Abstract:
BACKGROUND:The prevalence of symptoms suggesting distal symmetric polyneuropathy (DSP) was reported to be higher among deployed veterans (DV) to the Persian Gulf in 1990-1991 than to control non-deployed veterans (NDV). The authors therefore compared the prevalence of DSP by direct examination of DV and their spouses to control NDV and spouses. METHODS:The authors performed standardized neurologic examinations on 1,061 DV and 1,128 NDV selected from a cohort of veterans who previously participated in a national mail and telephone survey. Presence of DSP was evaluated by history, physical examination, and standardized electrophysiologic assessment of motor and sensory nerves. Similar examinations were performed without electrophysiologic tests in 484 DV spouses and 533 NDV spouses. Statistical analyses were performed with appropriate adjustments for the stratified sampling scheme. RESULTS:No differences between adjusted population prevalence of DSP in DV and NDV were found by electrophysiology (3.7% vs 6.3%, p = 0.07), by neurologic examination (3.1% vs 2.6%, p = 0.60), or by the methods combined (6.3% vs 7.3%, p = 0.47). Excluding veterans with non-military service related diseases that may cause DSP did not alter outcomes. DV potentially exposed to neurotoxins from the Khamisiyah ammunition depot explosion did not significantly differ in DSP prevalence compared to non-exposed DV. The prevalence of DSP in DV spouses did not differ from NDV spouses (2.7% vs 3.2%, p = 0.64). CONCLUSIONS:Neither veterans deployed during the Gulf War era nor their spouses had a higher prevalence of DSP compared to NDV and spouses.
journal_name
Neurologyjournal_title
Neurologyauthors
Davis LE,Eisen SA,Murphy FM,Alpern R,Parks BJ,Blanchard M,Reda DJ,King MK,Mithen FA,Kang HKdoi
10.1212/01.wnl.0000138426.88460.cbsubject
Has Abstractpub_date
2004-09-28 00:00:00pages
1070-7issue
6eissn
0028-3878issn
1526-632Xpii
63/6/1070journal_volume
63pub_type
历史文章,杂志文章,多中心研究相关文献
NEUROLOGY文献大全abstract::Four patients with a clinical syndrome closely resembling amyotrophic lateral sclerosis recovered completely, without treatment, 5 to 12 months after onset. Electrodiagnostic tests revealed acute and chronic denervation, with normal motor and sensory nerve conduction studies. The CSF was normal, and tests for paraprot...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.10.1541
更新日期:1991-10-01 00:00:00
abstract::Using the centralized diagnostic data resource for the population of Rochester, Minnesota, we determined the prevalence of medically diagnosed dementia for this community. There were 289 individuals with dementia who were residing in Rochester on January 1, 1975: 208 women and 81 men. The overall age- and sex-adjusted...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.6.773
更新日期:1989-06-01 00:00:00
abstract:OBJECTIVE:To describe a new familial association of late-onset dementia, patchy leukoencephalopathy, intracerebral hemorrhages, bilateral occipital calcifications (BOC), and external carotid artery dysplasia (ECAD). METHODS:At age 62, the proband, who was of Spanish descent, had left temporal hemorrhage in a backgroun...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.11.1661
更新日期:2000-12-12 00:00:00
abstract::We report a family with Machado-Joseph disease (MJD) that was previously diagnosed with dentatorubral-pallidoluysian atrophy (DRPLA), on the basis of the neuropathologic findings. Because the clinical and pathologic reevaluation strongly suggested a diagnosis of MJD, we conducted a genetic study in the family. Two pat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.4.1154
更新日期:1996-04-01 00:00:00
abstract::Migraine is associated with stimulus hypersensitivity, increased evoked cortical responses, and abnormal 5-HT levels in peripheral blood. We studied cortical auditory evoked potentials (AEPs) between attacks in 35 patients suffering from migraine without aura (MO, n = 25) or with aura (MA, n = 10) and in 25 healthy vo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.5.1404
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND:According to widely used criteria (Bohan and Peter criteria, 1975), dermatomyositis (DM) is differentiated from polymyositis (PM) only by skin changes. More recent criteria also include histopathologic characteristics enabling the distinction between PM and DM and the differentiation of sporadic inclusion bo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.61.3.316
更新日期:2003-08-12 00:00:00
abstract::We studied 20 patients with an acute parietal stroke with hemisensory disturbances but no visual field deficit and no or only slight motor weakness, without thalamic involvement on CT or MRI and found three main sensory syndromes. (1) The pseudothalamic sensory syndrome consists of a faciobrachiocrural impairment of e...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.10.1942
更新日期:1993-10-01 00:00:00
abstract::We present a clinical and morphological study concerning a kindred with slowly progressive X-linked muscular dystrophy (Becker type). Five males were affected; one died of heart failure at age 16. Severe and early cardiac disorder is unusual in this type of muscular dystrophy, and death at such an early age had not be...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.8.1144
更新日期:1979-08-01 00:00:00
abstract:BACKGROUND:Long-term treatment with valproate (VPA) or carbamazepine (CBZ) may induce reproductive endocrine disorders in patients with epilepsy. METHODS:Serum concentrations of reproductive hormones were studied in 17 women and 22 men with recently diagnosed epilepsy before they started either VPA or CBZ medication, ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.3.440
更新日期:2001-08-14 00:00:00
abstract::Impairment of object-bound movements of the hand performed under visual guidance ("optic ataxia") was a prominent sign in a patient with bilateral circumscribed infarctions in the posterior watershed territory. The sign was interpreted as resulting from defective integration of panoramic visual information with propri...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.2.170
更新日期:1979-02-01 00:00:00
abstract:BACKGROUND:The clinical characteristics of Tourette syndrome (TS) present challenges for the systematic determination of whether individuals are affected and severity. Vocal and motor tics wax and wane, decrease over time, and may be voluntarily suppressible, and therefore may be absent at interview. Current instrument...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.9.2108
更新日期:1999-12-10 00:00:00
abstract::Recent genetic studies show that the apolipoprotein E epsilon 4 allele (ApoE-epsilon 4) is a risk factor for Alzheimer's disease (AD). If ApoE-epsilon 4 individuals develop AD as they get older, we would expect a decrease in ApoE-epsilon 4 allele frequency with increasing age. We found a marked decline in ApoE-epsilon...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.8.1513
更新日期:1994-08-01 00:00:00
abstract::A 30-year-old woman was thought to have Friedreich's disease because of progressive ataxia, dysarthria, and titubation from age 3 years. Her diet was normal, and there were neither symptoms nor laboratory evidence of liver disease or fat malabsorption. Serum vitamin E content and the ratio of serum vitamin E to total ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.1.68
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVE:To assess the natural progression of muscle weakness in spinal muscular atrophy (SMA) IIIb. METHODS:Ten patients with SMA IIIb were followed for at least 10 years. Age at disease onset varied between 9 and 18 years. Patients were initially seen 2 to 10 years after disease onset. They were evaluated at approx...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000324623.89105.c4
更新日期:2008-08-26 00:00:00
abstract:OBJECTIVE:To describe clinical characteristics, imaging findings, morbidity, and mortality in a single-center cohort of 12 pediatric cavernous sinus thrombosis cases and to review all cases available in recent English literature. METHODS:Clinical data and radiographic studies on 12 cases from our institution were anal...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0000000000001886
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Tricyclic antidepressants (TCA) are often used in the treatment of painful polyneuropathy. Venlafaxine is a serotonin and weak noradrenaline reuptake inhibitor antidepressant with a different profile of other pharmacologic actions from those of TCA. OBJECTIVE:To test if venlafaxine would relieve painful pol...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/01.wnl.0000058749.49264.bd
更新日期:2003-04-22 00:00:00
abstract:OBJECTIVE:To compare the efficacy and safety of oral anticoagulants vs antiplatelets in patients with stroke and atherosclerotic plaques in the aortic arch or cervical or intracranial arteries, collectively described as supracardiac atherosclerosis. METHODS:We searched PubMed and Scopus until August 28, 2019, for rand...
journal_title:Neurology
pub_type: 杂志文章,meta分析
doi:10.1212/WNL.0000000000009823
更新日期:2020-08-04 00:00:00
abstract::Revascularization time windows for patients with acute ischemic stroke are generally restricted to 8 hours. Later treatment attempts require more accurate prediction of risk and benefit, as safety and efficacy at these time strata are less well demonstrated. Advanced imaging techniques identify irreversible infarction...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0b013e3182695826
更新日期:2012-09-25 00:00:00
abstract:OBJECTIVE:The authors imaged the medial longitudinal fasciculus (MLF) in 58 patients with MS and chronic internuclear ophthalmoparesis (INO) to determine which MRI technique best shows the characteristic lesion associated with this ocular motor syndrome. METHODS:Using quantitative infrared oculography, the authors det...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.5.762
更新日期:2001-09-11 00:00:00
abstract::We evaluated the ability of nurse clinicians to assess parkinsonian signs in older persons with a modified version of the motor section of the Unified Parkinson's Disease Rating Scale (UPDRS). After completing a structured training protocol, three nurse clinicians and a neurologist with expertise in movement disorders...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.6.1580
更新日期:1997-12-01 00:00:00
abstract::We tested the hypothesis that asymptomatic carriers of dopa-responsive dystonia (DRD) have increased dopamine D2 receptors in the striatum that protect them from the clinical manifestations of dopaminergic deficiency. We examined striatal D2-receptor binding in (1) symptomatic subjects (treated and untreated) and (2) ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.4.1028
更新日期:1998-04-01 00:00:00
abstract::The authors measured the association of early ischemic change on CT scan, measured using the Alberta Stroke Programme Early CT score (ASPECTS), and functional outcome in 825 patients with anterior circulation stroke treated with IV thrombolysis within 3 hours of onset. ASPECTS predicted outcome in a graded fashion (li...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000228221.44334.73
更新日期:2006-08-08 00:00:00
abstract:OBJECTIVE:To determine the stage of training at which neurology residents should achieve individual elements of the Accreditation Council for Graduate Medical Education neurology Milestones and to examine the relationship between perceived importance of Milestones and the stage by which they should be achieved. METHOD...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006361
更新日期:2018-10-16 00:00:00
abstract:OBJECTIVES:To examine the illusional sensation of movement evoked by vibration of an immobilized arm. METHODS:Patients with idiopathic focal dystonia were compared with those with idiopathic PD and with patients with dystonia secondary to PD. A 100-Hz transcutaneous vibratory stimulus was applied to the biceps brachii...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.8.1794
更新日期:1999-11-10 00:00:00
abstract:OBJECTIVE:The current literature provides discrepant results regarding preoperative sociodemographic and clinical factors, and no information about preoperative cerebral metabolic patterns associated with apathy after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson disease. METHODS:To resolve this is...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000941
更新日期:2014-10-28 00:00:00
abstract::To assess reversibility of focal cerebral ischemia, we performed a neurologic and pathologic study of 27 monkeys subjected to temporary middle cerebral artery occlusion. An implanted snare ligature occluded the artery in awake monkeys for 30 minutes, 4 hours, 8 hours, 16 hours, 24 hours, or permanently. Serial neurolo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.10.1295
更新日期:1981-10-01 00:00:00
abstract:BACKGROUND:Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is a rare multisystem disorder associated with plasma cell dyscrasia. There is increasing evidence that high-dose chemotherapy with autologous peripheral blood stem cell transplantation (Auto-PBSCT) is an efficacious t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000323811.42080.a4
更新日期:2008-11-18 00:00:00
abstract:OBJECTIVE:To assess the possible abnormalities in the baroreflex modulation of both the heart and the arterial vasculature, in order to better evaluate the role of baroreflex abnormalities in the generation of the cardiovascular symptoms and complications affecting the familial dysautonomia (FD) patient. METHODS:Twent...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000142034.92124.6a
更新日期:2004-10-26 00:00:00
abstract::The one-and-a-half syndrome is a clinical disorder of extraocular movements characterized by a conjugate horizontal gaze palsy in one direction plus an internuclear ophthalmoplegia in the other. The syndrome is usually due to a single unilateral lesion of the paramedian pontine reticular formation or the abducens nucl...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.8.971
更新日期:1983-08-01 00:00:00
abstract::Menstrual disorders and infertility are common among women with epilepsy of temporal lobe origin (TLE). Reproductive endocrine disorders may be the cause. Polycystic ovarian syndrome (PCO) and hypothalamic amenorrhea (hypogonadotropic hypogonadism, HH), in particular, are significantly overrepresented and attributable...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.2.306
更新日期:1994-02-01 00:00:00