Effects of statins on human cerebral cholesterol metabolism and secretion of Alzheimer amyloid peptide.

abstract：:We describe 263 patients with autosomal dominant cerebellar ataxia from the Holguín province, Cuba. There is evidence of a common ancestry and the population represents the largest homogeneous group of patients yet described. Primary features include gait ataxia, dysarthria, dysmetria, adiadochokinesia, cramps, tremor...

journal_title：Neurology

authors： Orozco Diaz G,Nodarse Fleites A,Cordovés Sagaz R,Auburger G

更新日期：1990-09-01 00:00:00

abstract：OBJECTIVE:Aiming to detect associations between neuroradiologic and EEG evaluations and long-term clinical outcome in order to detect possible prognostic factors, a detailed clinical and neuroimaging characterization of 67 cases of Aicardi syndrome (AIC), collected through a multicenter collaboration, was performed. M...

journal_title：Neurology

authors： Masnada S,Pichiecchio A,Formica M,Arrigoni F,Borrelli P,Accorsi P,Bonanni P,Borgatti R,Bernardina BD,Danieli A,Darra F,Deconinck N,De Giorgis V,Dulac O,Gataullina S,Giordano L,Guerrini R,La Briola F,Mastrangelo M,Mo

更新日期：2020-12-04 00:00:00

abstract：:The clinical and genetic findings are described for 16 patients from a large Italian family with a variant form of hereditary spastic paraplegia and congenital arachnoid cysts inherited as an autosomal dominant trait. A molecular study has revealed a novel missense mutation, T614I, in exon 17 of SPG4, which may play a...

journal_title：Neurology

authors： Orlacchio A,Gaudiello F,Totaro A,Floris R,St George-Hyslop PH,Bernardi G,Kawarai T

更新日期：2004-05-25 00:00:00

abstract：OBJECTIVE:The aim of this prospective study was to survey our patients about their experience with our clinic's telemedicine program to better understand telemedicine's utility for families, and to improve patient satisfaction and ultimately patient care. METHODS:This was a prospective survey study of patients and the...

journal_title：Neurology

authors： Qubty W,Patniyot I,Gelfand A

更新日期：2018-05-08 00:00:00

abstract：BACKGROUND:Hypothalamic hamartomas (HHs), rare developmental abnormalities of the inferior hypothalamus, often cause refractory, symptomatic, mixed epilepsy, including gelastic seizures. We present 37 patients with HH who underwent transcortical transventricular endoscopic resection. METHODS:Between October 2003 and A...

journal_title：Neurology

authors： Ng YT,Rekate HL,Prenger EC,Wang NC,Chung SS,Feiz-Erfan I,Johnsonbaugh RE,Varland MR,Kerrigan JF

更新日期：2008-04-22 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Human herpesvirus 8 (HHV-8) has been found in association with Kaposi's sarcomas in human immunodeficiency virus (HIV)-positive and -negative patients, primary effusion lymphomas (PELs), multicentric Castleman's disease, and multiple myeloma. The PELs share several features with acquired immuno...

journal_title：Neurology

authors： Corboy JR,Garl PJ,Kleinschmidt-DeMasters BK

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Frontotemporal dementia (FTD) is currently distinguished from AD primarily on the basis of behavioral features because studies of cognition have shown negligible or inconsistent differences. However, the poor discriminability of cognitive measures may relate to reliance on imprecise clinically diagnosed grou...

journal_title：Neurology

authors： Rascovsky K,Salmon DP,Ho GJ,Galasko D,Peavy GM,Hansen LA,Thal LJ

更新日期：2002-06-25 00:00:00

abstract：OBJECTIVE:To investigate the pathogenesis of proximal diabetic neuropathy (PDN) with nerve and muscle biopsies. BACKGROUND:Recent evidence suggests that nerve ischemia secondary to immune-mediated vasculopathy rather than diabetic microangiopathy may be responsible for PDN. METHOD:- Fifteen patients with PDN and two ...

journal_title：Neurology

authors： Kelkar P,Masood M,Parry GJ

更新日期：2000-07-12 00:00:00

abstract：:Episodic paroxysmal hemicrania (EPH) is a rare disorder characterized by discrete bouts of hemicranial headache separated by headache-free remissions. Although EPH resembles episodic cluster headache in the location and quality of pain as well as the pattern of associated autonomic features, it is distinguished by the...

journal_title：Neurology

authors： Newman LC,Gordon ML,Lipton RB,Kanner R,Solomon S

更新日期：1992-05-01 00:00:00

abstract：:An emerging issue in stroke prevention and stroke treatment is that therapies shown to be effective in clinical trials are not being used or are being used suboptimally. One of many explanations relates to cost, ranging from concerns about inappropriate use of societal resources to more immediate concerns of organizat...

journal_title：Neurology

authors： Matchar DB

更新日期：1998-09-01 00:00:00

abstract：:Dapsone produces a potentially reversible toxic neuropathy, with its primary effect on the soma and axons of motor neurons as opposed to myelin. There is very little evidence to suggest involvement of sensory axons in most cases; if present, it would appear minimal. A "dying back" of motor axons is postulated to produ...

journal_title：Neurology

authors： Gutmann L,Martin JD,Welton W

更新日期：1976-06-01 00:00:00

abstract：:Progressive thoracic myelopathy occurred in a patient with AIDS. Concurrent opportunistic infections included disseminated systemic cytomegalovirus, aspergillosis, and cutaneous herpes simplex virus (HSV). At autopsy, immune stains indicated that the myelopathy was caused by HSV type 2 infection of the spinal cord. ...

journal_title：Neurology

authors： Britton CB,Mesa-Tejada R,Fenoglio CM,Hays AP,Garvey GG,Miller JR

更新日期：1985-07-01 00:00:00

abstract：:IV immunoglobulin therapy can lead to vascular events through increased serum viscosity and possibly other mechanisms. The authors describe the successful use of tissue plasminogen activator in three of four patients who developed cerebral and peripheral arterial thrombosis after treatment with IV immunoglobulin. ...

journal_title：Neurology

authors： Okuda D,Flaster M,Frey J,Sivakumar K

更新日期：2003-06-10 00:00:00

abstract：OBJECTIVE:To develop and evaluate a model for staging cortical amyloid deposition using PET with high generalizability. METHODS:Three thousand twenty-seven individuals (1,763 cognitively unimpaired [CU], 658 impaired, 467 with Alzheimer disease [AD] dementia, 111 with non-AD dementia, and 28 with missing diagnosis) fr...

journal_title：Neurology

authors： Collij LE,Heeman F,Salvadó G,Ingala S,Altomare D,de Wilde A,Konijnenberg E,van Buchem M,Yaqub M,Markiewicz P,Golla SSV,Wottschel V,Wink AM,Visser PJ,Teunissen CE,Lammertsma AA,Scheltens P,van der Flier WM,Boellaard R

更新日期：2020-09-15 00:00:00

abstract：:Dr. Masur and colleagues(1) from the Childhood Absence Epilepsy Study Group tried to answer a few important questions regarding childhood absence epilepsy (CAE) in their article "Pretreatment cognitive deficits and treatment effects on attention in childhood absence epilepsy." First, they wanted to know whether childr...

journal_title：Neurology

authors： Thio LL

更新日期：2013-10-29 00:00:00

abstract：:A 35-year-old woman had cardiac arrest requiring treatment with a left ventricular assist device. After regaining consciousness, examination revealed upbeating nystagmus, otherwise normal bulbar function, left arm dysmetria, and numbness periorally and in areas she described as "a turtleneck of numbness with a T-shirt...

journal_title：Neurology

authors： Ryman DC,Ju YE

更新日期：2013-12-03 00:00:00

abstract：OBJECTIVE:To examine the lifetime prevalence and the concordance risk of cluster headache (CH) in a twin sample representative of the Swedish general population. METHODS:The authors assessed CH as defined by the second edition of the International Classification of Headache Disorders in 31,750 registered twins born fr...

journal_title：Neurology

authors： Ekbom K,Svensson DA,Pedersen NL,Waldenlind E

更新日期：2006-09-12 00:00:00

abstract：OBJECTIVE:To determine whether longitudinal cognitive decline is associated with increased risk of sleep disturbance in older, nondemented, community-dwelling women. METHODS:We studied 2,474 women (mean age 68.9 years) who were part of a prospective study started in 1986; women with baseline or follow-up evidence of p...

journal_title：Neurology

authors： Yaffe K,Blackwell T,Barnes DE,Ancoli-Israel S,Stone KL,Study of Osteoporotic Fractures Group.

更新日期：2007-07-17 00:00:00

abstract：:The Israeli Teratogen Information Service prospectively followed up 210 pregnancies with first trimester carbamazepine exposure. Pregnancy outcome was compared with that of two overlapping controls, matched and general (n = 629), exposed to nonteratogenic agents. Our study suggests a twofold increase in the rate of ma...

journal_title：Neurology

authors： Diav-Citrin O,Shechtman S,Arnon J,Ornoy A

更新日期：2001-07-24 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of eptinezumab, a humanized anti-calcitonin gene-related peptide monoclonal antibody, in the preventive treatment of chronic migraine (CM). METHODS:The Prevention of Migraine via Intravenous ALD403 Safety and Efficacy-2 (PROMISE-2) study was a phase 3, multicenter, randomi...

journal_title：Neurology

authors： Lipton RB,Goadsby PJ,Smith J,Schaeffler BA,Biondi DM,Hirman J,Pederson S,Allan B,Cady R

更新日期：2020-03-31 00:00:00

abstract：:Juvenile-onset dystonia that improves after levodopa may occur in both dopa-responsive dystonia (DRD) and juvenile parkinsonism (JP), clinically similar conditions with different prognoses and management goals. The authors show normal striatal uptake of the dopamine transporter ligand FP-CIT with SPECT in a clinically...

journal_title：Neurology

authors： O'Sullivan JD,Costa DC,Gacinovic S,Lees AJ

更新日期：2001-01-23 00:00:00

abstract：OBJECTIVE:To evaluate the production rate of CSF in patients with differing disease states. METHODS:The authors measured the production rate of CSF in three groups of patients: five patients with PD below age 60 (aged 51 +/- 4 years, mean +/- SD), nine with PD over age 60 (aged 69 +/- 6 years, mean +/- SD), and seven ...

journal_title：Neurology

authors： Silverberg GD,Heit G,Huhn S,Jaffe RA,Chang SD,Bronte-Stewart H,Rubenstein E,Possin K,Saul TA

更新日期：2001-11-27 00:00:00

abstract：:The clinical and electroencephalographic (EEG) effects of sodium valproate were studied in four patients by means of serial 24-hour EEG recordings and simultaneous hourly determinations of serum drug concentrations. The patients all had frequent clinical seizures and generalized spike-wave discharges. Valproate appear...

journal_title：Neurology

authors： Rowan AJ,Binnie CD,de Beer-Pawlikowski NK,Goedhart DM,Gutter T,van der Geest P,Meinardi H,Meijer JW

更新日期：1979-11-01 00:00:00

abstract：:A cross-sectional survey and subsequent longitudinal study among diabetic residents of Rochester, MN--The Rochester Diabetic Neuropathy Study (RDNS)--is population-based and uses quantitative, validated, and unique end points to detect, classify, and stage neuropathy. Nondiabetic persons, drawn from the same populatio...

journal_title：Neurology

authors： Dyck PJ,Kratz KM,Lehman KA,Karnes JL,Melton LJ 3rd,O'Brien PC,Litchy WJ,Windebank AJ,Smith BE,Low PA

更新日期：1991-06-01 00:00:00

abstract：:Epilepsy is associated with a high rate of premature mortality from direct and indirect effects of seizures, epilepsy, and antiseizure therapies. Sudden unexpected death in epilepsy (SUDEP) is the second leading neurologic cause of total lost potential life-years after stroke, yet SUDEP may account for less than half ...

journal_title：Neurology

authors： Devinsky O,Spruill T,Thurman D,Friedman D

更新日期：2016-02-23 00:00:00

abstract：:The term "Wernicke's area" is most often used as an anatomical label for the gyri forming the lower posterior left sylvian fissure. Although traditionally this region was held to support language comprehension, modern imaging and neuropsychological studies converge on the conclusion that this region plays a much large...

journal_title：Neurology

authors： Binder JR

更新日期：2015-12-15 00:00:00

abstract：OBJECTIVE:To assess the determinants of amyotrophic lateral sclerosis (ALS) phenotypes in a population-based cohort. METHODS:The study population included 2,839 patients with ALS diagnosed in Piemonte, Italy (1995-2015). Patients were classified according to motor (classic, bulbar, flail arm, flail leg, predominantly ...

journal_title：Neurology

authors： Chiò A,Moglia C,Canosa A,Manera U,D'Ovidio F,Vasta R,Grassano M,Brunetti M,Barberis M,Corrado L,D'Alfonso S,Iazzolino B,Peotta L,Sarnelli MF,Solara V,Zucchetti JP,De Marchi F,Mazzini L,Mora G,Calvo A

更新日期：2020-02-25 00:00:00

abstract：OBJECTIVE:To identify presurgical and postsurgical factors that are independently predictive of the outcome of anterior temporal lobectomy (ATL) for intractable epilepsy. BACKGROUND:There have been reports of prognostic factors in epilepsy surgery, but little is known about factors that independently predict outcome o...

journal_title：Neurology

authors： Radhakrishnan K,So EL,Silbert PL,Jack CR Jr,Cascino GD,Sharbrough FW,O'Brien PC

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVES:To correlate the two types of early ischemic change on noncontrast CT (NCCT) (parenchymal hypoattenuation [PH] and isolated focal swelling [IFS]) with concurrent assessment of cerebral perfusion and to compare their rates of progression to infarction. METHODS:We assessed cortical regions on NCCT for early i...

journal_title：Neurology

authors： Parsons MW,Pepper EM,Bateman GA,Wang Y,Levi CR

更新日期：2007-03-06 00:00:00

abstract：:A 79-year-old woman had rheumatic chorea that persisted after age 5 years and increased in severity at age 73. The continued chorea and late decompensation could have been due to incomplete functional resolution in the basal ganglia and decreasing reserve of striatal neurons with age. Sydenham's chorea persisting into...

journal_title：Neurology

authors： Gibb WR,Lees AJ,Scadding JW

更新日期：1985-01-01 00:00:00