Abstract:
:Epilepsy is associated with a high rate of premature mortality from direct and indirect effects of seizures, epilepsy, and antiseizure therapies. Sudden unexpected death in epilepsy (SUDEP) is the second leading neurologic cause of total lost potential life-years after stroke, yet SUDEP may account for less than half of all epilepsy-related deaths. Some epilepsy groups are especially vulnerable: individuals from low socioeconomic status groups and those with comorbid psychiatric illness die more often than controls. Despite clear evidence of an important public health problem, efforts to assess and prevent epilepsy-related deaths remain inadequate. We discuss factors contributing to the underestimation of SUDEP and other epilepsy-related causes of death. We suggest the need for a systematic classification of deaths directly due to epilepsy (e.g., SUDEP, drowning), due to acute symptomatic seizures, and indirectly due to epilepsy (e.g., suicide, chronic effects of antiseizure medications). Accurately estimating the frequency of epilepsy-related mortality is essential to support the development and assessment of preventive interventions. We propose that educational interventions and public health campaigns targeting medication adherence, psychiatric comorbidity, and other modifiable risk factors may reduce epilepsy-related mortality. Educational campaigns regarding sudden infant death syndrome and fires, which kill far fewer Americans than epilepsy, have been widely implemented. We have done too little to prevent epilepsy-related deaths. Everyone with epilepsy and everyone who treats people with epilepsy need to know that controlling seizures will save lives.
journal_name
Neurologyjournal_title
Neurologyauthors
Devinsky O,Spruill T,Thurman D,Friedman Ddoi
10.1212/WNL.0000000000002253subject
Has Abstractpub_date
2016-02-23 00:00:00pages
779-86issue
8eissn
0028-3878issn
1526-632Xpii
WNL.0000000000002253journal_volume
86pub_type
杂志文章,评审相关文献
NEUROLOGY文献大全abstract:OBJECTIVE:To compare access to caregiving between men and women with Parkinson disease (PD). METHODS:This was a cross-sectional and longitudinal study among participants with PD enrolled in the National Parkinson Foundation Parkinson's Outcomes Project from 2009 to 2014 at 21 international sites. The primary outcome m...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004764
更新日期:2018-01-02 00:00:00
abstract:OBJECTIVE:To assess the recovery process in patients after an acute optic neuritis (ON) attack, comparing static and dynamic visual functions. METHODS:In this prospective controlled study, 21 patients with unilateral, first-ever ON were followed over the course of 1 year. Standard visual tests, visual evoked potential...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31821f4602
更新日期:2011-06-14 00:00:00
abstract:BACKGROUND:About 20% of patients with familial hemiplegic migraine (FHM) develop progressive cerebellar signs. Genetic studies have established an association with mutations in the CACNA1A gene. However, the mechanisms underlying cerebellar involvement are largely unknown. OBJECTIVE:To use proton MR spectroscopy (1H-M...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000151855.98318.50
更新日期:2005-02-22 00:00:00
abstract::The authors demonstrate the potential for poststroke return of activation in regions normally involved in touch discrimination in a serial, whole-brain fMRI study of a patient with marked sensory loss followed by good recovery. A return of activation in ipsilesional primary and bilateral secondary somatosensory cortic...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.59.5.749
更新日期:2002-09-10 00:00:00
abstract:BACKGROUND:Cervical artery dissection is often attributed to an underlying arteriopathy related to a generalized extracellular matrix defect. OBJECTIVE:The authors compared the hemodynamic and morphologic properties of the carotid artery, as assessed noninvasively by ultrasonography, in patients with spontaneous inter...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.5.663
更新日期:2000-09-12 00:00:00
abstract:OBJECTIVE:To describe a large series of BIN1 patients, in which a novel founder mutation in the Roma population of southern Spain has been identified. METHODS:Patients diagnosed with centronuclear myopathy (CNM) at 5 major reference centers for neuromuscular disease in Spain (n = 53) were screened for BIN1 mutations. ...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000005862
更新日期:2018-07-24 00:00:00
abstract::In 41 cases of verified ruptured saccular aneurysm, we prospectively predicted the presence or absence of delayed symptomatic cerebral vasospasm. CT criteria quantifying the extent and location of subarachnoid blood (developed in our previous retrospective study) were used in this prospective series of patients. Twent...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.4.424
更新日期:1983-04-01 00:00:00
abstract::We determined the horizontal and vertical components of brain displacement on coronal MRIs in 10 patients with acute supratentorial masses. The vertical distances from the superior sagittal sinus to the pontomesencephalic junction (PMJ) and from the vertical midline of the brain to the PMJ did not differ from measurem...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.5.622
更新日期:1989-05-01 00:00:00
abstract:BACKGROUND:Physicians are often asked to predict outcome after acute stroke. Very little information is available that can reliably predict the likelihood of severe disability or death. OBJECTIVE:To develop a practical method for predicting a poor outcome after acute ischemic stroke. METHODS:Data from the placebo arm...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.7.952
更新日期:2000-10-10 00:00:00
abstract:BACKGROUND:Cerebral infarctions are common in older persons but their relationship with dementia and cognitive function remains controversial. METHODS:Participants were 164 older Catholic nuns, priests, and brothers who underwent annual clinical evaluation and brain autopsy at death. The authors quantified number and ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000055863.87435.b2
更新日期:2003-04-08 00:00:00
abstract::We established the frequency of Horner's syndrome (HS) in 248 elective patients after coronary artery bypass surgery. Patients were evaluated neurologically pre- and post-operatively and 6 months after surgery. Nineteen patients (7.7%) developed unilateral HS postoperatively, 12 involving the left eye. The finding per...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.1.181
更新日期:1996-01-01 00:00:00
abstract::Fluctuations in motor response eventually affect most patients with Parkinson's disease who have been exposed to chronic, intermittent levodopa administration for longer than 5 years. Response oscillations are often related to the timing of levodopa doses (predictable "wearing-off"), but random "on-off" effects also o...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:
更新日期:1994-07-01 00:00:00
abstract:OBJECTIVES:To quantify the quality of physicians' emergency first response to status epilepticus (SE) and to identify risk factors for nonadherence to treatment guidelines in a standardized simulated scenario. METHODS:In this prospective trial, 58 physicians (of different background) of the University Hospital Basel, ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008461
更新日期:2019-11-05 00:00:00
abstract::In the coterminous United States, MS mortality rates demonstrate a north-south gradient, which is confirmed by more sophisticated--and more expensive--prevalence studies. Mortality rates from idiopathic Parkinson's disease show a similar north-south gradient, and they correlate significantly with the MS mortality and ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.3.467
更新日期:1987-03-01 00:00:00
abstract::We studied 35 patients with nonseptic cardiogenic cerebral emboli. In 28 cases, there was sudden onset with maximal neurologic deficit within 1 hour; in 7 cases, there was progression in 24 hours. In six cases, neurologic abnormality worsened in the first week after an initial period of stabilization. CT showed eviden...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.6.896
更新日期:1985-06-01 00:00:00
abstract:BACKGROUND:Neurofibrillary tangles (NFTs), composed of hyperphosphorylated tau proteins, are one of the pathologic hallmarks of Alzheimer disease (AD). We aimed to determine whether patterns of gray matter atrophy from antemortem MRI correlate with Braak staging of NFT pathology. METHODS:Eighty-three subjects with Bra...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000324924.91351.7d
更新日期:2008-09-02 00:00:00
abstract::A 28-year-old nonimmunocompromised man developed secondary syphilis confirmed by serum and CSF findings. His course was complicated by chorioretinitis, extensive skin lesions, and spastic paraparesis secondary to syphilitic meningomyelitis. MRI of the spinal cord was strikingly abnormal. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.2_part_1.325
更新日期:1991-02-01 00:00:00
abstract::Thyrotropin-releasing hormone (TRH) exerts many effects upon spinal cord function in animals, and may also play a role in human spinal cord function. We have used the technique of quantitative autoradiography to anatomically localize specific receptors for TRH within human spinal cord. Highest concentrations of TRH re...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.3.328
更新日期:1985-03-01 00:00:00
abstract:OBJECTIVE:To compare the prognostic accuracy of various acute stroke prognostic scales using a large, independent, clinical trials dataset. METHODS:We directly compared 8 stroke prognostic scales, chosen based on focused literature review (Acute Stroke Registry and Analysis of Lausanne [ASTRAL]; iSCORE; iSCORE-revised...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004332
更新日期:2017-09-05 00:00:00
abstract:OBJECTIVE:To investigate whether quantitative MR techniques can be used to distinguish between mesial temporal sclerosis in patients with a history of prolonged febrile convulsion and in patients without such a history. METHODS:Quantitative hippocampal T2 relaxometry, hippocampal volumetry, and single voxel (1)H-MRS d...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.12.1659
更新日期:2001-06-26 00:00:00
abstract:BACKGROUND:The antivirally active MxA protein is induced by interferon (IFN) alpha/beta and inhibits the replication of single-stranded RNA viruses including measles virus (MV). The authors investigated whether the MxA gene contributed to the development of subacute sclerosing panencephalitis (SSPE) in Japanese individ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000106940.95749.8e
更新日期:2004-02-10 00:00:00
abstract::Of 101 patients with benign intracranial hypertension not related to vasculitis, neck stiffness occurred in 31, tinnitus in 27, distal extremity paresthesias in 22, joint pains in 13, low back pain in 5, and gait "ataxia" in 4. Symptoms resolved promptly upon lowering the intracranial pressure by lumbar puncture, and ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.9.1461
更新日期:1988-09-01 00:00:00
abstract::We analyzed our experience with cough, exertional, and vascular sexual headaches, evaluated the interrelationships among them, and examined the possible symptomatic cases. Seventy-two patients consulted us because of headaches precipitated by coughing (n = 30), physical exercise (n = 28), or sexual excitement (n = 14)...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.46.6.1520
更新日期:1996-06-01 00:00:00
abstract::This is a case study of a patient with the clinical diagnosis of meningoencephalitis. It demonstrates the in vivo development of plasma cells in the central nervous system. All the stages of in vitro mitogen-induced lymphocyte transformation previously described by light and electron microscopy are recapitulated in th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.27.5.448
更新日期:1977-05-01 00:00:00
abstract::A young girl who initially presented with jaw hypomobility at age 4 years subsequently developed signs of a slowly progressive myopathy. Rods were found in all sampled muscles, and were associated with fibrous contractures in the temporomandibular joint muscles. Rods in fibers undergoing necrosis displayed a pattern o...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.9.971
更新日期:1980-09-01 00:00:00
abstract::We analyzed the clinical, CT, and angiographic findings in 50 black patients with carotid transient ischemic attacks (TIAs). Thirty-two percent had TIAs lasting less than 1 hour, 26% had TIAs lasting 1 to 6 hours, and 42% had TIAs lasting 6 to 24 hours. Fifty-two percent of TIA patients had CT evidence of cerebral inf...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.9.1410
更新日期:1991-09-01 00:00:00
abstract::Neurologic abnormalities were seen in 13 of 20 patients with a history of chronic solvent vapor (primarily toluene) abuse for 2 or more years. The patients were evaluated after an abstinence period of at least 4 weeks, to avoid neurologic effects of acute intoxication. Neurologic signs included cognitive (60%), pyrami...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.5.698
更新日期:1986-05-01 00:00:00
abstract::Prostaglandins B1 and B2 were topically applied to the pial vessels of mice and arteriolar constriction was observed. This constriction could be significantly increased if serotonin was added to B1, but not when norepinephrine was added. Response to B2 was not enhanced by the simultaneous addition of either serotonin ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.25.12.1169
更新日期:1975-12-01 00:00:00
abstract:OBJECTIVES:Compensatory processes involving the recruitment of additional cerebral areas can limit cognitive impairment caused by brain damage as revealed by fMRI. Multiple sclerosis (MS) is characterized by frequent cognitive deficiencies and diffuse brain damage. Understanding the missing or disturbed processes resul...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181f612e3
更新日期:2010-10-05 00:00:00
abstract::The authors evaluated four patients with schizencephaly who underwent subtraction ictal SPECT coregistered to MRI (SISCOM) prior to epilepsy surgery. Three patients had a SISCOM alteration that was concordant with the epileptic brain tissue. Two of these patients were rendered seizure-free and one individual experienc...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000147262.70507.76
更新日期:2004-12-28 00:00:00