Recognizing and preventing epilepsy-related mortality: A call for action.


:Epilepsy is associated with a high rate of premature mortality from direct and indirect effects of seizures, epilepsy, and antiseizure therapies. Sudden unexpected death in epilepsy (SUDEP) is the second leading neurologic cause of total lost potential life-years after stroke, yet SUDEP may account for less than half of all epilepsy-related deaths. Some epilepsy groups are especially vulnerable: individuals from low socioeconomic status groups and those with comorbid psychiatric illness die more often than controls. Despite clear evidence of an important public health problem, efforts to assess and prevent epilepsy-related deaths remain inadequate. We discuss factors contributing to the underestimation of SUDEP and other epilepsy-related causes of death. We suggest the need for a systematic classification of deaths directly due to epilepsy (e.g., SUDEP, drowning), due to acute symptomatic seizures, and indirectly due to epilepsy (e.g., suicide, chronic effects of antiseizure medications). Accurately estimating the frequency of epilepsy-related mortality is essential to support the development and assessment of preventive interventions. We propose that educational interventions and public health campaigns targeting medication adherence, psychiatric comorbidity, and other modifiable risk factors may reduce epilepsy-related mortality. Educational campaigns regarding sudden infant death syndrome and fires, which kill far fewer Americans than epilepsy, have been widely implemented. We have done too little to prevent epilepsy-related deaths. Everyone with epilepsy and everyone who treats people with epilepsy need to know that controlling seizures will save lives.






Devinsky O,Spruill T,Thurman D,Friedman D




Has Abstract


2016-02-23 00:00:00














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    pub_type: 杂志文章


    authors: Dahodwala N,Shah K,He Y,Wu SS,Schmidt P,Cubillos F,Willis AW

    更新日期:2018-01-02 00:00:00

  • Sustained motion perception deficit following optic neuritis: Behavioral and cortical evidence.

    abstract:OBJECTIVE:To assess the recovery process in patients after an acute optic neuritis (ON) attack, comparing static and dynamic visual functions. METHODS:In this prospective controlled study, 21 patients with unilateral, first-ever ON were followed over the course of 1 year. Standard visual tests, visual evoked potential...


    pub_type: 杂志文章


    authors: Raz N,Dotan S,Benoliel T,Chokron S,Ben-Hur T,Levin N

    更新日期:2011-06-14 00:00:00

  • 1H-MRS alterations in the cerebellum of patients with familial hemiplegic migraine type 1.

    abstract:BACKGROUND:About 20% of patients with familial hemiplegic migraine (FHM) develop progressive cerebellar signs. Genetic studies have established an association with mutations in the CACNA1A gene. However, the mechanisms underlying cerebellar involvement are largely unknown. OBJECTIVE:To use proton MR spectroscopy (1H-M...


    pub_type: 杂志文章


    authors: Dichgans M,Herzog J,Freilinger T,Wilke M,Auer DP

    更新日期:2005-02-22 00:00:00

  • Reemergence of activation with poststroke somatosensory recovery: a serial fMRI case study.

    abstract::The authors demonstrate the potential for poststroke return of activation in regions normally involved in touch discrimination in a serial, whole-brain fMRI study of a patient with marked sensory loss followed by good recovery. A return of activation in ipsilesional primary and bilateral secondary somatosensory cortic...


    pub_type: 杂志文章


    authors: Carey LM,Abbott DF,Puce A,Jackson GD,Syngeniotis A,Donnan GA

    更新日期:2002-09-10 00:00:00

  • Arterial wall properties in carotid artery dissection: an ultrasound study.

    abstract:BACKGROUND:Cervical artery dissection is often attributed to an underlying arteriopathy related to a generalized extracellular matrix defect. OBJECTIVE:The authors compared the hemodynamic and morphologic properties of the carotid artery, as assessed noninvasively by ultrasonography, in patients with spontaneous inter...


    pub_type: 杂志文章


    authors: Guillon B,Tzourio C,Biousse V,Adraï V,Bousser MG,Touboul PJ

    更新日期:2000-09-12 00:00:00

  • A Roma founder BIN1 mutation causes a novel phenotype of centronuclear myopathy with rigid spine.

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    pub_type: 杂志文章,多中心研究


    authors: Cabrera-Serrano M,Mavillard F,Biancalana V,Rivas E,Morar B,Hernández-Laín A,Olive M,Muelas N,Khan E,Carvajal A,Quiroga P,Diaz-Manera J,Davis M,Ávila R,Domínguez C,Romero NB,Vílchez JJ,Comas D,Laing NG,Laporte J,Ka

    更新日期:2018-07-24 00:00:00

  • The relation of cerebral vasospasm to the extent and location of subarachnoid blood visualized by CT scan: a prospective study.

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    pub_type: 杂志文章


    authors: Kistler JP,Crowell RM,Davis KR,Heros R,Ojemann RG,Zervas T,Fisher CM

    更新日期:1983-04-01 00:00:00

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    abstract::We determined the horizontal and vertical components of brain displacement on coronal MRIs in 10 patients with acute supratentorial masses. The vertical distances from the superior sagittal sinus to the pontomesencephalic junction (PMJ) and from the vertical midline of the brain to the PMJ did not differ from measurem...


    pub_type: 杂志文章


    authors: Ropper AH

    更新日期:1989-05-01 00:00:00

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    abstract:BACKGROUND:Physicians are often asked to predict outcome after acute stroke. Very little information is available that can reliably predict the likelihood of severe disability or death. OBJECTIVE:To develop a practical method for predicting a poor outcome after acute ischemic stroke. METHODS:Data from the placebo arm...


    pub_type: 杂志文章


    authors: Frankel MR,Morgenstern LB,Kwiatkowski T,Lu M,Tilley BC,Broderick JP,Libman R,Levine SR,Brott T

    更新日期:2000-10-10 00:00:00

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    pub_type: 杂志文章


    authors: Schneider JA,Wilson RS,Cochran EJ,Bienias JL,Arnold SE,Evans DA,Bennett DA

    更新日期:2003-04-08 00:00:00

  • Horner's syndrome after coronary artery bypass surgery.

    abstract::We established the frequency of Horner's syndrome (HS) in 248 elective patients after coronary artery bypass surgery. Patients were evaluated neurologically pre- and post-operatively and 6 months after surgery. Nineteen patients (7.7%) developed unilateral HS postoperatively, 12 involving the left eye. The finding per...


    pub_type: 杂志文章


    authors: Barbut D,Gold JP,Heinemann MH,Hinton RB,Trifiletti RR

    更新日期:1996-01-01 00:00:00

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    abstract::Fluctuations in motor response eventually affect most patients with Parkinson's disease who have been exposed to chronic, intermittent levodopa administration for longer than 5 years. Response oscillations are often related to the timing of levodopa doses (predictable "wearing-off"), but random "on-off" effects also o...


    pub_type: 杂志文章,评审


    authors: Poewe WH

    更新日期:1994-07-01 00:00:00

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    abstract:OBJECTIVES:To quantify the quality of physicians' emergency first response to status epilepticus (SE) and to identify risk factors for nonadherence to treatment guidelines in a standardized simulated scenario. METHODS:In this prospective trial, 58 physicians (of different background) of the University Hospital Basel, ...


    pub_type: 杂志文章


    authors: Sutter R,Tisljar K,Opić P,De Marchis GM,Bassetti S,Bingisser R,Hunziker S,Marsch S

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    pub_type: 杂志文章


    authors: Lux WE,Kurtzke JF

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    abstract::We studied 35 patients with nonseptic cardiogenic cerebral emboli. In 28 cases, there was sudden onset with maximal neurologic deficit within 1 hour; in 7 cases, there was progression in 24 hours. In six cases, neurologic abnormality worsened in the first week after an initial period of stabilization. CT showed eviden...


    pub_type: 杂志文章


    authors: Weisberg LA

    更新日期:1985-06-01 00:00:00

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    pub_type: 杂志文章


    authors: Whitwell JL,Josephs KA,Murray ME,Kantarci K,Przybelski SA,Weigand SD,Vemuri P,Senjem ML,Parisi JE,Knopman DS,Boeve BF,Petersen RC,Dickson DW,Jack CR Jr

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    pub_type: 杂志文章


    authors: Strom T,Schneck SA

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    pub_type: 杂志文章


    authors: Manaker S,Winokur A,Rhodes CH,Rainbow TC

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    abstract:OBJECTIVE:To compare the prognostic accuracy of various acute stroke prognostic scales using a large, independent, clinical trials dataset. METHODS:We directly compared 8 stroke prognostic scales, chosen based on focused literature review (Acute Stroke Registry and Analysis of Lausanne [ASTRAL]; iSCORE; iSCORE-revised...


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    pub_type: 杂志文章


    authors: Scott RC,Gadian DG,Cross JH,Wood SJ,Neville BG,Connelly A

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    pub_type: 杂志文章


    authors: Torisu H,Kusuhara K,Kira R,Bassuny WM,Sakai Y,Sanefuji M,Takemoto M,Hara T

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    pub_type: 杂志文章


    authors: Round R,Keane JR

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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章


    authors: Glasser L,Payne C,Corrigan JJ Jr

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    pub_type: 杂志文章


    authors: Powers JM,Young GF,Bass EB Jr,Reed FE Jr

    更新日期:1980-09-01 00:00:00

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    pub_type: 杂志文章


    authors: Weisberg LA

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    pub_type: 杂志文章


    authors: Hormes JT,Filley CM,Rosenberg NL

    更新日期:1986-05-01 00:00:00

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    pub_type: 杂志文章


    authors: Rosenblum WI

    更新日期:1975-12-01 00:00:00

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    更新日期:2004-12-28 00:00:00