Abstract:
OBJECTIVE:To evaluate the clinical efficacy of a standardized special root extract from the plant Petasites hybridus as a preventive therapy for migraine. METHODS:This is a three-arm, parallel-group, randomized trial comparing Petasites extract 75 mg bid, Petasites extract 50 mg bid, or placebo bid in 245 patients with migraine. Eligible patients met International Headache Society criteria for migraine, were ages 18 to 65, and had at least two to six attacks per month over the preceding 3 months. The main outcome measure was the decrease in migraine attack frequency per month calculated as percentage change from baseline over a 4-month treatment period. RESULTS:Over 4 months of treatment, in the per-protocol analysis, migraine attack frequency was reduced by 48% for Petasites extract 75 mg bid (p = 0.0012 vs placebo), 36% for Petasites extract 50 mg bid (p = 0.127 vs placebo), and 26% for the placebo group. The proportion of patients with a > or =50% reduction in attack frequency after 4 months was 68% for patients in the Petasites extract 75-mg arm and 49% for the placebo arm (p < 0.05). Results were also significant in favor of Petasites 75 mg at 1, 2, and 3 months based on this endpoint. The most frequently reported adverse reactions considered possibly related to treatment were mild gastrointestinal events, predominantly burping. CONCLUSIONS:Petasites extract 75 mg bid is more effective than placebo and is well tolerated as a preventive therapy for migraine. Petasites 50 mg PO bid was not significantly more effective than placebo on the primary study endpoints.
journal_name
Neurologyjournal_title
Neurologyauthors
Lipton RB,Göbel H,Einhäupl KM,Wilks K,Mauskop Adoi
10.1212/01.wnl.0000147290.68260.11subject
Has Abstractpub_date
2004-12-28 00:00:00pages
2240-4issue
12eissn
0028-3878issn
1526-632Xpii
63/12/2240journal_volume
63pub_type
临床试验,杂志文章,随机对照试验相关文献
NEUROLOGY文献大全abstract::We followed 18 multiple sclerosis patients clinically and with repeated brain MRIs with and without gadolinium for over 1 year. Clinical evaluations included scoring on the Kurtzke Expanded Disability Status Scale (EDSS) and the Ambulation Index (AI) scale. There was a significant correlation between the change in EDS...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.11.2120
更新日期:1994-11-01 00:00:00
abstract:OBJECTIVE:In patients with MG it may be difficult to determine whether respiratory insufficiency is due to a defect in neuromuscular transmission. We therefore studied the clinical value of repetitive electrical stimulation of the phrenic nerve. METHODS:Repetitive phrenic nerve stimulation at 3 Hz was performed in 25 ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.5.1083
更新日期:1999-09-22 00:00:00
abstract:OBJECTIVE:To demonstrate that progress has been made in unifying brain death determination guidelines in the last decade by directly comparing the policies of the US News and World Report's top 50 ranked neurologic institutions from 2006 and 2015. METHODS:We solicited official hospital guidelines in 2015 from these to...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003597
更新日期:2017-02-07 00:00:00
abstract:OBJECTIVES:To investigate clinical, imaging, and pathologic associations of the cingulate island sign (CIS) in dementia with Lewy bodies (DLB). METHODS:We retrospectively identified and compared patients with a clinical diagnosis of DLB (n=39); patients with Alzheimer disease (AD) matched by age, sex, and education (n...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000734
更新日期:2014-08-26 00:00:00
abstract::A 16-year-old male with a 9-year history of spontaneously arrested hydrocephalus was noted to have hydrosyringomyelia and increased intracranial pressure shortly after sustaining minor head trauma. His symptoms resolved completely following ventriculoperitoneal shunt replacement. Hydrosyringomyelia may occur in the se...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.4.652
更新日期:1988-04-01 00:00:00
abstract::To learn if limb-kinetic apraxia (LKA) is associated with Parkinson disease (PD), participants with PD (on medications) and control subjects performed finger tapping (FT), measuring movement speed, and performed coin rotation (CR), measuring precise coordinated but independent finger movements and speed. There were no...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000250331.35912.a5
更新日期:2007-01-09 00:00:00
abstract::We performed a case-control study to investigate the role of recent infection as stroke risk factor and to identify pathogenetic pathways linking infection and stroke. We examined 166 consecutive patients with acute cerebrovascular ischemia and 166 patients hospitalized for nonvascular and noninflammatory neurologic d...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.1.196
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Cerebral microbleeds are known to be indicative of bleeding-prone microangiopathy and may predict incident intracerebral hemorrhage (ICH). In this study, we investigated whether microbleeds are associated with the incidence of warfarin-related ICH. METHODS:Twenty-four patients with ICH while on outpatient t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000339060.11702.dd
更新日期:2009-01-13 00:00:00
abstract::We investigated the prevalence of Parkinson's disease and other types of parkinsonism in a Sicilian population using a door-to-door two-phase approach. This design called for the administration of a brief screening instrument to all subjects who, on November 1, 1987, were residents of Terrasini (Palermo Province), San...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.10.1901
更新日期:1992-10-01 00:00:00
abstract::Tizanidine, an imidazoline that acts as an agonist at alpha 2-adrenergic receptors, has been shown to be effective in reducing spasticity caused by MS. This multicenter study (14 sites) assessed the efficacy and safety of oral tizanidine in patients who had spinal cord injury of > 12 months' duration. Of the 124 patie...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1994-11-01 00:00:00
abstract::Despite recent advances in the molecular genetics of Alzheimer's disease (AD), several fundamental questions concerning risk of illness are unresolved, namely, if Mendelian factors account for the incidence of the disease, and if AD is an inevitable consequence of the aging process. This study was designed to address ...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/wnl.46.3.641
更新日期:1996-03-01 00:00:00
abstract::Medical therapy is the mainstay for epilepsy, with most patients well controlled on a single antiepileptic drug (AED). In this non-refractory group, many patients have medication side effects and occasional seizures. Approximately 30% of patients with partial epilepsy and 25% of patients with generalized epilepsy are ...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.64.12_suppl_3.s2
更新日期:2005-06-28 00:00:00
abstract:BACKGROUND:Frontotemporal dementia (FTD) is currently distinguished from AD primarily on the basis of behavioral features because studies of cognition have shown negligible or inconsistent differences. However, the poor discriminability of cognitive measures may relate to reliance on imprecise clinically diagnosed grou...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.12.1801
更新日期:2002-06-25 00:00:00
abstract::Migraine, especially migraine with aura (MA), is an established risk factor for ischemic lesions of the brain. Recent evidence has also linked migraine to a broader range of ischemic vascular disorders including angina, myocardial infarction, coronary revascularization, claudication, and cardiovascular mortality. The ...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0b013e3181a71220
更新日期:2009-05-26 00:00:00
abstract:OBJECTIVE:To validate a neuropsychological algorithm for dementia diagnosis. METHODS:We developed a neuropsychological algorithm in a sample of 1,023 elderly residents of Cache County, UT. We compared algorithmic and clinical dementia diagnoses both based on DSM-III-R criteria. The algorithm diagnosed dementia when th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.6.1290
更新日期:2000-03-28 00:00:00
abstract::We recorded interictal spikes with closely spaced scalp electrodes and sphenoidal electrodes in four patients with temporal lobe epilepsy. We used multiple dipole modeling to study the number, three-dimensional intracerebral location, time activity, and functional relationship of the neuronal sources underlying the ep...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.45.1.118
更新日期:1995-01-01 00:00:00
abstract::Significant evidence has accrued suggesting that antibodies to voltage-gated calcium channel are observed in at least some patients with sporadic ALS (SALS) and that such antibodies alter the function of these ion channels in vitro and in vivo. Further, passive transfer of these immunoglobulin-containing fractions int...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.47.4_suppl_2.40s
更新日期:1996-10-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that, in the context of robotic therapy designed to enhance proprioceptive feedback via a Hebbian model, integrity of both somatosensory and motor systems would be important in understanding interparticipant differences in treatment-related motor gains. METHODS:In 30 patients with chro...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/WNL.0000000000007041
更新日期:2019-03-05 00:00:00
abstract::Spontaneous arm levitation (SAL) is well-recognized in cortical-basal ganglionic degeneration, but not in other neurodegenerative diseases. We report six cases of progressive supranuclear palsy (PSP) with SAL. Pathologic examination in four revealed the classic features of PSP with additional areas of focal cortical d...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.4.879
更新日期:1999-03-10 00:00:00
abstract:OBJECTIVE:To investigate the sensitivity of MRI of the spine compared with CT myelography (CTM) in detecting CSF leaks. METHODS:Between July 1998 and October 2010, 12 patients with orthostatic headache and a CTM-confirmed spinal CSF leak underwent an MRI of the spine with and without contrast. Using CTM as the gold st...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000435555.13695.22
更新日期:2013-11-12 00:00:00
abstract:OBJECTIVE:To investigate the safety and efficacy of escalating doses of the semi-synthetic triterpenoid omaveloxolone in patients with mitochondrial myopathy. METHODS:In cohorts of 8-13, 53 participants were randomized double-blind to 12 weeks of treatment with omaveloxolone 5, 10, 20, 40, 80, or 160 mg, or placebo. O...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0000000000008861
更新日期:2020-02-18 00:00:00
abstract:OBJECTIVE:To test the hypothesis that physical activity modifies the association between white matter hyperintensity (WMH) burden and motor function in healthy older persons without dementia. METHODS:Total daily activity (exercise and nonexercise physical activity) was measured for up to 11 days with actigraphy (Actic...
journal_title:Neurology
pub_type: 社论
doi:10.1212/WNL.0000000000001417
更新日期:2015-03-31 00:00:00
abstract:OBJECTIVE:To evaluate teriflunomide as add-on therapy to ongoing stable-dosed interferon-β (IFNβ) in patients with relapsing forms of multiple sclerosis (RMS). METHODS:A total of 118 patients with RMS were randomly assigned 1:1:1 to receive oral placebo or teriflunomide, 7 or 14 mg, once daily for 24 weeks; 86 patient...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0b013e318258f7d4
更新日期:2012-06-05 00:00:00
abstract::In four patients who received periocular injections of botulinum toxin for blepharospasm, abnormal neuromuscular transmission was demonstrated by single-fiber EMG in arm muscles. The time course with which the abnormalities developed and cleared, as well as the inverse relationship between the neuromuscular jitter and...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.4.545
更新日期:1986-04-01 00:00:00
abstract:OBJECTIVE:We assessed whether clinical and imaging features of subjects with apraxia of speech (AOS) more severe than aphasia (dominant AOS) are more similar to agrammatic primary progressive aphasia (agPPA) or to primary progressive AOS (PPAOS). METHODS:Sixty-seven subjects (PPAOS = 18, dominant AOS = 10, agPPA = 9, ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31829c5ed5
更新日期:2013-07-23 00:00:00
abstract:OBJECTIVE:To determine the diagnostic accuracy and clinical utility of electromagnetic source imaging (EMSI) in presurgical evaluation of patients with epilepsy. METHODS:We prospectively recorded magnetoencephalography (MEG) simultaneously with EEG and performed EMSI, comprising electric source imaging, magnetic sourc...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006877
更新日期:2019-02-05 00:00:00
abstract::The Finnish Twin Cohort includes all Finnish same-sexed twins born before 1958 and alive in 1967; the number of individuals alive in 1975 was 33,247. We performed a search for cases with Parkinson's disease among this cohort by linking the Twin Cohort Register with the Finnish Hospital Discharge Register and the Finni...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.8.1217
更新日期:1988-08-01 00:00:00
abstract:OBJECTIVE:To verify whether the change in L-dopa plasma levels after a single dose of carbidopa/L-dopa 50/200 (controlled-release) transiently modifies frontal components of somatosensory evoked potentials (SEPs) in patients with PD in parallel with improvement of motor performance. BACKGROUND:Apomorphine, a potent do...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.7.1451
更新日期:1999-10-22 00:00:00
abstract::Mutations in DJ-1 are a cause of autosomal recessive parkinsonism. Polymorphism of genes implicated in hereditary forms of parkinsonism may be a predisposing factor in sporadic Parkinson's disease (PD). The authors analyzed whether a polymorphism (g.168_185del) within exon 1 of DJ-1 contributes to the risk of sporadic...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000083992.28066.7e
更新日期:2003-10-14 00:00:00
abstract::An 18-year-old man had noticed increasing difficulty in walking for 4 years. Examination disclosed spastic paraparesis and posterior column signs suggestive of subacute combined degeneration of the spinal cord. Urinalysis, urinary thin-layer chromatography, and intestinal biopsy disclosed typical cystinuria. Perniciou...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.25.10.994
更新日期:1975-10-01 00:00:00