Familial language network vulnerability in primary progressive aphasia.

abstract：:We review adjunctive ketogenic diet (KD) and modified Atkins diet (MAD) treatment of refractory epilepsy in adults. Only a few studies have been published, all open-label. Because of the disparate, uncontrolled nature of the studies, we analyzed all studies individually, without a meta-analysis. Across all studies, 32...

journal_title：Neurology

authors： Klein P,Tyrlikova I,Mathews GC

更新日期：2014-11-18 00:00:00

abstract：OBJECTIVE:To determine how memory-encoding tasks elicit functional perfusion change in subjects with amnestic mild cognitive impairment (aMCI). METHODS:Twelve subjects with aMCI and 14 age-matched cognitively normal (CN) subjects were recruited for this study. Arterial spin-labeling perfusion MRI (ASL-MRI) was employe...

journal_title：Neurology

authors： Xu G,Antuono PG,Jones J,Xu Y,Wu G,Ward D,Li SJ

更新日期：2007-10-23 00:00:00

abstract：OBJECTIVE:To study the presenting features and value of routine diagnostic procedures in patients with leptomeningeal metastases (LMM) related to the primary malignancy to improve diagnostic assessment. METHODS:The authors studied the presenting features and value of routine diagnostic procedures in relation to the hi...

journal_title：Neurology

authors： van Oostenbrugge RJ,Twijnstra A

更新日期：1999-07-22 00:00:00

abstract：OBJECTIVE:To determine whether cardiac magnetic resonance imaging (CMR) could be useful in identifying previously undiagnosed cardiomyopathies in a cohort of patients with ischemic stroke who underwent standard etiologic investigation and to describe the type and frequency of these cardiomyopathies. METHODS:We perform...

journal_title：Neurology

authors： Fonseca AC,Marto JP,Pimenta D,Guimarães T,Alves PN,Inácio N,Viana-Baptista M,Pinho E Melo T,Pinto FJ,Ferro JM,Almeida AG

更新日期：2020-01-07 00:00:00

abstract：:"Healthy citizens are the greatest asset any country can have."-Sir Winston Churchill. ...

journal_title：Neurology

authors： Sharma M

更新日期：2014-01-28 00:00:00

abstract：OBJECTIVE:The NIH Stroke Scale (NIHSS) may not appropriately assess the spectrum of posterior circulation (PC)-related neurologic deficits. We determined the cutoff baseline NIHSS score that predicts independent daily life activity during the chronic stage in anterior circulation (AC) vs PC ischemic strokes. METHODS:A...

journal_title：Neurology

authors： Sato S,Toyoda K,Uehara T,Toratani N,Yokota C,Moriwaki H,Naritomi H,Minematsu K

更新日期：2008-06-10 00:00:00

abstract：:We treated 64 emergency room patients with a primary vascular headache with dihydroergotamine (DHE), meperidine, or butorphanol. Post-treatment pain scores were lowest in the DHE group (p less than 0.01). Eight of 21 patients receiving DHE had greater than 90% reduction in pain compared with three of 19 patients recei...

journal_title：Neurology

authors： Belgrade MJ,Ling LJ,Schleevogt MB,Ettinger MG,Ruiz E

更新日期：1989-04-01 00:00:00

abstract：OBJECTIVES:To examine the illusional sensation of movement evoked by vibration of an immobilized arm. METHODS:Patients with idiopathic focal dystonia were compared with those with idiopathic PD and with patients with dystonia secondary to PD. A 100-Hz transcutaneous vibratory stimulus was applied to the biceps brachii...

journal_title：Neurology

authors： Rome S,Grünewald RA

更新日期：1999-11-10 00:00:00

abstract：:We compared the neurologic and cognitive performance of 15 young veterans who suffered unilateral penetrating missile wounds to the basal forebrain 15 years ago in the Vietnam War with uninjured controls and patients with lesions elsewhere in the brain. The subjects performed worse on tests of episodic memory, reasoni...

journal_title：Neurology

authors： Salazar AM,Grafman J,Schlesselman S,Vance SC,Mohr JP,Carpenter M,Pevsner P,Ludlow C,Weingartner H

更新日期：1986-04-01 00:00:00

abstract：:The technique of intrathecal enhancement using metrizamide (Amipaque) combined with CT imaging enables both the morphologic and dynamic (serial) evaluation of the intracranial cerebrospinal fluid pathways. Three distinct metrizamide CT cisternographic patterns (delayed, intermediate, and normal) emerge in pediatric pa...

journal_title：Neurology

authors： Drayer BP,Rosenbaum AE

更新日期：1978-01-01 00:00:00

abstract：:Dopa-responsive dystonia (DRD) is an autosomal dominant disorder typically presenting as dystonia with diurnal variability. Described is an 8-year-old boy who had had waddling gait, generalized hypotonia, and proximal weakness since early childhood. He responded well to low-dose L-dopa. He had a point mutation of the ...

journal_title：Neurology

authors： Kong CK,Ko CH,Tong SF,Lam CW

更新日期：2001-09-25 00:00:00

abstract：BACKGROUND:Virtually all adult studies of APOE genotypes and cognition have included individuals over 60. In older adults, epsilon 4 carriers may manifest greater cognitive asymmetries than non-epsilon 4 carriers even in the absence of overall mean differences. General cognitive ability may also be affected by aging an...

journal_title：Neurology

authors： Schultz MR,Lyons MJ,Franz CE,Grant MD,Boake C,Jacobson KC,Xian H,Schellenberg GD,Eisen SA,Kremen WS

更新日期：2008-05-06 00:00:00

abstract：OBJECTIVE:To determine factors (including the role of specific disease modulatory treatments [DMTs]) associated with (1) baseline, (2) on-treatment, and (3) change (from treatment start to on-treatment assessment) in plasma neurofilament light chain (pNfL) concentrations in relapsing-remitting multiple sclerosis (RRMS)...

journal_title：Neurology

authors： Delcoigne B,Manouchehrinia A,Barro C,Benkert P,Michalak Z,Kappos L,Leppert D,Tsai JA,Plavina T,Kieseier BC,Lycke J,Alfredsson L,Kockum I,Kuhle J,Olsson T,Piehl F

更新日期：2020-03-17 00:00:00

abstract：:To learn if limb-kinetic apraxia (LKA) is associated with Parkinson disease (PD), participants with PD (on medications) and control subjects performed finger tapping (FT), measuring movement speed, and performed coin rotation (CR), measuring precise coordinated but independent finger movements and speed. There were no...

journal_title：Neurology

authors： Quencer K,Okun MS,Crucian G,Fernandez HH,Skidmore F,Heilman KM

更新日期：2007-01-09 00:00:00

abstract：:Morphologic findings of thymuses from 32 anti-acetylcholine receptor (AChR)-negative myasthenia gravis patients, 12 with and 20 without antibodies against the muscle-specific kinase (MuSK), were compared with those from 30 AChR-positive subjects. In contrast with the high frequency of thymic hyperplastic changes in AC...

journal_title：Neurology

authors： Lauriola L,Ranelletti F,Maggiano N,Guerriero M,Punzi C,Marsili F,Bartoccioni E,Evoli A

更新日期：2005-02-08 00:00:00

abstract：:In a prospective cohort of 124 encephalopathic term infants, six infants had an acute focal stroke. All six encephalopathic patients with strokes presented with seizures. Neurodevelopmental outcome at 30 months was abnormal in all six patients and significantly worse when compared with the entire cohort overall. These...

journal_title：Neurology

authors： Ramaswamy V,Miller SP,Barkovich AJ,Partridge JC,Ferriero DM

更新日期：2004-06-08 00:00:00

abstract：:[Methyl-3H]epsilon-N-trimethyl-L-lysine was administered to patients with primary systemic carnitine deficiency and to controls. In both groups, labeled carnitine appeared in blood and urine within 2 hours, and the specific radioactivity of urinary carnitine peaked between 2 and 6 hours. The specific radioactivity of ...

journal_title：Neurology

authors： Rebouche CJ,Engel AG

更新日期：1981-07-01 00:00:00

abstract：:We reviewed the clinical and laboratory features of 81 patients who had trigeminal sensory neuropathy (TSN) and a connective tissue disease (CTD). The neuropathy developed before the symptoms of CTD in 6/81 patients (7%), and in 38/81 patients (47%) TSN and CTD were diagnosed concurrently. The most frequently associat...

journal_title：Neurology

authors： Hagen NA,Stevens JC,Michet CJ Jr

更新日期：1990-06-01 00:00:00

abstract：:No uniformly accepted hypothesis explains the genesis and rupture of intracranial aneurysms. We followed 5,184 men and women prospectively for 26 years; 36 cases of aneurysmal subarachnoid hemorrhage (SAH) accounted for 62% of all intracranial hemorrhages. Blood pressure before SAH was higher in these patients than in...

journal_title：Neurology

authors： Sacco RL,Wolf PA,Bharucha NE,Meeks SL,Kannel WB,Charette LJ,McNamara PM,Palmer EP,D'Agostino R

更新日期：1984-07-01 00:00:00

abstract：:Although the long-term effects of acute anoxia have been studied, the effects of chronic hypoxia on the developing human brain have received little attention. We studied children with a cyanotic congenital heart defect to assess the impact of chronic hypoxia by eight measures: neurologic examination, visual evoked res...

journal_title：Neurology

authors： O'Dougherty M,Wright FS,Loewenson RB,Torres F

更新日期：1985-01-01 00:00:00

abstract：:Free amino acid determinations in the cerebrospinal fluid of patients with Parkinson's disease or other extrapyramidal disorders showed that in both groups most amino acids were increased. Significantly increased amino acids were neutral and basic amino acids. Amino acid clusters were present and corresponded with the...

journal_title：Neurology

authors： Lakke JP,Teelken AW

更新日期：1976-05-01 00:00:00

abstract：OBJECTIVE:Causes of benign positional vertigo (BPV) are mostly unknown. The aim of this study was to elucidate an association of osteoporosis with idiopathic BPV. METHODS:Two hundred nine consecutive patients with a confirmed diagnosis of idiopathic BPV underwent bone mineral densitometry of anterior-posterior lumbar ...

journal_title：Neurology

authors： Jeong SH,Choi SH,Kim JY,Koo JW,Kim HJ,Kim JS

更新日期：2009-03-24 00:00:00

abstract：OBJECTIVE:To assess the expression of heat shock proteins (HSP) in glioma cells in vitro and in vivo and to examine their role in resistance to apoptosis. BACKGROUND:HSP are expressed in response to various forms of stress. Constitutive HSP expression may confer resistance to cytotoxic stimuli in human cancers. METHO...

journal_title：Neurology

authors： Hermisson M,Strik H,Rieger J,Dichgans J,Meyermann R,Weller M

更新日期：2000-03-28 00:00:00

abstract：OBJECTIVE:SCN8A encodes the sodium channel voltage-gated α8-subunit (Nav1.6). SCN8A mutations have recently been associated with epilepsy and neurodevelopmental disorders. We aimed to delineate the phenotype associated with SCN8A mutations. METHODS:We used high-throughput sequence analysis of the SCN8A gene in 683 pat...

journal_title：Neurology

authors： Larsen J,Carvill GL,Gardella E,Kluger G,Schmiedel G,Barisic N,Depienne C,Brilstra E,Mang Y,Nielsen JE,Kirkpatrick M,Goudie D,Goldman R,Jähn JA,Jepsen B,Gill D,Döcker M,Biskup S,McMahon JM,Koeleman B,Harris M,Bra

更新日期：2015-02-03 00:00:00

abstract：:The authors report the neuropathologic findings in a case of Sneddon's syndrome. There were multiple small, predominantly cortical, infarcts, with focal hyperplasia and fibrotic occlusion of arterial vessels in the superficial white matter, cortex, and leptomeninges. A very occasional arterial thrombus was seen. These...

journal_title：Neurology

authors： Hilton DA,Footitt D

更新日期：2003-04-08 00:00:00

abstract：:We have performed positron emission tomography (PET) with 2-deoxy-2[18F]fluoro-D-glucose (FDG) in eight infants and children (aged 18 days to 5 years) with medically refractory epilepsy of neonatal onset. It was hypothesized that in at least some of these infants a surgical approach (focal resection, cerebral hemisphe...

journal_title：Neurology

authors： Chugani HT,Shewmon DA,Peacock WJ,Shields WD,Mazziotta JC,Phelps ME

更新日期：1988-08-01 00:00:00

abstract：OBJECTIVE:To report 2 patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who presented acutely with Miller Fisher syndrome and polyneuritis cranialis, respectively. METHODS:Patient data were obtained from medical records from the University Hospital "Príncipe de Asturias," Alcalá de He...

journal_title：Neurology

authors： Gutiérrez-Ortiz C,Méndez-Guerrero A,Rodrigo-Rey S,San Pedro-Murillo E,Bermejo-Guerrero L,Gordo-Mañas R,de Aragón-Gómez F,Benito-León J

更新日期：2020-08-04 00:00:00

abstract：BACKGROUND:Clinical trials involving patients with glioblastoma (GBM) distinguish cohorts who are treated with enzyme-inducing anticonvulsants (EIAC). Such anticonvulsants induce hepatic P450 microsomal enzymes, which accelerate the metabolism of certain chemotherapy and molecular targeted agents. However, the resultan...

journal_title：Neurology

authors： Jaeckle KA,Ballman K,Furth A,Buckner JC

更新日期：2009-10-13 00:00:00

abstract：OBJECTIVE:To investigate the possible association of persistent enterovirus (EV) infection with the development of ALS. BACKGROUND:Although ALS is a clinically well-defined motor neuron disease, little is known about the etiology and pathogenesis of the sporadic cases. Among the different causes that have been hypothe...

journal_title：Neurology

authors： Berger MM,Kopp N,Vital C,Redl B,Aymard M,Lina B

更新日期：2000-01-11 00:00:00

abstract：:Delusions and other manifestations of psychotic behavior are common side effects in Parkinson's disease (PD) patients chronically treated with dopaminergic drugs. Clozapine, a dibenzodiazepine derivative, is an antipsychotic drug largely devoid of extrapyramidal side effects. We evaluated the effects of low doses of c...

journal_title：Neurology

authors： Rabey JM,Treves TA,Neufeld MY,Orlov E,Korczyn AD

更新日期：1995-03-01 00:00:00