Somatosensory system integrity explains differences in treatment response after stroke.

Abstract:

OBJECTIVE:To test the hypothesis that, in the context of robotic therapy designed to enhance proprioceptive feedback via a Hebbian model, integrity of both somatosensory and motor systems would be important in understanding interparticipant differences in treatment-related motor gains. METHODS:In 30 patients with chronic stroke, behavioral performance, neural injury, and neural function were quantified for somatosensory and motor systems. Patients then received a 3-week robot-based therapy targeting finger movements with enhanced proprioceptive feedback. RESULTS:Hand function improved after treatment (Box and Blocks score increase of 2.8 blocks, p = 0.001) but with substantial variability: 9 patients showed improvement exceeding the minimal clinically important difference (6 blocks), while 8 patients (all of whom had >2-SD greater proprioception deficit compared to 25 healthy controls) showed no improvement. In terms of baseline behavioral assessments, a somatosensory measure (finger proprioception assessed robotically) best predicted treatment gains, outperforming all measures of motor behavior. When the neural basis underlying variability in treatment response was examined, somatosensory-related variables were again the strongest predictors. A multivariate model combining total sensory system injury and sensorimotor cortical connectivity (between ipsilesional primary motor and secondary somatosensory cortices) explained 56% of variance in treatment-induced hand functional gains (p = 0.002). CONCLUSIONS:Measures related to the somatosensory network best explained interparticipant differences in treatment-related hand function gains. These results underscore the importance of baseline somatosensory integrity for improving hand function after stroke and provide insights useful for individualizing rehabilitation therapy. CLINICALTRIALSGOV IDENTIFIER:NCT02048826.

journal_name

Neurology

journal_title

Neurology

authors

Ingemanson ML,Rowe JR,Chan V,Wolbrecht ET,Reinkensmeyer DJ,Cramer SC

doi

10.1212/WNL.0000000000007041

subject

Has Abstract

pub_date

2019-03-05 00:00:00

pages

e1098-e1108

issue

10

eissn

0028-3878

issn

1526-632X

pii

WNL.0000000000007041

journal_volume

92

pub_type

临床试验,杂志文章
  • Root stimulation studies in the evaluation of patients with motor neuron disease.

    abstract::Nerve root stimulation may be employed in patients with motor neuron disease (MND) to rule out motor neuropathy with conduction block. The diagnostic utility of these studies is unknown, in part because the range of amplitude changes across nerve root segments in patients with active neuronal degeneration has not been...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.50.6.1907

    authors: Raynor EM,Shefner JM,Ross MH,Logigian EL,Hinchey JA

    更新日期:1998-06-01 00:00:00

  • Disordered swallowing due to a syrinx: correction by shunting.

    abstract::Disturbed deglutition is common in diseases of the brainstem and lower cranial nerves, but little is known about the mechanisms involved. We studied a 49-year-old man with symptoms of syringomyelia and syringobulbia lasting 7 years. Esophageal motility studies showed inability to initiate swallowing, esophageal hypomo...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.34.11.1497

    authors: Bleck TP,Shannon KM

    更新日期:1984-11-01 00:00:00

  • Medial medullary infarction with central sparing.

    abstract::A 35-year-old woman had cardiac arrest requiring treatment with a left ventricular assist device. After regaining consciousness, examination revealed upbeating nystagmus, otherwise normal bulbar function, left arm dysmetria, and numbness periorally and in areas she described as "a turtleneck of numbness with a T-shirt...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000436939.70528.03

    authors: Ryman DC,Ju YE

    更新日期:2013-12-03 00:00:00

  • International Classification of Diseases (ICD-11) and neurologic disorders: the future.

    abstract::When the WHO's Topic Advisory Group for Neurology (TAG) started work on revision of the ICD-10 diagnostic codes in June 2009, the issues were daunting. The existing classification was produced a generation ago and the need to move to the digital age was becoming imperative. Appreciating modern advances in genetics and...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e31829a333c

    authors: Shakir R,Bergen D

    更新日期:2013-07-09 00:00:00

  • Alpha-methyl-L-tryptophan PET detects epileptogenic cortex in children with intractable epilepsy.

    abstract:BACKGROUND:In children with tuberous sclerosis, the PET tracer alpha[11C]methyl-L-tryptophan (AMT) has been shown to be selectively taken up by epileptogenic tubers, thus allowing differentiation from nonepileptogenic tubers in the interictal state. OBJECTIVE:To determine whether cortical areas showing increased AMT u...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000049468.05050.f2

    authors: Juhász C,Chugani DC,Muzik O,Shah A,Asano E,Mangner TJ,Chakraborty PK,Sood S,Chugani HT

    更新日期:2003-03-25 00:00:00

  • Postmenopausal hormone therapy and Alzheimer disease: A prospective cohort study.

    abstract:OBJECTIVE:To explore the association between postmenopausal hormone therapy (HT) and Alzheimer disease (AD). METHODS:Twenty-year follow-up data from the Kuopio Osteoporosis Risk Factor and Prevention study cohort were used. Self-administered questionnaires were sent to all women aged 47-56 years, residing in Kuopio Pr...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000003696

    authors: Imtiaz B,Tuppurainen M,Rikkonen T,Kivipelto M,Soininen H,Kröger H,Tolppanen AM

    更新日期:2017-03-14 00:00:00

  • Cognitive effects of one season of head impacts in a cohort of collegiate contact sport athletes.

    abstract:OBJECTIVE:To determine whether exposure to repetitive head impacts over a single season negatively affects cognitive performance in collegiate contact sport athletes. METHODS:This is a prospective cohort study at 3 Division I National Collegiate Athletic Association athletic programs. Participants were 214 Division I ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3182582fe7

    authors: McAllister TW,Flashman LA,Maerlender A,Greenwald RM,Beckwith JG,Tosteson TD,Crisco JJ,Brolinson PG,Duma SM,Duhaime AC,Grove MR,Turco JH

    更新日期:2012-05-29 00:00:00

  • Impact of multiple sclerosis relapses on progression diminishes with time.

    abstract:OBJECTIVE:The relationship between relapses and long-term disability in multiple sclerosis (MS) remains to be fully elucidated. Current literature is conflicting and focused on early relapses. We investigated the effects of relapses at different stages on disability progression. METHODS:We conducted a retrospective re...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3181c1e44f

    authors: Tremlett H,Yousefi M,Devonshire V,Rieckmann P,Zhao Y,UBC Neurologists.

    更新日期:2009-11-17 00:00:00

  • Study of the afferent pathways from the rectum with a new distention control device.

    abstract::Quantitative studies of the afferent pathways from hollow viscera have been limited by the lack of an easily controlled, reproducible visceral stimulus. We adapted a slow distention device to allow for rapid distention to study the afferent pathways from the rectum. The device produced a pressure increase of 10 mm Hg ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.45.8.1510

    authors: Loening-Baucke V,Anderson RH,Yamada T,Zhu YX

    更新日期:1995-08-01 00:00:00

  • Controlled-release carbidopa/levodopa (Sinemet 50/200 CR4): clinical and pharmacokinetic studies.

    abstract::Several controlled-release carbidopa/levodopa preparations have been formulated to achieve a more stable and extended antiparkinsonian action. The most effective is Sinemet CR (Sinemet CR4), with an erodible polymer matrix that retards release of levodopa. In 19 parkinsonians with prominent dose-by-dose fluctuations, ...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章

    doi:

    authors: LeWitt PA,Nelson MV,Berchou RC,Galloway MP,Kesaree N,Kareti D,Schlick P

    更新日期:1989-11-01 00:00:00

  • Assessment of hand function in a patient with chronic sensory demyelinating neuropathy.

    abstract::A 60-year-old man presented with progressive large fiber sensory loss in the right first three fingers and, to a lesser extent, in both fourth and fifth fingers. Electrophysiologic studies were characteristic of chronic sensory demyelinating polyneuropathy, a variant of chronic inflammatory demyelinating polyneuropath...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.49.1.253

    authors: Thonnard JL,Detrembleur C,Van den Bergh PY

    更新日期:1997-07-01 00:00:00

  • Motor perseverative behavior on a line cancellation task.

    abstract:OBJECTIVES:To study the behavioral and neuroanatomic characteristics of perseverative behavior encountered on a target cancellation task in patients with neglect. METHODS:Motor perseverative behavior during line cancellation task was evaluated retrospectively in 60 patients with left hemispatial neglect from right hem...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.52.8.1569

    authors: Na DL,Adair JC,Kang Y,Chung CS,Lee KH,Heilman KM

    更新日期:1999-05-12 00:00:00

  • Intermittent negative pressure ventilation in the treatment of respiratory failure in progressive neuromuscular disease.

    abstract::Five men with degenerative neuromuscular diseases (three with amyotrophic lateral sclerosis [ALS] and two with Duchenne's muscular dystrophy [DMD]) who had respiratory failure were treated with intermittent negative pressure ventilation (NPV). One patient with ALS in severe acute respiratory failure was successfully t...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.37.12.1874

    authors: Braun SR,Sufit RL,Giovannoni R,O'Connor M,Peters H

    更新日期:1987-12-01 00:00:00

  • Spinal cord venous infarction following endoscopic sclerotherapy for esophageal varices.

    abstract::The authors report an unusual case of venous infarction of the spinal cord associated with endoscopic sclerotherapy for esophageal varices. MR imaging findings included signal abnormalities and abnormal enhancement of the affected spinal cord and T-8 vertebral body. A review of the hemodynamic changes associated with ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.47.4.1081

    authors: Heller SL,Meyer JR,Russell EJ

    更新日期:1996-10-01 00:00:00

  • Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials.

    abstract:OBJECTIVE:To revise the 1999 Airlie House consensus guidelines for the design and implementation of preclinical therapeutic studies and clinical trials in amyotrophic lateral sclerosis (ALS). METHODS:A consensus committee comprising 140 key members of the international ALS community (ALS researchers, clinicians, patie...

    journal_title:Neurology

    pub_type: 共识发展会议,杂志文章

    doi:10.1212/WNL.0000000000007242

    authors: van den Berg LH,Sorenson E,Gronseth G,Macklin EA,Andrews J,Baloh RH,Benatar M,Berry JD,Chio A,Corcia P,Genge A,Gubitz AK,Lomen-Hoerth C,McDermott CJ,Pioro EP,Rosenfeld J,Silani V,Turner MR,Weber M,Brooks BR,Miller

    更新日期:2019-04-02 00:00:00

  • The apolipoprotein epsilon 4 allele in Parkinson's disease with and without dementia.

    abstract::The epsilon 4 isoform of apolipoprotein E (Apo-E) may confer genetic susceptibility for familial and sporadic Alzheimer's disease (AD). Because dementia in AD and Parkinson's disease (PD) share many biologic and clinical features, we determined the Apo-E genotypes for 79 patients with PD, 22 of whom were demented, and...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.44.7.1330

    authors: Marder K,Maestre G,Cote L,Mejia H,Alfaro B,Halim A,Tang M,Tycko B,Mayeux R

    更新日期:1994-07-01 00:00:00

  • Depressive symptoms and white matter dysfunction in retired NFL players with concussion history.

    abstract:OBJECTIVE:To determine whether correlates of white matter integrity can provide general as well as specific insight into the chronic effects of head injury coupled with depression symptom expression in professional football players. METHOD:We studied 26 retired National Football League (NFL) athletes who underwent dif...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e318299ccf8

    authors: Strain J,Didehbani N,Cullum CM,Mansinghani S,Conover H,Kraut MA,Hart J Jr,Womack KB

    更新日期:2013-07-02 00:00:00

  • Multiple sclerosis and childhood infections.

    abstract::Migration from an area where MS is common to an area where it is rare (and vice versa) affects the risk of MS, provided migration occurs in childhood. A childhood infection might explain this effect. Therefore, the age pattern of infectious diseases in different regions was examined. A higher proportion of children sh...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.36.10.1386

    authors: Alter M,Zhang ZX,Davanipour Z,Sobel E,Zibulewski J,Schwartz G,Friday G

    更新日期:1986-10-01 00:00:00

  • Congenital retardation and central motor defect with later evolution of seizure disorder, orofacial dysplasia, and amyotrophy. A clinicopathologic report.

    abstract::Retarded mental and motor development was observed during the first year of life of a full-term female who had been delivered with difficulty. Generalized psychomotor seizures and dysplastic "acromegalic" facial changes began to develop when she was 8 years old, and generalized amyotrophy developed over the next sever...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.26.9.869

    authors: Landau WM,Torack RM,Guggenheim MA

    更新日期:1976-09-01 00:00:00

  • Subacute, reversible motor neuron disease.

    abstract::Four patients with a clinical syndrome closely resembling amyotrophic lateral sclerosis recovered completely, without treatment, 5 to 12 months after onset. Electrodiagnostic tests revealed acute and chronic denervation, with normal motor and sensory nerve conduction studies. The CSF was normal, and tests for paraprot...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.41.10.1541

    authors: Tucker T,Layzer RB,Miller RG,Chad D

    更新日期:1991-10-01 00:00:00

  • Applying the ATN scheme in a memory clinic population: The ABIDE project.

    abstract:OBJECTIVE:To apply the ATN scheme to memory clinic patients, to assess whether it discriminates patient populations with specific features. METHODS:We included 305 memory clinic patients (33% subjective cognitive decline [SCD]: 60 ± 9 years, 61% M; 19% mild cognitive impairment [MCI]: 68 ± 9 years, 68% M; 48% dementia...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000008361

    authors: Altomare D,de Wilde A,Ossenkoppele R,Pelkmans W,Bouwman F,Groot C,van Maurik I,Zwan M,Yaqub M,Barkhof F,van Berckel BN,Teunissen CE,Frisoni GB,Scheltens P,van der Flier WM

    更新日期:2019-10-22 00:00:00

  • Neuroinflammation drives anxiety and depression in relapsing-remitting multiple sclerosis.

    abstract:OBJECTIVE:To explore the inflammatory processes in the pathogenesis of psychiatric symptoms and the prognostic value of psychiatric comorbidities in multiple sclerosis (MS). METHODS:Four hundred five patients with relapsing-remitting (RR) MS underwent psychiatric evaluation by means of Beck Depression Inventory II (BD...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000004411

    authors: Rossi S,Studer V,Motta C,Polidoro S,Perugini J,Macchiarulo G,Giovannetti AM,Pareja-Gutierrez L,Calò A,Colonna I,Furlan R,Martino G,Centonze D

    更新日期:2017-09-26 00:00:00

  • Higher probability of prodromal Parkinson disease is related to lower cognitive performance.

    abstract:OBJECTIVE:Given the limited information on cognitive function before Parkinson disease (PD) clinical onset in the general population, we sought to assess prodromal PD (pPD) probability and relate it to detailed cognitive performance in a community cohort. METHODS:In a population-based cohort of 1,629 dementia-free and...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000007453

    authors: Bougea A,Maraki MI,Yannakoulia M,Stamelou M,Xiromerisiou G,Kosmidis MH,Ntanasi E,Dardiotis E,Hadjigeorgiou GM,Sakka P,Anastasiou CA,Stefanis L,Scarmeas N

    更新日期:2019-05-07 00:00:00

  • Sensory Guillain-Barré syndrome.

    abstract:OBJECTIVE:To report eight cases of sensory Guillain-Barré syndrome (GBS). BACKGROUND:The concept of sensory equivalent to ascending paralysis of GBS was raised in 1958, and the diagnostic criteria for a sensory loss and areflexia variant of GBS were proposed in 1981. However, clinical cases meeting these criteria have...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.56.1.82

    authors: Oh SJ,LaGanke C,Claussen GC

    更新日期:2001-01-09 00:00:00

  • A family with hereditary ataxia: HLA typing.

    abstract::In a previously unreported family with olivopontocerebellar atrophy, the kindred contained over 600 individuals in five generations. Of 83 offsping of affected individuals who over over 38.8 years of age (the mean age of the onset of disease in this family), 47 had ataxia; there was autosomal dominant transmission. Cl...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.30.1.12

    authors: Nino HE,Noreen HJ,Dubey DP,Resch JA,Namboodiri K,Elston RC,Yunis EJ

    更新日期:1980-01-01 00:00:00

  • Effect of tryptophan depletion on symptoms of motion sickness in migraineurs.

    abstract::Seven hours after 39 migraineurs and 37 controls consumed an amino acid drink that contained or omitted l-tryptophan (thereby reducing brain serotonin synthesis), motion sickness was provoked by the visual illusion of movement. Tryptophan depletion boosted dizziness, nausea, and the illusion of movement in controls to...

    journal_title:Neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1212/01.wnl.0000172339.15577.a6

    authors: Drummond PD

    更新日期:2005-08-23 00:00:00

  • Thrombolytic stroke therapy: past, present, and future.

    abstract::Until 1995, treatment of strokes consisted exclusively of efforts to prevent recurrence. Proof that tissue plasminogen activator is useful for acute management is changing the approach to stroke patients. The development process has been difficult and the current treatment recommendations have been controversial. Rece...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.53.1.14

    authors: Zivin JA

    更新日期:1999-07-13 00:00:00

  • Infantile spasm-associated microencephaly in tuberous sclerosis complex and cortical dysplasia.

    abstract:OBJECTIVE:In children with and without infantile spasms, this study determined brain volumes and cell densities in epilepsy surgery patients with tuberous sclerosis complex (TSC) and cortical dysplasia with balloon cells (CD). METHODS:We compared TSC (n = 18) and CD (n = 17) patients with normal/autopsy controls (n = ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000252952.62543.20

    authors: Chandra PS,Salamon N,Nguyen ST,Chang JW,Huynh MN,Cepeda C,Leite JP,Neder L,Koh S,Vinters HV,Mathern GW

    更新日期:2007-02-06 00:00:00

  • A new explanation for recessive myotonia congenita: exon deletions and duplications in CLCN1.

    abstract:OBJECTIVE:To assess whether exon deletions or duplications in CLCN1 are associated with recessive myotonia congenita (MC). METHODS:We performed detailed clinical and electrophysiologic characterization in 60 patients with phenotypes consistent with MC. DNA sequencing of CLCN1 followed by multiplex ligation-dependent p...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e318259e19c

    authors: Raja Rayan DL,Haworth A,Sud R,Matthews E,Fialho D,Burge J,Portaro S,Schorge S,Tuin K,Lunt P,McEntagart M,Toscano A,Davis MB,Hanna MG

    更新日期:2012-06-12 00:00:00

  • Phenytoin elimination in childhood: effect of concentration-dependent kinetics.

    abstract::The effect of phenytoin (PHT) concentration on the elimination rate of PHT was evaluated in infants, children, and young adults ranging in age from 1 day to 22 years. As PHT concentration increased, the effective half-life (t50%) increased. In eight children, age 7 months to 4.83 years with initial concentrations betw...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.30.2.196

    authors: Dodson WE

    更新日期:1980-02-01 00:00:00