Regional cerebral glucose metabolism in dementia with Lewy bodies and Alzheimer's disease.


OBJECTIVE:To delineate the features of regional cerebral metabolic rate of glucose (CMRglc) in dementia with Lewy bodies (DLB). METHODS:We compared absolute CMRglc in 12 patients with a clinical diagnosis of DLB, 12 patients with a clinical diagnosis of Alzheimer's disease (AD), and 12 normal volunteers (NC), using 18F-fluorodeoxyglucose (FDG) and PET. The three groups were matched for age and sex, and there were no differences in disease duration or severity of cognitive disturbances between the DLB and AD groups. RESULTS:CMRglc was significantly lower in patients with DLB than in that of NC in most parts of the brain, except the sensorimotor cortices, basal ganglia, thalamus, and pons. Between the DLB and AD groups, there were significant regional CMRglc differences in the medial and lateral occipital lobes. In DLB and AD, the CMRglc reduction patterns were similar, though the global metabolic reduction was larger in DLB, and the occipital CMRglc reduction in DLB could differentiate DLB from AD. The relative occipital CMRglc (normalized to the sensorimotor CMRglc) was a useful measure for the differential diagnosis of DLB from AD. The sensitivity and the specificity were 92% when using the minimal value of the normalized occipital CMRglc in the NC group as the cut-off point. CONCLUSION:These different regional CMRglc reductions substantiate the pathologic, neurochemical, and clinical differences between DLB and AD.






Ishii K,Imamura T,Sasaki M,Yamaji S,Sakamoto S,Kitagaki H,Hashimoto M,Hirono N,Shimomura T,Mori E




Has Abstract


1998-07-01 00:00:00












  • Serum and CSF vitamin A concentrations in idiopathic intracranial hypertension.

    abstract:BACKGROUND:Elevated serum retinol, CSF retinol, and serum retinol binding protein (RBP) levels have been found in some patients with idiopathic intracranial hypertension (IIH), but serum and CSF retinol levels have not been studied in matched serum and CSF samples in patients with IIH. OBJECTIVE:To determine whether s...


    pub_type: 杂志文章


    authors: Tabassi A,Salmasi AH,Jalali M

    更新日期:2005-06-14 00:00:00

  • Investigation of leptomeningeal enhancement in MS: a postcontrast FLAIR MRI study.

    abstract:OBJECTIVE:To investigate possible leptomeningeal contrast enhancement using postcontrast fluid-attenuated inversion recovery (FLAIR) MRI as an additional marker of inflammation in patients with multiple sclerosis (MS). METHODS:A cohort of 112 patients (73 women) with clinically definitive MS or a clinically isolated s...


    pub_type: 杂志文章


    authors: Eisele P,Griebe M,Szabo K,Wolf ME,Alonso A,Engelhardt B,Hennerici MG,Gass A

    更新日期:2015-02-24 00:00:00

  • Sensitivity and specificity of transcranial Doppler ultrasonography in the diagnosis of vasospasm following subarachnoid hemorrhage.

    abstract::Vasospasm is the leading cause of death and disability in patients with aneurysmal subarachnoid hemorrhage (SAH). Transcranial Doppler ultrasonography (TCD) can detect the arterial narrowing noninvasively, but the sensitivity and specificity of this technique have not been reported in a population of patients with a h...


    pub_type: 杂志文章


    authors: Sloan MA,Haley EC Jr,Kassell NF,Henry ML,Stewart SR,Beskin RR,Sevilla EA,Torner JC

    更新日期:1989-11-01 00:00:00

  • Conjugal amyotrophic lateral sclerosis: a report on two couples from southern France.

    abstract::We report two conjugal cases of amyotrophic lateral sclerosis (ALS) occurring between 1977 and 1991 in southern France (Languedoc-Roussillon). Although conjugal ALS may occur by chance, the description of two cases in the same area points to a role of environmental or genetic factors in the etiology of the disease. ...


    pub_type: 杂志文章


    authors: Camu W,Cadilhac J,Billiard M

    更新日期:1994-03-01 00:00:00

  • Psychosocial aspects of Parkinson's disease.

    abstract::Although Parkinson's disease has a definite neurologic basis, patients and relatives experience a multitude of stresses, only partly related to motor symptoms. Subjective and behavioral problems may be regarded as secondary disease symptoms. In an integrated approach, patients and relatives receive psychological couns...


    pub_type: 杂志文章


    authors: Ellgring H,Seiler S,Perleth B,Frings W,Gasser T,Oertel W

    更新日期:1993-12-01 00:00:00

  • A family with different clinical forms of acid maltase deficiency (glycogenosis type II): biochemical and genetic studies.

    abstract::In the same family, the generalized or infantile form of acid maltase deficiency (glycogenosis type II, Pompe disease) and the muscular or adult-onset form affected different individuals. Autosomal-recessive inheritance for the two clinical forms was demonstrated in this family by assay of acid alpha-glucosidase in mu...


    pub_type: 杂志文章


    authors: Loonen MC,Busch HF,Koster JF,Martin JJ,Niermeijer MF,Schram AW,Brouwer-Kelder B,Mekes W,Slee RG,Tager JM

    更新日期:1981-10-01 00:00:00

  • Cognitive impairments associated with early Parkinson's disease.

    abstract::We administered a battery of cognitive tests to 41 recently diagnosed Parkinson patients and 41 controls to assess the early neuropsychological changes associated with Parkinson's disease (PD). Parkinson subjects did as well as controls on tasks assessing attention and select language and visuospatial measures. Howeve...


    pub_type: 杂志文章


    authors: Levin BE,Llabre MM,Weiner WJ

    更新日期:1989-04-01 00:00:00

  • Altered brain activation in cognitively intact individuals at high risk for Alzheimer's disease.

    abstract:OBJECTIVE:To determine whether brain function is altered in cognitively normal individuals at high risk for AD several years before the typical age at onset for this illness. BACKGROUND:Neuropathologic alterations in AD precede cognitive impairment by several years. It is unknown whether functional alterations in neur...


    pub_type: 杂志文章


    authors: Smith CD,Andersen AH,Kryscio RJ,Schmitt FA,Kindy MS,Blonder LX,Avison MJ

    更新日期:1999-10-22 00:00:00

  • Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.

    abstract:OBJECTIVE:To determine the current best practice for treatment of infantile spasms in children. METHODS:Database searches of MEDLINE from 1966 and EMBASE from 1980 and searches of reference lists of retrieved articles were performed. Inclusion criteria were the documented presence of infantile spasms and hypsarrhythmi...


    pub_type: 杂志文章,评审


    authors: Mackay MT,Weiss SK,Adams-Webber T,Ashwal S,Stephens D,Ballaban-Gill K,Baram TZ,Duchowny M,Hirtz D,Pellock JM,Shields WD,Shinnar S,Wyllie E,Snead OC 3rd,American Academy of Neurology.,Child Neurology Society.

    更新日期:2004-05-25 00:00:00

  • Primary prevention trials in Alzheimer disease.

    abstract::Many new treatments under development for Alzheimer disease (AD) will be disease-modifying rather than symptomatic. Clinical evaluation of these treatments will require primary and secondary prevention trials. We describe some of the methodologic challenges in designing primary prevention trials for AD and illustrate ...


    pub_type: 杂志文章,评审


    authors: Green RC,DeKosky ST

    更新日期:2006-11-14 00:00:00

  • International Classification of Diseases (ICD-11) and neurologic disorders: the future.

    abstract::When the WHO's Topic Advisory Group for Neurology (TAG) started work on revision of the ICD-10 diagnostic codes in June 2009, the issues were daunting. The existing classification was produced a generation ago and the need to move to the digital age was becoming imperative. Appreciating modern advances in genetics and...


    pub_type: 杂志文章


    authors: Shakir R,Bergen D

    更新日期:2013-07-09 00:00:00

  • Tuberculous meningitis in the southwest United States: a community-based study.

    abstract::This community-based study analyzed 54 patients with definite or probable tuberculous meningitis (TBM) in New Mexico from 1970 through 1990. Patients ranged in age from 4 months to 86 years. The highest age-specific incidence occurred in the elderly, but 22% of patients were less than 10 years old. Native American pat...


    pub_type: 杂志文章


    authors: Davis LE,Rastogi KR,Lambert LC,Skipper BJ

    更新日期:1993-09-01 00:00:00

  • Frequency and risk factors of antibody-induced secondary failure of botulinum neurotoxin therapy.

    abstract:OBJECTIVE:To investigate the risk factors of neutralizing antibody (NAB)-induced complete secondary treatment failure (cSTF) during long-term botulinum neurotoxin (BoNT) treatment in various neurologic indications. METHODS:This monocenter retrospective cohort study analyzed the data of 471 patients started on BoNT the...


    pub_type: 杂志文章


    authors: Walter U,Mühlenhoff C,Benecke R,Dressler D,Mix E,Alt J,Wittstock M,Dudesek A,Storch A,Kamm C

    更新日期:2020-05-19 00:00:00

  • The state of clinical research in neurology.

    abstract:OBJECTIVE:To study and provide an update on the state of clinical research in neurology in the United States. METHODS:US American Academy of Neurology members and chairs of departments of neurology were surveyed regarding clinical research in 2016. NIH data on the neuroscience pipeline and extramural grant funding wer...


    pub_type: 杂志文章


    authors: Hall DA,Ramos AR,Gelfand JM,Videnovic A,Benatar M,Cahill C,Kluger BM,Goldman M

    更新日期:2018-04-10 00:00:00

  • Low-dose clozapine in the treatment of levodopa-induced mental disturbances in Parkinson's disease.

    abstract::Delusions and other manifestations of psychotic behavior are common side effects in Parkinson's disease (PD) patients chronically treated with dopaminergic drugs. Clozapine, a dibenzodiazepine derivative, is an antipsychotic drug largely devoid of extrapyramidal side effects. We evaluated the effects of low doses of c...


    pub_type: 临床试验,杂志文章


    authors: Rabey JM,Treves TA,Neufeld MY,Orlov E,Korczyn AD

    更新日期:1995-03-01 00:00:00

  • FDG-PET improves surgical outcome in negative MRI Taylor-type focal cortical dysplasias.

    abstract:OBJECTIVE:To determine the diagnostic accuracy and prognostic value of ¹⁸FDG-PET in a recent series of patients operated for intractable partial epilepsy associated with histologically proven Taylor-type focal cortical dysplasia (TTFCD) and negative MRI. METHODS:Of 23 consecutive patients (12 male, 7-38 years old) wit...


    pub_type: 杂志文章


    authors: Chassoux F,Rodrigo S,Semah F,Beuvon F,Landre E,Devaux B,Turak B,Mellerio C,Meder JF,Roux FX,Daumas-Duport C,Merlet P,Dulac O,Chiron C

    更新日期:2010-12-14 00:00:00

  • Prospective study of military service and mortality from ALS.

    abstract:BACKGROUND:Two recent studies suggest that the risk of ALS is increased among Gulf War veterans. It is not known whether military service outside of the Gulf War is associated with increased risk of ALS. METHODS:The authors prospectively assessed the relation between service in the military and ALS mortality among par...


    pub_type: 杂志文章


    authors: Weisskopf MG,O'Reilly EJ,McCullough ML,Calle EE,Thun MJ,Cudkowicz M,Ascherio A

    更新日期:2005-01-11 00:00:00

  • Nerve regeneration patterns after acute ischemic injury.

    abstract::We performed morphologic studies on regeneration of the cat's hind limb nerves, following simultaneous ligation of the aorta and right femoral artery. There were 2 regeneration patterns depending on the extent of ischemic necrosis. When nerve infarcts were limited only to intrafascicular regions, there was no basic ch...


    pub_type: 杂志文章


    authors: Korthals JK,Gieron MA,Wisniewski HM

    更新日期:1989-07-01 00:00:00

  • Evidence for a genetic association between monoamine oxidase A and restless legs syndrome.

    abstract:BACKGROUND:Impairment in the central dopaminergic system has been consistently suggested as an etiologic factor in restless legs syndrome (RLS). OBJECTIVE:To investigate a possible role for the MAOA and MAOB genes in RLS using a population-based association study. METHODS:In addition to a dinucleotide repeat located ...


    pub_type: 杂志文章


    authors: Desautels A,Turecki G,Montplaisir J,Brisebois K,Sequeira A,Adam B,Rouleau GA

    更新日期:2002-07-23 00:00:00

  • Lifetime cumulative incidence of dementia in a community-dwelling elderly population in Japan.

    abstract:OBJECTIVE:To estimate the lifetime cumulative incidence of dementia and its subtypes from a community-dwelling elderly population in Japan. METHODS:A total of 1,193 community-dwelling Japanese individuals without dementia, aged 60 years or older, were followed up prospectively for 17 years. The cumulative incidence of...


    pub_type: 杂志文章


    authors: Yoshida D,Ohara T,Hata J,Shibata M,Hirakawa Y,Honda T,Furuta Y,Oishi E,Sakata S,Kanba S,Kitazono T,Ninomiya T

    更新日期:2020-08-04 00:00:00

  • Deep brain stimulation of the VIM thalamic nucleus modifies several features of essential tremor.

    abstract:BACKGROUND:Pharmacologic interventions (e.g., beta blockers) and thalamic lesions have failed to alter the pathophysiology of essential tremor (ET) beyond a reduction in tremor amplitude. Deep brain stimulation (DBS) of the ventral intermediate (VIM) nucleus of the thalamus successfully reduces tremor rating scores. It...


    pub_type: 临床试验,杂志文章


    authors: Vaillancourt DE,Sturman MM,Verhagen Metman L,Bakay RA,Corcos DM

    更新日期:2003-10-14 00:00:00

  • Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease.

    abstract:BACKGROUND:To date, there is no accepted clinical diagnostic test for Parkinson disease (PD) that is based on biochemical analysis of blood or CSF. The discovery of mutations in the SNCA gene encoding α-synuclein in familial parkinsonism and the accumulation of α-synuclein in the PD brain suggested a critical role for ...


    pub_type: 杂志文章,随机对照试验


    authors: Tokuda T,Qureshi MM,Ardah MT,Varghese S,Shehab SA,Kasai T,Ishigami N,Tamaoka A,Nakagawa M,El-Agnaf OM

    更新日期:2010-11-16 00:00:00

  • APOE is a correlate of phenotypic heterogeneity in Alzheimer disease in a national cohort.

    abstract:OBJECTIVE:To compare the proportion of APOE ε4 genotype carriers in aphasic vs amnestic variants of Alzheimer disease (AD). METHOD:The proportion of APOE ε4 carriers was compared among the following 3 groups: (1) 42 patients with primary progressive aphasia (PPA) and AD pathology (PPA/AD) enrolled in the Northwestern ...


    pub_type: 杂志文章


    authors: Weintraub S,Teylan M,Rader B,Chan KCG,Bollenbeck M,Kukull WA,Coventry C,Rogalski E,Bigio E,Mesulam MM

    更新日期:2020-02-11 00:00:00

  • Markers of dopamine metabolism in Parkinson's disease. The Parkinson Study Group.

    abstract::We used two analytic methods (a multichannel coulometric electrode array with high-performance liquid chromatography, and gas chromatography-mass spectrophotometry) to measure CSF dopamine (DA) and its metabolites in mildly affected, unmedicated subjects with Parkinson's disease (PD). The mean (+/- SD) concentration o...


    pub_type: 杂志文章


    authors: LeWitt PA,Galloway MP,Matson W,Milbury P,McDermott M,Srivastava DK,Oakes D

    更新日期:1992-11-01 00:00:00

  • Cerebral microbleeds are a risk factor for warfarin-related intracerebral hemorrhage.

    abstract:BACKGROUND:Cerebral microbleeds are known to be indicative of bleeding-prone microangiopathy and may predict incident intracerebral hemorrhage (ICH). In this study, we investigated whether microbleeds are associated with the incidence of warfarin-related ICH. METHODS:Twenty-four patients with ICH while on outpatient t...


    pub_type: 杂志文章


    authors: Lee SH,Ryu WS,Roh JK

    更新日期:2009-01-13 00:00:00

  • SCN2A mutation associated with neonatal epilepsy, late-onset episodic ataxia, myoclonus, and pain.

    abstract:BACKGROUND:Inherited and de novo mutations in sodium channel genes underlie a variety of channelopathies. Mutations in SCN2A, encoding the brain sodium channel Na(V)1.2, have previously been reported to be associated with benign familial neonatal infantile seizures, febrile seizures plus, and intractable epilepsy of in...


    pub_type: 杂志文章


    authors: Liao Y,Anttonen AK,Liukkonen E,Gaily E,Maljevic S,Schubert S,Bellan-Koch A,Petrou S,Ahonen VE,Lerche H,Lehesjoki AE

    更新日期:2010-10-19 00:00:00

  • A controlled trial with vasopressin analogue (DGAVP) on cognitive recovery immediately after head trauma.

    abstract::Recent evidence suggests that the vasopressin analogue desglycinamide-arginine8-vasopressin (DGAVP) might specifically benefit mild brain trauma patients. We investigated the effect of intranasal DGAVP treatment in 32 patients who had sustained a mild head injury for 3 months in a double-blind, placebo-controlled, mat...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bohnen NI,Twijnstra A,Jolles J

    更新日期:1993-01-01 00:00:00

  • Reduced basal ganglia volumes in Tourette's syndrome using three-dimensional reconstruction techniques from magnetic resonance images.

    abstract::Using a 1.5-tesla GE Signa MR scanner, we imaged the brains of 14 right-handed Tourette's syndrome (TS) patients (11 men, three women), aged 18 to 49 years, who had minimal lifetime neuroleptic exposure. We also studied an equal number of normal controls individually matched for age, sex, and handedness and group-matc...


    pub_type: 杂志文章


    authors: Peterson B,Riddle MA,Cohen DJ,Katz LD,Smith JC,Hardin MT,Leckman JF

    更新日期:1993-05-01 00:00:00

  • Timing of milestone competency acquisition in neurology residency: What by when?

    abstract:OBJECTIVE:To determine the stage of training at which neurology residents should achieve individual elements of the Accreditation Council for Graduate Medical Education neurology Milestones and to examine the relationship between perceived importance of Milestones and the stage by which they should be achieved. METHOD...


    pub_type: 杂志文章


    authors: Jones LK Jr,Eggers SDZ,Capobianco DJ,Boes CJ

    更新日期:2018-10-16 00:00:00

  • Partial epilepsy presenting as focal paroxysmal pain.

    abstract::A 3-year old, previously well child developed paroxysms of left thigh pain. Evaluation was unremarkable except for interictal and postictal EEG epileptiform activity in the right parietal and posterior temporal regions. The painful spells were controlled with anticonvulsant medication. Episodes of paroxysmal, unexplai...


    pub_type: 杂志文章


    authors: Trevathan E,Cascino GD

    更新日期:1988-02-01 00:00:00