Rates of β-amyloid accumulation are independent of hippocampal neurodegeneration.

abstract：:Dyskinesias are usually seen in Parkinson's disease (PD) patients after several years of L-dopa therapy. Their presence has been attributed to supersensitivity of striatal D1 and D2 receptors. We have used PET to assess striatal D2 receptor binding in untreated PD patients and striatal D1 and D2 binding in L-dopa-trea...

journal_title：Neurology

authors： Turjanski N,Lees AJ,Brooks DJ

更新日期：1997-09-01 00:00:00

abstract：:Dysfunction of NADH: ubiquinone oxidoreductase (complex I) of the mitochondrial electron transport chain has been linked to the pathogenesis of Parkinson's disease. While simple assays of complex I activity are unlikely to be useful in the preclinical detection of Parkinson's disease, other more sophisticated physical...

journal_title：Neurology

authors： Parker WD Jr

更新日期：1991-05-01 00:00:00

abstract：OBJECTIVE:To determine the incidence and clinical effects of antibodies that develop during treatment with natalizumab. METHODS:In two randomized, double-blind, placebo-controlled studies (natalizumab safety and efficacy in relapsing remitting multiple sclerosis [MS, AFFIRM] and safety and efficacy of natalizumab in c...

journal_title：Neurology

authors： Calabresi PA,Giovannoni G,Confavreux C,Galetta SL,Havrdova E,Hutchinson M,Kappos L,Miller DH,O'Connor PW,Phillips JT,Polman CH,Radue EW,Rudick RA,Stuart WH,Lublin FD,Wajgt A,Weinstock-Guttman B,Wynn DR,Lynn F,Panzar

更新日期：2007-10-02 00:00:00

abstract：:We review adjunctive ketogenic diet (KD) and modified Atkins diet (MAD) treatment of refractory epilepsy in adults. Only a few studies have been published, all open-label. Because of the disparate, uncontrolled nature of the studies, we analyzed all studies individually, without a meta-analysis. Across all studies, 32...

journal_title：Neurology

authors： Klein P,Tyrlikova I,Mathews GC

更新日期：2014-11-18 00:00:00

abstract：BACKGROUND:The paradoxical phenomenon of relative longevity among obese patients with established diseases has been reported for various disease conditions. The authors sought to investigate whether the obesity paradox also applies to intracerebral hemorrhage (ICH) survivors. METHODS:A total of 1,604 patients with ICH...

journal_title：Neurology

authors： Kim BJ,Lee SH,Ryu WS,Kim CK,Lee J,Yoon BW

更新日期：2011-02-08 00:00:00

abstract：BACKGROUND:Mild parkinsonian signs (MPS) are associated with prevalent and incident dementia but it is not known whether they are associated with mild cognitive impairment (MCI). OBJECTIVE:To determine whether MPS and specific MPS (changes in axial function, rigidity, tremor) are associated with MCI in nondemented com...

journal_title：Neurology

authors： Louis ED,Schupf N,Manly J,Marder K,Tang MX,Mayeux R

更新日期：2005-04-12 00:00:00

abstract：:Reflex sympathetic dystrophy (RSD) is a relatively common disabling disorder of unknown pathophysiology. From a cohort of 52 patients, carefully selected to fulfill the recently formulated diagnostic criteria for RSD, venous blood samples were taken for typing of class I and II major histocompatibility antigens. The f...

journal_title：Neurology

authors： Kemler MA,van de Vusse AC,van den Berg-Loonen EM,Barendse GA,van Kleef M,Weber WE

更新日期：1999-10-12 00:00:00

abstract：:We investigated the activation of frontal and occipital cortical areas in 14 normal volunteers during voluntary saccades in light or dark and during imagined saccades using functional magnetic resonance imaging (FMRI) with electro-oculogram monitoring. Voluntary saccades in light or dark and imagined saccades led to a...

journal_title：Neurology

authors： Bodis-Wollner I,Bucher SF,Seelos KC,Paulus W,Reiser M,Oertel WH

更新日期：1997-08-01 00:00:00

abstract：OBJECTIVE:Guillain-Barré syndrome (GBS) is characterized by nerve infiltration of leukocytes and autoantibodies of the immunoglobulin G (IgG) isotype directed against nerve constituents. Leukocyte receptors for IgG (FcgammaR) constitute an important link between the humoral and cellular parts of the immune system and c...

journal_title：Neurology

authors： van der Pol WL,van den Berg LH,Scheepers RH,van der Bom JG,van Doorn PA,van Koningsveld R,van den Broek MC,Wokke JH,van de Winkel JG

更新日期：2000-04-25 00:00:00

abstract：:We performed serial baseline and gadolinium (Gd)-DTPA-enhanced MRI in 4 patients with definite multiple sclerosis. Studies were performed every month for a total of 4 scans. We obtained short TR/short TE sequences at 10 and 60 minutes after Gd-DTPA injection. All patients had multiple hyperintense lesions seen on base...

journal_title：Neurology

authors： Bastianello S,Pozzilli C,Bernardi S,Bozzao L,Fantozzi LM,Buttinelli C,Fieschi C

更新日期：1990-04-01 00:00:00

abstract：OBJECTIVE:To determine whether groups of surrogates for patients with severe acute brain injury (SABI) with poor prognosis can be identified based on their prioritization of goals-of-care (GOC) decisional concerns, an online survey of 1,588 adults recruited via a probability-based panel representative of the US populat...

journal_title：Neurology

authors： Hwang DY,Knies AK,Mampre D,Kolenikov S,Schalk M,Hammer H,White DB,Holloway RG,Sheth KN,Fraenkel L

更新日期：2020-05-12 00:00:00

abstract：OBJECTIVE:To determine the role of weight loss in the treatment of idiopathic intracranial hypertension (IIH) in obese women. METHODS:Chart review of 250 patients with suspected IIH revealed 58 women who met our criteria, did not undergo early surgical intervention, and had adequate documentation of visual status, pap...

journal_title：Neurology

authors： Kupersmith MJ,Gamell L,Turbin R,Peck V,Spiegel P,Wall M

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVE:To assess whether exon deletions or duplications in CLCN1 are associated with recessive myotonia congenita (MC). METHODS:We performed detailed clinical and electrophysiologic characterization in 60 patients with phenotypes consistent with MC. DNA sequencing of CLCN1 followed by multiplex ligation-dependent p...

journal_title：Neurology

authors： Raja Rayan DL,Haworth A,Sud R,Matthews E,Fialho D,Burge J,Portaro S,Schorge S,Tuin K,Lunt P,McEntagart M,Toscano A,Davis MB,Hanna MG

更新日期：2012-06-12 00:00:00

abstract：:Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels > or = 1.53 microg/mL predicted progression to need for ambulatory assistance during follow-up (s...

journal_title：Neurology

authors： Rinker JR 2nd,Trinkaus K,Cross AH

更新日期：2006-10-10 00:00:00

abstract：:Erythrocyte calcium transport as a function of free [Ca++] was examined using inside-out vesicles from eight pairs of patients with Duchenne dystrophy and age- and sex-matched controls. The Km for Ca++ of the transport protein and the Vmax were higher in the Duchenne vesicles in seven of the eight pairs. The mean Km a...

journal_title：Neurology

authors： Mollman JE,Cardenas JC,Pleasure DE

更新日期：1980-11-01 00:00:00

abstract：:The biochemical hallmark of adult Refsum disease (ARD) is an isolated deficiency in the breakdown of phytanic acid. This usually results from a PHYH gene defect, although some cases have been found to carry a PEX7 defect. We describe the phenotype of such a patient, indistinguishable from that of classic ARD. Hence, w...

journal_title：Neurology

authors： Horn MA,van den Brink DM,Wanders RJ,Duran M,Poll-The BT,Tallaksen CM,Stokke OH,Moser H,Skjeldal OH

更新日期：2007-02-27 00:00:00

abstract：:Epilepsia partialis continua (EPC) may occur during nonketotic hyperglycemia but has not been described with diabetic ketoacidosis. The authors report a patient with EPC associated with ketotic hyperglycemia. Brain MRI showed two areas of abnormal signal intensity in the left precentral gyrus and in the right cerebell...

journal_title：Neurology

authors： Placidi F,Floris R,Bozzao A,Romigi A,Baviera ME,Tombini M,Izzi F,Sperli F,Marciani MG

更新日期：2001-08-14 00:00:00

abstract：OBJECTIVE:To test the diagnostic accuracy of the horizontal head impulse test (h-HIT) of vestibulo-ocular reflex (VOR) function in distinguishing acute peripheral vestibulopathy (APV) from stroke. Most patients with acute vertigo, nausea/vomiting, and unsteady gait have benign APV (vestibular neuritis or labyrinthitis)...

journal_title：Neurology

authors： Newman-Toker DE,Kattah JC,Alvernia JE,Wang DZ

更新日期：2008-06-10 00:00:00

abstract：:The American Academy of Neurology has published a comprehensive review and guidelines for the use of disease-modifying therapies (DMTs) in multiple sclerosis (MS) for the first time since 2002. These guidelines represent the work of MS experts, patients, and guideline experts and are based on their review of randomize...

journal_title：Neurology

authors： Corboy JR,Weinshenker BG,Wingerchuk DM

更新日期：2018-06-12 00:00:00

abstract：OBJECTIVE:To study the effect of pregnancy on the frequency of neuromyelitis optica spectrum disorder (NMOSD) relapse and evaluate rates of pregnancy-related complications in an international multicenter setting. METHODS:We administered a standardized survey to 217 women with NMOSD from 7 medical centers and reviewed ...

journal_title：Neurology

authors： Klawiter EC,Bove R,Elsone L,Alvarez E,Borisow N,Cortez M,Mateen F,Mealy MA,Sorum J,Mutch K,Tobyne SM,Ruprecht K,Buckle G,Levy M,Wingerchuk D,Paul F,Cross AH,Jacobs A,Chitnis T,Weinshenker B

更新日期：2017-11-28 00:00:00

abstract：:A 60-year-old man presented with progressive large fiber sensory loss in the right first three fingers and, to a lesser extent, in both fourth and fifth fingers. Electrophysiologic studies were characteristic of chronic sensory demyelinating polyneuropathy, a variant of chronic inflammatory demyelinating polyneuropath...

journal_title：Neurology

authors： Thonnard JL,Detrembleur C,Van den Bergh PY

更新日期：1997-07-01 00:00:00

abstract：OBJECTIVE:To characterize presenting symptomatology in patients with semantic dementia (SD) and to investigate whether left and right temporal variants of the disease have distinct behavioral and cognitive profiles. METHODS:Retrospective examination of case notes was performed in 47 consecutive referrals of patients w...

journal_title：Neurology

authors： Thompson SA,Patterson K,Hodges JR

更新日期：2003-11-11 00:00:00

abstract：:The most consistent electroencephalographic finding in 16 cases of Sturge-Weber syndrome was a unilateral reduction of background amplitude in the waking record. Comparable asymmetries were noted in those patients in whom sleep recording also was done. Physiologic responses (to hyperventilation and photic driving) usu...

journal_title：Neurology

authors： Brenner RP,Sharbrough FW

更新日期：1976-07-01 00:00:00

abstract：:X-linked spinal and bulbar muscular atrophy (SBMA) is usually associated with feminization and hypogonadism. We were unable to find androgen receptor (AR) in the scrotal skin of three patients with SBMA, and propose that AR abnormality is the cause of the disease. ...

journal_title：Neurology

authors： Matsuura T,Demura T,Aimoto Y,Mizuno T,Moriwaka F,Tashiro K

更新日期：1992-09-01 00:00:00

abstract：OBJECTIVES:We aimed to determine the incidence of electrographic seizures in children in the pediatric intensive care unit who underwent EEG monitoring, risk factors for electrographic seizures, and whether electrographic seizures were associated with increased odds of mortality. METHODS:Eleven sites in North America ...

journal_title：Neurology

authors： Abend NS,Arndt DH,Carpenter JL,Chapman KE,Cornett KM,Gallentine WB,Giza CC,Goldstein JL,Hahn CD,Lerner JT,Loddenkemper T,Matsumoto JH,McBain K,Nash KB,Payne E,Sánchez SM,Fernández IS,Shults J,Williams K,Yang A,Dlu

更新日期：2013-07-23 00:00:00

abstract：OBJECTIVE:To understand the experience and identify drivers and mitigating factors of burnout and well-being among US neurologists. METHODS:Inductive data analysis was applied to free text comments (n = 676) from the 2016 American Academy of Neurology survey of burnout, career satisfaction, and well-being. RESULTS:Re...

journal_title：Neurology

authors： Miyasaki JM,Rheaume C,Gulya L,Ellenstein A,Schwarz HB,Vidic TR,Shanafelt TD,Cascino TL,Keran CM,Busis NA

更新日期：2017-10-17 00:00:00

abstract：:Hoarding behavior associated with focal brain injury is rarely reported. The authors report a 46-year-old man with pathologic collecting behavior after a left orbitofrontal and caudate injury from an aneurysmal rupture of anterior communicating artery. His hoarding, an impulse control disorder or an ego-syntonic compu...

journal_title：Neurology

authors： Hahm DS,Kang Y,Cheong SS,Na DL

更新日期：2001-02-13 00:00:00

abstract：OBJECTIVE:To examine the severity of impairments in the decision-making abilities (understanding, appreciation, reasoning, and choice) and competency to make a decision to use an Alzheimer disease (AD)-slowing medication in patients with AD and the relationships between these impairments, insight, and overall cognition...

journal_title：Neurology

authors： Karlawish JH,Casarett DJ,James BD,Xie SX,Kim SY

更新日期：2005-05-10 00:00:00

abstract：:In multifocal motor neuropathy (MMN), little is known of the long-term effect of human immunoglobulin (HIG) infusions as a maintenance therapy. We report a patient who improved after an initial HIG infusion of 2 g/kg and continued to improve both clinically and electrophysiologically during maintenance HIG treatment c...

journal_title：Neurology

authors： Van den Berg LH,Franssen H,Wokke JH

更新日期：1995-05-01 00:00:00

abstract：:Using the centralized diagnostic data resource for the population of Rochester, Minnesota, we determined the prevalence of medically diagnosed dementia for this community. There were 289 individuals with dementia who were residing in Rochester on January 1, 1975: 208 women and 81 men. The overall age- and sex-adjusted...

journal_title：Neurology

authors： Kokmen E,Beard CM,Offord KP,Kurland LT

更新日期：1989-06-01 00:00:00