Abstract:
OBJECTIVE:To determine if migraine with aura is associated with neuroinflammation, which has been suggested by preclinical models of cortical spreading depression (CSD) as well as imaging of human pain conditions. METHODS:Thirteen migraineurs with aura and 16 healthy controls received integrated PET/MRI brain scans with [11C]PBR28, a radioligand that binds to the 18 kDa translocator protein, a marker of glial activation. Standardized uptake value ratio (SUVR) was compared between groups, and regressed against clinical variables, using region of interest and whole-brain voxelwise analyses. RESULTS:Compared to healthy controls, migraineurs demonstrated SUVR elevations in nociceptive processing areas (e.g., thalamus and primary/secondary somatosensory and insular cortices) as well as in areas previously shown to be involved in CSD generation (visual cortex). SUVR levels in frontoinsular cortex, primary/secondary somatosensory cortices, and basal ganglia were correlated with frequency of migraine attacks. CONCLUSIONS:These findings demonstrate that migraine with aura is associated with neuroimmune activation/neuroinflammation, and support a possible link between CSD and glial activation, previously observed in animals.
journal_name
Neurologyjournal_title
Neurologyauthors
Albrecht DS,Mainero C,Ichijo E,Ward N,Granziera C,Zürcher NR,Akeju O,Bonnier G,Price J,Hooker JM,Napadow V,Loggia ML,Hadjikhani Ndoi
10.1212/WNL.0000000000007371subject
Has Abstractpub_date
2019-04-23 00:00:00pages
e2038-e2050issue
17eissn
0028-3878issn
1526-632Xpii
WNL.0000000000007371journal_volume
92pub_type
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