Extended use of glatiramer acetate (Copaxone) is well tolerated and maintains its clinical effect on multiple sclerosis relapse rate and degree of disability. Copolymer 1 Multiple Sclerosis Study Group.


:When 251 relapsing-remitting patients with multiple sclerosis were randomized to receive daily subcutaneous injections of glatiramer acetate, previously called copolymer 1 (Copaxone; n = 125) or placebo (n = 126) for 24 months, there were no laboratory abnormalities associated with glatiramer acetate treatment and it was well tolerated with few side effects. Patients receiving glatiramer acetate had significantly fewer relapses and were more likely to be neurologically improved, whereas those receiving placebo were more likely to worsen. This study was extended for 1 to 11 months (mean of 5.2 months for the glatiramer acetate group and 5.9 months for the placebo group). The blinding and study conditions used during the core 24-month study were unchanged throughout the extension. The results of this extension study confirm the excellent tolerance and safety profile of glatiramer acetate for injection. The clinical benefit of glatiramer acetate for both the relapse rate and for neurologic disability was sustained at the end of the extension trial.






Johnson KP,Brooks BR,Cohen JA,Ford CC,Goldstein J,Lisak RP,Myers LW,Panitch HS,Rose JW,Schiffer RB,Vollmer T,Weiner LP,Wolinsky JS




Has Abstract


1998-03-01 00:00:00












  • Dietary treatment in adults with refractory epilepsy: a review.

    abstract::We review adjunctive ketogenic diet (KD) and modified Atkins diet (MAD) treatment of refractory epilepsy in adults. Only a few studies have been published, all open-label. Because of the disparate, uncontrolled nature of the studies, we analyzed all studies individually, without a meta-analysis. Across all studies, 32...


    pub_type: 杂志文章,评审


    authors: Klein P,Tyrlikova I,Mathews GC

    更新日期:2014-11-18 00:00:00

  • A case-control and nerve biopsy study of CREST multiple mononeuropathy.

    abstract::From 536 patients with the CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasis), seven were identified as having peripheral neuropathy not attributable to another cause. Peripheral neuropathy developed 0 to 25 years after their first symptoms of scleroderma. Unex...


    pub_type: 杂志文章


    authors: Dyck PJ,Hunder GG,Dyck PJ

    更新日期:1997-12-01 00:00:00

  • Mitochondrial DNA haplogroups and mutations in children with acquired central demyelination.

    abstract:OBJECTIVE:We investigated mitochondrial DNA (mtDNA) variants in children with a first episode of acquired demyelinating syndromes (PD-ADS) of the CNS and their relationship to disease phenotype, including subsequent diagnosis of multiple sclerosis (MS). METHODS:This exploratory analysis included the initial 213 childr...


    pub_type: 杂志文章


    authors: Venkateswaran S,Zheng K,Sacchetti M,Gagne D,Arnold DL,Sadovnick AD,Scherer SW,Banwell B,Bar-Or A,Simon DK,Canadian Pediatric Demyelinating Disease Network.

    更新日期:2011-03-01 00:00:00

  • Hippocampal mean diffusivity and memory in healthy elderly individuals: a cross-sectional study.

    abstract:BACKGROUND:The relationship between age-related memory decline and hippocampal anatomic changes is a matter of debate. OBJECTIVES:To investigate the relationship between age-related memory decline and MRI hippocampal anatomic changes in a cohort of healthy individuals. METHODS:In this cross-sectional study, 76 health...


    pub_type: 杂志文章


    authors: Carlesimo GA,Cherubini A,Caltagirone C,Spalletta G

    更新日期:2010-01-19 00:00:00

  • Effects of anti-CD4 antibody treatment on lymphocyte subsets and stimulated tumor necrosis factor alpha production: a study of 29 multiple sclerosis patients entered into a clinical trial of cM-T412.

    abstract::T lymphocytes may play a central role in MS. The search for more targeted immunosuppression than is currently available has led to recent clinical trials of novel therapeutics. We studied 29 patients in a double-blind placebo-controlled trial of the chimeric monoclonal anti-CD4 antibody, cM-T412 (Centocor, Leiden, Hol...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Llewellyn-Smith N,Lai M,Miller DH,Rudge P,Thompson AJ,Cuzner ML

    更新日期:1997-04-01 00:00:00

  • Specificity of the fivefold increase in AD in mothers of adults with Down syndrome.

    abstract:BACKGROUND:In a previous study, the authors found that the risk of AD among mothers who were 35 years or younger when their children with Down syndrome (DS) were born was five times that of mothers of children with other forms of mental retardation. The current study investigated the specificity of the familial aggrega...


    pub_type: 杂志文章


    authors: Schupf N,Kapell D,Nightingale B,Lee JH,Mohlenhoff J,Bewley S,Ottman R,Mayeux R

    更新日期:2001-09-25 00:00:00

  • A short-term randomized MRI study of high-dose oral vs intravenous methylprednisolone in MS.

    abstract:OBJECTIVE:To compare the efficacy, tolerability, and safety of IV methylprednisolone (IV MP) vs oral methylprednisolone (oMP) at equivalent high doses in patients with multiple sclerosis (MS) experiencing a recent relapse. METHODS:Patients with a clinical relapse within the previous 2 weeks and at least 1 gadolinium (...


    pub_type: 杂志文章,随机对照试验


    authors: Martinelli V,Rocca MA,Annovazzi P,Pulizzi A,Rodegher M,Martinelli Boneschi F,Scotti R,Falini A,Sormani MP,Comi G,Filippi M

    更新日期:2009-12-01 00:00:00

  • Postprandial and orthostatic hypotension in Parkinson's disease.

    abstract::In this study, the 24-hour pattern of blood pressure (BP), heart rate, and urinary catecholamine (CA) excretion and the response of BP and plasma CA to the tilt test have been investigated in 13 untreated patients affected by Parkinson's disease (PD) and in 11 age-matched healthy controls. Seven of the 13 PD subjects ...


    pub_type: 杂志文章


    authors: Micieli G,Martignoni E,Cavallini A,Sandrini G,Nappi G

    更新日期:1987-03-01 00:00:00

  • Effect of L-dopa on visual evoked potential in patients with Parkinson's disease.

    abstract::In 47 patients with Parkinson's disease, we studied the visual evoked potential (VEP) using the pattern-reversal checkerboard (CBVEP) and the grating (GVEP) stimuli before and after 3 months of L-dopa therapy. The P100 latency in both CBVEP and GVEP was prolonged before L-dopa therapy, usually commensurate with the de...


    pub_type: 杂志文章


    authors: Bhaskar PA,Vanchilingam S,Bhaskar EA,Devaprabhu A,Ganesan RA

    更新日期:1986-08-01 00:00:00

  • Acute late-onset encephalopathy after radiotherapy: an unusual life-threatening complication.

    abstract::Unusual late-onset complications of brain irradiation, characterized by reversible neurologic focal signs, seizures, and MRI alterations, have recently been reported and classified as stroke-like migraine attacks after radiation therapy (SMART)(1) and peri-ictal pseudoprogression (PIPG).(2.) ...


    pub_type: 杂志文章


    authors: Di Stefano AL,Berzero G,Vitali P,Galimberti CA,Ducray F,Ceroni M,Bastianello S,Colombo AA,Simoncelli A,Brunelli MC,Giometto B,Diamanti L,Gaviani P,Salmaggi A,Silvani A,Marchioni E

    更新日期:2013-09-10 00:00:00

  • Immunocytochemical analysis of the cellular infiltrate in brain lesions in subacute sclerosing panencephalitis.

    abstract::We studied lymphocyte subsets and major histocompatibility complex (MHC) class II antigens in frozen brain tissues from three patients with subacute sclerosing panencephalitis (SSPE) using immunocytochemical techniques. Perivascular cuffs consisted predominantly of T cells and MHC class II-positive cells. In the paren...


    pub_type: 杂志文章


    authors: Nagano I,Nakamura S,Yoshioka M,Kogure K

    更新日期:1991-10-01 00:00:00

  • Normal pressure hydrocephalus, parkinsonism, and primary empty sella--coincidence or cause-effect?

    abstract::The triad of normal-pressure hydrocephalus, parkinsonism, and primary empty sella appeared in a 70-year-old woman. There was dramatic resolution of the extrapyramidal signs and symptoms on treatment with levodopa-carbidopa and ventriculojugular shunt. The syndrome may be the result of several mechanisms, but an altera...


    pub_type: 杂志文章


    authors: Spagna VA,Maeder MC,Johnson JC,Mazzaferri EL

    更新日期:1978-11-01 00:00:00

  • Linkage of the locus for cerebral cavernous hemangiomas to human chromosome 7q in four families of Mexican-American descent.

    abstract:OBJECTIVE:To determine with greater precision the map location of the locus associated with familial cavernous hemangiomas. BACKGROUND:Cavernous malformations of the brain are a significant cause of seizures, progressive or apoplectic neurologic deficit, and headache. Prevalence estimates from autopsy series vary from...


    pub_type: 杂志文章


    authors: Polymeropoulos MH,Hurko O,Hsu F,Rubenstein J,Basnet S,Lane K,Dietz H,Spetzler RF,Rigamonti D

    更新日期:1997-03-01 00:00:00

  • Neurology and neurologic practice in China.

    abstract::In the wake of dramatic economic success during the past 2 decades, the specialized field of neurology has undergone a significant transformation in China. With an increase in life expectancy, the problems of aging and cognition have grown. Lifestyle alterations have been associated with an epidemiologic transition bo...


    pub_type: 杂志文章


    authors: Shi FD,Jia JP

    更新日期:2011-11-29 00:00:00

  • Morphometry of dermal nerve fibers in human skin.

    abstract:OBJECTIVE:We aimed to assess the innervation density of dermal nerves in human skin biopsies by bright-field immunohistochemistry. METHODS:The size of dermal area where nerve length was quantified was validated in 30 skin biopsy sections (5 controls and 5 patients with small-fiber neuropathy [SFN]). It was obtained di...


    pub_type: 杂志文章


    authors: Lauria G,Cazzato D,Porretta-Serapiglia C,Casanova-Molla J,Taiana M,Penza P,Lombardi R,Faber CG,Merkies IS

    更新日期:2011-07-19 00:00:00

  • The metabolic anatomy of tremor in Parkinson's disease.

    abstract:OBJECTIVE:To identify regional metabolic brain networks related specifically to the presence of tremor in PD. BACKGROUND:The pathophysiology of parkinsonian tremor is unknown. Because tremor in PD occurs mainly in repose, we used resting state PET with 18F-fluorodeoxyglucose (FDG) to identify specific metabolic brain ...


    pub_type: 杂志文章


    authors: Antonini A,Moeller JR,Nakamura T,Spetsieris P,Dhawan V,Eidelberg D

    更新日期:1998-09-01 00:00:00

  • Diagnosis of patients presenting to a Huntington disease (HD) clinic without a family history of HD.

    abstract::About 9% of patients presenting to a Huntington disease (HD) clinic for evaluation of possible HD lacked a family history of the disorder. HD was the final diagnosis in 53 to 83% of these patients. As a group, HD-affected individuals without a family history of HD were older and had fewer CAG repeats than the average ...


    pub_type: 杂志文章


    authors: Nance MA,Westphal B,Nugent S

    更新日期:1996-12-01 00:00:00

  • Unilateral thalamic deep brain stimulation for refractory essential tremor and Parkinson's disease tremor.

    abstract:OBJECTIVE:To determine the efficacy and tolerability of unilateral thalamic deep brain stimulation (DBS) for patients with medically refractory essential tremor (ET) and the tremor associated with Parkinson's disease (PD). BACKGROUND:The tremor of ET and PD may produce functional disability despite optimal medical the...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ondo W,Jankovic J,Schwartz K,Almaguer M,Simpson RK

    更新日期:1998-10-01 00:00:00

  • Broca's area aphasias: aphasia after lesions including the frontal operculum.

    abstract::We report 9 cases of aphasia following lesions in the region of the left frontal operculum. It is not possible to capture their variety of clinical manifestations with the simple labels of "Broca's area aphasia." or "Broca's area aphasia." Analysis of the breakdown of various components of speech and language in these...


    pub_type: 杂志文章


    authors: Alexander MP,Naeser MA,Palumbo C

    更新日期:1990-02-01 00:00:00

  • Neuropsychiatric symptomatology predicts seizure recurrence in newly treated patients.

    abstract:OBJECTIVES:To test the hypothesis that neuropsychiatric symptomatology is predictive of the success of seizure control in patients newly treated with antiepileptic drugs (AEDs), and that this predictive value adds to that provided by other clinical, imaging, and genomic factors in a multivariate model. METHODS:One hun...


    pub_type: 杂志文章


    authors: Petrovski S,Szoeke CE,Jones NC,Salzberg MR,Sheffield LJ,Huggins RM,O'Brien TJ

    更新日期:2010-09-14 00:00:00

  • Primary lateral sclerosis as a phenotypic manifestation of familial ALS.

    abstract::Primary lateral sclerosis (PLS) is a diagnosis of exclusion in patients with progressive spinobulbar spasticity and could be part of the clinical spectrum of ALS. Unlike ALS, which is familial in 5 to 10% of the cases, PLS has been described as a sporadic disorder in adults. The authors report two patients with PLS fr...


    pub_type: 杂志文章


    authors: Brugman F,Wokke JH,Vianney de Jong JM,Franssen H,Faber CG,Van den Berg LH

    更新日期:2005-05-24 00:00:00

  • Long-latency event-related potentials in the evaluation of cognitive function in children.

    abstract::The endogenous auditory P300 event-related potential (P3) has been used to differentiate functional and organic cognitive disorders in adults. We found that children with organic cognitive impairments (as determined by the Halstead-Reitan [HR] test) had greater P3 latencies than children with normal HR evaluations. Th...


    pub_type: 杂志文章


    authors: Finley WW,Faux SF,Hutcheson J,Amstutz L

    更新日期:1985-03-01 00:00:00

  • Lyme borreliosis in Bell's palsy. Long Island Neuroborreliosis Collaborative Study Group.

    abstract::Lyme borreliosis (LB) causes a range of neurologic manifestations, the most common of which is facial nerve paralysis. To evaluate nervous system LB, we organized a neurologic collaborative study group in Suffolk County, NY, a region of high LB incidence. Between July and September 1989, LB serologies were performed o...


    pub_type: 杂志文章


    authors: Halperin JJ,Golightly M

    更新日期:1992-07-01 00:00:00

  • The minor symptoms of increased intracranial pressure: 101 patients with benign intracranial hypertension.

    abstract::Of 101 patients with benign intracranial hypertension not related to vasculitis, neck stiffness occurred in 31, tinnitus in 27, distal extremity paresthesias in 22, joint pains in 13, low back pain in 5, and gait "ataxia" in 4. Symptoms resolved promptly upon lowering the intracranial pressure by lumbar puncture, and ...


    pub_type: 杂志文章


    authors: Round R,Keane JR

    更新日期:1988-09-01 00:00:00

  • Prevalence and correlates of periodic limb movements in OSA and the effect of CPAP therapy.

    abstract:OBJECTIVE:We sought to assess the prevalence, correlates, and consequences of periodic limb movements of sleep (PLMS) in persons with obstructive sleep apnea (OSA) and the effect (worsening or improvement) of continuous positive airway pressure (CPAP) therapy on PLMS in a large prospective multicenter randomized contro...


    pub_type: 杂志文章


    authors: Budhiraja R,Javaheri S,Pavlova MK,Epstein LJ,Omobomi O,Quan SF

    更新日期:2020-04-28 00:00:00

  • Autopsy-proven amyotrophic lateral sclerosis, Waldenström's macroglobulinemia, and antibodies to sulfated glucuronic acid paragloboside.

    abstract::Antibodies to myelin-associated glycoprotein (MAG) are found in patients with both monoclonal gammopathy and sensorimotor peripheral neuropathy but almost never in patients with amyotrophic lateral sclerosis (ALS). Ninety percent of patients with anti-MAG activity also have antibodies to sulfated glucuronic acid parag...


    pub_type: 杂志文章


    authors: Rowland LP,Sherman WL,Hays AP,Lange DJ,Latov N,Trojaborg W,Younger DS

    更新日期:1995-04-01 00:00:00

  • Myasthenic crisis after intravenous administration of iodinated contrast agent.

    abstract::Two women with myasthenia gravis became apneic immediately after IV injection of iodinated contrast material for CT. Aggravation of myasthenia continued for days after this initial reaction. ...


    pub_type: 杂志文章


    authors: Chagnac Y,Hadani M,Goldhammer Y

    更新日期:1985-08-01 00:00:00

  • Manganese intoxication in the rhesus monkey: a clinical, imaging, pathologic, and biochemical study.

    abstract::We gave three adult rhesus monkeys seven IV injections of manganese chloride at approximately 1-week intervals. We evaluated neurologic status by serial clinical examinations and performed a levodopa test if the animal developed features of basal ganglia dysfunction. After the animals were killed, we performed neuropa...


    pub_type: 杂志文章


    authors: Olanow CW,Good PF,Shinotoh H,Hewitt KA,Vingerhoets F,Snow BJ,Beal MF,Calne DB,Perl DP

    更新日期:1996-02-01 00:00:00

  • Congenital retardation and central motor defect with later evolution of seizure disorder, orofacial dysplasia, and amyotrophy. A clinicopathologic report.

    abstract::Retarded mental and motor development was observed during the first year of life of a full-term female who had been delivered with difficulty. Generalized psychomotor seizures and dysplastic "acromegalic" facial changes began to develop when she was 8 years old, and generalized amyotrophy developed over the next sever...


    pub_type: 杂志文章


    authors: Landau WM,Torack RM,Guggenheim MA

    更新日期:1976-09-01 00:00:00

  • Emergency treatment of status epilepticus.

    abstract::Status epilepticus occurs in more than 50,000 people in the United States each year and should be considered a neurologic emergency. A variety of drugs are used to treat status epilepticus, including i.v. benzodiazepines, phenytoin, and barbiturates. They are all short of being ideal, primarily because of difficulties...


    pub_type: 杂志文章,评审


    authors: Runge JW,Allen FH

    更新日期:1996-06-01 00:00:00