Abstract:
BACKGROUND:Pharmacologic interventions (e.g., beta blockers) and thalamic lesions have failed to alter the pathophysiology of essential tremor (ET) beyond a reduction in tremor amplitude. Deep brain stimulation (DBS) of the ventral intermediate (VIM) nucleus of the thalamus successfully reduces tremor rating scores. It is unknown how VIM DBS alters the pathophysiologic characteristics of ET. OBJECTIVE:To determine the effects of VIM DBS on the neurophysiologic characteristics of ET. METHODS:Hand tremor and EMG activity of forearm extensor and flexor muscles were recorded in six patients with ET ON-DBS and OFF-DBS and from six age- and sex-matched control subjects. Hand tremor was assessed across different inertial loads. The amplitude, frequency, regularity, and tremor-EMG coherence were analyzed. RESULTS:VIM DBS reduced the amplitude, increased the frequency, decreased the regularity, and reduced the 1 to 8 Hz tremor-EMG coherence of ET. ON-DBS, patients with ET had greater tremor amplitude, lower frequency, more regularity, and greater tremor-EMG coherence compared to control subjects. CONCLUSIONS:Whereas pharmacologic and thalamic lesions have previously failed to change characteristics of ET beyond amplitude reduction, VIM DBS modified multiple features of ET. The changes in ET after VIM DBS provide strong evidence for clinical efficacy.
journal_name
Neurologyjournal_title
Neurologyauthors
Vaillancourt DE,Sturman MM,Verhagen Metman L,Bakay RA,Corcos DMdoi
10.1212/01.wnl.0000086371.78447.d2subject
Has Abstractpub_date
2003-10-14 00:00:00pages
919-25issue
7eissn
0028-3878issn
1526-632Xjournal_volume
61pub_type
临床试验,杂志文章相关文献
NEUROLOGY文献大全abstract::We used the Mayo Clinic medical records linkage system to detect all cases of intracranial vascular malformation (IVM) among residents of Olmsted County, Minnesota from 1965 to 1992 and found 48 IVMs over the 27-year period, including four patients with IVM detected at autopsy, without prior symptoms. Twenty-nine of 4...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.4.949
更新日期:1996-04-01 00:00:00
abstract::Recent epidemiologic studies of multiple sclerosis (MS) in Australia defined the State of Queensland as a medium-frequency zone and the more southerly placed cities of Perth, Newcastle, and Hobart as high-frequency zones. Clinical profiles in the patient populations of both frequency zones were remarkably similar in m...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.6.980
更新日期:1988-06-01 00:00:00
abstract::In many parkinsonian syndromes, neuromelanin (NM)-containing dopaminergic neurons of the substantia nigra (SN) are selectively targeted by the noxius pathogens. Studies of the constitutional and functional features of human NM allow the formulation of a logical hypothesis on its role in parkinsonian syndromes. In the ...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.67.7_suppl_2.s8
更新日期:2006-10-10 00:00:00
abstract::Spontaneous circadian fluctuations of motor symptoms in Parkinson's disease (PD) often occur, with dysfunction typically less severe in the early morning than in the afternoon. In 23 PD patients with or without a history of circadian motor fluctuations, we studied contrast sensitivity (CS), a non-motor function, consi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.3_part_1.467
更新日期:1990-03-01 00:00:00
abstract::Interictal and ictal fluorodeoxyglucose scans were obtained with positron CT from four patients with spontaneous recurrent partial seizures, one with epilepsia partialis continua, and one with a single partial seizure induced by electrical stimulation of the hippocampus. Ictal metabolic patterns were different for eac...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.4.400
更新日期:1983-04-01 00:00:00
abstract::Fatal familial insomnia (FFI), a condition characterized by inability to sleep, dysautonomia, motor disturbances, and selective thalamic atrophy is a prion disease linked to a GAC----AAC mutation at codon 178 of the prion gene. These data were obtained from one kindred. We now report a second kindred affected by FFI a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.3.669
更新日期:1992-03-01 00:00:00
abstract::We examined six patients with an abrupt change in behavior after infarction involving the inferior genu of the internal capsule. The acute syndrome featured fluctuating alertness, inattention, memory loss, apathy, abulia, and psychomotor retardation, suggesting frontal lobe dysfunction. Contralateral hemiparesis and d...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.10.1966
更新日期:1992-10-01 00:00:00
abstract::This study concerns the expression of Met-enkephalin (MEnk) in the striatum and the external segment of the globus pallidus proper (GPe) in normal controls, idiopathic Parkinson's disease (PD), and striatonigral degeneration (SND). For this purpose, we developed a sensitive immunoperoxidase technique to visualize MEnk...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.7.1051
更新日期:1990-07-01 00:00:00
abstract:OBJECTIVE:This study prospectively examined the relationships among late night salivary cortisol (NSC) levels and depressive symptoms, memory performance, and hippocampal volumes in patients with medically intractable temporal lobe epilepsy (TLE) and the potential mediating effects of cortisol in the relationships betw...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31824e8efb
更新日期:2012-04-03 00:00:00
abstract::Thirteen patients presented with brief, repetitive, stereotyped transient ischemic attacks, large artery atherostenoses or occlusions with impaired collateral flow to a cortical perfusion borderzone, and orthostatic hypotension (OH). OH was caused by diabetes mellitus, aging, and treatments for ischemic heart disease ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.1.30
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE:To compare the efficacy, tolerability, and safety of IV methylprednisolone (IV MP) vs oral methylprednisolone (oMP) at equivalent high doses in patients with multiple sclerosis (MS) experiencing a recent relapse. METHODS:Patients with a clinical relapse within the previous 2 weeks and at least 1 gadolinium (...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0b013e3181c3fd5b
更新日期:2009-12-01 00:00:00
abstract::The malformation of inverse cerebellum and occipital encephalocele is situated morphologically between the Arnold-Chiari and Dandy-Walker malformations. In the three reported cases, hydrocephalus was not present, concomitant malformations of the lamina terminalis were present in two, and polymicrogyria was found in al...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.27.3.246
更新日期:1977-03-01 00:00:00
abstract::Patients with Parkinson's disease (PD) commonly complain of impaired visual function and difficulty reading, despite normal visual acuity. Although previous studies have evaluated contrast sensitivity, color vision, visuospatial processing, visual hallucinations, and ocular movements, none has systematically evaluated...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000103444.45882.d8
更新日期:2004-01-27 00:00:00
abstract:OBJECTIVE:To investigate the relationship between visual hallucinations in Parkinson disease (PD) and levels of γ-aminobutyric acid (GABA) in the primary visual cortex. METHODS:We utilized magnetic resonance spectroscopy to investigate occipital GABA levels in 36 participants with PD, 19 with and 17 without complex vi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006007
更新日期:2018-08-14 00:00:00
abstract:OBJECTIVE:To determine whether cognitive impairment in Parkinson disease (PD) and Alzheimer disease (AD) derives from the same network pathology. METHODS:We analyzed 18F-fluorodeoxyglucose PET scans from 40 patients with AD and 40 age-matched healthy controls from the Alzheimer's Disease Neuroimaging Initiative and sc...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003285
更新日期:2016-11-01 00:00:00
abstract::We used two analytic methods (a multichannel coulometric electrode array with high-performance liquid chromatography, and gas chromatography-mass spectrophotometry) to measure CSF dopamine (DA) and its metabolites in mildly affected, unmedicated subjects with Parkinson's disease (PD). The mean (+/- SD) concentration o...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.11.2111
更新日期:1992-11-01 00:00:00
abstract::Changes in estrogen levels at menarche, menstruation, pregnancy, and menopause may trigger or change the prevalence of migraine. The fall in estrogen that occurs with menstruation is the trigger for menstrual migraine, whereas the sustained high estrogen levels during pregnancy frequently result in headache relief. Es...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:
更新日期:1992-03-01 00:00:00
abstract::Sensory disturbance in the unilateral hand and ipsilateral mouth region, the cheiro-oral syndrome, may be due to cortical, thalamic, or brainstem lesions. We report five patients with this syndrome due to infarction at the border of the posterior limb of the internal capsule and the corona radiata. The sensory fibers ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.1_part_1.51
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:To conduct a systematic review on the association between tetanus vaccination and the risk of multiple sclerosis (MS). METHODS:The authors searched the databases Medline, LILACS, EMBASE, and Science Citation Index including the period 1966 to September 1, 2005. Eligible studies had to meet the following incl...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000225079.51201.f9
更新日期:2006-07-25 00:00:00
abstract:OBJECTIVE:We aimed to assess the innervation density of dermal nerves in human skin biopsies by bright-field immunohistochemistry. METHODS:The size of dermal area where nerve length was quantified was validated in 30 skin biopsy sections (5 controls and 5 patients with small-fiber neuropathy [SFN]). It was obtained di...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318225ab51
更新日期:2011-07-19 00:00:00
abstract:OBJECTIVE:To conduct a validation study of 123I-N-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) nortropane (123I-FP-CIT) SPECT dopaminergic imaging in the clinical diagnosis of dementia with Lewy bodies (DLB) with autopsy as the gold standard. METHODS:Patients >60 years of age with dementia who had undergone 123I-FP-...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003512
更新日期:2017-01-17 00:00:00
abstract::The defect occurring when a patient fails to report a visual stimulus presented in a visual half-field may be attributed to hemianopia (deafferentation) caused by a geniculocalcarine lesion. However, failure to report a stimulus presented in a visual field may also be caused by hemispatial visual inattention. We repor...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.8.1125
更新日期:1989-08-01 00:00:00
abstract::People with AD have deficient contrast sensitivity and impaired face discrimination. The authors presented photographs of unfamiliar faces of three different sizes to enhance the low, middle, or high facial frequency information (cycles per face). Patients with AD demonstrated normal discrimination of small faces only...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.54.12.2316
更新日期:2000-06-27 00:00:00
abstract::The authors report an unusual case of venous infarction of the spinal cord associated with endoscopic sclerotherapy for esophageal varices. MR imaging findings included signal abnormalities and abnormal enhancement of the affected spinal cord and T-8 vertebral body. A review of the hemodynamic changes associated with ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.4.1081
更新日期:1996-10-01 00:00:00
abstract:OBJECTIVES:This study examines the anatomical correlates of naming vs recognizing faces using a novel measure that utilizes culturally relevant and age-appropriate items, the Northwestern University Famous Faces (NUFFACE) Test, in primary progressive aphasia (PPA), a syndrome characterized by progressive language defic...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182a08f83
更新日期:2013-08-13 00:00:00
abstract::We conducted a retrospective study to determine the frequency of depression, hallucinations, and delusions in patients with diffuse Lewy body disease (DLBD) and to compare these findings with those in Alzheimer's disease (AD) and Parkinson's disease (PD). One hundred twelve subjects were included in the study. Of thes...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.5.1148
更新日期:1996-11-01 00:00:00
abstract::Cerebral necrosis following stroke exposes brain antigens to the immune system, potentially initiating an antibody response. The authors measured levels of antibodies to specific neuronal antigens, neurofilaments (NF), and a ubiquitous antigen, cardiolipin (CL), in 45 patients following an acute first-ever stroke, wit...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.4.529
更新日期:2001-02-27 00:00:00
abstract::Hippocampal sulcal cavities are usually considered incidental findings on brain MRI. In a group of 92 elderly volunteers, the authors graded the number and size of hippocampal sulcal cavities with brain MRI to obtain a cavity score. Cavity scores increased with age, and were higher in subjects carrying the APOE epsilo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.11.2150
更新日期:2000-06-13 00:00:00
abstract::Clinical trials have demonstrated that risk of cardiovascular events may be reduced in patients with stroke, using blood pressure (BP) reduction and statin therapy, independently of the presence of specific risk factors. These results suggest an alternative approach to secondary stroke prevention, focused more on glob...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000171745.13592.cb
更新日期:2005-07-12 00:00:00
abstract::Neurologic complications of brain tissue-derived rabies vaccine may be chronic or progressive. Lymphocytes and serum from three patients with this form of encephalitis were studied. Two patients had positive lymphoproliferation to purified myelin, two had antibody to white matter, and one had antibody to myelin basic ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.1.42
更新日期:1988-01-01 00:00:00