Assessment of hand function in a patient with chronic sensory demyelinating neuropathy.

Abstract:

:A 60-year-old man presented with progressive large fiber sensory loss in the right first three fingers and, to a lesser extent, in both fourth and fifth fingers. Electrophysiologic studies were characteristic of chronic sensory demyelinating polyneuropathy, a variant of chronic inflammatory demyelinating polyneuropathy. Plasma exchange was unsuccessful, but intravenous immunoglobulin (IVIG) led to complete recovery of sensation for 2 months, although neurophysiologic abnormalities persisted. A battery of noninvasive tests to measure hand grip strength, tactile sensation at the fingertips, and motor control of prehension during precision grip revealed marked abnormalities in the right hand before IVIG. One month after IVIG, all test results had normalized, but they returned to pretreatment levels after 3 months. Functional evaluation of the hand may be a sensitive method to objectively quantify loss of and changes in cutaneous mechanoreceptor function of the fingers in large fiber sensory neuropathy.

journal_name

Neurology

journal_title

Neurology

authors

Thonnard JL,Detrembleur C,Van den Bergh PY

doi

10.1212/wnl.49.1.253

subject

Has Abstract

pub_date

1997-07-01 00:00:00

pages

253-7

issue

1

eissn

0028-3878

issn

1526-632X

journal_volume

49

pub_type

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