Hypertensive Disorders of Pregnancy and Cognitive Impairment: A Prospective Cohort Study.


OBJECTIVE:To determine the association between hypertensive disorders of pregnancy (HDP) and cognitive impairment 15 years after pregnancy, we measured cognitive performance in 115 women with a history of HDP and in 481 women with a previous normotensive pregnancy. METHODS:This was a nested cohort study embedded in a population-based prospective cohort from early pregnancy onwards. Cognitive function was assessed with cognitive tests 15 years after the index pregnancy (median 14.7 years, 90% range [13.9-16.1]). Cognitive performance was measured in different cognitive domains: executive function, processing speed, verbal memory, motor function, and visuospatial ability. A global cognition factor (g-factor) was derived from principal component analysis. RESULTS:Of the women with HDP, 80 (69.6%) had gestational hypertension (GH) and 35 (30.4%) had preeclampsia. Women with HDP had a lower g-factor than women with a previous normotensive pregnancy (mean -0.22, 90% range [-2.06-1.29]). HDP was negatively associated with the 15-word learning test: immediate recall (-0.25, 95% CI [-0.44 to -0.06]) and delayed recall (-0.30, 95% CI [-0.50 to -0.10]). Women with GH perform significantly worse on their 15-word learning test than women with a previous normotensive pregnancy. CONCLUSION:A history of HDP is independently associated with poorer working memory and verbal learning 15 years after pregnancy. This association is mainly driven by women with GH. Clinicians and women who experienced HDP should be aware of this risk.






Adank MC,Hussainali RF,Oosterveer LC,Ikram MA,Steegers EAP,Miller EC,Schalekamp-Timmermans S




Has Abstract


2021-02-02 00:00:00














  • Local alterations of hemostatic-fibrinolytic mechanisms in reforming subdural hematomas.

    abstract::Multiple chemical and coagulation determinations were undertaken on the subdural hematoma fluid from the reformed effusions of two patients. It was found that plasma or blood repeatedly reentered the subdural cavity. Coagulation studies compared the in vitro effects of subdural fluid with those of cerebrospinal fluid,...


    pub_type: 杂志文章


    authors: Labadie EL,Glover D

    更新日期:1975-07-01 00:00:00

  • 'Sympathetically maintained pain.' I. Phentolamine block questions the concept.

    abstract::Patients with "reflex sympathetic dystrophy" or "causalgia" underwent sympathetic blocks. In protocol A (77 patients), we infused placebo (saline) for 30 minutes followed by phentolamine (35 mg). In protocol B (23 patients), the saline phase was followed by double-blind infusion of phentolamine or phenylephrine (500 m...


    pub_type: 临床试验,杂志文章


    authors: Verdugo RJ,Ochoa JL

    更新日期:1994-06-01 00:00:00

  • Far-field somatosensory evoked potentials after stimulation of the tibial nerve.

    abstract::In 21 normal subjects, far-field somatosensory potentials were recorded from the scalp after stimulation of the tibial nerve at the ankle (tibial SEP). With the use of a knee reference contralateral to the side of stimulation, the tibial SEP consisted of three major positive peaks, P17, P24, and P31, and three additio...


    pub_type: 杂志文章


    authors: Yamada T,Machida M,Kimura J

    更新日期:1982-10-01 00:00:00

  • Visual agnosia without alexia.

    abstract::A 41-year-old man presented with bilateral posterior cerebral artery infarcts. He had visual object agnosia and prosopagnosia with preservation of reading abilities. There was also defective visual memory, topographic orientation, and color perception, as well as simultanagnosia. From the clinical facts and CT finding...


    pub_type: 杂志文章


    authors: Gomori AJ,Hawryluk GA

    更新日期:1984-07-01 00:00:00

  • Quantifying physical decline in juvenile neuronal ceroid lipofuscinosis (Batten disease).

    abstract:OBJECTIVE:To use the Unified Batten Disease Rating Scale (UBDRS) to measure the rate of decline in physical and functional capability domains in patients with juvenile neuronal ceroid lipofuscinosis (JNCL) or Batten disease, a neurodegenerative lysosomal storage disorder. We have evaluated the UBDRS in subjects with JN...


    pub_type: 杂志文章


    authors: Kwon JM,Adams H,Rothberg PG,Augustine EF,Marshall FJ,Deblieck EA,Vierhile A,Beck CA,Newhouse NJ,Cialone J,Levy E,Ramirez-Montealegre D,Dure LS,Rose KR,Mink JW

    更新日期:2011-11-15 00:00:00

  • CT and MRI findings among African-Americans with Alzheimer's disease, vascular dementia, and stroke without dementia.

    abstract::We compared CT and MRI findings among 78 Alzheimer's disease (AD), 66 vascular dementia (VaD), and 41 stroke without dementia (SWD) African-American patients to identify possible neuroimaging indicators of dementia. The patients with AD and VaD were generally older and less educated than those with SWD. VaD and SWD pa...


    pub_type: 杂志文章


    authors: Charletta D,Gorelick PB,Dollear TJ,Freels S,Harris Y

    更新日期:1995-08-01 00:00:00

  • Natural history of SMA IIIb: muscle strength decreases in a predictable sequence and magnitude.

    abstract:OBJECTIVE:To assess the natural progression of muscle weakness in spinal muscular atrophy (SMA) IIIb. METHODS:Ten patients with SMA IIIb were followed for at least 10 years. Age at disease onset varied between 9 and 18 years. Patients were initially seen 2 to 10 years after disease onset. They were evaluated at approx...


    pub_type: 杂志文章


    authors: Deymeer F,Serdaroglu P,Parman Y,Poda M

    更新日期:2008-08-26 00:00:00

  • New NBIA subtype: genetic, clinical, pathologic, and radiographic features of MPAN.

    abstract:OBJECTIVE:To assess the frequency of mutations in C19orf12 in the greater neurodegeneration with brain iron accumulation (NBIA) population and further characterize the associated phenotype. METHODS:Samples from 161 individuals with idiopathic NBIA were screened, and C19orf12 mutations were identified in 23 subjects. D...


    pub_type: 杂志文章


    authors: Hogarth P,Gregory A,Kruer MC,Sanford L,Wagoner W,Natowicz MR,Egel RT,Subramony SH,Goldman JG,Berry-Kravis E,Foulds NC,Hammans SR,Desguerre I,Rodriguez D,Wilson C,Diedrich A,Green S,Tran H,Reese L,Woltjer RL,Hayfli

    更新日期:2013-01-15 00:00:00

  • Mild cognitive impairment: incidence and vascular risk factors in a population-based cohort.

    abstract:OBJECTIVE:We examined the incidence of mild cognitive impairment (MCI) and its potential vascular risk factors in a prospective population-based study. METHODS:An age-stratified random population-based cohort (baseline n = 1,982), followed for up to 4 years, was annually assessed for cognitive and everyday functioning...


    pub_type: 杂志文章


    authors: Ganguli M,Fu B,Snitz BE,Hughes TF,Chang CC

    更新日期:2013-06-04 00:00:00

  • Monoamine neurotransmitters in diffuse reversible forebrain ischemia and early recirculation: increased dopaminergic activity.

    abstract::Regional levels of brain monoamines and their metabolites were examined in a rat model of reversible and diffuse forebrain ischemia with and without reperfusion. During ischemia, blood flow decreased by 87 to 95%, but recovered to control values during recirculation. Norepinephrine and serotonin decreased in the cereb...


    pub_type: 杂志文章


    authors: Harik SI,Yoshida S,Busto R,Ginsberg MD

    更新日期:1986-07-01 00:00:00

  • Symptomatic spinal epidural lipomatosis in a patient with Cushing's disease.

    abstract::Spinal epidural lipomatosis (SEL) is a rare complication of iatrogenic Cushing's syndrome (CS). There is only one case reported of symptomatic SEL in association with endogenous CS. We present a patient with compressive myeloradiculopathy due to SEL and Cushing's disease and suggest that in SEL of hypercortisolism, th...


    pub_type: 杂志文章


    authors: Sivakumar K,Sheinart K,Lidov M,Cohen B

    更新日期:1995-12-01 00:00:00

  • Psychological stress as risk factor for exacerbations in multiple sclerosis.

    abstract::We prospectively evaluated the relationship between a common psychological stressor and relapses in multiple sclerosis (MS) in a group of 32 MS patients exposed to the threat of missile attacks during the Persian Gulf War of 1991. The number of relapses during the war and the following 2 months was significantly lower...


    pub_type: 杂志文章


    authors: Nisipeanu P,Korczyn AD

    更新日期:1993-07-01 00:00:00

  • Single nucleotide polymorphism of TAG-1 influences IVIg responsiveness of Japanese patients with CIDP.

    abstract:OBJECTIVE:Chronic inflammatory demyelinating polyneuropathy (CIDP) is characterized by immune-mediated peripheral demyelination. Although corticosteroid, IV immunoglobulin (IVIg) and plasma exchange have been established as the most effective therapeutics, subpopulations of patients show little or no response to either...


    pub_type: 杂志文章


    authors: Iijima M,Tomita M,Morozumi S,Kawagashira Y,Nakamura T,Koike H,Katsuno M,Hattori N,Tanaka F,Yamamoto M,Sobue G

    更新日期:2009-10-27 00:00:00

  • Predictive value of the intracarotid amobarbital test in bihemispheric seizure onset.

    abstract::The intracarotid amobarbital test (IAT) is used to lateralize language function and assess hemispheric memory. In this study 23 non-lesional epileptic patients were evaluated. The magnitude of the difference in IAT scores between the two hemispheres was significantly greater in the patients whose seizures lateralized ...


    pub_type: 临床试验,杂志文章


    authors: Swearer JM,Kane KJ,Phillips CA,Weaver JP,Anderson TD,Lavoie MS

    更新日期:1999-01-15 00:00:00

  • Corpus callosotomy for epilepsy. I. Seizure effects.

    abstract::Twenty-two patients were analyzed 2 or more years after corpus callosum section (9 partial, 13 total). Forty-one percent had class 1 outcome (elimination of secondarily generalized and complex partial seizures), 32% had class 2 outcome (elimination of secondarily generalized seizures), and 27% had class 3 outcome (no ...


    pub_type: 杂志文章


    authors: Spencer SS,Spencer DD,Williamson PD,Sass K,Novelly RA,Mattson RH

    更新日期:1988-01-01 00:00:00

  • Evidence for widespread movement-associated functional MRI changes in patients with PPMS.

    abstract:BACKGROUND:Previous work has suggested that functional reorganization of cortical motor areas might have a role in limiting the motor deficits in patients with MS. OBJECTIVE:To test whether movement-associated cortical changes in MS might extend beyond the "classic" motor areas and involve sites for multimodal integra...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rocca MA,Matthews PM,Caputo D,Ghezzi A,Falini A,Scotti G,Comi G,Filippi M

    更新日期:2002-03-26 00:00:00

  • Motor axon loss is associated with hand dysfunction in Charcot-Marie-Tooth disease 1a.

    abstract:BACKGROUND:Charcot Marie Tooth type 1a (CMT1a) is a primarily demyelinating neuropathy, characterized by slowly progressive muscle weakness, atrophy, and sensory loss, and is most pronounced in both feet and hands. There is increasing evidence that muscle weakness is determined by motor axonal dysfunction. OBJECTIVE:T...


    pub_type: 杂志文章


    authors: Videler AJ,van Dijk JP,Beelen A,de Visser M,Nollet F,van Schaik IN

    更新日期:2008-10-14 00:00:00

  • Narp immunostaining of human hypocretin (orexin) neurons: loss in narcolepsy.

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    pub_type: 杂志文章


    authors: Blouin AM,Thannickal TC,Worley PF,Baraban JM,Reti IM,Siegel JM

    更新日期:2005-10-25 00:00:00

  • Singing paraplegia: a distinctive manifestation of a spinal dural arteriovenous fistula.

    abstract::The unique case of a baritone with a spinal dural arteriovenous fistula (SDAVF) causing recurrent, acute paraplegia during singing is described. This case underscores the presence of impaired venous drainage in these lesions and the high level of clinical suspicion required for their diagnosis in patients with any mye...


    pub_type: 杂志文章


    authors: Khurana VG,Perez-Terzic CM,Petersen RC,Krauss WE

    更新日期:2002-04-23 00:00:00

  • Phase I/II multicenter ketogenic diet study for adult superrefractory status epilepticus.

    abstract:OBJECTIVE:To investigate the feasibility, safety, and efficacy of a ketogenic diet (KD) for superrefractory status epilepticus (SRSE) in adults. METHODS:We performed a prospective multicenter study of patients 18 to 80 years of age with SRSE treated with a KD treatment algorithm. The primary outcome measure was signif...


    pub_type: 杂志文章,多中心研究


    authors: Cervenka MC,Hocker S,Koenig M,Bar B,Henry-Barron B,Kossoff EH,Hartman AL,Probasco JC,Benavides DR,Venkatesan A,Hagen EC,Dittrich D,Stern T,Radzik B,Depew M,Caserta FM,Nyquist P,Kaplan PW,Geocadin RG

    更新日期:2017-03-07 00:00:00

  • Subacute encephalomyelitis of AIDS and its relation to HTLV-III infection.

    abstract::Subacute encephalitis, characterized by demyelination, gliosis of the gray and white matter, focal necrosis, microglial nodules, atypical oligodendrocyte nuclei, and multinucleation of cells, was present in 27 of 30 (90%) autopsied patients with acquired immune deficiency syndrome (AIDS) or AIDS-related complex. Subac...


    pub_type: 杂志文章


    authors: de la Monte SM,Ho DD,Schooley RT,Hirsch MS,Richardson EP Jr

    更新日期:1987-04-01 00:00:00

  • Efficacy of rapid IV administration of valproic acid for status epilepticus.

    abstract::Although not approved by the US Food and Drug Administration for the treatment of status epilepticus (SE), valproic acid (VPA) is an emerging option for this purpose. The authors reviewed 63 patients (30 men) with SE treated with IV VPA (average dose, 31.5 mg/kg). Analysis of demographic, clinical, and treatment infor...


    pub_type: 杂志文章,评审


    authors: Limdi NA,Shimpi AV,Faught E,Gomez CR,Burneo JG

    更新日期:2005-01-25 00:00:00

  • Current treatment pathways in ALS: a European perspective.

    abstract::This article presents the findings relating to the European subgroup of 91 patients in an international survey of the current diagnosis and treatment of patients with amyotrophic lateral sclerosis (ALS). The mean time between first symptoms and first consultation with a physician was 4.9 months, and mean delay in seei...


    pub_type: 杂志文章


    authors: Dengler R

    更新日期:1999-01-01 00:00:00

  • Experimental spinal cord injury: effects of trauma or ischemia on TRH and muscarinic receptors.

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    pub_type: 杂志文章


    authors: Faden AI,Pilotte NS,Burt DR

    更新日期:1986-05-01 00:00:00

  • Migraine in pregnancy.

    abstract::Migraine does not increase the risk for complications of pregnancy for the mother or for the fetus: the incidences of toxemia, miscarriages, abnormal labour, congenital anomalies, and stillbirths are comparable to those of the general population. Several retrospective studies have shown a tendency for migraine to impr...


    pub_type: 杂志文章,评审


    authors: Aubé M

    更新日期:1999-01-01 00:00:00

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    pub_type: 杂志文章


    authors: Pasi M,Charidimou A,Boulouis G,Auriel E,Ayres A,Schwab KM,Goldstein JN,Rosand J,Viswanathan A,Pantoni L,Greenberg SM,Gurol ME

    更新日期:2018-01-09 00:00:00

  • Association of orthostatic hypotension with incident dementia, stroke, and cognitive decline.

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    pub_type: 杂志文章


    authors: Rawlings AM,Juraschek SP,Heiss G,Hughes T,Meyer ML,Selvin E,Sharrett AR,Windham BG,Gottesman RF

    更新日期:2018-08-21 00:00:00

  • Diffuse "anoxic" myelopathy.

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    pub_type: 杂志文章


    authors: Azzarelli B,Roessmann U

    更新日期:1977-11-01 00:00:00

  • Traumatic brainstem deafness with normal brainstem auditory evoked potentials.

    abstract::A 48-year-old woman became totally deaf after a head injury. Magnetic resonance imaging showed bilateral contusions around the inferior colliculi and the brainstem auditory evoked potentials (BAEP) failed to show any abnormality. This case demonstrates that small, symmetrical, bilateral lesions around the inferior col...


    pub_type: 杂志文章


    authors: Hu CJ,Chan KY,Lin TJ,Hsiao SH,Chang YM,Sung SM

    更新日期:1997-05-01 00:00:00

  • Capecitabine-induced multifocal leukoencephalopathy: a report of five cases.

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    pub_type: 杂志文章


    authors: Videnovic A,Semenov I,Chua-Adajar R,Baddi L,Blumenthal DT,Beck AC,Simuni T,Futterer S,Gradishar W,Tellez C,Raizer JJ

    更新日期:2005-12-13 00:00:00