Role of cortisol in mood and memory in patients with intractable temporal lobe epilepsy.

Abstract:

OBJECTIVE:This study prospectively examined the relationships among late night salivary cortisol (NSC) levels and depressive symptoms, memory performance, and hippocampal volumes in patients with medically intractable temporal lobe epilepsy (TLE) and the potential mediating effects of cortisol in the relationships between these variables. METHODS:Participants included 24 adults with well-characterized medically refractory TLE (right = 11; left = 12; bitemporal = 1). All patients provided saliva samples and completed measures of mood, anxiety, and memory (objective and subjective). MRI-based volumetric analyses of the hippocampi were also conducted. RESULTS:As hypothesized, cortisol was found to be negatively related to several memory measures such that patients with higher cortisol levels demonstrated lower memory performance. However, unexpectedly, cortisol was not related to current symptoms of depression or anxiety, subjective memory ratings, or hippocampal volumes. Consistent with previous findings in the literature, a number of other relationships among the study variables were observed (objective memory and hippocampal volume; subjective memory and mood/anxiety). Results of mediator analyses suggested that cortisol does not mediate the relationship between depression and memory dysfunction or the relationship between depression and hippocampal atrophy. CONCLUSIONS:While cortisol may play a role in memory performance in patients with TLE, it does not fully explain the relationship between depression and mesial temporal dysfunction, likely reflecting the complex and multifactorial relationships among these variables. Results confirm the relationship between memory performance and structural brain integrity and provide further support for a role of depression in subjective memory complaints.

journal_name

Neurology

journal_title

Neurology

authors

Busch RM,Frazier T,Chapin JS,Hamrahian AH,Diehl B,Alexopoulos A,Unnwongse K,Naugle RI,Kubu CS,Tesar GE,Najm IM

doi

10.1212/WNL.0b013e31824e8efb

subject

Has Abstract

pub_date

2012-04-03 00:00:00

pages

1064-8

issue

14

eissn

0028-3878

issn

1526-632X

pii

WNL.0b013e31824e8efb

journal_volume

78

pub_type

杂志文章
  • PM2.5 associated with gray matter atrophy reflecting increased Alzheimers risk in older women.

    abstract:OBJECTIVE:To examine whether late-life exposure to PM2.5 (particulate matter with aerodynamic diameters <2.5-µm) contributes to progressive brain atrophy predictive of Alzheimer's disease (AD) using a community-dwelling cohort of women (aged 70-89) with up to two brain MRI scans (MRI-1: 2005-6; MRI-2: 2010-11). METHOD...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000011149

    authors: Younan D,Wang X,Casanova R,Barnard R,Gaussoin SA,Saldana S,Petkus AJ,Beavers DP,Resnick SM,Manson JE,Serre ML,Vizuete W,Henderson VW,Sachs BC,Salinas JA,Gatz M,Espeland MA,Chui HC,Shumaker SA,Rapp SR,Chen JC,Wom

    更新日期:2020-11-18 00:00:00

  • Medial plantar neuropathy.

    abstract::We have described four cases of medial plantar neuropathy that was confirmed by the near-nerve sensory nerve conduction study. The common compression site in medial plantar neuropathy is at the entrance to the fibromuscular tunnel behind the navicular tuberosity, distal to the tarsal tunnel, where Tinel's sign is loca...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.37.8.1408

    authors: Oh SJ,Lee KW

    更新日期:1987-08-01 00:00:00

  • Longitudinal and cross-sectional analysis of atrophy in pharmacoresistant temporal lobe epilepsy.

    abstract:BACKGROUND:Whether recurrent epileptic seizures induce brain damage is debated. Disease progression in epilepsy has been evaluated only in a few community-based studies involving patients with seizures well controlled by medication. These studies concluded that epilepsy does not inevitably lead to global cerebral damag...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000345969.57574.f5

    authors: Bernhardt BC,Worsley KJ,Kim H,Evans AC,Bernasconi A,Bernasconi N

    更新日期:2009-05-19 00:00:00

  • A magnetization transfer imaging study of normal-appearing white matter in multiple sclerosis.

    abstract::We attempted to define the role of subtle changes in the normal-appearing white matter (NAWM) in the development of disability in multiple sclerosis (MS). Twenty-seven clinically definite MS patients with either relapsing-remitting or chronic-progressive courses and 10 sex- and age-matched controls entered the study. ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.45.3.478

    authors: Filippi M,Campi A,Dousset V,Baratti C,Martinelli V,Canal N,Scotti G,Comi G

    更新日期:1995-03-01 00:00:00

  • Underdevelopment of the postural control system in autism.

    abstract:OBJECTIVE:To determine if abnormalities exist in postural control in autism and if they are related to age. METHODS:Dynamic posturography was performed in 79 autistic individuals without mental retardation and 61 healthy volunteers between ages 5 and 52 years. Both the sensory organization and the movement coordinatio...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000145771.98657.62

    authors: Minshew NJ,Sung K,Jones BL,Furman JM

    更新日期:2004-12-14 00:00:00

  • Quantitative MRI in hypomyelinating disorders: Correlation with motor handicap.

    abstract:OBJECTIVE:To assess the correlation of tissue parameters estimated by quantitative magnetic resonance (MR) techniques and motor handicap in patients with hypomyelination. METHODS:Twenty-eight patients with different causes of hypomyelination (12 males, 16 females; mean age 10 years) and 61 controls (33 males, 28 femal...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000003000

    authors: Steenweg ME,Wolf NI,van Wieringen WN,Barkhof F,van der Knaap MS,Pouwels PJ

    更新日期:2016-08-23 00:00:00

  • Tuberculous meningitis in the southwest United States: a community-based study.

    abstract::This community-based study analyzed 54 patients with definite or probable tuberculous meningitis (TBM) in New Mexico from 1970 through 1990. Patients ranged in age from 4 months to 86 years. The highest age-specific incidence occurred in the elderly, but 22% of patients were less than 10 years old. Native American pat...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.43.9.1775

    authors: Davis LE,Rastogi KR,Lambert LC,Skipper BJ

    更新日期:1993-09-01 00:00:00

  • Pathologic findings in prospectively ascertained essential tremor subjects.

    abstract:OBJECTIVE:To assess pathologic changes in prospectively characterized subjects with essential tremor (ET). METHODS:Subjects enrolled in the Sun Health Research Institute Brain and Body Donation Program were examined annually by a movement disorders neurologist, and semiannually by a behavioral neurologist and neuropsy...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000310425.76205.02

    authors: Shill HA,Adler CH,Sabbagh MN,Connor DJ,Caviness JN,Hentz JG,Beach TG

    更新日期:2008-04-15 00:00:00

  • Epileptic skew deviation.

    abstract::We describe a 43-year-old neurologically intact patient who reported episodes of diplopia and oscillopsia associated with a right-beating nystagmus and a skew deviation. These symptoms and signs were related to a left posterior epileptic EEG discharge. We suggest that these ocular motor signs derived from an ictal act...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.50.5.1469

    authors: Galimberti CA,Versino M,Sartori I,Manni R,Martelli A,Tartara A

    更新日期:1998-05-01 00:00:00

  • Cognitive effects of one season of head impacts in a cohort of collegiate contact sport athletes.

    abstract:OBJECTIVE:To determine whether exposure to repetitive head impacts over a single season negatively affects cognitive performance in collegiate contact sport athletes. METHODS:This is a prospective cohort study at 3 Division I National Collegiate Athletic Association athletic programs. Participants were 214 Division I ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3182582fe7

    authors: McAllister TW,Flashman LA,Maerlender A,Greenwald RM,Beckwith JG,Tosteson TD,Crisco JJ,Brolinson PG,Duma SM,Duhaime AC,Grove MR,Turco JH

    更新日期:2012-05-29 00:00:00

  • The child neurology clinical workforce in 2015: Report of the AAP/CNS Joint Taskforce.

    abstract:OBJECTIVES:More than a decade has passed since the last major workforce survey of child neurologists in the United States; thus, a reassessment of the child neurology workforce is needed, along with an inaugural assessment of a new related field, neurodevelopmental disabilities. METHODS:The American Academy of Pediatr...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000003147

    authors: Kang PB,Bale JF Jr,Mintz M,Joshi SM,Gilbert DL,Radabaugh C,Ruch-Ross H,Section on Neurology Executive Committee of the American Academy of Pediatrics, and the Board of Directors of the Child Neurology Society.

    更新日期:2016-09-27 00:00:00

  • Subcortical aphasia: the core profile of capsulostriatal infarction.

    abstract::There has been disagreement about the precise characteristics of "subcortical aphasia." We evaluated 14 patients with aphasia after subcortical lesions and controlled for duration, general anatomic site of lesions (capsulostriatal only), and etiology. The clinical profiles of the patients were quite similar, varying i...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.44.10.1824

    authors: Mega MS,Alexander MP

    更新日期:1994-10-01 00:00:00

  • Brodmann area 12: an historical puzzle relevant to FTLD.

    abstract:BACKGROUND:Brodmann brain maps, assembled in 1909, are still in use, but understanding of their animal-human homology is uncertain. Furthermore, in 1909, Brodmann did not identify human area 12 (BA12), a location now important to understanding of frontotemporal lobar degeneration (FTLD). METHODS:We re-examined Brodman...

    journal_title:Neurology

    pub_type: 历史文章,杂志文章

    doi:10.1212/WNL.0b013e3182190cd8

    authors: Kawamura M,Miller MW,Ichikawa H,Ishihara K,Sugimoto A

    更新日期:2011-05-03 00:00:00

  • Meta-analysis and cost-effectiveness of second-line antiepileptic drugs for status epilepticus.

    abstract:OBJECTIVE:Compare the cost and effectiveness of nonbenzodiazepine antiepileptic drugs (non-BZD AEDs) for treatment of BZD-resistant convulsive status epilepticus (SE). METHODS:Decision analysis model populated with effectiveness data from a systematic review and meta-analysis of the literature, and cost data from publ...

    journal_title:Neurology

    pub_type: 杂志文章,meta分析

    doi:10.1212/WNL.0000000000007503

    authors: Sánchez Fernández I,Gaínza-Lein M,Lamb N,Loddenkemper T

    更新日期:2019-05-14 00:00:00

  • Linkage of the locus for cerebral cavernous hemangiomas to human chromosome 7q in four families of Mexican-American descent.

    abstract:OBJECTIVE:To determine with greater precision the map location of the locus associated with familial cavernous hemangiomas. BACKGROUND:Cavernous malformations of the brain are a significant cause of seizures, progressive or apoplectic neurologic deficit, and headache. Prevalence estimates from autopsy series vary from...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.48.3.752

    authors: Polymeropoulos MH,Hurko O,Hsu F,Rubenstein J,Basnet S,Lane K,Dietz H,Spetzler RF,Rigamonti D

    更新日期:1997-03-01 00:00:00

  • Hypertensive Disorders of Pregnancy and Cognitive Impairment: A Prospective Cohort Study.

    abstract:OBJECTIVE:To determine the association between hypertensive disorders of pregnancy (HDP) and cognitive impairment 15 years after pregnancy, we measured cognitive performance in 115 women with a history of HDP and in 481 women with a previous normotensive pregnancy. METHODS:This was a nested cohort study embedded in a ...

    journal_title:Neurology

    pub_type: 评论,杂志文章

    doi:10.1212/WNL.0000000000011363

    authors: Adank MC,Hussainali RF,Oosterveer LC,Ikram MA,Steegers EAP,Miller EC,Schalekamp-Timmermans S

    更新日期:2021-02-02 00:00:00

  • Factors influencing osmotic fragility of red blood cells in Duchenne muscular dystrophy.

    abstract::Factors affecting osmotic fragility were studied in red blood cells of patients with Duchenne muscular dystrophy. The mean osmotic fragility (MOF), operationally defined as the NaCl concentration for 50% hemolysis, was found to be higher by 3.63 +/- 0.51 mM in Duchenne cells than in normal cells having an MOF of 60.1 ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.30.7.726

    authors: Kim HD,Luthra MG,Watts RP,Stern LZ

    更新日期:1980-07-01 00:00:00

  • The clinical spectrum of cerebral amyloid angiopathy: presentations without lobar hemorrhage.

    abstract::Cerebral amyloid angiopathy is a common cause of spontaneous lobar hemorrhage in elderly patients. We discuss seven patients with amyloid angiopathy presenting without major lobar hemorrhage. The patients' presentations fell into two groups: recurrent transient neurologic symptoms and rapidly progressive dementia. The...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.43.10.2073

    authors: Greenberg SM,Vonsattel JP,Stakes JW,Gruber M,Finklestein SP

    更新日期:1993-10-01 00:00:00

  • Nicotine-sensitive paresis.

    abstract::Immediately after a patient with myoclonus epilepsy smoked a nicotine-containing cigarette, tetraparesis and hyperreflexia with ankle clonus developed, but disappeared within several minutes. During paresis, the H-reflex size of the soleus muscle increased, EEG showed more slow waves than before smoking, and the cereb...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.42.2.382

    authors: Yokota T,Kagamihara Y,Hayashi H,Tsukagoshi H,Tanabe H

    更新日期:1992-02-01 00:00:00

  • Focused ultrasound thalamotomy in Parkinson disease: Nonmotor outcomes and quality of life.

    abstract:OBJECTIVE:To examine nonmotor outcomes and correlates of quality of life (QoL) 3 and 12 months after unilateral focused ultrasound thalamotomy in tremor-dominant Parkinson disease (TDPD). METHODS:Twenty-seven patients with TDPD in a double-blind, sham-controlled, randomized clinical trial underwent comprehensive neuro...

    journal_title:Neurology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1212/WNL.0000000000006279

    authors: Sperling SA,Shah BB,Barrett MJ,Bond AE,Huss DS,Gonzalez Mejia JA,Elias WJ

    更新日期:2018-10-02 00:00:00

  • Controlled study of the antiparkinsonian activity and tolerability of cabergoline.

    abstract::Cabergoline, a new ergoline derivative, is a D2-specific dopaminergic agonist that is more potent and longer-acting than other agonist agents. We conducted a randomized, double-blind study of increasing doses of cabergoline taken once a day. Twenty-five patients with Parkinson's disease taking stable doses of levodopa...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1212/wnl.43.3_part_1.613

    authors: Hutton JT,Morris JL,Brewer MA

    更新日期:1993-03-01 00:00:00

  • Vestibular thalamus: Two distinct graviceptive pathways.

    abstract:OBJECTIVE:To determine whether there are distinct thalamic regions statistically associated with either contraversive or ipsiversive disturbance of verticality perception measured by subjective visual vertical (SVV). METHODS:We used modern statistical lesion behavior mapping on a sample of 37 stroke patients with isol...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000002238

    authors: Baier B,Conrad J,Stephan T,Kirsch V,Vogt T,Wilting J,Müller-Forell W,Dieterich M

    更新日期:2016-01-12 00:00:00

  • Absence of IgG1 response in the cerebrospinal fluid of relapsing neuromyelitis optica.

    abstract::The authors studied immunoglobulin (Ig) G subclasses in the CSF and sera of patients with relapsing neuromyelitis optica (RNMO) and typical multiple sclerosis (MS). Although the total IgG concentrations were elevated in the CSF of patients with RNMO and MS, IgG1% and IgG1 index were significantly elevated only in pati...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.62.1.144

    authors: Nakashima I,Fujihara K,Fujimori J,Narikawa K,Misu T,Itoyama Y

    更新日期:2004-01-13 00:00:00

  • Autoantibodies in postinfectious acute cerebellar ataxia.

    abstract::The authors found serum immunoglobulin M (IgM) autoantibody in a patient with typical acute cerebellar ataxia (ACA) and identified the antigen molecule as triosephosphate isomerase (TPI). TPI antigenicity to the patient's antibody was the highest in the cerebellar tissue. Eight of 23 patients with ACA had increased Ig...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000178802.38268.1e

    authors: Uchibori A,Sakuta M,Kusunoki S,Chiba A

    更新日期:2005-10-11 00:00:00

  • Serum triglycerides in Alzheimer disease: Relation to neuroimaging and CSF biomarkers.

    abstract:OBJECTIVE:To investigate the association of triglyceride (TG) principal component scores with Alzheimer disease (AD) and the amyloid, tau, neurodegeneration, and cerebrovascular disease (A/T/N/V) biomarkers for AD. METHODS:Serum levels of 84 TG species were measured with untargeted lipid profiling of 689 participants ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000009436

    authors: Bernath MM,Bhattacharyya S,Nho K,Barupal DK,Fiehn O,Baillie R,Risacher SL,Arnold M,Jacobson T,Trojanowski JQ,Shaw LM,Weiner MW,Doraiswamy PM,Kaddurah-Daouk R,Saykin AJ,Alzheimer's Disease Neuroimaging Initiative and Alzheim

    更新日期:2020-05-19 00:00:00

  • Natalizumab treatment is associated with peripheral sequestration of proinflammatory T cells.

    abstract:BACKGROUND:Natalizumab is an antibody directed against integrin alpha4 that reduces disease activity in patients with multiple sclerosis (MS) by blocking migration of T and B cells into the CNS. The goal of this study was to characterize the effects of natalizumab treatment on cytokine production and expression of acti...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3181a8266f

    authors: Kivisäkk P,Healy BC,Viglietta V,Quintana FJ,Hootstein MA,Weiner HL,Khoury SJ

    更新日期:2009-06-02 00:00:00

  • Brain white matter volume abnormalities in Lesch-Nyhan disease and its variants.

    abstract:OBJECTIVE:We sought to examine brain white matter abnormalities based on MRI in adults with Lesch-Nyhan disease (LND) or an attenuated variant (LNV) of this rare, X-linked neurodevelopmental disorder of purine metabolism. METHODS:In this observational study, we compared 21 adults with LND, 17 with LNV, and 33 age-, se...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000001128

    authors: Schretlen DJ,Varvaris M,Vannorsdall TD,Gordon B,Harris JC,Jinnah HA

    更新日期:2015-01-13 00:00:00

  • APOE epsilon2/epsilon4 polymorphism and cerebral microbleeds on gradient-echo MRI.

    abstract::The association of APOE genotypes with cerebral microbleeds (CMBs) was examined on the basis of the location of CMBs in 414 patients who were admitted primarily because of stroke. With respect to possession of the epsilon2 or epsilon4 allele, the adjusted odds ratio was 1.94 (1.05 to 3.58) for lobar CMBs but 1.21 (0.6...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000183311.48144.7f

    authors: Kim M,Bae HJ,Lee J,Kang L,Lee S,Kim S,Lee JE,Lee KM,Yoon BW,Kwon O,Koo JS,Kim BK

    更新日期:2005-11-08 00:00:00

  • Spatial disorientation in Alzheimer's disease: the remembrance of things passed.

    abstract:BACKGROUND:Patients with Alzheimer's disease (AD) and many older adults become lost even in familiar surroundings. This is commonly attributed to memory impairment, but it may reflect impaired spatial cognition. METHODS:The authors examined the role of memory, perceptual, and cognitive mechanisms in spatial disorienta...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.61.11.1491

    authors: Monacelli AM,Cushman LA,Kavcic V,Duffy CJ

    更新日期:2003-12-09 00:00:00

  • A reliable method for localizing deep intracranial sources of the EEG.

    abstract::We have demonstrated the reliability of a noninvasive method for successfully localizing the intracranial origin of the EEG. The dipole localization method (DLM) is a computer-assisted, mathematical method based on electrical field theory and is similar to localization methods currently used by electrocardiologists. I...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.35.12.1702

    authors: Smith DB,Sidman RD,Flanigin H,Henke J,Labiner D

    更新日期:1985-12-01 00:00:00