Naming vs knowing faces in primary progressive aphasia: a tale of 2 hemispheres.


OBJECTIVES:This study examines the anatomical correlates of naming vs recognizing faces using a novel measure that utilizes culturally relevant and age-appropriate items, the Northwestern University Famous Faces (NUFFACE) Test, in primary progressive aphasia (PPA), a syndrome characterized by progressive language deficits and associated with cortical atrophy in areas important for word and object representations. METHODS:NUFFACE Test performance of 27 controls (mean age 62.3 years) was compared with that of 30 patients with PPA (mean age 62 years). Associations between NUFFACE Test performance and cortical thickness measures were quantified within the PPA group. RESULTS:Patients with PPA displayed significant impairment on the NUFFACE Test, demonstrating that it is a useful measure of famous-face identification for individuals with relatively young-onset dementias. Despite widespread distribution of atrophy in the PPA group, face naming impairments were correlated with atrophy of the left anterior temporal lobe while face recognition impairments were correlated with bitemporal atrophy. CONCLUSIONS:In addition to their clinical relevance for highlighting the distinction between face naming and recognition impairments in individuals with young-onset dementia, these findings add new insights into the dissociable clinico-anatomical substrates of lexical retrieval and object knowledge.






Gefen T,Wieneke C,Martersteck A,Whitney K,Weintraub S,Mesulam MM,Rogalski E




Has Abstract


2013-08-13 00:00:00














  • Edema associated with calcified lesions in neurocysticercosis.

    abstract:OBJECTIVE:To determine serial MRI and CT abnormalities around calcified cysts due to cysticercosis in previously treated patients during periods of seizure activity. BACKGROUND:Some patients with calcified lesions due to cysticercosis have seizures. How and why seizures occur in this setting are unknown. METHODS:Thre...


    pub_type: 杂志文章


    authors: Nash TE,Patronas NJ

    更新日期:1999-09-11 00:00:00

  • Juan Valverde de Hamusco's unauthorized reproduction of a brain dissection by Andreas Vesalius.

    abstract:OBJECTIVE:The objective of the present work is to examine images of the brain dissection by Flemish-born anatomist Andreas Vesalius (1514-1564) as originally represented in the Fabrica (1543), and later copied without Vesalius' permission by Spanish anatomist Juan Valverde de Hamusco (c1525-c1587) in Historia de la com...


    pub_type: 传,历史文章,杂志文章


    authors: Lanska DJ,Lanska JR

    更新日期:2013-02-26 00:00:00

  • 18F-fluorodopa PET study of striatal dopamine uptake in the diagnosis of dementia with Lewy bodies.

    abstract::Using (18)F-fluorodopa PET and a constant 0.0062 influx rate in the putamen, dementia with Lewy bodies (n = 7) was distinguished from AD (n = 10) with a sensitivity of 86% and a specificity of 100%. A constant 0.0071 influx rate in the caudate yielded a sensitivity of 71% and a specificity of 100% for distinction of t...


    pub_type: 杂志文章


    authors: Hu XS,Okamura N,Arai H,Higuchi M,Matsui T,Tashiro M,Shinkawa M,Itoh M,Ido T,Sasaki H

    更新日期:2000-11-28 00:00:00

  • Development and initial validation of a screening tool for Parkinson disease surgical candidates.

    abstract::As there is currently no standardized assessment tool for evaluating Parkinson disease (PD) patients for deep brain stimulation (DBS), the authors developed the Florida Surgical Questionnaire for Parkinson Disease (FLASQ-PD). Part I of the study was a retrospective analysis of 174 patients presenting for a surgical sc...


    pub_type: 杂志文章,多中心研究


    authors: Okun MS,Fernandez HH,Pedraza O,Misra M,Lyons KE,Pahwa R,Tarsy D,Scollins L,Corapi K,Friehs GM,Grace J,Romrell J,Foote KD

    更新日期:2004-07-13 00:00:00

  • Congenital muscular dystrophies with defective glycosylation of dystroglycan: a population study.

    abstract:BACKGROUND:Congenital muscular dystrophies (CMD) with reduced glycosylation of alpha-dystroglycan (alpha-DG) are a heterogeneous group of conditions associated with mutations in six genes encoding proven or putative glycosyltransferases. OBJECTIVES:The aim of the study was to establish the prevalence of mutations in t...


    pub_type: 杂志文章,多中心研究


    authors: Mercuri E,Messina S,Bruno C,Mora M,Pegoraro E,Comi GP,D'Amico A,Aiello C,Biancheri R,Berardinelli A,Boffi P,Cassandrini D,Laverda A,Moggio M,Morandi L,Moroni I,Pane M,Pezzani R,Pichiecchio A,Pini A,Minetti C,Mon

    更新日期:2009-05-26 00:00:00

  • Acute hypothalamic stimulation and ongoing cluster headache attacks.

    abstract::Long-term hypothalamic stimulation is effective in improving drug-resistant chronic cluster headache (CH). We assessed acute hypothalamic stimulation to resolve ongoing CH attacks in 16 patients implanted to prevent chronic CH, investigating 136 attacks. A pain intensity reduction of > or =50% occurred in 25 of 108 ev...


    pub_type: 杂志文章


    authors: Leone M,Franzini A,Broggi G,Mea E,Cecchini AP,Bussone G

    更新日期:2006-11-28 00:00:00

  • Hemispatial and directional performance biases in motor neglect.

    abstract::Motivationally responsive motor deficits may occur in isolation or as part of more general neglect syndromes. We describe three patients with two discrete syndromes of isolated motor neglect, differentiated primarily by their performance in motor tasks enacted within or toward the contralesional hemispace. The lesions...


    pub_type: 杂志文章


    authors: Simon ES,Hegarty AM,Mehler MF

    更新日期:1995-03-01 00:00:00

  • Mixed-location cerebral hemorrhage/microbleeds: Underlying microangiopathy and recurrence risk.

    abstract:OBJECTIVE:To assess the predominant type of cerebral small vessel disease (SVD) and recurrence risk in patients who present with a combination of lobar and deep intracerebral hemorrhage (ICH)/microbleed locations (mixed ICH). METHODS:Of 391 consecutive patients with primary ICH enrolled in a prospective registry, 75 (...


    pub_type: 杂志文章


    authors: Pasi M,Charidimou A,Boulouis G,Auriel E,Ayres A,Schwab KM,Goldstein JN,Rosand J,Viswanathan A,Pantoni L,Greenberg SM,Gurol ME

    更新日期:2018-01-09 00:00:00

  • Effects of anti-CD4 antibody treatment on lymphocyte subsets and stimulated tumor necrosis factor alpha production: a study of 29 multiple sclerosis patients entered into a clinical trial of cM-T412.

    abstract::T lymphocytes may play a central role in MS. The search for more targeted immunosuppression than is currently available has led to recent clinical trials of novel therapeutics. We studied 29 patients in a double-blind placebo-controlled trial of the chimeric monoclonal anti-CD4 antibody, cM-T412 (Centocor, Leiden, Hol...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Llewellyn-Smith N,Lai M,Miller DH,Rudge P,Thompson AJ,Cuzner ML

    更新日期:1997-04-01 00:00:00

  • Journal club: pretreatment EEG in childhood absence epilepsy.

    abstract::Childhood absence epilepsy (CAE) is defined by absence seizures in a normally developing child, with onset between 4 and 10 years of age.(1) Typical absence seizures consist of behavioral arrest with or without automatisms, usually last 30-60 seconds, and demonstrate a characteristic 3-Hz generalized spike-wave (GSW) ...


    pub_type: 杂志文章,随机对照试验


    authors: Bernson-Leung ME,Mazumdar M

    更新日期:2014-05-06 00:00:00

  • Sign language aphasia due to left occipital lesion in a deaf signer.

    abstract::Localization of sign language production and comprehension in deaf people has been described as similar to that of spoken language aphasia. However, sign language employs a visuospatial modality through visual information. We present the first report of a deaf signer who showed substantial sign language aphasia with s...


    pub_type: 杂志文章


    authors: Saito K,Otsuki M,Ueno S

    更新日期:2007-10-02 00:00:00

  • Reactivity of T cells from seronegative patients with myasthenia gravis to T cell epitopes of the human acetylcholine receptor.

    abstract::Seronegative (SN) patients with myasthenia gravis (MG) have clinical and electrophysiologic features similar to those of seropositive (SP) patients, and they respond to the same therapeutic measures. However, because SN patients lack detectable (by standard radioimmunoassays) serum antibodies to acetylcholine receptor...


    pub_type: 杂志文章


    authors: Karni A,Zisman E,Katz-Levy Y,Paas-Rozner M,Dayan M,Brautbar C,Abramsky O,Sela M,Mozes E

    更新日期:1997-06-01 00:00:00

  • Short- and long-term outcome of chronic pallidal neurostimulation in monogenic isolated dystonia.

    abstract:OBJECTIVES:Deep brain stimulation of the internal pallidum (GPi-DBS) is an established therapeutic option in treatment-refractory dystonia, and the identification of factors predicting surgical outcome is needed to optimize patient selection. METHODS:In this retrospective multicenter study, GPi-DBS outcome of 8 patien...


    pub_type: 杂志文章,多中心研究


    authors: Brüggemann N,Kühn A,Schneider SA,Kamm C,Wolters A,Krause P,Moro E,Steigerwald F,Wittstock M,Tronnier V,Lozano AM,Hamani C,Poon YY,Zittel S,Wächter T,Deuschl G,Krüger R,Kupsch A,Münchau A,Lohmann K,Volkmann J,Kle

    更新日期:2015-03-03 00:00:00

  • Tapping linked to function and structure in premanifest and symptomatic Huntington disease.

    abstract:OBJECTIVE:Motor signs are functionally disabling features of Huntington disease. Characteristic motor signs define disease manifestation. Their severity and onset are assessed by the Total Motor Score of the Unified Huntington's Disease Rating Scale, a categorical scale limited by interrater variability and insensitivi...


    pub_type: 杂志文章,多中心研究


    authors: Bechtel N,Scahill RI,Rosas HD,Acharya T,van den Bogaard SJ,Jauffret C,Say MJ,Sturrock A,Johnson H,Onorato CE,Salat DH,Durr A,Leavitt BR,Roos RA,Landwehrmeyer GB,Langbehn DR,Stout JC,Tabrizi SJ,Reilmann R

    更新日期:2010-12-14 00:00:00

  • Tracheostomy can fatally exacerbate sleep-disordered breathing in multiple system atrophy.

    abstract::Tracheostomy has been employed to release the airway obstruction at the glottic level and to prevent sudden death in patients with multiple system atrophy (MSA). However, sudden death is possible even after tracheostomy. Nocturnal polysomnography showed that the apnea-hypopnea index became higher after tracheostomy, a...


    pub_type: 杂志文章


    authors: Jin K,Okabe S,Chida K,Abe N,Kimpara T,Ohnuma A,Nomura H,Itoyama Y,Onodera H

    更新日期:2007-05-08 00:00:00

  • Epilepsy in multiple sclerosis: A nationwide population-based register study.

    abstract:OBJECTIVE:To determine the cumulative incidence of epilepsy in a population-based cohort of patients with multiple sclerosis (MS) and to investigate the association between epilepsy and clinical features of MS. METHODS:All available patients in the Swedish MS register (n = 14,545) and 3 age- and sex-matched controls p...


    pub_type: 杂志文章


    authors: Burman J,Zelano J

    更新日期:2017-12-12 00:00:00

  • Arterial wall properties in carotid artery dissection: an ultrasound study.

    abstract:BACKGROUND:Cervical artery dissection is often attributed to an underlying arteriopathy related to a generalized extracellular matrix defect. OBJECTIVE:The authors compared the hemodynamic and morphologic properties of the carotid artery, as assessed noninvasively by ultrasonography, in patients with spontaneous inter...


    pub_type: 杂志文章


    authors: Guillon B,Tzourio C,Biousse V,Adraï V,Bousser MG,Touboul PJ

    更新日期:2000-09-12 00:00:00

  • Tourette's syndrome and 'PANDAS': will the relation bear out? Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection.

    abstract::Despite strong evidence of the importance of hereditary factors in the etiology of Tourette's syndrome (TS), research findings have consistently pointed to a role of environmental influences. A recent line of research has suggested that tic disorders and associated behavioral disturbances, such as obsessive-compulsive...


    pub_type: 评论,杂志文章,评审


    authors: Kurlan R

    更新日期:1998-06-01 00:00:00

  • Dietary treatment in adults with refractory epilepsy: a review.

    abstract::We review adjunctive ketogenic diet (KD) and modified Atkins diet (MAD) treatment of refractory epilepsy in adults. Only a few studies have been published, all open-label. Because of the disparate, uncontrolled nature of the studies, we analyzed all studies individually, without a meta-analysis. Across all studies, 32...


    pub_type: 杂志文章,评审


    authors: Klein P,Tyrlikova I,Mathews GC

    更新日期:2014-11-18 00:00:00

  • Serum and muscle potassium in experimental alcoholic myopathy.

    abstract::We investigated the possible role of potassium deficiency, a recognized cause of myopathy, in the pathogenesis of experimental acute alcoholic myopathy (EAM) in the rat. Alcohol-treated animals receiving the same dietary potassium as controls developed mild hypokalemia; however, muscle potassium was preserved or eleva...


    pub_type: 杂志文章


    authors: Haller RG,Carter NW,Ferguson E,Knochel JP

    更新日期:1984-04-01 00:00:00

  • Residual function in motor cortex contralateral to amputated hand.

    abstract:OBJECTIVE:To investigate residual function of the motor cortex corresponding to the hand of the amputated arm (MCamp). METHODS:Focal transcranial magnetic stimulation (TMS) of MCamp was performed in 10 patients 22 to 52 years after arm amputation to inhibit tonic muscle contraction in the intact hand ipsilateral to co...


    pub_type: 杂志文章


    authors: Röricht S,Meyer BU

    更新日期:2000-02-22 00:00:00

  • IV thrombolysis in very severe and severe ischemic stroke: Results from the SITS-ISTR Registry.

    abstract:OBJECTIVE:To study the safety of off-label IV thrombolysis in patients with very severe stroke (NIH Stroke Scale [NIHSS] scores >25) compared with severe stroke (NIHSS scores 15-25), where treatment is within European regulations. METHODS:Data were analyzed from 57,247 patients with acute ischemic stroke receiving IV ...


    pub_type: 杂志文章


    authors: Mazya MV,Lees KR,Collas D,Rand VM,Mikulik R,Toni D,Wahlgren N,Ahmed N

    更新日期:2015-12-15 00:00:00

  • Loss of independence in early Parkinson disease: A 5-year population-based incident cohort study.

    abstract:OBJECTIVE:To determine the risk, predictors, and prognosis of independence loss and institutionalization in patients with early Parkinson disease (PD). METHODS:We conducted a prospective population-based 5-year longitudinal study following 189 patients with incident PD and 174 controls matched for age, sex, and comorb...


    pub_type: 杂志文章,多中心研究


    authors: Bjornestad A,Tysnes OB,Larsen JP,Alves G

    更新日期:2016-10-11 00:00:00

  • Multimodal characterization of older APOE2 carriers reveals selective reduction of amyloid load.

    abstract:OBJECTIVE:To comprehensively assess neurobiological effects of the protective APOE2 allele in the aged brain using a cross-sectional multimodal neuroimaging approach. METHODS:Multimodal neuroimaging data were obtained from a total of 572 older individuals without dementia (cognitively normal and mild cognitive impairm...


    pub_type: 杂志文章


    authors: Grothe MJ,Villeneuve S,Dyrba M,Bartrés-Faz D,Wirth M,Alzheimer's Disease Neuroimaging Initiative.

    更新日期:2017-02-07 00:00:00

  • Salla disease: a new lysosomal storage disorder with disturbed sialic acid metabolism.

    abstract::Salla disease is a lysosomal storage disorder associated with increased urinary excretion of free sialic acid. The main clinical features in 34 patients were severe psychomotor retardation of early onset, ataxia, athetosis, rigidity, spasticity, and impaired speech. Growth retardation, thick calvarium, and exotropia w...


    pub_type: 杂志文章


    authors: Renlund M,Aula P,Raivio KO,Autio S,Sainio K,Rapola J,Koskela SL

    更新日期:1983-01-01 00:00:00

  • Cerebrovascular ischemic events in wind instrument players.

    abstract::Two cases of ischemic stroke due to carotid artery dissection occurring during wind instrument playing, probably caused by increased intrathoracic and subsequent intrapharyngeal pressure, are presented. A review of the literature revealed three similar patients with other types of cerebrovascular events, such as parad...


    pub_type: 杂志文章


    authors: Evers S,Altenmüller E,Ringelstein EB

    更新日期:2000-09-26 00:00:00

  • Cranial autonomic symptoms in pediatric migraine are the rule, not the exception.

    abstract:OBJECTIVE:The presence of cranial autonomic symptoms often leads to a misdiagnosis of "sinus headache" in adult migraineurs, leading to unnecessary treatments and delaying appropriate migraine therapy. In this study, we examined the frequency of cranial autonomic symptoms in pediatric/adolescent patients with migraine....


    pub_type: 杂志文章,多中心研究


    authors: Gelfand AA,Reider AC,Goadsby PJ

    更新日期:2013-07-30 00:00:00

  • Sleep, major depressive disorder, and Alzheimer disease: A Mendelian randomization study.

    abstract:OBJECTIVE:To explore the causal relationships between sleep, major depressive disorder (MDD), and Alzheimer disease (AD). METHODS:We conducted bidirectional 2-sample Mendelian randomization analyses. Genetic associations were obtained from the largest genome-wide association studies currently available in UK Biobank (...


    pub_type: 杂志文章


    authors: Huang J,Zuber V,Matthews PM,Elliott P,Tzoulaki J,Dehghan A

    更新日期:2020-10-06 00:00:00

  • Structural brain imaging and multivariate analysis enable virtual lumbar punctures.

    abstract::Functional brain imaging has been a standard tool in the basic and clinical neurosciences for at least 2 decades, and structural brain imaging can claim an even longer track record of successful use for diagnosis of neurodegenerative disease. It is instructive to recall the ways in which brain imaging has been used to...


    pub_type: 评论,社论


    authors: Habeck C,Whitwell JL

    更新日期:2013-01-08 00:00:00

  • Nonseptic cardiogenic cerebral embolic stroke: clinical-CT correlations.

    abstract::We studied 35 patients with nonseptic cardiogenic cerebral emboli. In 28 cases, there was sudden onset with maximal neurologic deficit within 1 hour; in 7 cases, there was progression in 24 hours. In six cases, neurologic abnormality worsened in the first week after an initial period of stabilization. CT showed eviden...


    pub_type: 杂志文章


    authors: Weisberg LA

    更新日期:1985-06-01 00:00:00