Abstract:
:Dapsone produces a potentially reversible toxic neuropathy, with its primary effect on the soma and axons of motor neurons as opposed to myelin. There is very little evidence to suggest involvement of sensory axons in most cases; if present, it would appear minimal. A "dying back" of motor axons is postulated to produce the clinical features of primarily distal weakness and wasting. Recovery appears to occur via axon regeneration and peripheral sprouting. The sporadic occurrence of this neuropathy may be due to slow acetylation of dapsone in some patients.
journal_name
Neurologyjournal_title
Neurologyauthors
Gutmann L,Martin JD,Welton Wdoi
10.1212/wnl.26.6.514subject
Has Abstractpub_date
1976-06-01 00:00:00pages
514-6issue
6 PT 1eissn
0028-3878issn
1526-632Xjournal_volume
26pub_type
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