Regional cerebral glucose metabolism in dementia with Lewy bodies and Alzheimer's disease.

abstract：OBJECTIVE:To determine if migraine with aura is associated with neuroinflammation, which has been suggested by preclinical models of cortical spreading depression (CSD) as well as imaging of human pain conditions. METHODS:Thirteen migraineurs with aura and 16 healthy controls received integrated PET/MRI brain scans wi...

journal_title：Neurology

authors： Albrecht DS,Mainero C,Ichijo E,Ward N,Granziera C,Zürcher NR,Akeju O,Bonnier G,Price J,Hooker JM,Napadow V,Loggia ML,Hadjikhani N

更新日期：2019-04-23 00:00:00

abstract：OBJECTIVE:To test the hypotheses predicted in a hypothetical model of Alzheimer disease (AD) biomarkers that rates of β-amyloid (Aβ) accumulation on PET imaging are not related to hippocampal neurodegeneration whereas rates of neurodegenerative brain atrophy depend on the presence of both amyloid and neurodegeneration ...

journal_title：Neurology

authors： Jack CR Jr,Wiste HJ,Knopman DS,Vemuri P,Mielke MM,Weigand SD,Senjem ML,Gunter JL,Lowe V,Gregg BE,Pankratz VS,Petersen RC

更新日期：2014-05-06 00:00:00

abstract：:Of 53 patients with drug-induced seizures seen in the last decade, 45% had single seizures, 40% had multiple convulsions, and 15% had status epilepticus. Generalized seizures with focal features were common, but simple partial (motor) seizures occurred in only two patients. Isoniazid, insulin, lidocaine, and psychotro...

journal_title：Neurology

authors： Messing RO,Closson RG,Simon RP

更新日期：1984-12-01 00:00:00

abstract：OBJECTIVE:To conduct a comprehensive analysis of circulating metabolites and incident stroke in large prospective population-based settings. METHODS:We investigated the association of metabolites with risk of stroke in seven prospective cohort studies including 1,791 incident stroke events among 38,797 participants in...

journal_title：Neurology

authors： Vojinovic D,Kalaoja M,Trompet S,Fischer K,Shipley MJ,Li S,Havulinna AS,Perola M,Salomaa V,Yang Q,Sattar N,Jousilahti P,Amin N,Satizabal CL,Taba N,Sabayan B,Vasan RS,Ikram MA,Stott DJ,Ala-Korpela M,Jukema JW,Sesh

更新日期：2020-12-02 00:00:00

abstract：:Despite evidence for the efficacy of thrombolytic therapy in acute ischemic stroke, only 1 to 7% of patients receive this therapy. The authors sought to determine the reasons for exclusion from tissue plasminogen activator (tPA) in an acute setting and found avoidable causes in 18% of patients. Improvements in intraho...

journal_title：Neurology

authors： Cocho D,Belvís R,Martí-Fàbregas J,Molina-Porcel L,Díaz-Manera J,Aleu A,Pagonabarraga J,García-Bargo D,Mauri A,Martí-Vilalta JL

更新日期：2005-02-22 00:00:00

abstract：:Patients with "reflex sympathetic dystrophy" or "causalgia" underwent sympathetic blocks. In protocol A (77 patients), we infused placebo (saline) for 30 minutes followed by phentolamine (35 mg). In protocol B (23 patients), the saline phase was followed by double-blind infusion of phentolamine or phenylephrine (500 m...

journal_title：Neurology

authors： Verdugo RJ,Ochoa JL

更新日期：1994-06-01 00:00:00

abstract：OBJECTIVE:To relate signs and symptoms to morphologic changes and presence of multiple mitochondrial DNA (mtDNA) deletions in a patient with autosomal dominant progressive external ophthalmoplegia (adPEO) and mitochondrial myopathy. BACKGROUND:An etiologic association between the somatic multiple mtDNA deletions in ad...

journal_title：Neurology

authors： Moslemi AR,Melberg A,Holme E,Oldfors A

更新日期：1999-07-13 00:00:00

abstract：:Three children with cerebral oligodendrogliomas causing partial complex or generalized seizures presented with completely normal neurologic examinations. CT showed low-density, nonenhancing surface lesions. Although these CT features are usually associated with infarcts or cysts, neoplasm was suspected because of irre...

journal_title：Neurology

authors： Varma RR,Crumrine PK,Bergman I,Latchaw RE,Price RA,Vries J,Painter MJ

更新日期：1983-06-01 00:00:00

abstract：OBJECTIVE:To determine the role of circulating microvesicles (MV) on long-term cardiovascular outcomes after stroke, we measured them in patients with first-ever stroke with a 3-year follow-up. METHODS:In the Prospective Cohort With Incident Stroke Berlin (PROSCIS-B), patients with first-ever ischemic stroke were foll...

journal_title：Neurology

authors： Huo S,Kränkel N,Nave AH,Sperber PS,Rohmann JL,Piper SK,Heuschmann P,Landmesser U,Endres M,Siegerink B,Liman TGG

更新日期：2020-11-12 00:00:00

abstract：:In children, seizures associated with status epilepticus (SE) include a number of types that are age-related. These types of seizures are not associated with SE in older patients. Likewise, etiologies of SE in children are also unique to this patient population, in particular those responsible for SE in the neonate. C...

journal_title：Neurology

authors： Lockman LA

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND:Neurofibrillary tangles (NFTs), composed of hyperphosphorylated tau proteins, are one of the pathologic hallmarks of Alzheimer disease (AD). We aimed to determine whether patterns of gray matter atrophy from antemortem MRI correlate with Braak staging of NFT pathology. METHODS:Eighty-three subjects with Bra...

journal_title：Neurology

authors： Whitwell JL,Josephs KA,Murray ME,Kantarci K,Przybelski SA,Weigand SD,Vemuri P,Senjem ML,Parisi JE,Knopman DS,Boeve BF,Petersen RC,Dickson DW,Jack CR Jr

更新日期：2008-09-02 00:00:00

abstract：:We studied a patient with autopsy-proven Hallervorden-Spatz syndrome (HSS) and the previously unreported finding of high-density lesions in the basal ganglia on CT. The diagnosis of HSS should be considered in a patient with dystonia and basal ganglia mineralization on CT. ...

journal_title：Neurology

authors： Tennison MB,Bouldin TW,Whaley RA

更新日期：1988-01-01 00:00:00

abstract：:Four toluene abusers had evidence of severe multifocal central nervous system damage. Impairment of cognitive, cerebellar, brainstem, auditory, and pyramidal tract function, as well as CT evidence of cerebral cortical, cerebellar, and brainstem atrophy, have been noted. In addition, we found opsoclonus, ocular flutter...

journal_title：Neurology

authors： Lazar RB,Ho SU,Melen O,Daghestani AN

更新日期：1983-10-01 00:00:00

abstract：:Since the first development of diagnostic criteria for multiple sclerosis (MS), there have been regular revisions of disease definitions and diagnostic thresholds aimed at improving specificity while maintaining sensitivity. The central requirements for diagnosis of MS are dissemination in space (DIS) and disseminatio...

journal_title：Neurology

authors： Selchen D,Bhan V,Blevins G,Devonshire V,Duquette P,Grand'Maison F,Kremenchutzky M,Lapierre Y,Li D,von Riedemann SJ,Freedman M

更新日期：2012-12-04 00:00:00

abstract：:The results of a multicenter, double-blind, placebo-controlled clinical trial of the efficacy and safety of progabide (PGB) in the treatment of partial seizures are presented. This study was performed with a number of rigorous controls not usually present in clinical trials. These included uniform co-medication in whi...

journal_title：Neurology

authors： Leppik IE,Dreifuss FE,Porter R,Bowman T,Santilli N,Jacobs M,Crosby C,Cloyd J,Stackman J,Graves N

更新日期：1987-06-01 00:00:00

abstract：:Since cytomegalovirus (CMV) has been implicated in the pathogenesis of Rasmussen's syndrome, we treated four patients with ganciclovir, a potent anti-CMV drug. A 7-year-old girl with seizures escalating to 60/day over 3 months despite triple antiepileptic drug therapy became seizure-free 5 days after initiation of tre...

journal_title：Neurology

authors： McLachlan RS,Levin S,Blume WT

更新日期：1996-10-01 00:00:00

abstract：:Despite recent advances in the molecular genetics of Alzheimer's disease (AD), several fundamental questions concerning risk of illness are unresolved, namely, if Mendelian factors account for the incidence of the disease, and if AD is an inevitable consequence of the aging process. This study was designed to address ...

journal_title：Neurology

authors： Lautenschlager NT,Cupples LA,Rao VS,Auerbach SA,Becker R,Burke J,Chui H,Duara R,Foley EJ,Glatt SL,Green RC,Jones R,Karlinsky H,Kukull WA,Kurz A,Larson EB,Martelli K,Sadovnick AD,Volicer L,Waring SC,Growdon JH,Fa

更新日期：1996-03-01 00:00:00

abstract：:We report a patient with unusual MRI abnormalities that had the physical characteristics of ferromagnetic artifact. We believe that the MRI artifacts were due to microscopic embolic metal fragments, most likely from a mechanical heart valve prosthesis. Potential sources of metal emboli should be considered in patients...

journal_title：Neurology

authors： Wingerchuk DM,Krecke KN,Fulgham JR

更新日期：1997-11-01 00:00:00

abstract：:A 28-year-old nonimmunocompromised man developed secondary syphilis confirmed by serum and CSF findings. His course was complicated by chorioretinitis, extensive skin lesions, and spastic paraparesis secondary to syphilitic meningomyelitis. MRI of the spinal cord was strikingly abnormal. ...

journal_title：Neurology

authors： Strom T,Schneck SA

更新日期：1991-02-01 00:00:00

abstract：:We evaluated the neuroprotective effect of MK-801, a noncompetitive, selective N-methyl-D-aspartate receptor antagonist, in a neonatal hypoxic-ischemic animal model. Seven-day-old rats underwent bilateral ligation of the carotid arteries followed by exposure to an 8% oxygen atmosphere for 1 hr. We sacrificed the anima...

journal_title：Neurology

authors： Hattori H,Morin AM,Schwartz PH,Fujikawa DG,Wasterlain CG

更新日期：1989-05-01 00:00:00

abstract：:A moderately retarded Japanese boy, with a normal male karyotype (46,XY), was diagnosed to have a subcortical band heterotopia or double cortex syndrome. The band heterotopia was relatively thick compared with that of other patients reported. On T2-weighted coronal MR sections, there were numerous radial linear struct...

journal_title：Neurology

authors： Ono J,Mano T,Andermann E,Harada K,Sakurai K,Ikeda T,Yoshihara N,Shimizu K,Okada S,Andermann F

更新日期：1997-06-01 00:00:00

abstract：:Moderate hypothermia (33 degrees C) was induced for 7 and 3 days, respectively, in two patients with multiple sclerosis. In both patients, striking improvement of clinical signs persisted throughout the period of cooling, indicating the potential for sustained reversal of the neurologic deficit. Hypothermia may aid ma...

journal_title：Neurology

authors： Symington GR,Mackay IR,Currie TT

更新日期：1977-03-01 00:00:00

abstract：OBJECTIVE:To compare the effectiveness of upper extremity virtual reality rehabilitation training (VR) to time-matched conventional training (CT) in the subacute phase after stroke. METHODS:In this randomized, controlled, single-blind phase III multicenter trial, 120 participants with upper extremity motor impairment ...

journal_title：Neurology

authors： Brunner I,Skouen JS,Hofstad H,Aßmus J,Becker F,Sanders AM,Pallesen H,Qvist Kristensen L,Michielsen M,Thijs L,Verheyden G

更新日期：2017-12-12 00:00:00

abstract：OBJECTIVE:To compare characteristics between Black and White patients with amyotrophic lateral sclerosis (ALS) in order to identify disparities and phenotypic variability. METHODS:We performed database review for patients seen between 1997 and 2020 at the Emory ALS Center in Atlanta, Georgia. Patients with ALS were in...

journal_title：Neurology

authors： Brand D,Polak M,Glass JD,Fournier CN

更新日期：2020-12-28 00:00:00

abstract：OBJECTIVE:To examine the relationship of migraine and other severe headaches with panic disorder. METHODS:Representative samples of persons with migraine, non-migrainous severe headaches, and controls with no history of severe headaches, identified by a telephone survey, were interviewed in person, using a standardize...

journal_title：Neurology

authors： Breslau N,Schultz LR,Stewart WF,Lipton R,Welch KM

更新日期：2001-02-13 00:00:00

abstract：:Oligoclonal bands ( OCBs ) were examined in CSF from 23 normal controls, 8 cases of inflammatory neurologic diseases, 24 cases of noninflammatory neurologic diseases, 27 sporadic cases of MS, and the 29 MS twin pairs, by isoelectric focusing followed by silver staining or western transblotting and immunoperoxidase sta...

journal_title：Neurology

authors： Xu XH,McFarlin DE

更新日期：1984-06-01 00:00:00

abstract：:The association of the human leukocyte antigen (HLA)-DR2 allele with brain MRI signal abnormalities and with the development of MS was assessed in 178 patients enrolled in the Optic Neuritis Treatment Trial. HLA haplotype DR2 was present in 85 (48%) of the 178 patients. Its presence was associated with increased odds ...

journal_title：Neurology

authors： Hauser SL,Oksenberg JR,Lincoln R,Garovoy J,Beck RW,Cole SR,Moke PS,Kip KE,Gal RL,Long DT

更新日期：2000-05-09 00:00:00

abstract：:We report a woman with a chronic inflammatory myopathy who developed muscle stiffness and dystonic postures of both upper extremities. Electromyography demonstrated that involuntary complex repetitive discharges of muscle caused the posture. Rare cases of dystonic posturing may be of peripheral, and not central system...

journal_title：Neurology

authors： Preston DC,Finkleman RS,Munsat TL

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:To report outcomes of pregnancies that occurred during the fingolimod clinical development program. METHODS:Pregnancy outcomes from phase II, phase III, and phase IV clinical studies (with optional extensions) were reported by clinical trial investigators. Fingolimod exposure in utero was defined as fingolim...

journal_title：Neurology

authors： Karlsson G,Francis G,Koren G,Heining P,Zhang X,Cohen JA,Kappos L,Collins W

更新日期：2014-02-25 00:00:00

abstract：:The authors performed linkage analysis in 39 families with autosomal recessive early-onset PD (AR-EOPD) negative for parkin and DJ-1 mutations. Eight families including three Japanese, two Taiwanese, one Turkish, one Israeli, and one Philippine showed evidence of linkage with PARK6 with multipoint log of the odds (lod...

journal_title：Neurology

authors： Hatano Y,Sato K,Elibol B,Yoshino H,Yamamura Y,Bonifati V,Shinotoh H,Asahina M,Kobayashi S,Ng AR,Rosales RL,Hassin-Baer S,Shinar Y,Lu CS,Chang HC,Wu-Chou YH,Ataç FB,Kobayashi T,Toda T,Mizuno Y,Hattori N

更新日期：2004-10-26 00:00:00