Abstract:
BACKGROUND:Bee sting therapy is increasingly used to treat patients with multiple sclerosis (MS) in the belief that it can stabilize or ameliorate the disease. However, there are no clinical studies to justify its use. METHODS:In a randomized, crossover study, we assigned 26 patients with relapsing-remitting or relapsing secondary progressive MS to 24 weeks of medically supervised bee sting therapy or 24 weeks of no treatment. Live bees (up to a maximum of 20) were used to administer bee venom three times per week. The primary outcome was the cumulative number of new gadolinium-enhancing lesions on T1-weighted MRI of the brain. Secondary outcomes were lesion load on T2*-weighted MRI, relapse rate, disability (Expanded Disability Status Scale, Multiple Sclerosis Functional Composite, Guy's Neurologic Disability Scale), fatigue (Abbreviated Fatigue Questionnaire, Fatigue Impact Scale), and health-related quality of life (Medical Outcomes Study 36-Item Short Form General Health Survey). RESULTS:During bee sting therapy, there was no significant reduction in the cumulative number of new gadolinium-enhancing lesions. The T2*-weighted lesion load further progressed, and there was no significant reduction in relapse rate. There was no improvement of disability, fatigue, and quality of life. Bee sting therapy was well tolerated, and there were no serious adverse events. CONCLUSIONS:In this trial, treatment with bee venom in patients with relapsing multiple sclerosis did not reduce disease activity, disability, or fatigue and did not improve quality of life.
journal_name
Neurologyjournal_title
Neurologyauthors
Wesselius T,Heersema DJ,Mostert JP,Heerings M,Admiraal-Behloul F,Talebian A,van Buchem MA,De Keyser Jdoi
10.1212/01.wnl.0000184442.02551.4bsubject
Has Abstractpub_date
2005-12-13 00:00:00pages
1764-8issue
11eissn
0028-3878issn
1526-632Xpii
01.wnl.0000184442.02551.4bjournal_volume
65pub_type
杂志文章,随机对照试验相关文献
NEUROLOGY文献大全abstract::The authors conducted a randomized, double-blind, placebo-controlled, twofold crossover study in 16 patients with MS who presented with severe spasticity to investigate safety, tolerability, and efficacy of oral Delta(9)-Tetrahydrocannabinol (THC) and Cannabis sativa plant extract. Both drugs were safe, but adverse ev...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.58.9.1404
更新日期:2002-05-14 00:00:00
abstract::Cerebral necrosis following stroke exposes brain antigens to the immune system, potentially initiating an antibody response. The authors measured levels of antibodies to specific neuronal antigens, neurofilaments (NF), and a ubiquitous antigen, cardiolipin (CL), in 45 patients following an acute first-ever stroke, wit...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.4.529
更新日期:2001-02-27 00:00:00
abstract:OBJECTIVE:Prospective memory (PM) describes the ability to fulfill previously planned intentions and is highly dependent on executive functions. Previous studies have shown deficits in executive functions in patients with juvenile myoclonic epilepsy (JME) and in their unaffected siblings. JME has a strong genetic predi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318202010a
更新日期:2010-12-14 00:00:00
abstract:OBJECTIVE:To determine whether droxidopa, an oral norepinephrine precursor, improves symptomatic neurogenic orthostatic hypotension (nOH). METHODS:Patients with symptomatic nOH due to Parkinson disease, multiple system atrophy, pure autonomic failure, or nondiabetic autonomic neuropathy underwent open-label droxidopa ...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0000000000000615
更新日期:2014-07-22 00:00:00
abstract:OBJECTIVE:Asians who carry the HLA-B*1502 allele have an elevated risk of developing Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) when treated with the antiepileptic drugs (AEDs) carbamazepine (CBZ) and phenytoin (PHT). With a focus on Singapore, this analysis identifies circumstances in which ge...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31826aac73
更新日期:2012-09-18 00:00:00
abstract::In 17 patients with cough syncope, electroencephalograms showed normal interictal recordings in 12 patients, minimally abnormal recordings in 4, and a moderately abnormal recording in 1. Fourteen episodes of cough syncope (six patients) were recorded, with the EEGs showing diffuse theta and delta slowing during the ep...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.3.371
更新日期:1984-03-01 00:00:00
abstract::We studied two unrelated patients with autosomal recessive multisystem triglyceride storage disease. Cultured fibroblasts accumulated 10 times more triglyceride than controls under glycerol or palmitate feeding. Mutant fibroblasts could not degrade accumulated triglycerides of endogenous origin, but normally degraded ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.7.1107
更新日期:1988-07-01 00:00:00
abstract:OBJECTIVE:To investigate the feasibility, safety, and efficacy of a ketogenic diet (KD) for superrefractory status epilepticus (SRSE) in adults. METHODS:We performed a prospective multicenter study of patients 18 to 80 years of age with SRSE treated with a KD treatment algorithm. The primary outcome measure was signif...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000003690
更新日期:2017-03-07 00:00:00
abstract::The effect of phenytoin (PHT) concentration on the elimination rate of PHT was evaluated in infants, children, and young adults ranging in age from 1 day to 22 years. As PHT concentration increased, the effective half-life (t50%) increased. In eight children, age 7 months to 4.83 years with initial concentrations betw...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.2.196
更新日期:1980-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the impact of early blood pressure (BP) changes on diffusion-weighted imaging (DWI) lesion evolution and clinical outcome in patients with stroke treated with IV tissue plasminogen activator (tPA). METHODS:We prospectively evaluated 80 patients with stroke with a documented middle cerebral artery...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000318294.36223.69
更新日期:2008-08-19 00:00:00
abstract::Regional cerebral glucose metabolism was studied in 16 patients with idiopathic torticollis, using positron emission tomography. Analysis of subcortical regions revealed no consistent focal abnormality of cerebral metabolic rate for glucose, but there was a bilateral breakdown of the normal relationships between the t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.5.653
更新日期:1986-05-01 00:00:00
abstract:BACKGROUND:Cerebral microbleeds (CMB) may be indicative of a hemorrhage-prone microangiopathy. OBJECTIVE:To determine if increased numbers of these lesions are predictive of intracerebral hemorrhage (ICH), especially in terms of a distributional association. METHODS:The authors examined consecutively 227 patients wit...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000101463.50798.0d
更新日期:2004-01-13 00:00:00
abstract::About 9% of patients presenting to a Huntington disease (HD) clinic for evaluation of possible HD lacked a family history of the disorder. HD was the final diagnosis in 53 to 83% of these patients. As a group, HD-affected individuals without a family history of HD were older and had fewer CAG repeats than the average ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.6.1578
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND:Multiple sclerosis (MS) is a neurodegenerative disease associated with marked impairments in health-related quality of life (HRQoL). Although standard clinical end points such as the Expanded Disability Status Scale and annualized relapse rate remain useful in assessing MS activity and severity, these measur...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181dbb884
更新日期:2010-04-27 00:00:00
abstract::Diffusion-weighted MRI (DWI) was used in three patients with autopsy-proven sporadic Creutzfeldt-Jakob disease (CJD) to provide a rapid noninvasive way to make this sometimes confusing diagnosis. DWI prompted the diagnosis of CJD at an early stage and appears to be particularly useful for monitoring the progression of...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.1.205
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Migraine and headache in general have been associated with subsequent risk of stroke, primarily in retrospective case-control studies. Prospective data evaluating the association between specific headache forms and stroke are sparse. METHODS:A prospective cohort study was conducted among 39,754 US health pr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000154528.21485.3A
更新日期:2005-03-22 00:00:00
abstract::The progressive myoclonus epilepsies (PMEs) are a devastating group of rare disorders(1) that manifest with increasing action myoclonus, which is also present at rest but activates with stimuli such as noise, light, or touch. Ultimately, patients become wheelchair-bound and experience early death. Neurologic signs tha...
journal_title:Neurology
pub_type: 评论,杂志文章
doi:10.1212/WNL.0000000000000091
更新日期:2014-02-04 00:00:00
abstract:BACKGROUND:The relationship between age-related memory decline and hippocampal anatomic changes is a matter of debate. OBJECTIVES:To investigate the relationship between age-related memory decline and MRI hippocampal anatomic changes in a cohort of healthy individuals. METHODS:In this cross-sectional study, 76 health...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181cb3e39
更新日期:2010-01-19 00:00:00
abstract::Patients with mild cognitive impairment (MCI) were assessed, and a metabolic profile associated with conversion to AD at 18-month follow-up was sought. As compared with nonconverters (n = 10), converters (n = 7) had lower fluorodeoxyglucose uptake in the right temporoparietal cortex (p = 0.02, corrected for cluster si...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000055847.17752.e6
更新日期:2003-04-22 00:00:00
abstract::There are indications of increasing incidence of MS in Saudi Arabia. Of 806 neurology inpatients, 16 had MS, 21 myasthenia gravis, and 10 amyotrophic lateral sclerosis, with a ratio of 1:1.3:0.6, respectively. The symptomatology and site of lesions are similar to that seen in the West, but the course and evolution mig...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.4.621
更新日期:1988-04-01 00:00:00
abstract:OBJECTIVE:To assess the surgical and hardware complications in a series of 81 consecutive patients undergoing subthalamic (STN) deep brain stimulation (DBS) for Parkinson disease (PD). METHODS:The authors prospectively documented surgical and hardware complications occurring at the time of surgery and at subsequent ne...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000134650.91974.1a
更新日期:2004-08-24 00:00:00
abstract:BACKGROUND:Few population-based studies with long-term follow-up have compared risk of recurrent stroke and cardiac events after first ischemic stroke. The relative risk of these two outcomes may inform treatment decisions. METHODS:In the population-based Northern Manhattan Study, first ischemic stroke patients age 40...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000201253.93811.f6
更新日期:2006-03-14 00:00:00
abstract::In vivo proton magnetic resonance spectroscopy (MRS) may be used to quantify brainstem neuronal degeneration in ALS because of the neuronal localization of N-acetylaspartate and N-acetylaspartylglutamate, together termed NA, which are estimated with this technique. We measured the ratio of NA to creatine/phosphocreati...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.1.72
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:To investigate clinical and economic consequences following generic substitution of one vs multiple generics of topiramate (Topamax; Ortho-McNeil Neurologics, Titusville, NJ). METHODS:Medical and pharmacy claims data of Régie de l'Assurance-Maladie du Québec from January 2006 to October 2007 were used. Patie...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181aa5300
更新日期:2009-06-16 00:00:00
abstract::Epilepsy surgery is a well-established treatment for certain types of intractable epilepsy. While there is a relatively high number of epilepsy surgery centers in Canada and the United States, the same cannot be said about many other parts of the world, such as South America. Although there are notable exceptions, suc...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006029
更新日期:2018-08-21 00:00:00
abstract::Some epilepsy patients quickly develop resistance to antiepileptic drugs (AEDs). We report a case of a patient with refractory epilepsy with daily seizures who initially responded to levetiracetam daily therapy, but then returned to baseline seizure frequency. However, when levetiracetam was given once weekly, the pat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000198500.84481.da
更新日期:2006-02-28 00:00:00
abstract::Rare reflex epilepsies are a clinical curiosity but may also give insight into neurocognitive processes. The authors present a patient whose seizures were precipitated by drawing but not by writing. This dissociation complements previous reports on selective impairment of writing. EEG revealed a focus in the right fro...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000200953.62141.89
更新日期:2006-03-14 00:00:00
abstract::Antibodies to myelin-associated glycoprotein (MAG) are found in patients with both monoclonal gammopathy and sensorimotor peripheral neuropathy but almost never in patients with amyotrophic lateral sclerosis (ALS). Ninety percent of patients with anti-MAG activity also have antibodies to sulfated glucuronic acid parag...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.4.827
更新日期:1995-04-01 00:00:00
abstract:OBJECTIVE:To determine the risk, predictors, and prognosis of independence loss and institutionalization in patients with early Parkinson disease (PD). METHODS:We conducted a prospective population-based 5-year longitudinal study following 189 patients with incident PD and 174 controls matched for age, sex, and comorb...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000003213
更新日期:2016-10-11 00:00:00
abstract::Cerebral cholesterol metabolism has been linked with production of amyloid peptide (Abeta) crucial in AD. The association between use of cholesterol-lowering drugs (statins) and AD disease is currently being intensely discussed. In this case-control study on elderly nondemented subjects, the authors provide the first ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.59.8.1257
更新日期:2002-10-22 00:00:00