Abstract:
BACKGROUND:The paradoxical phenomenon of relative longevity among obese patients with established diseases has been reported for various disease conditions. The authors sought to investigate whether the obesity paradox also applies to intracerebral hemorrhage (ICH) survivors. METHODS:A total of 1,604 patients with ICH from 33 centers with nationwide coverage were prospectively enrolled to this cohort between October 2002 and March 2004. Baseline information including body mass index (BMI) was collected at admission, and mortality status was ascertained from the governmental mortality archive on December 2006. Associations between obesity and 30-day mortality or long-term risk of death were analyzed. RESULTS:Among the 1,356 patients with ICH included, the 30-day mortality rate was 7.2% and the long-term mortality rate was 26.9% after a mean follow-up of 33.6 ± 15.5 months. Neither BMI nor obesity status were associated with 30-day mortality after ICH. However, BMI was independently associated with a lower risk of long-term mortality (hazard ratio [HR] 0.91 per 1-kg/m(2) increase; 95% confidence interval [CI] 0.87-0.95). As compared with patients of normal weight, underweight subjects had a higher risk of death (HR 1.64; 95% CI 1.11-2.40), and conversely, overweight (HR 0.69; 95% CI 0.49-0.96) or obese (HR 0.61; 95% CI 0.43-0.88) subjects showed a lower risk of post-ICH death. CONCLUSION:In our study, obesity was associated with a lower risk of long-term death but not with 30-day mortality after ICH. Thus, it may be considered that an obesity status in a patient with ICH be treated as an indication of metabolic reservoir capacity and an increased likelihood of survival.
journal_name
Neurologyjournal_title
Neurologyauthors
Kim BJ,Lee SH,Ryu WS,Kim CK,Lee J,Yoon BWdoi
10.1212/WNL.0b013e31820b7667subject
Has Abstractpub_date
2011-02-08 00:00:00pages
567-73issue
6eissn
0028-3878issn
1526-632Xpii
WNL.0b013e31820b7667journal_volume
76pub_type
杂志文章,多中心研究相关文献
NEUROLOGY文献大全abstract:OBJECTIVE:To learn to which portions of a line normal subjects would attend when watching this line actually moving or when perceiving movement even in the absence of actual movement, an illusory movement. METHODS:Twenty normal subjects watched a computer monitor on which either lines or dots moved to the right or lef...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000120546.14213.c7
更新日期:2004-04-27 00:00:00
abstract::Serial determinations of spinal fluid homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) were made in four patients with the Lesch-Nyhan syndrome over a 5-year period. Control spinal fluids for age-matched comparison were obtained from 194 neurologic and nonneurologic pediatric patients. A rapid decline i...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.6.907
更新日期:1985-06-01 00:00:00
abstract:BACKGROUND:Most cavernous sinus dural arteriovenous malformations (CSdAVM) have a benign clinical course. Those CSdAVM that drain into cortical veins have an increased risk for neurologic complications. OBJECTIVE:To find whether a specific clinical sign predicts cortical venous drainage (CVD) in CSdAVM. METHODS:The r...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.58.10.1521
更新日期:2002-05-28 00:00:00
abstract:OBJECTIVE:To evaluate the clinical efficacy of a standardized special root extract from the plant Petasites hybridus as a preventive therapy for migraine. METHODS:This is a three-arm, parallel-group, randomized trial comparing Petasites extract 75 mg bid, Petasites extract 50 mg bid, or placebo bid in 245 patients wit...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/01.wnl.0000147290.68260.11
更新日期:2004-12-28 00:00:00
abstract::A cross-sectional survey and subsequent longitudinal study among diabetic residents of Rochester, MN--The Rochester Diabetic Neuropathy Study (RDNS)--is population-based and uses quantitative, validated, and unique end points to detect, classify, and stage neuropathy. Nondiabetic persons, drawn from the same populatio...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.6.799
更新日期:1991-06-01 00:00:00
abstract::We used proton magnetic resonance spectroscopy (1H MRS) to investigate the temporal lobes of 25 patients with temporal lobe epilepsy. Spectra were obtained from 2 x 2 x 2 cm cubes in the medial region of the temporal lobe, and were analyzed on the basis of signals from N-acetylaspartate (NAA), creatine + phosphocreati...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.8.1411
更新日期:1994-08-01 00:00:00
abstract::When 251 relapsing-remitting patients with multiple sclerosis were randomized to receive daily subcutaneous injections of glatiramer acetate, previously called copolymer 1 (Copaxone; n = 125) or placebo (n = 126) for 24 months, there were no laboratory abnormalities associated with glatiramer acetate treatment and it ...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/wnl.50.3.701
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:Silent infarcts are commonly discovered on cranial MRI in the elderly. OBJECTIVE:To examine the association between risk of stroke and presence of silent infarcts, alone and in combination with other stroke risk factors. METHODS:Participants (3,324) in the Cardiovascular Health Study (CHS) without a histor...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.7.1222
更新日期:2001-10-09 00:00:00
abstract:BACKGROUND:In epilepsy as in other disorders, family history information is often obtained by asking patients about the medical histories of their relatives rather than interviewing or examining the relatives directly. The accuracy of this type of information for epilepsy and other seizure disorders is unclear. METHOD...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182088286
更新日期:2011-01-25 00:00:00
abstract::It was not until the first half of the 19th century that the vascular nature of strokes was readily recognized and accepted. Brain "softenings" were distinguished from hemorrhagic "apoplexy," but stroke etiology remained unstudied. The terms artherosclerosis, thrombosis, embolism, and lacune were introduced to indicat...
journal_title:Neurology
pub_type: 历史文章,杂志文章
doi:10.1212/WNL.0b013e3181b59c1a
更新日期:2009-09-01 00:00:00
abstract::We examined serum-mediated cytotoxicity on cultured rat oligodendrocytes, using serum from patients with acute or chronic progressive multiple sclerosis and normal controls. We found heat-labile serum factors in serum from MS and also in controls. The cytotoxic effects of MS and normal sera were not restored by adding...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.2.276
更新日期:1986-02-01 00:00:00
abstract:OBJECTIVE:To investigate the possible association of persistent enterovirus (EV) infection with the development of ALS. BACKGROUND:Although ALS is a clinically well-defined motor neuron disease, little is known about the etiology and pathogenesis of the sporadic cases. Among the different causes that have been hypothe...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.1.20
更新日期:2000-01-11 00:00:00
abstract:OBJECTIVES:To quantify the quality of physicians' emergency first response to status epilepticus (SE) and to identify risk factors for nonadherence to treatment guidelines in a standardized simulated scenario. METHODS:In this prospective trial, 58 physicians (of different background) of the University Hospital Basel, ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008461
更新日期:2019-11-05 00:00:00
abstract:OBJECTIVE:To determine whether congenital arhinia/Bosma arhinia microphthalmia syndrome (BAMS) and facioscapulohumeral muscular dystrophy type 2 (FSHD2), 2 seemingly unrelated disorders both caused by heterozygous pathogenic missense variants in the SMCHD1 gene, might represent different ends of a broad single phenotyp...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000005958
更新日期:2018-08-07 00:00:00
abstract:OBJECTIVES:Based on the hippocampus disconnection hypothesis in Alzheimer disease (AD), which postulates that uncoupling from cortical inputs contributes to disinhibition-like changes in hippocampus activity, we suggested that in patients with AD, the more the intrinsic functional connectivity between hippocampus and p...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001575
更新日期:2015-05-12 00:00:00
abstract:BACKGROUND:Pharmacologic interventions (e.g., beta blockers) and thalamic lesions have failed to alter the pathophysiology of essential tremor (ET) beyond a reduction in tremor amplitude. Deep brain stimulation (DBS) of the ventral intermediate (VIM) nucleus of the thalamus successfully reduces tremor rating scores. It...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/01.wnl.0000086371.78447.d2
更新日期:2003-10-14 00:00:00
abstract:OBJECTIVE:To characterize the prevalence and prognostic significance of major driver molecular alterations in adult midline diffuse gliomas (MLG). METHODS:Adults with histologically proven MLG diagnosed between 1996 and 2017 were identified from our tumor bank, systematically reviewed, and reclassified according to WH...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000005658
更新日期:2018-06-05 00:00:00
abstract:OBJECTIVE:To validate the Narcolepsy Severity Scale (NSS), a brief clinical instrument to evaluate the severity and consequences of symptoms in patients with narcolepsy type 1 (NT1). METHODS:A 15-item scale to assess the frequency and severity of excessive daytime sleepiness, cataplexy, hypnagogic hallucinations, slee...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003787
更新日期:2017-04-04 00:00:00
abstract::Although people with migraine are aware of their headaches they are often not aware that they have migraine. This can lead to inappropriate or ineffective use of treatments, delays in seeking appropriate care, and miscommunication during clinical encounters. This article assesses self-recognition of migraine and ident...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.9_suppl_6.s21
更新日期:2002-05-14 00:00:00
abstract:OBJECTIVE:The 36-item Short Form Health Survey Questionnaire (SF-36) is a widely used generic health status measure. Recently it has been adapted to produce a disease-specific measure for MS-the 54-item Multiple Sclerosis Quality of Life Scale (MSQOL-54)-composed of five unchanged SF-36 scales; three altered SF-36 scal...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.1.68
更新日期:2001-07-10 00:00:00
abstract:OBJECTIVE:To determine whether the incidence and clinical features of pediatric multiple sclerosis (MS) and other forms of pediatric acquired demyelinating syndromes (ADS) vary by race/ethnicity in a population-based cohort. METHODS:We used a combination of electronic database searches followed by complete medical rec...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31822facdd
更新日期:2011-09-20 00:00:00
abstract:OBJECTIVE:To examine the relationships between age at onset and duration of seizure disorder with severity of hippocampal sclerosis (HS) and cognitive functioning in patients with HS and unilateral temporal lobe epilepsy. METHODS:Twenty-six subjects had left temporal lobe seizure onset; 20 had right temporal onset. Me...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.2.184
更新日期:2001-07-24 00:00:00
abstract::PET-demonstrated decreases in [11C]flumazenil binding occur in anterior mesial temporal structures on the side of epileptogenesis in unilateral mesial temporal lobe epilepsy. We performed quantitative autoradiography on anterior mesial and lateral temporal specimens from 11 subjects with unilateral mesial temporal lob...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.5.934
更新日期:1995-05-01 00:00:00
abstract::Automatisms are commonly seen in epilepsy, either ictally or postictally. However, most automatisms are simple, with hand movements, mouth smacking, nose-rubbing, repetition of a single word, or coughing, grunting, or screeching. Complex automatisms are less common and striking. The authors report two cases of seizure...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000031430.40085.93
更新日期:2002-11-12 00:00:00
abstract:OBJECTIVE:To investigate the cognitive skills of patients with relapsing remitting multiple sclerosis (RRMS), secondary progressive MS (SPMS), and primary progressive MS (PPMS) relative to healthy control subjects and to assess whether there is heterogeneity in the type of cognitive disabilities demonstrated by patient...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000129828.03714.90
更新日期:2004-07-27 00:00:00
abstract:OBJECTIVE:To investigate brain amyloid pathology in a dementia-risk population defined as cardiovascular risk factors, aging, and dementia risk (CAIDE) score of at least 6 but with normal cognition and to examine associations between brain amyloid load and cognitive performance and vascular risk factors. METHODS:A sub...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004827
更新日期:2018-01-16 00:00:00
abstract:BACKGROUND:Sleep-disordered breathing (SDB) and respiratory failure (RF) are complications of acid maltase deficiency (AMD), a rare hereditary myopathy. OBJECTIVE:To define the relationship between lung and respiratory muscle function, to establish incidence and patterns of SDB, and to determine daytime predictors of ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.7.1290
更新日期:2001-10-09 00:00:00
abstract::We report a patient with unusual MRI abnormalities that had the physical characteristics of ferromagnetic artifact. We believe that the MRI artifacts were due to microscopic embolic metal fragments, most likely from a mechanical heart valve prosthesis. Potential sources of metal emboli should be considered in patients...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.5.1451
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVES:To evaluate the frequency, clinical and etiologic features, and short- and long-term outcomes of early recurrent TIA. METHODS:This prospective observational cohort study enrolled all consecutive patients with TIA referred to our emergency department and diagnosed by a vascular neurologist. Expedited assessm...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000010317
更新日期:2020-09-22 00:00:00
abstract:OBJECTIVE:To explore the causal relationships between sleep, major depressive disorder (MDD), and Alzheimer disease (AD). METHODS:We conducted bidirectional 2-sample Mendelian randomization analyses. Genetic associations were obtained from the largest genome-wide association studies currently available in UK Biobank (...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000010463
更新日期:2020-10-06 00:00:00