Longitudinal MRI in multiple sclerosis: correlation between disability and lesion burden.

Abstract:

:We followed 18 multiple sclerosis patients clinically and with repeated brain MRIs with and without gadolinium for over 1 year. Clinical evaluations included scoring on the Kurtzke Expanded Disability Status Scale (EDSS) and the Ambulation Index (AI) scale. There was a significant correlation between the change in EDSS or AI and the change in number of lesions on MRI and between cumulative number of lesions on MRI and cumulative change in EDSS or AI. Our findings support the validity of MRI as a measure of clinical activity and potentially as an objective quantitative outcome measure for assessing response to therapy.

journal_name

Neurology

journal_title

Neurology

authors

Khoury SJ,Guttmann CR,Orav EJ,Hohol MJ,Ahn SS,Hsu L,Kikinis R,Mackin GA,Jolesz FA,Weiner HL

doi

10.1212/wnl.44.11.2120

subject

Has Abstract

pub_date

1994-11-01 00:00:00

pages

2120-4

issue

11

eissn

0028-3878

issn

1526-632X

journal_volume

44

pub_type

杂志文章
  • Silent stroke in the NINCDS Stroke Data Bank.

    abstract::Previous brain infarctions seen on CT are common in the absence of history of stroke. Eleven percent of patients (135/1,203) without stroke history had ischemic lesions on their first CT, unrelated to the presenting stroke. Stroke Data Bank files were reviewed to determine whether the occurrence, location, and CT char...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.38.11.1674

    authors: Chodosh EH,Foulkes MA,Kase CS,Wolf PA,Mohr JP,Hier DB,Price TR,Furtado JG Jr

    更新日期:1988-11-01 00:00:00

  • Subdural empyema in bacterial meningitis.

    abstract:OBJECTIVE:To evaluate the occurrence, treatment, and outcome of subdural empyema complicating community-acquired bacterial meningitis in adults. METHODS:Case series from a prospective nationwide cohort study from Dutch hospitals from 2006 to 2011. RESULTS:Subdural empyema was diagnosed in 28 of 1,034 episodes (2.7%),...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3182752d0e

    authors: Jim KK,Brouwer MC,van der Ende A,van de Beek D

    更新日期:2012-11-20 00:00:00

  • The effects of storage and shaking on the settling properties of phenytoin suspension.

    abstract::Phenytoin suspension (PHY-S) is reported to settle, resulting in uneven drug distribution and variable patient dosing. We designed this study to determine the rate of settling and the amount of agitation needed to resuspend the preparation. To determine the rate of settling, we thoroughly shook three bottles of PHY-S ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.39.2.207

    authors: Sarkar MA,Garnett WR,Karnes HT

    更新日期:1989-02-01 00:00:00

  • Incidence of stroke in relation to cognitive function and dementia in the Kungsholmen Project.

    abstract:OBJECTIVE:To investigate whether cognitive function is related to incidence of stroke. METHODS:A population-based cohort of 1551 subjects with no clinical history or signs of stroke, age 75 years and over at baseline, were followed up for 3 years. Individuals with a first-ever stroke event that was recorded in the Sto...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.54.11.2103

    authors: Zhu L,Fratiglioni L,Guo Z,Winblad B,Viitanen M

    更新日期:2000-06-13 00:00:00

  • Migraine practice patterns among neurologists.

    abstract:OBJECTIVE:To assess the attitudes, knowledge, and practice patterns of US neurologists regarding migraine management relative to the US Headache Consortium Guidelines (the Guidelines). METHODS:Two samples of 600 neurologists each were selected from the American Academy of Neurology membership database. The first group...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.62.11.1926

    authors: Lipton RB,Bigal ME,Rush SR,Yenkosky JP,Liberman JN,Bartleson JD,Silberstein SD

    更新日期:2004-06-08 00:00:00

  • Surgery for intracerebral hemorrhage.

    abstract::Intracerebral hemorrhage (ICH) represents 8 to 15% of all strokes in the United States and 20 to 30% of all strokes in Japan and China. Although ICH represents a relatively small fraction of total strokes, it is a formidable disease, with a 30-day mortality rate two- to sixfold higher than that for ischemic stroke. Fu...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.51.3_suppl_3.s69

    authors: Fayad PB,Awad IA

    更新日期:1998-09-01 00:00:00

  • A score that predicts 1-year functional status in patients with anti-NMDA receptor encephalitis.

    abstract:OBJECTIVE:To construct a grading score that predicts neurologic function 1 year after diagnosis of anti-NMDA receptor (NMDAR) encephalitis. METHODS:Three hundred eighty-two patients with detailed information and functional status at 1 year were studied. Factors associated with poor status (defined as modified Rankin S...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000006783

    authors: Balu R,McCracken L,Lancaster E,Graus F,Dalmau J,Titulaer MJ

    更新日期:2019-01-15 00:00:00

  • Measurement of narcolepsy symptoms: The Narcolepsy Severity Scale.

    abstract:OBJECTIVE:To validate the Narcolepsy Severity Scale (NSS), a brief clinical instrument to evaluate the severity and consequences of symptoms in patients with narcolepsy type 1 (NT1). METHODS:A 15-item scale to assess the frequency and severity of excessive daytime sleepiness, cataplexy, hypnagogic hallucinations, slee...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000003787

    authors: Dauvilliers Y,Beziat S,Pesenti C,Lopez R,Barateau L,Carlander B,Luca G,Tafti M,Morin CM,Billiard M,Jaussent I

    更新日期:2017-04-04 00:00:00

  • Metformin vs sulfonylurea use and risk of dementia in US veterans aged ≥65 years with diabetes.

    abstract:OBJECTIVE:To determine whether metformin is associated with a lower incidence of dementia than sulfonylureas. METHODS:This was a retrospective cohort study of US veterans ≥65 years of age with type 2 diabetes who were new users of metformin or a sulfonylurea and had no dementia. Follow-up began after 2 years of therap...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000004586

    authors: Orkaby AR,Cho K,Cormack J,Gagnon DR,Driver JA

    更新日期:2017-10-31 00:00:00

  • Racial/ethnic variation of APOE alleles for lobar intracerebral hemorrhage.

    abstract:OBJECTIVE:APOE ε2 and ε4 alleles have been associated with lobar intracerebral hemorrhage (ICH) in predominately white populations; we sought to evaluate whether this held true among black and Hispanic populations. METHODS:The Ethnic/Racial Variations of Intracerebral Hemorrhage study is a prospective, multicenter cas...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000005908

    authors: Sawyer RP,Sekar P,Osborne J,Kittner SJ,Moomaw CJ,Flaherty ML,Langefeld CD,Anderson CD,Rosand J,Woo D

    更新日期:2018-07-31 00:00:00

  • Statin therapy in acute cardioembolic stroke with no guidance-based indication.

    abstract:OBJECTIVE:It is uncertain whether patients with cardioembolic stroke and without a guidance-based indication for statin therapy should be administered a statin for prevention of subsequent vascular events. This study was performed to determine whether the statin therapy is beneficial in preventing major vascular events...

    journal_title:Neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1212/WNL.0000000000009397

    authors: Park HK,Lee JS,Hong KS,Cho YJ,Park JM,Kang K,Lee SJ,Kim JG,Cha JK,Kim DH,Nah HW,Han MK,Kim BJ,Park TH,Park SS,Lee KB,Lee J,Lee BC,Yu KH,Oh MS,Kim JT,Choi KH,Kim DE,Ryu WS,Choi JC,Kwon JH,Kim WJ,Shin

    更新日期:2020-05-12 00:00:00

  • Functional neurology after the Second World War: The beginnings of neurology on screen (III).

    abstract::Treatment of functional symptoms has a long history, and interventions were often used in soldiers returning from battle. On the 75th anniversary of the end of the Second World War, I review the portrayal of neurology in documentary film. Two documentaries were released in 1946 and 1948 (Let There Be Light and Shades ...

    journal_title:Neurology

    pub_type: 历史文章,杂志文章

    doi:10.1212/WNL.0000000000009593

    authors: Wijdicks EFM

    更新日期:2020-06-09 00:00:00

  • IgG receptor IIa alleles determine susceptibility and severity of Guillain-Barré syndrome.

    abstract:OBJECTIVE:Guillain-Barré syndrome (GBS) is characterized by nerve infiltration of leukocytes and autoantibodies of the immunoglobulin G (IgG) isotype directed against nerve constituents. Leukocyte receptors for IgG (FcgammaR) constitute an important link between the humoral and cellular parts of the immune system and c...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章

    doi:10.1212/wnl.54.8.1661

    authors: van der Pol WL,van den Berg LH,Scheepers RH,van der Bom JG,van Doorn PA,van Koningsveld R,van den Broek MC,Wokke JH,van de Winkel JG

    更新日期:2000-04-25 00:00:00

  • Covert recognition in acquired and developmental prosopagnosia.

    abstract:BACKGROUND:Some patients with prosopagnosia have covert recognition, meaning that they retain some familiarity or knowledge of facial identity of which they are not aware. OBJECTIVE:To test the hypothesis that prosopagnosic patients with right occipitotemporal lesions and impaired face perception lack covert processin...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.57.7.1161

    authors: Barton JJ,Cherkasova M,O'Connor M

    更新日期:2001-10-09 00:00:00

  • Developmental venous anomaly in adult patients with diffuse glioma: A clinically relevant coexistence?

    abstract:OBJECTIVE:To determine the prevalence of developmental venous anomaly in adult patients with diffuse glioma. METHODS:We performed a retrospective cohort study (2010-2016) of consecutive adult patients harboring a supratentorial diffuse glioma in 2 centers: Sainte-Anne Hospital (experimental and control sets) and Pitié...

    journal_title:Neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1212/WNL.0000000000006690

    authors: Roux A,Edjlali M,Porelli S,Tauziede-Espariat A,Zanello M,Dezamis E,Zah-Bi G,Sanson M,Puget S,Capelle L,Varlet P,Oppenheim C,Pallud J

    更新日期:2019-01-01 00:00:00

  • Two randomized migraine studies of galcanezumab: Effects on patient functioning and disability.

    abstract:OBJECTIVE:To evaluate changes from baseline in patient-reported outcomes for measures of functioning and disability among patients with migraine treated with galcanezumab or placebo. METHODS:Patients with episodic migraine (4-14 monthly migraine headache days) were treated with either galcanezumab (Evaluation of LY295...

    journal_title:Neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1212/WNL.0000000000007856

    authors: Ford JH,Ayer DW,Zhang Q,Carter JN,Leroux E,Skljarevski V,Aurora SK,Tockhorn-Heidenreich A,Lipton RB

    更新日期:2019-07-30 00:00:00

  • Intramedullary spinal cysticercosis.

    abstract::Intramedullary cysticercosis of the spinal cord is rare; there have been only 26 previous cases. We describe a patient with low back pain, paraparesis, lumbosacral sensory loss, and signs of meningeal irritation. The clinical diagnosis was spinal cord tumor, but at surgery there was a cysticercus cyst within the lumbo...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.29.11.1531

    authors: Akiguchi I,Fujiwara T,Matsuyama H,Muranaka H,Kameyama M

    更新日期:1979-11-01 00:00:00

  • Recent advances in the treatment of orthostatic hypotension.

    abstract::Orthostatic hypotension is a fall in blood pressure on standing that causes symptoms of dizziness, visual changes, and discomfort in the head and neck. The goal of treatment is the improvement of the patient's functional capacity, rather than a target blood pressure. For treatment to be successful, it must be individu...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:

    authors: Robertson D,Davis TL

    更新日期:1995-04-01 00:00:00

  • Glutamic acid decarboxylase autoimmunity in Batten disease and other disorders.

    abstract::Degenerative diseases of the CNS, such as stiff-person syndrome (SPS), progressive cerebellar ataxia, and Rasmussen encephalitis, have been characterized by the presence of autoantibodies. Recent findings in individuals with Batten disease and in animal models for the disorder indicate that this condition may be assoc...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/01.wnl.0000145836.72059.3b

    authors: Pearce DA,Atkinson M,Tagle DA

    更新日期:2004-12-14 00:00:00

  • Serum levels of alpha-tocopherol (vitamin E) in Parkinson's disease.

    abstract::To elucidate the possible role of vitamin E in the pathogenesis of Parkinson's disease (PD), we compared serum levels of alpha-tocopherol (vitamin E), measured by high-performance liquid chromatography, and the vitamin E/cholesterol ratio of 42 Parkinson's disease (PD) patients using their spouses as the control group...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.42.5.1064

    authors: Férnandez-Calle P,Molina JA,Jiménez-Jiménez FJ,Vázquez A,Pondal M,García-Ruiz PJ,Urra DG,Domingo J,Codoceo R

    更新日期:1992-05-01 00:00:00

  • LGI1 mutations in temporal lobe epilepsies.

    abstract:BACKGROUND AND OBJECTIVES:A number of familial temporal lobe epilepsies (TLE) have been recently recognized. Mutations in LGI1 (leucine-rich, glioma-inactivated 1 gene) have been found in a few families with the syndrome of autosomal dominant partial epilepsy with auditory features (ADPEAF). The authors aimed to determ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000118213.94650.81

    authors: Berkovic SF,Izzillo P,McMahon JM,Harkin LA,McIntosh AM,Phillips HA,Briellmann RS,Wallace RH,Mazarib A,Neufeld MY,Korczyn AD,Scheffer IE,Mulley JC

    更新日期:2004-04-13 00:00:00

  • Repetitive transcranial magnetic stimulation of the motor cortex ameliorates spasticity in multiple sclerosis.

    abstract:OBJECTIVE:To investigate whether repetitive transcranial magnetic stimulation (rTMS) can modify spasticity. METHODS:We used high-frequency (5 Hz) and low-frequency (1 Hz) rTMS protocols in 19 remitting patients with relapsing-remitting multiple sclerosis and lower limb spasticity. RESULTS:A single session of 1 Hz rTM...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章

    doi:10.1212/01.wnl.0000257818.16952.62

    authors: Centonze D,Koch G,Versace V,Mori F,Rossi S,Brusa L,Grossi K,Torelli F,Prosperetti C,Cervellino A,Marfia GA,Stanzione P,Marciani MG,Boffa L,Bernardi G

    更新日期:2007-03-27 00:00:00

  • Calcification in brainstem gliomas.

    abstract::Calcification in brainstem gliomas is an unusual histologic and and radiologic finding. To date, radiologic evidence of calcification in these tumors has not been reported. The two patients described here had evidence of calcification on either computerized tomography (CT) or plain skull films. Increasing availability...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.28.8.832

    authors: Duffner PK,Klein DM,Cohen ME

    更新日期:1978-08-01 00:00:00

  • Long-term cerebral white and gray matter changes after preeclampsia.

    abstract:OBJECTIVE:To determine whether changes in cerebral structure are present after preeclampsia that may explain increased cerebrovascular risk in these women. METHODS:We conducted a case control study in women between 5 and 15 years after either a preeclamptic or normotensive pregnancy. Brain MRI was performed. Analysis ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000003765

    authors: Siepmann T,Boardman H,Bilderbeck A,Griffanti L,Kenworthy Y,Zwager C,McKean D,Francis J,Neubauer S,Yu GZ,Lewandowski AJ,Sverrisdottir YB,Leeson P

    更新日期:2017-03-28 00:00:00

  • Severe neurologic complications after hematopoietic stem cell transplantation in children.

    abstract:OBJECTIVE:To describe and evaluate the incidence and risk factors of severe neurologic events (SNE) in pediatric recipients of allogeneic or autologous hematopoietic stem cell transplantation (HSCT) for hematologic or nonhematologic diseases. METHODS:Retrospective analysis of 272 consecutive children admitted to the G...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000036608.42104.b9

    authors: Faraci M,Lanino E,Dini G,Fondelli MP,Morreale G,Dallorso S,Manzitti C,Calevo MG,Gaggero R,Castagnola E,Haupt R

    更新日期:2002-12-24 00:00:00

  • Structural brain imaging and multivariate analysis enable virtual lumbar punctures.

    abstract::Functional brain imaging has been a standard tool in the basic and clinical neurosciences for at least 2 decades, and structural brain imaging can claim an even longer track record of successful use for diagnosis of neurodegenerative disease. It is instructive to recall the ways in which brain imaging has been used to...

    journal_title:Neurology

    pub_type: 评论,社论

    doi:10.1212/WNL.0b013e31827b9305

    authors: Habeck C,Whitwell JL

    更新日期:2013-01-08 00:00:00

  • Singing paraplegia: a distinctive manifestation of a spinal dural arteriovenous fistula.

    abstract::The unique case of a baritone with a spinal dural arteriovenous fistula (SDAVF) causing recurrent, acute paraplegia during singing is described. This case underscores the presence of impaired venous drainage in these lesions and the high level of clinical suspicion required for their diagnosis in patients with any mye...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.58.8.1279

    authors: Khurana VG,Perez-Terzic CM,Petersen RC,Krauss WE

    更新日期:2002-04-23 00:00:00

  • Early myocardial disease and cramping myalgia in Becker-type muscular dystrophy: a kindred.

    abstract::We present a clinical and morphological study concerning a kindred with slowly progressive X-linked muscular dystrophy (Becker type). Five males were affected; one died of heart failure at age 16. Severe and early cardiac disorder is unusual in this type of muscular dystrophy, and death at such an early age had not be...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.29.8.1144

    authors: Kuhn E,Fiehn W,Schröder JM,Assmus H,Wagner A

    更新日期:1979-08-01 00:00:00

  • Practice parameter: pharmacologic treatment of spasticity in children and adolescents with cerebral palsy (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child

    abstract:OBJECTIVE:To evaluate published evidence of efficacy and safety of pharmacologic treatments for childhood spasticity due to cerebral palsy. METHODS:A multidisciplinary panel systematically reviewed relevant literature from 1966 to July 2008. RESULTS:For localized/segmental spasticity, botulinum toxin type A is establ...

    journal_title:Neurology

    pub_type: 杂志文章,实务指引,评审

    doi:10.1212/WNL.0b013e3181cbcd2f

    authors: Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society.,Delgado MR,Hirtz D,Aisen M,Ashwal S,Fehlings DL,McLaughlin J,Morrison LA,Shrader MW,Tilton A,Vargus-Adams

    更新日期:2010-01-26 00:00:00

  • "Dark Victory" (prognosis negative): The beginnings of neurology on screen.

    abstract::In "Dark Victory," released in theaters in 1939, the diagnosis and management of a progressive brain tumor was a central part of the screenplay, and this film marked the beginnings of the depiction of neurologic disease in cinema. Bette Davis' cinematic portrayal of a young woman dying from a brain tumor is close to t...

    journal_title:Neurology

    pub_type: 历史文章,杂志文章

    doi:10.1212/WNL.0000000000002571

    authors: Wijdicks EFM

    更新日期:2016-04-12 00:00:00