminability of cognitive measures may relate to reliance on imprecise clinically diagnosed grou...


    pub_type: 杂志文章


    authors: Rascovsky K,Salmon DP,Ho GJ,Galasko D,Peavy GM,Hansen LA,Thal LJ

    更新日期:2002-06-25 00:00:00

  • Body mass index and the risk of Parkinson disease.

    abstract:OBJECTIVE:To examine the association between body mass index (BMI) and the risk of Parkinson disease (PD). METHODS:Study cohorts included 22,367 Finnish men and 23,439 women 25 to 59 years of age without a history of PD at baseline. Hazards ratios (HRs) of incident PD were estimated for different levels of BMI. RESUL...


    pub_type: 杂志文章


    authors: Hu G,Jousilahti P,Nissinen A,Antikainen R,Kivipelto M,Tuomilehto J

    更新日期:2006-12-12 00:00:00

  • Saccadic duration and intrasaccadic fatigue in myasthenic and nonmyasthenic ocular palsies.

    abstract::We measured the duration and amplitude of saccades in three normal subjects, eight patients with myasthenia gravis, and eight patients with nonmyasthenic ocular palsies. Saccades were examined at the start of a repetitive saccade task, after 3 minutes of activity, and 1 minute after administration of edrophonium. The ...


    pub_type: 杂志文章


    authors: Barton JJ,Jama A,Sharpe JA

    更新日期:1995-11-01 00:00:00