Comparison of Phenotypic Characteristics and Prognosis Between Black and White Patients in a Tertiary ALS Clinic.


OBJECTIVE:To compare characteristics between Black and White patients with amyotrophic lateral sclerosis (ALS) in order to identify disparities and phenotypic variability. METHODS:We performed database review for patients seen between 1997 and 2020 at the Emory ALS Center in Atlanta, Georgia. Patients with ALS were included for analyses if race was self-reported as Black or White and symptom onset was prior to January 1, 2017. Variables examined include race, age at onset, diagnostic delay, site of onset, median income, C9orf72 mutation status, feeding tube and tracheostomy status, vital capacity, Amyotrophic Lateral Sclerosis Functional Rating Scale-revised(ALSFRS-R) score, and survival time. RESULTS:A total of 2,363 patient records were queried, and 1,298 were included in analysis; 203 self-identified as Black and 1,095 as White. Black patients had younger age at symptom onset, lower frequency of C9orf72 mutations, lower median income, longer diagnostic delay, and lower baseline ALSFRS-R and vital capacity compared to White patients. Black patients had a longer median survival than White patients; however, race was not an independent predictor of survival time when controlling for age at symptom onset, bulbar onset, and C9orf72 positivity. CONCLUSIONS:Black patients with ALS had longer median survival compared to White patients, but race was not independently associated with survival after controlling for age, site of onset, and C9orf72 status, factors known to predict prognosis. Black patients with ALS had longer diagnostic delay and lower baseline ventilatory and functional status at first clinic visit compared to White patients, which could be suggestive of barriers to tertiary care. Further studies are needed to identify the underlying causes of ALS racial differences.






Brand D,Polak M,Glass JD,Fournier CN




Has Abstract


2020-12-28 00:00:00








  • Reliability of the diagnosis of a first seizure.

    abstract::We studied the interrater variability among three neurologists of the diagnosis of a seizure in 100 patients evaluated for a possible "first seizure." We found that use of simple descriptive diagnostic criteria and discussion among the neurologists themselves improved the diagnostic agreement. ...


    pub_type: 杂志文章


    authors: van Donselaar CA,Geerts AT,Meulstee J,Habbema JD,Staal A

    更新日期:1989-02-01 00:00:00

  • Effectiveness of opicapone and switching from entacapone in fluctuating Parkinson disease.

    abstract:OBJECTIVE:To evaluate the effectiveness of opicapone as add-on to levodopa and the effects of switching from entacapone over 1 year of treatment in patients with fluctuating Parkinson disease. METHODS:After completion of a placebo- and entacapone-controlled double-blind study of opicapone (5, 25, or 50 mg), 495 patien...


    pub_type: 杂志文章


    authors: Ferreira JJ,Lees AJ,Poewe W,Rascol O,Rocha JF,Keller B,Soares-da-Silva P

    更新日期:2018-05-22 00:00:00

  • Accelerated lymphocyte recovery after alemtuzumab does not predict multiple sclerosis activity.

    abstract:OBJECTIVE:To test the hypothesis that accelerated peripheral blood mononuclear cell recovery after alemtuzumab treatment of multiple sclerosis is associated with recurrent disease activity and to investigate the claim that CD4 counts greater than 388.5 × 10(6) cells/mL at 12 months can be used to identify patients who ...


    pub_type: 杂志文章


    authors: Kousin-Ezewu O,Azzopardi L,Parker RA,Tuohy O,Compston A,Coles A,Jones J

    更新日期:2014-06-17 00:00:00

  • Treatment of restless legs syndrome with gabapentin: a double-blind, cross-over study.

    abstract:OBJECTIVE:To assess the effects of gabapentin on sensory and motor symptoms in patients with restless legs syndrome (RLS). METHODS:Patients with RLS (22 idiopathic, 2 secondary to iron deficiency) were randomized and treated for 6 weeks with either gabapentin or placebo. After a 1-week washout they crossed over to the...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Garcia-Borreguero D,Larrosa O,de la Llave Y,Verger K,Masramon X,Hernandez G

    更新日期:2002-11-26 00:00:00

  • B and T lymphocytes in man. III. B, t, and "null" lymphocytes in multiple sclerosis.

    abstract::T, B, and "null" lymphocytes were determined in peripheral blood obtained from 24 control subjects and 15 multiple sclerosis patients. The total number of lymphocytes and T lymphocytes were reduced significantly in multiple sclerosis patients as compared with those of controls. Although the percentage of B lymphocytes...


    pub_type: 杂志文章


    authors: Reddy MM,Goh KO

    更新日期:1976-10-01 00:00:00

  • The clinical-DWI mismatch: a new diagnostic approach to the brain tissue at risk of infarction.

    abstract:OBJECTIVE:To evaluate the usefulness of a mismatch between the severity of acute clinical manifestations and the diffusion-weighted imaging (DWI) lesion in predicting early stroke outcome and infarct volume. METHODS:One hundred sixty-six patients with a hemispheric ischemic stroke of <12 hours' duration were studied. ...


    pub_type: 杂志文章


    authors: Dávalos A,Blanco M,Pedraza S,Leira R,Castellanos M,Pumar JM,Silva Y,Serena J,Castillo J

    更新日期:2004-06-22 00:00:00

  • Effects of cannabis on cognitive function in patients with multiple sclerosis.

    abstract:BACKGROUND:While neuropsychological deficits have been reported in healthy individuals who use street cannabis, data in patients with multiple sclerosis (MS) are lacking. Given that MS is associated with cognitive deterioration, the aim of this study was to determine the neuropsychological effects of cannabis use in th...


    pub_type: 杂志文章


    authors: Honarmand K,Tierney MC,O'Connor P,Feinstein A

    更新日期:2011-03-29 00:00:00

  • Plasma tau correlates with basal forebrain atrophy rates in people at risk for Alzheimer disease.

    abstract:OBJECTIVE:To investigate whether baseline concentrations of plasma total tau (t-tau) and neurofilament light (NfL) chain proteins are associated with annual percent change (APC) of the basal forebrain cholinergic system (BFCS) in cognitively intact older adults at risk for Alzheimer disease (AD). METHODS:This was a la...


    pub_type: 杂志文章


    authors: Cavedo E,Lista S,Houot M,Vergallo A,Grothe MJ,Teipel S,Zetterberg H,Blennow K,Habert MO,Potier MC,Dubois B,Hampel H,INSIGHT-preAD Study Group.,Alzheimer Precision Medicine Initiative

    更新日期:2020-01-07 00:00:00

  • Competency to consent to medical treatment in cognitively impaired patients with Parkinson's disease.

    abstract:OBJECTIVES:To investigate capacity to consent to medical treatment (competency) in cognitively impaired patients with PD. BACKGROUND:Although competency has been studied empirically in patients with cortical dementia (AD), no empirical studies have examined competency in patients with PD or other subcortical neurodege...


    pub_type: 杂志文章


    authors: Dymek MP,Atchison P,Harrell L,Marson DC

    更新日期:2001-01-09 00:00:00

  • Microdysgenesis in resected temporal neocortex: incidence and clinical significance in focal epilepsy.

    abstract::Fifty patients underwent superficial temporal lobectomy for intractable temporal lobe epilepsy. Total cure rate was 52%, and significant improvement was achieved in 88%. Cytoarchitectural changes in gray and white tissue were analyzed under light microscopy. Neuronal dysgenesis was correlated with the duration of seiz...


    pub_type: 杂志文章


    authors: Hardiman O,Burke T,Phillips J,Murphy S,O'Moore B,Staunton H,Farrell MA

    更新日期:1988-07-01 00:00:00

  • Long-term treatment with vagus nerve stimulation in patients with refractory epilepsy. The Vagus Nerve Stimulation Study Group E01-E05.

    abstract:OBJECTIVE:To perform an open-label, long-term efficacy and safety/tolerability study of vagus nerve stimulation (VNS) of 454 patients with refractory epilepsy. METHODS:Subjects were enrolled from five clinical trials of VNS between 1988 and 1995 after undergoing an implantation of a pulse generator in the chest and a ...


    pub_type: 杂志文章


    authors: Morris GL 3rd,Mueller WM

    更新日期:1999-11-10 00:00:00

  • Midline hyperplasia with malformation of the fornical system.

    abstract::A physically and intellectually normally developed boy had a resection of a lumbar myelomeningocele shortly after birth and a shunt was inserted for hydrocephalus. He died at age 12 years after a traffic accident. Autopsy disclosed a hyperplasia of the cerebellar vermis. An abnormal median-sagittal triangular fiber tr...


    pub_type: 杂志文章


    authors: Friede RL,Briner J

    更新日期:1978-12-01 00:00:00

  • Gram-negative bacterial molecules associate with Alzheimer disease pathology.

    abstract:OBJECTIVE:We determined whether Gram-negative bacterial molecules are associated with Alzheimer disease (AD) neuropathology given that previous studies demonstrate Gram-negative Escherichia coli bacteria can form extracellular amyloid and Gram-negative bacteria have been reported as the predominant bacteria found in no...


    pub_type: 杂志文章


    authors: Zhan X,Stamova B,Jin LW,DeCarli C,Phinney B,Sharp FR

    更新日期:2016-11-29 00:00:00

  • Delayed psychosis after right temporoparietal stroke or trauma: relation to epilepsy.

    abstract::We observed acute onset of delayed psychosis in 8 patients 1 month to 11 years after right temporoparietooccipital (TPO) stroke or trauma. The psychotic disorder included hallucinations and, in some patients delusions and agitation. All patients had spatioconstructional difficulties. None had an earlier psychiatric di...


    pub_type: 杂志文章


    authors: Levine DN,Finklestein S

    更新日期:1982-03-01 00:00:00

  • Severity of REM atonia loss in idiopathic REM sleep behavior disorder predicts Parkinson disease.

    abstract:BACKGROUND:Over 50% of persons with idiopathic REM sleep behavior disorder (RBD) will develop Parkinson disease (PD) or dementia. At present, there is no way to predict who will develop disease. Since polysomnography is performed in all patients with idiopathic RBD at diagnosis, there is an opportunity to analyze if ba...


    pub_type: 杂志文章


    authors: Postuma RB,Gagnon JF,Rompré S,Montplaisir JY

    更新日期:2010-01-19 00:00:00

  • Semantic memory activation in individuals at risk for developing Alzheimer disease.

    abstract:OBJECTIVE:To determine whether whole-brain, event-related fMRI can distinguish healthy older adults with known Alzheimer disease (AD) risk factors (family history, APOE epsilon4) from controls using a semantic memory task involving discrimination of famous from unfamiliar names. METHODS:Sixty-nine cognitively asymptom...


    pub_type: 杂志文章


    authors: Seidenberg M,Guidotti L,Nielson KA,Woodard JL,Durgerian S,Antuono P,Zhang Q,Rao SM

    更新日期:2009-08-25 00:00:00

  • A new explanation for recessive myotonia congenita: exon deletions and duplications in CLCN1.

    abstract:OBJECTIVE:To assess whether exon deletions or duplications in CLCN1 are associated with recessive myotonia congenita (MC). METHODS:We performed detailed clinical and electrophysiologic characterization in 60 patients with phenotypes consistent with MC. DNA sequencing of CLCN1 followed by multiplex ligation-dependent p...


    pub_type: 杂志文章


    authors: Raja Rayan DL,Haworth A,Sud R,Matthews E,Fialho D,Burge J,Portaro S,Schorge S,Tuin K,Lunt P,McEntagart M,Toscano A,Davis MB,Hanna MG

    更新日期:2012-06-12 00:00:00

  • Cerebral microembolism in symptomatic and asymptomatic high-grade internal carotid artery stenosis.

    abstract::Using transcranial Doppler (TCD) ultrasonography in patients with high-grade (> or = 70%) internal carotid artery (ICA) stenosis, we examined the relation between the rate of TCD-detected silent microembolism of the ipsilateral middle cerebral artery and a history of recent (< 121 days) ischemic symptoms attributable ...


    pub_type: 杂志文章


    authors: Siebler M,Kleinschmidt A,Sitzer M,Steinmetz H,Freund HJ

    更新日期:1994-04-01 00:00:00

  • A dose-comparison trial of topiramate as monotherapy in recently diagnosed partial epilepsy.

    abstract:OBJECTIVE:To evaluate topiramate as monotherapy in adults and children with recently diagnosed, localization-related epilepsy, comparing two dosages of topiramate in a multicenter, randomized, double-blind study. METHODS:Adults and children (>/=3 years of age) were eligible if the maximum interval since epilepsy diagn...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Gilliam FG,Veloso F,Bomhof MA,Gazda SK,Biton V,Ter Bruggen JP,Neto W,Bailey C,Pledger G,Wu SC

    更新日期:2003-01-28 00:00:00

  • Predicting developmental outcomes in preterm infants: A simple white matter injury imaging rule.

    abstract:OBJECTIVE:To develop a simple imaging rule to predict neurodevelopmental outcomes at 4.5 years in a cohort of preterm neonates with white matter injury (WMI) based on lesion location and examine whether clinical variables enhance prediction. METHODS:Sixty-eight preterm neonates born 24-32 weeks' gestation (median 27.7...


    pub_type: 杂志文章


    authors: Cayam-Rand D,Guo T,Grunau RE,Benavente-Fernández I,Synnes A,Chau V,Branson H,Latal B,McQuillen P,Miller SP

    更新日期:2019-09-24 00:00:00

  • Reactivity of T cells from seronegative patients with myasthenia gravis to T cell epitopes of the human acetylcholine receptor.

    abstract::Seronegative (SN) patients with myasthenia gravis (MG) have clinical and electrophysiologic features similar to those of seropositive (SP) patients, and they respond to the same therapeutic measures. However, because SN patients lack detectable (by standard radioimmunoassays) serum antibodies to acetylcholine receptor...


    pub_type: 杂志文章


    authors: Karni A,Zisman E,Katz-Levy Y,Paas-Rozner M,Dayan M,Brautbar C,Abramsky O,Sela M,Mozes E

    更新日期:1997-06-01 00:00:00

  • Global and regional volume changes in the brains of patients with phenylketonuria.

    abstract:BACKGROUND:Although phenylketonuria is a treatable disease, patients with late or nonoptimal phenylalanine-restricted diet may experience brain damage. The authors used tridimensional MRI and a voxelwise analysis method to investigate possible volume changes in the brain parenchyma of patients with phenylketonuria. ME...


    pub_type: 杂志文章


    authors: Pérez-Dueñas B,Pujol J,Soriano-Mas C,Ortiz H,Artuch R,Vilaseca MA,Campistol J

    更新日期:2006-04-11 00:00:00

  • Plasmapheresis in multiple sclerosis: preliminary findings.

    abstract::In seven of eight patients with progressive multiple sclerosis subjected to long-term plasmapheresis in combination with azathioprine and pulsed prednisone therapy, we found modest improvement of neurologic function. There was no change in auditory and visual evoked responses or serum demyelinating activity. In six of...


    pub_type: 杂志文章


    authors: Dau PC,Petajan JH,Johnson KP,Panitch HS,Bornstein MB

    更新日期:1980-10-01 00:00:00

  • Peripheral neuropathy in Krabbe disease: effect of hematopoietic stem cell transplantation.

    abstract:BACKGROUND:Hematopoietic stem cell transplantation (HSCT) may slow the progression of Krabbe disease (KD) if performed early in the disease. The authors' studies indicate that more than 90% of patients with KD have severe abnormalities in peripheral nerve conduction. OBJECTIVE:To assess the effect of HSCT on nerve con...


    pub_type: 杂志文章


    authors: Siddiqi ZA,Sanders DB,Massey JM

    更新日期:2006-07-25 00:00:00

  • HLA-DRB1*15 influences the development of brain tissue damage in early PPMS.

    abstract:OBJECTIVES:To investigate whether (1) there were differences between HLA-DRB1*15-positive and -negative patients at baseline, and (2) HLA-DRB1*15-positive patients showed a greater development of brain and spinal cord damage, as assessed by MRI, and greater progression of disability, during a 5-year follow-up, compared...


    pub_type: 杂志文章


    authors: Tur C,Ramagopalan S,Altmann DR,Bodini B,Cercignani M,Khaleeli Z,Miller DH,Thompson AJ,Ciccarelli O

    更新日期:2014-11-04 00:00:00

  • A clinico-neurophysiological study of urogenital dysfunction in MOG-antibody transverse myelitis.

    abstract:OBJECTIVE:To assess the clinical, urodynamic, and neurophysiologic features of patients with persisting bladder, bowel, and sexual dysfunction after transverse myelitis in myelin oligodendrocyte glycoprotein antibody (MOG-Ab) disease. METHODS:Patients with a history of MOG-Ab disease-related transverse myelitis seen p...


    pub_type: 杂志文章


    authors: Li V,Malladi P,Simeoni S,Pakzad M,Everett R,Satukijchai C,Leite MI,Palace J,Panicker JN

    更新日期:2020-11-24 00:00:00

  • Practice Parameter: evaluation and treatment of depression, psychosis, and dementia in Parkinson disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology.

    abstract:OBJECTIVE:To make evidence-based treatment recommendations for patients with Parkinson disease (PD) with dementia, depression, and psychosis based on these questions: 1) What tools are effective to screen for depression, psychosis, and dementia in PD? 2) What are effective treatments for depression and psychosis in PD?...


    pub_type: 杂志文章,实务指引


    authors: Miyasaki JM,Shannon K,Voon V,Ravina B,Kleiner-Fisman G,Anderson K,Shulman LM,Gronseth G,Weiner WJ,Quality Standards Subcommittee of the American Academy of Neurology.

    更新日期:2006-04-11 00:00:00

  • Management and outcome of CSF-JC virus PCR-negative PML in a natalizumab-treated patient with MS.

    abstract:OBJECTIVE:To describe the diagnosis and management of a 49-year-old woman with multiple sclerosis (MS) developing a progressive hemiparesis and expanding MRI lesion suspicious of progressive multifocal leukoencephalopathy (PML) 19 months after starting natalizumab. RESULTS:Polyomavirus JC (JCV)-specific qPCR in CSF wa...


    pub_type: 杂志文章


    authors: Kuhle J,Gosert R,Bühler R,Derfuss T,Sutter R,Yaldizli O,Radue EW,Ryschkewitsch C,Major EO,Kappos L,Frank S,Hirsch HH

    更新日期:2011-12-06 00:00:00

  • Relationship between risk factor control and vascular events in the SAMMPRIS trial.

    abstract:OBJECTIVE:The Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) study is the first stroke prevention trial to include protocol-driven intensive management of multiple risk factors. In this prespecified analysis, we aimed to investigate the relationship betwee...


    pub_type: 杂志文章,随机对照试验


    authors: Turan TN,Nizam A,Lynn MJ,Egan BM,Le NA,Lopes-Virella MF,Hermayer KL,Harrell J,Derdeyn CP,Fiorella D,Janis LS,Lane B,Montgomery J,Chimowitz MI

    更新日期:2017-01-24 00:00:00

  • Identification of a negative bitemporal component (N300) of the event-related potentials demonstrated by noncephalic recordings.

    abstract::We studied the scalp distribution of auditory event-related potentials (P300), using simultaneously a cephalic (linked ears) and a noncephalic (balanced sternovertebra) reference. The recordings with noncephalic reference showed that infrequent, attended auditory stimuli evoke a negative bitemporal component (N300) as...


    pub_type: 杂志文章


    authors: Neshige R,Lüders H

    更新日期:1988-11-01 00:00:00