Nerve ultrasound improves detection of treatment-responsive chronic inflammatory neuropathies.

Abstract:

OBJECTIVE:To examine the diagnostic accuracy of nerve ultrasound in a prospective cohort of consecutive patients with a clinical suspicion of chronic inflammatory neuropathies, including chronic inflammatory demyelinating polyneuropathy, Lewis-Sumner syndrome, and multifocal motor neuropathy, and to determine the added value in the detection of treatment-responsive patients. METHODS:Between February 2015 and July 2018, we included 100 consecutive incident patients with a clinical suspicion of chronic inflammatory neuropathy. All patients underwent nerve ultrasound, extensive standardized nerve conduction studies (NCS), and other relevant diagnostic investigations. We evaluated treatment response using predefined criteria. A diagnosis of chronic inflammatory neuropathy was established when NCS were abnormal (fulfilling criteria of demyelination of the European Federation of Neurological Societies/Peripheral Nerve Society) or when the degree of nerve enlargement detected by sonography was compatible with chronic inflammatory neuropathy and there was response to treatment. RESULTS:A diagnosis of chronic inflammatory neuropathy was established in 38 patients. Sensitivity and specificity of nerve ultrasound and NCS were 97.4% and 69.4% and 78.9% and 93.5%, respectively. The added value of nerve ultrasound in detection of treatment-responsive chronic inflammatory neuropathy was 21.1% compared to NCS alone. CONCLUSIONS:Nerve ultrasound and NCS are complementary techniques with superior sensitivity in the former and specificity in the latter. Addition of nerve ultrasound significantly improves the detection of chronic inflammatory neuropathies. Therefore, it deserves a prominent place in the diagnostic workup of chronic inflammatory neuropathies. CLASSIFICATION OF EVIDENCE:This study provides Class IV evidence that nerve ultrasound is an accurate diagnostic tool to detect chronic inflammatory neuropathies.

journal_name

Neurology

journal_title

Neurology

authors

Herraets IJT,Goedee HS,Telleman JA,van Eijk RPA,van Asseldonk JT,Visser LH,van den Berg LH,van der Pol WL

doi

10.1212/WNL.0000000000008978

subject

Has Abstract

pub_date

2020-04-07 00:00:00

pages

e1470-e1479

issue

14

eissn

0028-3878

issn

1526-632X

pii

WNL.0000000000008978

journal_volume

94

pub_type

杂志文章
  • Late in-stent thrombosis following carotid angioplasty and stenting.

    abstract::Acute in-stent thrombosis is a well-known complication of carotid angioplasty and stenting (CAS) and often due to resistance to or inadequate treatment with platelet-inhibiting agents. The authors report three cases of a delayed in-stent thrombosis after more than a week but less than 3 months after CAS. In all cases,...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000216141.01262.77

    authors: Buhk JH,Wellmer A,Knauth M

    更新日期:2006-05-23 00:00:00

  • Singing paraplegia: a distinctive manifestation of a spinal dural arteriovenous fistula.

    abstract::The unique case of a baritone with a spinal dural arteriovenous fistula (SDAVF) causing recurrent, acute paraplegia during singing is described. This case underscores the presence of impaired venous drainage in these lesions and the high level of clinical suspicion required for their diagnosis in patients with any mye...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.58.8.1279

    authors: Khurana VG,Perez-Terzic CM,Petersen RC,Krauss WE

    更新日期:2002-04-23 00:00:00

  • The BAER profile: a method for reporting electrophysiologic brainstem examinations in clinical practice.

    abstract::We present a method for graphically reporting the results of brainstem auditory evoked response examinations on the basis of multiple parameters. The method is based on a transform that normalizes the many latency and amplitude measures obtained from the averaged evoked responses of normal subjects tested under standa...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.29.2.242

    authors: Lolas F,Hoeppner TJ,Morrell F

    更新日期:1979-02-01 00:00:00

  • Accuracy of family history information on epilepsy and other seizure disorders.

    abstract:BACKGROUND:In epilepsy as in other disorders, family history information is often obtained by asking patients about the medical histories of their relatives rather than interviewing or examining the relatives directly. The accuracy of this type of information for epilepsy and other seizure disorders is unclear. METHOD...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3182088286

    authors: Ottman R,Barker-Cummings C,Leibson CL,Vasoli VM,Hauser WA,Buchhalter JR

    更新日期:2011-01-25 00:00:00

  • Sex disparities in access to caregiving in Parkinson disease.

    abstract:OBJECTIVE:To compare access to caregiving between men and women with Parkinson disease (PD). METHODS:This was a cross-sectional and longitudinal study among participants with PD enrolled in the National Parkinson Foundation Parkinson's Outcomes Project from 2009 to 2014 at 21 international sites. The primary outcome m...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000004764

    authors: Dahodwala N,Shah K,He Y,Wu SS,Schmidt P,Cubillos F,Willis AW

    更新日期:2018-01-02 00:00:00

  • Congenital muscular dystrophies with defective glycosylation of dystroglycan: a population study.

    abstract:BACKGROUND:Congenital muscular dystrophies (CMD) with reduced glycosylation of alpha-dystroglycan (alpha-DG) are a heterogeneous group of conditions associated with mutations in six genes encoding proven or putative glycosyltransferases. OBJECTIVES:The aim of the study was to establish the prevalence of mutations in t...

    journal_title:Neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1212/01.wnl.0000346518.68110.60

    authors: Mercuri E,Messina S,Bruno C,Mora M,Pegoraro E,Comi GP,D'Amico A,Aiello C,Biancheri R,Berardinelli A,Boffi P,Cassandrini D,Laverda A,Moggio M,Morandi L,Moroni I,Pane M,Pezzani R,Pichiecchio A,Pini A,Minetti C,Mon

    更新日期:2009-05-26 00:00:00

  • Whole-brain diffusion MR histograms differ between MS subtypes.

    abstract:OBJECTIVE:To determine whether quantitative whole-brain MR diffusion histograms in patients with MS differ from those of normal control subjects. BACKGROUND:MRI detects macroscopic cerebral lesions in MS, but the white matter lesion burden on MRI correlates imperfectly to clinical disability. Previous reports have fur...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章

    doi:10.1212/wnl.54.7.1421

    authors: Nusbaum AO,Tang CY,Wei T,Buchsbaum MS,Atlas SW

    更新日期:2000-04-11 00:00:00

  • Relation between MR abnormalities and patterns of cognitive impairment in multiple sclerosis.

    abstract:OBJECTIVE:This study correlated the extent of abnormalities detected by different magnetic resonance imaging (MRI) techniques [proton density (PD)-weighted, T1-weighted, and magnetization transfer imaging (MTI)] with the overall cognitive, frontal lobe, and memory impairments in patients with MS. PATIENTS:There were 3...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.50.6.1601

    authors: Rovaris M,Filippi M,Falautano M,Minicucci L,Rocca MA,Martinelli V,Comi G

    更新日期:1998-06-01 00:00:00

  • Riboflavin-responsive lipid myopathy and carnitine deficiency.

    abstract::We used riboflavin to treat a patient with lipid myopathy, reduced exercise capacity, intolerance to fasting, and reduced concentrations of carnitine in muscle and serum. Although carnitine concentrations did not change, exercise capacity doubled, and response to fasting improved. Muscle enzyme assay showed that palmi...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.31.12.1557

    authors: Carroll JE,Shumate JB,Brooke MH,Hagberg JM

    更新日期:1981-12-01 00:00:00

  • Internal carotid artery stent placement without emboli protection: results and long-term outcome.

    abstract::Patients with symptomatic > or = 60% (n = 134), asymptomatic > or = 80% (n = 143), and asymptomatic progressive > or = 60% (n = 25) internal carotid artery stenosis underwent stenting and were followed clinically and by Doppler-assisted duplex imaging for 27.1 +/- 15.6 months. Stroke and death from stroke occurred wit...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章

    doi:10.1212/01.wnl.0000167604.56223.70

    authors: Bibl D,Lampl C,Biberhofer I,Kerschner K,Kypta A,Bergmann J,Kaindlstorfer A,Röper C,Yazdi K,Engleder C,Hofmann R,Deibl M,Leisch F,Ransmayr G

    更新日期:2005-07-12 00:00:00

  • Determinants of brain iron in multiple sclerosis: a quantitative 3T MRI study.

    abstract:OBJECTIVES:Abnormal high cerebral iron deposition may be implicated in chronic neurologic disorders, including multiple sclerosis (MS). R2* relaxometry has been recently validated in a postmortem study to indicate brain iron accumulation in a quantitative manner. We used this technique to assess brain iron levels in di...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e318236ef0e

    authors: Khalil M,Langkammer C,Ropele S,Petrovic K,Wallner-Blazek M,Loitfelder M,Jehna M,Bachmaier G,Schmidt R,Enzinger C,Fuchs S,Fazekas F

    更新日期:2011-11-01 00:00:00

  • Thalamic glutamate/glutamine in restless legs syndrome: increased and related to disturbed sleep.

    abstract:OBJECTIVE:To evaluate possible abnormal increase in thalamic glutamate/glutamine levels for restless legs syndrome (RLS) indicating increased glutamatergic activity producing arousal that at night disrupts and shortens sleep. METHODS:(1)H MRS of the right thalamus was performed using a 1.5 T GE MRI scanner and the PRO...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e318294b3f6

    authors: Allen RP,Barker PB,Horská A,Earley CJ

    更新日期:2013-05-28 00:00:00

  • Chronic progressive myelopathy associated with HTLV-I: oligoclonal IgG and anti-HTLV-I IgG antibodies in cerebrospinal fluid and serum.

    abstract::Among 22 patients with human T-lymphotropic virus type I (HTLV-I)-associated chronic progressive myelopathy, agarose isoelectric focusing (AIF) revealed oligoclonal IgG bands in 21: in 3 in CSF only; in 11 in CSF and to some extent in serum; and in 7, identical patterns in CSF and serum. By immunoblot after AIF of CSF...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.39.12.1566

    authors: Link H,Cruz M,Gessain A,Gout O,de Thé G,Kam-Hansen S

    更新日期:1989-12-01 00:00:00

  • Evidence against the existence of a temporal lobe epilepsy personality syndrome.

    abstract::The existence and specificity of a characteristic behavioral syndrome among patients with temporal lobe epilepsy (TLE) remains controversial. The behavioral pattern of many epilepsy patients differs from that of age-, sex-, and socioeconomic-matched control subjects. Patients with TLE and other forms of epilepsy can e...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:

    authors: Devinsky O,Najjar S

    更新日期:1999-01-01 00:00:00

  • Transient ischemic attacks: a prospective study of 225 patients.

    abstract::Between the years 1964 and 1973, 225 patients with transient ischemic attacks (TIAs) due primarily to atherosclerosis were evaluated and treated. They have now been followed for from 3 to 14 years (average 5.5 years). As of 1976, 82 of the 225 patients were dead, 21 from cerebral infarction, 52 from heart disease and ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.28.8.746

    authors: Toole JF,Yuson CP,Janeway R,Johnston F,Davis C,Cordell AR,Howard G

    更新日期:1978-08-01 00:00:00

  • Summary of evidence-based guideline: complementary and alternative medicine in multiple sclerosis: report of the guideline development subcommittee of the American Academy of Neurology.

    abstract:OBJECTIVE:To develop evidence-based recommendations for complementary and alternative medicine (CAM) in multiple sclerosis (MS). METHODS:We searched the literature (1970-March 2011; March 2011-September 2013 MEDLINE search), classified articles, and linked recommendations to evidence. RESULTS AND RECOMMENDATIONS:Clin...

    journal_title:Neurology

    pub_type: 杂志文章,meta分析

    doi:10.1212/WNL.0000000000000250

    authors: Yadav V,Bever C Jr,Bowen J,Bowling A,Weinstock-Guttman B,Cameron M,Bourdette D,Gronseth GS,Narayanaswami P

    更新日期:2014-03-25 00:00:00

  • Deep gray matter involvement in neurobrucellosis.

    abstract::A 27-year-old man, recent visitor to the Middle East, presented with 6-week history of fever (up to 102°F) followed by altered behavior and left hemiparesis. CSF was acellular with raised protein (138 mg/dL). CSF bacterial culture was sterile; adenosine deaminase normal (3 U/L); cryptococcal antigen, Venereal Disease ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e31827deb63

    authors: Rajan R,Khurana D,Kesav P

    更新日期:2013-01-15 00:00:00

  • Efficacy of High-Intensity Aerobic Exercise on Brain MRI Measures in Multiple Sclerosis.

    abstract:OBJECTIVE:To determine whether 24 weeks of high-intensity progressive aerobic exercise (PAE) affects brain MRI measures in people with multiple sclerosis (MS). METHODS:We conducted a randomized, controlled, phase 2 trial (with a crossover follow-up) including an exercise group (supervised PAE followed by self-guided p...

    journal_title:Neurology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1212/WNL.0000000000011241

    authors: Langeskov-Christensen M,Grøndahl Hvid L,Nygaard MKE,Ringgaard S,Jensen HB,Nielsen HH,Petersen T,Stenager E,Eskildsen SF,Dalgas U

    更新日期:2021-01-12 00:00:00

  • PET studies of cerebral glucose metabolism in idiopathic torticollis.

    abstract::Regional cerebral glucose metabolism was studied in 16 patients with idiopathic torticollis, using positron emission tomography. Analysis of subcortical regions revealed no consistent focal abnormality of cerebral metabolic rate for glucose, but there was a bilateral breakdown of the normal relationships between the t...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.36.5.653

    authors: Stoessl AJ,Martin WR,Clark C,Adam MJ,Ammann W,Beckman JH,Bergstrom M,Harrop R,Rogers JG,Ruth TJ

    更新日期:1986-05-01 00:00:00

  • Discrepancy between stimulus response and tolerance of pain in Alzheimer disease.

    abstract:BACKGROUND:Affective-motivational and sensory-discriminative aspects of pain were investigated in patients with mild to moderate Alzheimer disease (AD) and healthy elderly controls using the cold pressor test tolerance and repetitive stimuli of warmth and heat stimuli, evaluating the stimulus-response function. METHOD...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000001465

    authors: Jensen-Dahm C,Werner MU,Jensen TS,Ballegaard M,Andersen BB,Høgh P,Waldemar G

    更新日期:2015-04-14 00:00:00

  • The unruptured intracranial aneurysm treatment score: a multidisciplinary consensus.

    abstract:OBJECTIVE:We endeavored to develop an unruptured intracranial aneurysm (UIA) treatment score (UIATS) model that includes and quantifies key factors involved in clinical decision-making in the management of UIAs and to assess agreement for this model among specialists in UIA management and research. METHODS:An internat...

    journal_title:Neurology

    pub_type: 共识发展会议,杂志文章

    doi:10.1212/WNL.0000000000001891

    authors: Etminan N,Brown RD Jr,Beseoglu K,Juvela S,Raymond J,Morita A,Torner JC,Derdeyn CP,Raabe A,Mocco J,Korja M,Abdulazim A,Amin-Hanjani S,Al-Shahi Salman R,Barrow DL,Bederson J,Bonafe A,Dumont AS,Fiorella DJ,Gruber A,H

    更新日期:2015-09-08 00:00:00

  • Detection and cellular localization of enterovirus RNA sequences in spinal cord of patients with ALS.

    abstract:OBJECTIVE:To investigate the possible association of persistent enterovirus (EV) infection with the development of ALS. BACKGROUND:Although ALS is a clinically well-defined motor neuron disease, little is known about the etiology and pathogenesis of the sporadic cases. Among the different causes that have been hypothe...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.54.1.20

    authors: Berger MM,Kopp N,Vital C,Redl B,Aymard M,Lina B

    更新日期:2000-01-11 00:00:00

  • Randomized, placebo-controlled trial of rofecoxib in the acute treatment of migraine.

    abstract:OBJECTIVE:To investigate the clinical profile of rofecoxib, a long-acting (approximately 17-hour half-life) selective cyclo-oxygenase-2 inhibitor, for the acute treatment of migraine. METHODS:A randomized, double-blind, placebo-controlled, parallel-group study was conducted. Patients age > or =18 treated a moderate or...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1212/01.wnl.0000123260.61631.c4

    authors: Silberstein S,Tepper S,Brandes J,Diamond M,Goldstein J,Winner P,Venkatraman S,Vrijens F,Malbecq W,Lines C,Visser WH,Reines S,Yuen E

    更新日期:2004-05-11 00:00:00

  • The Workforce Task Force report: clinical implications for neurology.

    abstract::The American Academy of Neurology Workforce Task Force (WFTF) report predicts a future shortfall of neurologists in the United States. The WFTF data also suggest that for most states, the current demand for neurologist services already exceeds the supply, and by 2025 the demand for neurologists will be even higher. Th...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/WNL.0b013e31829d8783

    authors: Freeman WD,Vatz KA,Griggs RC,Pedley T

    更新日期:2013-07-30 00:00:00

  • Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease.

    abstract::We investigated the association of PD with a recently reported I93M mutation of the ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene, and with a new and common polymorphic variant S18Y of the same gene. We did not identify the I93M mutation in any of 139 unrelated PD cases or 113 controls. However, S18Y polymorph...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.53.8.1858

    authors: Maraganore DM,Farrer MJ,Hardy JA,Lincoln SJ,McDonnell SK,Rocca WA

    更新日期:1999-11-10 00:00:00

  • The ability of persons with Alzheimer disease (AD) to make a decision about taking an AD treatment.

    abstract:OBJECTIVE:To examine the severity of impairments in the decision-making abilities (understanding, appreciation, reasoning, and choice) and competency to make a decision to use an Alzheimer disease (AD)-slowing medication in patients with AD and the relationships between these impairments, insight, and overall cognition...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.WNL.0000160000.01742.9D

    authors: Karlawish JH,Casarett DJ,James BD,Xie SX,Kim SY

    更新日期:2005-05-10 00:00:00

  • Self-awareness of migraine: interpreting the labels that headache sufferers apply to their headaches.

    abstract::Although people with migraine are aware of their headaches they are often not aware that they have migraine. This can lead to inappropriate or ineffective use of treatments, delays in seeking appropriate care, and miscommunication during clinical encounters. This article assesses self-recognition of migraine and ident...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.58.9_suppl_6.s21

    authors: Lipton RB,Stewart WF,Liberman JN

    更新日期:2002-05-14 00:00:00

  • Respiratory chain and mitochondrial DNA in muscle and brain in Parkinson's disease patients.

    abstract::There are several reports of a defect of complex I in the substantia nigra (SN) of Parkinson's disease (PD) patients. To evaluate whether this is specific to dopaminergic neurons or the phenotypically relevant consequence of a widespread failure of the mitochondrial oxidative phosphorylation (OXPHOS) system, we measur...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.43.11.2262

    authors: DiDonato S,Zeviani M,Giovannini P,Savarese N,Rimoldi M,Mariotti C,Girotti F,Caraceni T

    更新日期:1993-11-01 00:00:00

  • Syphilitic meningomyelitis.

    abstract::A 28-year-old nonimmunocompromised man developed secondary syphilis confirmed by serum and CSF findings. His course was complicated by chorioretinitis, extensive skin lesions, and spastic paraparesis secondary to syphilitic meningomyelitis. MRI of the spinal cord was strikingly abnormal. ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.41.2_part_1.325

    authors: Strom T,Schneck SA

    更新日期:1991-02-01 00:00:00

  • Head impulse test in unilateral vestibular loss: vestibulo-ocular reflex and catch-up saccades.

    abstract:BACKGROUND:Quantitative head impulse test (HIT) measures the gain of the angular vestibulo-ocular reflex (VOR) during head rotation as the ratio of eye to head acceleration. Bedside HIT identifies subsequent catch-up saccades after the head rotation as indirect signs of VOR deficit. OBJECTIVE:To determine the VOR defi...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000299117.48935.2e

    authors: Weber KP,Aw ST,Todd MJ,McGarvie LA,Curthoys IS,Halmagyi GM

    更新日期:2008-02-05 00:00:00