A randomized crossover study of bee sting therapy for multiple sclerosis.


BACKGROUND:Bee sting therapy is increasingly used to treat patients with multiple sclerosis (MS) in the belief that it can stabilize or ameliorate the disease. However, there are no clinical studies to justify its use. METHODS:In a randomized, crossover study, we assigned 26 patients with relapsing-remitting or relapsing secondary progressive MS to 24 weeks of medically supervised bee sting therapy or 24 weeks of no treatment. Live bees (up to a maximum of 20) were used to administer bee venom three times per week. The primary outcome was the cumulative number of new gadolinium-enhancing lesions on T1-weighted MRI of the brain. Secondary outcomes were lesion load on T2*-weighted MRI, relapse rate, disability (Expanded Disability Status Scale, Multiple Sclerosis Functional Composite, Guy's Neurologic Disability Scale), fatigue (Abbreviated Fatigue Questionnaire, Fatigue Impact Scale), and health-related quality of life (Medical Outcomes Study 36-Item Short Form General Health Survey). RESULTS:During bee sting therapy, there was no significant reduction in the cumulative number of new gadolinium-enhancing lesions. The T2*-weighted lesion load further progressed, and there was no significant reduction in relapse rate. There was no improvement of disability, fatigue, and quality of life. Bee sting therapy was well tolerated, and there were no serious adverse events. CONCLUSIONS:In this trial, treatment with bee venom in patients with relapsing multiple sclerosis did not reduce disease activity, disability, or fatigue and did not improve quality of life.






Wesselius T,Heersema DJ,Mostert JP,Heerings M,Admiraal-Behloul F,Talebian A,van Buchem MA,De Keyser J




Has Abstract


2005-12-13 00:00:00














  • Angioplasty and stenting for stroke prevention: good questions that need answers.

    abstract::Extracranial and intracranial angioplasty and stenting of the cerebral vessels are being performed more frequently. One clinical trial demonstrated equivalent outcomes between extracranial carotid angioplasty and carotid endarterectomy, but the results in both groups were suboptimal. Concerns remain about the iatrogen...


    pub_type: 杂志文章,评审


    authors: Chaturvedi S,Fessler R

    更新日期:2002-09-10 00:00:00

  • Immune reconstitution inflammatory syndrome associated with PML in AIDS: a treatable disorder.

    abstract::An HIV-1-infected patient with progressive multifocal leukoencephalopathy presented clinical deterioration and contrast-enhancing lesions on brain nuclear MR after the initiation of highly active antiretroviral therapy (HAART). Brain biopsy identified an inflammatory reaction compatible with immune reconstitution infl...


    pub_type: 杂志文章


    authors: Martinez JV,Mazziotti JV,Efron ED,Bonardo P,Jordan R,Sevlever G,Martinez M,Verbanaz SC,Salazar ZS,Pardal MF,Reisin R

    更新日期:2006-11-14 00:00:00

  • Quantitative strength testing in ALS clinical trials.

    abstract:OBJECTIVE:To study the attributes of quantitative strength testing using hand-held dynamometry (HHD) as an efficacy measure in 2 large phase 3 amyotrophic lateral sclerosis (ALS) trials. METHODS:In the phase 3 trials of ceftriaxone and dexpramipexole, 513 and 943 patients, respectively, were enrolled in double-blind, ...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Shefner JM,Liu D,Leitner ML,Schoenfeld D,Johns DR,Ferguson T,Cudkowicz M

    更新日期:2016-08-09 00:00:00

  • Plasma tau correlates with basal forebrain atrophy rates in people at risk for Alzheimer disease.

    abstract:OBJECTIVE:To investigate whether baseline concentrations of plasma total tau (t-tau) and neurofilament light (NfL) chain proteins are associated with annual percent change (APC) of the basal forebrain cholinergic system (BFCS) in cognitively intact older adults at risk for Alzheimer disease (AD). METHODS:This was a la...


    pub_type: 杂志文章


    authors: Cavedo E,Lista S,Houot M,Vergallo A,Grothe MJ,Teipel S,Zetterberg H,Blennow K,Habert MO,Potier MC,Dubois B,Hampel H,INSIGHT-preAD Study Group.,Alzheimer Precision Medicine Initiative

    更新日期:2020-01-07 00:00:00

  • Validating and comparing stroke prognosis scales.

    abstract:OBJECTIVE:To compare the prognostic accuracy of various acute stroke prognostic scales using a large, independent, clinical trials dataset. METHODS:We directly compared 8 stroke prognostic scales, chosen based on focused literature review (Acute Stroke Registry and Analysis of Lausanne [ASTRAL]; iSCORE; iSCORE-revised...


    pub_type: 杂志文章


    authors: Quinn TJ,Singh S,Lees KR,Bath PM,Myint PK,VISTA Collaborators.

    更新日期:2017-09-05 00:00:00

  • A prion protein missense variant is integrated in kuru plaque cores in patients with Gerstmann-Sträussler syndrome.

    abstract::Kuru plaques are the pathologic hallmark in Gerstmann-Sträussler syndrome (GSS). To demonstrate that prion protein (PrP) is a component of kuru plaque cores, we fractionated and sequenced kuru plaque core derived peptides, following digestion with Achromobacter lyticus protease I. We identified 3 PrP-derived peptides ...


    pub_type: 杂志文章


    authors: Kitamoto T,Yamaguchi K,Doh-ura K,Tateishi J

    更新日期:1991-02-01 00:00:00

  • Change in body mass index and risk of incident Alzheimer disease.

    abstract:OBJECTIVE:To examine the association of change in body mass index (BMI) with risk of Alzheimer disease (AD). METHODS:Nine hundred eighteen older Catholic clergy participating in the Religious Orders Study without dementia at baseline were studied. Outcome measures were the clinical diagnosis of AD and change in cognit...


    pub_type: 杂志文章


    authors: Buchman AS,Wilson RS,Bienias JL,Shah RC,Evans DA,Bennett DA

    更新日期:2005-09-27 00:00:00

  • Wolfram syndrome: evidence of a diffuse neurodegenerative disease by magnetic resonance imaging.

    abstract::Wolfram syndrome is an autosomal recessive disorder beginning in childhood that consists of four cardinal features: optic atrophy, diabetes mellitus, diabetes insipidus, and neurosensory hearing loss. Aside from these features, the clinical picture is highly variable and may include other neurologic abnormalities such...


    pub_type: 杂志文章


    authors: Rando TA,Horton JC,Layzer RB

    更新日期:1992-06-01 00:00:00

  • Neuropathology of primary adult-onset dystonia.

    abstract:BACKGROUND:Idiopathic adult-onset primary dystonia usually affects the upper body and remains focal. Underlying mechanisms are unknown, and there are only limited neuropathologic studies in the literature. Recently, ubiquitinated perinuclear inclusion bodies were found in the brainstem of patients with DYT1-related dys...


    pub_type: 杂志文章


    authors: Holton JL,Schneider SA,Ganesharajah T,Gandhi S,Strand C,Shashidharan P,Barreto J,Wood NW,Lees AJ,Bhatia KP,Revesz T

    更新日期:2008-02-26 00:00:00

  • Improving uniformity in brain death determination policies over time.

    abstract:OBJECTIVE:To demonstrate that progress has been made in unifying brain death determination guidelines in the last decade by directly comparing the policies of the US News and World Report's top 50 ranked neurologic institutions from 2006 and 2015. METHODS:We solicited official hospital guidelines in 2015 from these to...


    pub_type: 杂志文章


    authors: Wang HH,Varelas PN,Henderson GV,Wijdicks EF,Greer DM

    更新日期:2017-02-07 00:00:00

  • Surgery for intracerebral hemorrhage.

    abstract::Intracerebral hemorrhage (ICH) represents 8 to 15% of all strokes in the United States and 20 to 30% of all strokes in Japan and China. Although ICH represents a relatively small fraction of total strokes, it is a formidable disease, with a 30-day mortality rate two- to sixfold higher than that for ischemic stroke. Fu...


    pub_type: 杂志文章,评审


    authors: Fayad PB,Awad IA

    更新日期:1998-09-01 00:00:00

  • Faster cognitive decline in elders without dementia and decreased risk of cancer mortality: NEDICES Study.

    abstract:OBJECTIVE:To assess whether faster cognitive decline in elders without dementia is associated with decreased risk of cancer mortality. METHODS:In this population-based, prospective study of 2,627 people without dementia aged 65 years and older (Neurological Disorders in Central Spain), a 37-item version of the Mini-Me...


    pub_type: 杂志文章


    authors: Benito-León J,Romero JP,Louis ED,Bermejo-Pareja F

    更新日期:2014-04-22 00:00:00

  • Differences in cognitive impairment of relapsing remitting, secondary, and primary progressive MS.

    abstract:OBJECTIVE:To investigate the cognitive skills of patients with relapsing remitting multiple sclerosis (RRMS), secondary progressive MS (SPMS), and primary progressive MS (PPMS) relative to healthy control subjects and to assess whether there is heterogeneity in the type of cognitive disabilities demonstrated by patient...


    pub_type: 杂志文章


    authors: Huijbregts SC,Kalkers NF,de Sonneville LM,de Groot V,Reuling IE,Polman CH

    更新日期:2004-07-27 00:00:00

  • Magnetic resonance brain tumor imaging in canine glioma.

    abstract::This study investigates a canine model of experimental brain tumor. Particularly addressed was the usefulness of gadolinium contrast-enhanced MRI for differentiating brain tumor tissue from cerebral edema. Cultured canine glioma cells were injected into the left hemispheres of six adult mongrel dogs. All dogs develope...


    pub_type: 杂志文章


    authors: Whelan HT,Clanton JA,Moore PM,Tolner DJ,Kessler RM,Whetsell WO Jr

    更新日期:1987-07-01 00:00:00

  • Mitochondrial DNA alterations as a source of human disorders.

    abstract::The mitochondrial genome has an underdeveloped "DNA repair repertoire" compared with the nuclear genome, making the mitochondrial DNA more susceptible to mutations by endogenous factors such as defects of the mitochondrial polymerase itself, and by exogenous factors such as radiation and UV light. Increased sensitivit...


    pub_type: 杂志文章,评审


    authors: Tritschler HJ,Medori R

    更新日期:1993-02-01 00:00:00

  • Sex difference in prevalence of depression after stroke.

    abstract:OBJECTIVE:This study investigated the sex difference in prevalence of depression at 90 days after first-ever stroke. METHODS:Patients with first-ever stroke (n = 786) were identified from the population-based Brain Attack Surveillance in Corpus Christi project (2011-2016). Poststroke depressive symptoms were assessed ...


    pub_type: 杂志文章


    authors: Dong L,Sánchez BN,Skolarus LE,Stulberg E,Morgenstern LB,Lisabeth LD

    更新日期:2020-05-12 00:00:00

  • Clinical and genetic study of a large Italian family linked to SPG12 locus.

    abstract:BACKGROUND:Seven loci for autosomal dominant hereditary spastic paraplegia (ADHSP) have been mapped. To date, two families of SPG12 (chromosome 19q13) have been analyzed; however, there is not enough clinical information on SPG12 to establish locus-phenotype correlations. METHODS:The authors studied 60 individuals fro...


    pub_type: 杂志文章


    authors: Orlacchio A,Kawarai T,Rogaeva E,Song YQ,Paterson AD,Bernardi G,St George-Hyslop PH

    更新日期:2002-11-12 00:00:00

  • Characterization of patients with longstanding idiopathic REM sleep behavior disorder.

    abstract:OBJECTIVE:To evaluate the presence of prodromal markers of Parkinson disease (PD) in patients with longstanding idiopathic REM sleep behavior disorder (IRBD), a small subgroup of individuals with IRBD with long-term follow-up thought not to be at risk of developing PD. METHODS:Demographic, clinical, and neuroimaging m...


    pub_type: 杂志文章


    authors: Iranzo A,Stefani A,Serradell M,Martí MJ,Lomeña F,Mahlknecht P,Stockner H,Gaig C,Fernández-Arcos A,Poewe W,Tolosa E,Högl B,Santamaria J,SINBAR (Sleep Innsbruck Barcelona) group.

    更新日期:2017-07-18 00:00:00

  • Differential changes in neurochemical markers of striatal dopamine nerve terminals in idiopathic Parkinson's disease.

    abstract::To determine the extent that different dopamine (DA) neuronal markers provide similar estimates of striatal (caudate and putamen) DA nerve terminal loss in idiopathic Parkinson's disease (PD), we compared, in postmortem striatum of 12 patients with PD and 10 matched controls, levels of five different DA neuronal marke...


    pub_type: 杂志文章


    authors: Wilson JM,Levey AI,Rajput A,Ang L,Guttman M,Shannak K,Niznik HB,Hornykiewicz O,Pifl C,Kish SJ

    更新日期:1996-09-01 00:00:00

  • Friedreich's disease: V. Variant form with vitamin E deficiency and normal fat absorption.

    abstract::A 30-year-old woman was thought to have Friedreich's disease because of progressive ataxia, dysarthria, and titubation from age 3 years. Her diet was normal, and there were neither symptoms nor laboratory evidence of liver disease or fat malabsorption. Serum vitamin E content and the ratio of serum vitamin E to total ...


    pub_type: 杂志文章


    authors: Stumpf DA,Sokol R,Bettis D,Neville H,Ringel S,Angelini C,Bell R

    更新日期:1987-01-01 00:00:00

  • Network dysfunction predicts speech production after left hemisphere stroke.

    abstract:OBJECTIVE:To investigate the role of multiple distributed brain networks, including the default mode, fronto-temporo-parietal, and cingulo-opercular networks, which mediate domain-general and task-specific processes during speech production after aphasic stroke. METHODS:We conducted an observational functional MRI stu...


    pub_type: 杂志文章


    authors: Geranmayeh F,Leech R,Wise RJS

    更新日期:2016-04-05 00:00:00

  • Evidence-based guideline: diagnostic accuracy of CSF 14-3-3 protein in sporadic Creutzfeldt-Jakob disease: report of the guideline development subcommittee of the American Academy of Neurology.

    abstract:OBJECTIVE:To assess the available evidence for the diagnostic accuracy of CSF testing for protein 14-3-3 in patients with suspected sporadic Creutzfeldt-Jakob disease (sCJD). METHODS:The authors performed a systematic review of the available literature from 1995 to January 1, 2011, to identify articles involving patie...


    pub_type: 杂志文章


    authors: Muayqil T,Gronseth G,Camicioli R

    更新日期:2012-10-02 00:00:00

  • Saccades in children with spina bifida and Chiari type II malformation.

    abstract:BACKGROUND:Saccades are essential for optimal visual function. Chiari type II malformation (CII) is a congenital anomaly of the cerebellum and brainstem, associated with spina bifida. OBJECTIVE:To investigate the effects of CII on saccades and correlate saccadic parameters with brain MRI measurements. METHODS:Saccade...


    pub_type: 杂志文章


    authors: Salman MS,Sharpe JA,Eizenman M,Lillakas L,To T,Westall C,Steinbach MJ,Dennis M

    更新日期:2005-06-28 00:00:00

  • A controlled trial with vasopressin analogue (DGAVP) on cognitive recovery immediately after head trauma.

    abstract::Recent evidence suggests that the vasopressin analogue desglycinamide-arginine8-vasopressin (DGAVP) might specifically benefit mild brain trauma patients. We investigated the effect of intranasal DGAVP treatment in 32 patients who had sustained a mild head injury for 3 months in a double-blind, placebo-controlled, mat...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bohnen NI,Twijnstra A,Jolles J

    更新日期:1993-01-01 00:00:00

  • Diffusion tensor imaging and cognitive function in older adults with no dementia.

    abstract:OBJECTIVE:To determine the patterns of diffusivity associated with cognitive domain functions in older adults without dementia. METHODS:We studied older adults without dementia (n = 220) who underwent neuropsychometric testing and a diffusion tensor imaging (DTI) examination at 3 T in a cross-sectional study. Memory, ...


    pub_type: 杂志文章


    authors: Kantarci K,Senjem ML,Avula R,Zhang B,Samikoglu AR,Weigand SD,Przybelski SA,Edmonson HA,Vemuri P,Knopman DS,Boeve BF,Ivnik RJ,Smith GE,Petersen RC,Jack CR Jr

    更新日期:2011-07-05 00:00:00

  • Prevalence of headaches in a Chinese elderly population in Kinmen: age and gender effect and cross-cultural comparisons.

    abstract:OBJECTIVE:To investigate the prevalence of headaches in a Chinese elderly population. BACKGROUND:There are few headache surveys in the elderly. Previous studies have shown a low headache prevalence in Chinese. METHODS: TARGET POPULATION:eligible registered residents > or = 65 years old (N = 2,003) in two townships o...


    pub_type: 杂志文章


    authors: Wang SJ,Liu HC,Fuh JL,Liu CY,Lin KP,Chen HM,Lin CH,Wang PN,Hsu LC,Wang HC,Lin KN

    更新日期:1997-07-01 00:00:00

  • Sensitivity of MRI of the spine compared with CT myelography in orthostatic headache with CSF leak.

    abstract:OBJECTIVE:To investigate the sensitivity of MRI of the spine compared with CT myelography (CTM) in detecting CSF leaks. METHODS:Between July 1998 and October 2010, 12 patients with orthostatic headache and a CTM-confirmed spinal CSF leak underwent an MRI of the spine with and without contrast. Using CTM as the gold st...


    pub_type: 杂志文章


    authors: Starling A,Hernandez F,Hoxworth JM,Trentman T,Halker R,Vargas BB,Hastriter E,Dodick D

    更新日期:2013-11-12 00:00:00

  • Longitudinal and cross-sectional analysis of atrophy in pharmacoresistant temporal lobe epilepsy.

    abstract:BACKGROUND:Whether recurrent epileptic seizures induce brain damage is debated. Disease progression in epilepsy has been evaluated only in a few community-based studies involving patients with seizures well controlled by medication. These studies concluded that epilepsy does not inevitably lead to global cerebral damag...


    pub_type: 杂志文章


    authors: Bernhardt BC,Worsley KJ,Kim H,Evans AC,Bernasconi A,Bernasconi N

    更新日期:2009-05-19 00:00:00

  • Prognostic significance of blood pressure variability after thrombolysis in acute stroke.

    abstract:OBJECTIVE:To evaluate the impact of early blood pressure (BP) changes on diffusion-weighted imaging (DWI) lesion evolution and clinical outcome in patients with stroke treated with IV tissue plasminogen activator (tPA). METHODS:We prospectively evaluated 80 patients with stroke with a documented middle cerebral artery...


    pub_type: 杂志文章


    authors: Delgado-Mederos R,Ribo M,Rovira A,Rubiera M,Munuera J,Santamarina E,Delgado P,Maisterra O,Alvarez-Sabin J,Molina CA

    更新日期:2008-08-19 00:00:00

  • Plasma exchange in chronic progressive multiple sclerosis: a long-term study.

    abstract::Plasma exchange (PE) was shown in a previous double-blind randomized controlled study to confer significant additional benefit at 1 year upon patients with chronic progressive multiple sclerosis (CPMS) treated with immunosuppressive drug therapy (ISDT). Efficacy over an extended term, indications for retreatment, and ...


    pub_type: 杂志文章


    authors: Khatri BO,McQuillen MP,Hoffmann RG,Harrington GJ,Schmoll D

    更新日期:1991-03-01 00:00:00