Determinants of brain iron in multiple sclerosis: a quantitative 3T MRI study.

abstract：:People with AD have deficient contrast sensitivity and impaired face discrimination. The authors presented photographs of unfamiliar faces of three different sizes to enhance the low, middle, or high facial frequency information (cycles per face). Patients with AD demonstrated normal discrimination of small faces only...

journal_title：Neurology

authors： Cronin-Golomb A,Cronin-Golomb M,Dunne TE,Brown AC,Jain K,Cipolloni PB,Auerbach SH

更新日期：2000-06-27 00:00:00

abstract：OBJECTIVE:To evaluate the safety and efficacy of l-serine in humans with hereditary sensory autonomic neuropathy type I (HSAN1). METHODS:In this randomized, placebo-controlled, parallel-group trial with open-label extension, patients aged 18-70 years with symptomatic HSAN1 were randomized to l-serine (400 mg/kg/day) o...

journal_title：Neurology

authors： Fridman V,Suriyanarayanan S,Novak P,David W,Macklin EA,McKenna-Yasek D,Walsh K,Aziz-Bose R,Oaklander AL,Brown R,Hornemann T,Eichler F

更新日期：2019-01-22 00:00:00

abstract：:Men and women with dementia of the Alzheimer type (DAT) had more brain atrophy and ventricular dilatation, measured by quantitative CT, than did respective age- and sex-matched healthy controls (p less than 0.05). The male DAT patients with mild dementia had a larger mean third ventricle volume, whereas male patients ...

journal_title：Neurology

authors： Creasey H,Schwartz M,Frederickson H,Haxby JV,Rapoport SI

更新日期：1986-12-01 00:00:00

abstract：OBJECTIVE:To investigate whether dietary patterns (Mediterranean diet [MedDiet], Dietary Approaches to Stop Hypertension [DASH], and A Priori Diet Quality Score [APDQS]) during adulthood are associated with midlife cognitive performance. METHODS:We studied 2,621 Coronary Artery Risk Development in Young Adults (CARDIA...

journal_title：Neurology

authors： McEvoy CT,Hoang T,Sidney S,Steffen LM,Jacobs DR Jr,Shikany JM,Wilkins JT,Yaffe K

更新日期：2019-04-02 00:00:00

abstract：OBJECTIVE:The authors investigated chronic cerebellar reorganization following unilateral cortical lesions in children and adults using PET to measure benzodiazepine receptor (BZR) binding with [11C]flumazenil (FMZ) and glucose metabolism with 2-deoxy-2[18F]fluoro-D-glucose (FDG). BACKGROUND:Crossed cerebellar diaschi...

journal_title：Neurology

authors： Niimura K,Chugani DC,Muzik O,Chugani HT

更新日期：1999-03-10 00:00:00

abstract：:Electrophysiologic studies were carried out on 11 patients with Holmes-Adie syndrome, 8 of whom had reduced or absent ankle jerks. Conduction velocities and evoked nerve and muscle compound action potentials in the peroneal, posterior tibial, and sural nerves were normal. The H reflex was absent (or virtually absent) ...

journal_title：Neurology

authors： Miyasaki JM,Ashby P,Sharpe JA,Fletcher WA

更新日期：1988-02-01 00:00:00

abstract：:A 11-year-old boy of short stature had recurrent right temporal pounding headaches of 7 months' duration, and progressive visual loss for 3 days. There was a left hemianopia, alexia without agraphia, and diffuse muscle weakness. Investigation established the presence of a mitochondrial myopathy with pyruvate and lacti...

journal_title：Neurology

authors： Skoglund RR

更新日期：1979-05-01 00:00:00

abstract：OBJECTIVE:To discuss the indications and timing for resective surgery in patients with Sturge-Weber syndrome (SWS) and medication-resistant epilepsy. BACKGROUND:SWS that causes epilepsy severe enough to merit surgery is rare. Because of the variable natural history of the disease, it is difficult to establish clear-cu...

journal_title：Neurology

authors： Arzimanoglou AA,Andermann F,Aicardi J,Sainte-Rose C,Beaulieu MA,Villemure JG,Olivier A,Rasmussen T

更新日期：2000-11-28 00:00:00

abstract：OBJECTIVE:To assess the importance of MAPT variant p.A152T in the risk of synucleinopathies. METHODS:In this case-control study, we screened a large global series of patients and controls, and assessed associations between p.A152T and disease risk. We included 3,229 patients with clinical Parkinson disease (PD), 442 w...

journal_title：Neurology

authors： Labbé C,Ogaki K,Lorenzo-Betancor O,Soto-Ortolaza AI,Walton RL,Rayaprolu S,Fujioka S,Murray ME,Heckman MG,Puschmann A,McCarthy A,Lynch T,Siuda J,Opala G,Rudzinska M,Krygowska-Wajs A,Barcikowska M,Czyzewski K,Sanotsky Y

更新日期：2015-11-10 00:00:00

abstract：:We report an infant with molybdenum cofactor deficiency (MCD) and a unique clinical presentation of hemiplegia, hypotonia, dystonia, and bilateral basal ganglia changes. Biochemistry revealed absent serum homocysteine, low concentrations of plasma cystine, high levels of urinary S-sulfocysteine and sulfite, and high l...

journal_title：Neurology

authors： Graf WD,Oleinik OE,Jack RM,Weiss AH,Johnson JL

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Expert knowledge may compensate for age-related declines in basic cognitive and sensory-motor abilities in some skill domains. We investigated the influence of age and aviation expertise (indexed by Federal Aviation Administration pilot ratings) on longitudinal flight simulator performance. METHODS:Over a 3...

journal_title：Neurology

authors： Taylor JL,Kennedy Q,Noda A,Yesavage JA

更新日期：2007-02-27 00:00:00

abstract：:We studied the effects of intravenous immunoglobulin (IVIg) in 12 patients with motor neuron syndromes associated with high titers of anti-GM1 antibodies. Five of the patients had conduction blocks. The study design was a double-blind, placebo-controlled, crossover trial with IVIg (0.4 g/kg body weight per day injecte...

journal_title：Neurology

authors： Azulay JP,Blin O,Pouget J,Boucraut J,Billé-Turc F,Carles G,Serratrice G

更新日期：1994-03-01 00:00:00

abstract：:We report 9 cases of aphasia following lesions in the region of the left frontal operculum. It is not possible to capture their variety of clinical manifestations with the simple labels of "Broca's area aphasia." or "Broca's area aphasia." Analysis of the breakdown of various components of speech and language in these...

journal_title：Neurology

authors： Alexander MP,Naeser MA,Palumbo C

更新日期：1990-02-01 00:00:00

abstract：:CSF does not normally contain motile cells within flagella or cilia. When motile cells are seen in the CSF, they may be incorrectly assumed to be amebae. We studied a patient with a traumatic mucocele, in whom motile ciliated respiratory epithelial cells were seen in the CSF and within a frontal lobe brain abscess. ...

journal_title：Neurology

authors： Davis LE,Visvesvara GS,McLaren DL,Randell R,Fenoglio CC,McLaren LC,Purdy M,Cooper V,Healy GR

更新日期：1985-10-01 00:00:00

abstract：OBJECTIVE:To investigate whether plasma interleukin-6 (IL-6) is cross-sectionally related to poorer cognitive function and whether a baseline plasma IL-6 measurement can predict risk for decline in cognitive function in longitudinal follow-up of a population-based sample of nondisabled elderly people. METHODS:A prospe...

journal_title：Neurology

authors： Weaver JD,Huang MH,Albert M,Harris T,Rowe JW,Seeman TE

更新日期：2002-08-13 00:00:00

abstract：:Eighty-eight multiple sclerosis case-friend pairs were interviewed by telephone to elicit information about early-life exposures. Available mothers were also interviewed. Risk factors included childhood diseases, exposures to animals, and residence. We found a positive association between MS and having measles at a la...

journal_title：Neurology

authors： Sullivan CB,Visscher BR,Detels R

更新日期：1984-09-01 00:00:00

abstract：OBJECTIVE:Structural and functional lesion localization in patients with hemispatial neglect. DESIGN:Location and severity of brain damage on CT and SPECT correlated with neglect performance as assessed with a battery of drawings, line bisection, and line and shape cancellation subtests. PATIENTS:Participants include...

journal_title：Neurology

authors： Leibovitch FS,Black SE,Caldwell CB,Ebert PL,Ehrlich LE,Szalai JP

更新日期：1998-04-01 00:00:00

abstract：:Prostaglandins B1 and B2 were topically applied to the pial vessels of mice and arteriolar constriction was observed. This constriction could be significantly increased if serotonin was added to B1, but not when norepinephrine was added. Response to B2 was not enhanced by the simultaneous addition of either serotonin ...

journal_title：Neurology

authors： Rosenblum WI

更新日期：1975-12-01 00:00:00

abstract：:Between 1982 and 1989, 197 patients with Parkinson's disease were treated with selegiline and levodopa for at least 0.3 years. Two groups of patients were included: a group of 65 patients (stage 2 or 3 on the Hoehn and Yahr Scale) who recently had been started on levodopa and were not experiencing response fluctuation...

journal_title：Neurology

authors： Lieberman A

更新日期：1992-04-01 00:00:00

abstract：OBJECTIVE:To describe a clinical syndrome of cerebellar ataxia associated with muscle coenzyme Q10 (CoQ10) deficiency. BACKGROUND:Muscle CoQ10 deficiency has been reported only in a few patients with a mitochondrial encephalomyopathy characterized by 1) recurrent myoglobinuria; 2) brain involvement (seizures, ataxia, ...

journal_title：Neurology

authors： Musumeci O,Naini A,Slonim AE,Skavin N,Hadjigeorgiou GL,Krawiecki N,Weissman BM,Tsao CY,Mendell JR,Shanske S,De Vivo DC,Hirano M,DiMauro S

更新日期：2001-04-10 00:00:00

abstract：:Information on 1,343 hospitalized patients in the Cornell Neurology Database with final diagnoses of transient ischemic attacks (TIA), reversible ischemic neurologic deficits (RIND), or ischemic stroke was examined in order to determine the duration of ischemic deficits. Episodes resolved within the first 24 hours (cl...

journal_title：Neurology

authors： Levy DE

更新日期：1988-05-01 00:00:00

abstract：:Titus Lucretius Carus was an ancient Roman philosopher of the Epicurean school whose epic poem On the Nature of Things described numerous aspects of the natural world. In fact, much contemporary scientific understanding is consistent with or inspired by his work. Among Lucretius's contributions to neurology were his d...

journal_title：Neurology

authors： Hyam JA,Paterson DJ,Aziz TZ,Green AL

更新日期：2011-09-06 00:00:00

abstract：:A 48-year-old man presented with progressive spastic paraparesis and diffuse white matter involvement on neuroimaging that suggested a primary demyelinating disease. Brain biopsy 3 years after onset of symptoms demonstrated idiopathic granulomatous angiitis. In patients with MRI features of diffuse white matter diseas...

journal_title：Neurology

authors： Finelli PF,Onyiuke HC,Uphoff DF

更新日期：1997-12-01 00:00:00

abstract：OBJECTIVE:To study the association of PD with preceding smoking, alcohol, and coffee consumption using a case-control design. METHODS:The authors used the medical records linkage system of the Rochester Epidemiology Project to identify 196 subjects who developed PD in Olmsted County, MN, during the years 1976 to 1995....

journal_title：Neurology

authors： Benedetti MD,Bower JH,Maraganore DM,McDonnell SK,Peterson BJ,Ahlskog JE,Schaid DJ,Rocca WA

更新日期：2000-11-14 00:00:00

abstract：:"Healthy citizens are the greatest asset any country can have."-Sir Winston Churchill. ...

journal_title：Neurology

authors： Sharma M

更新日期：2014-01-28 00:00:00

abstract：:Azathioprine has the longest continuing history of clinical use in the treatment of multiple sclerosis (MS) of any immunosuppressive therapy besides corticosteroids. To date, 19 clinical trials of azathioprine in MS have been reported, and another eight are under way. A review of the reported trials indicates little e...

journal_title：Neurology

authors： Silberberg DH

更新日期：1988-07-01 00:00:00

abstract：:A kindred is described with a dominantly inherited "pure" cerebellar ataxia in which the currently known spinocerebellar ataxias have been excluded. In the eight subjects studied, a notable clinical feature is slow progression, with the three least affected having only a mild degree of gait ataxia after three or more ...

journal_title：Neurology

authors： Storey E,Gardner RJ,Knight MA,Kennerson ML,Tuck RR,Forrest SM,Nicholson GA

更新日期：2001-11-27 00:00:00

abstract：BACKGROUND:Semiology is very useful in the diagnosis and classification of seizures. Some clinical signs occur primarily with specific localization-related epilepsies. OBJECTIVE:To evaluate postictal nose-rubbing as a potential diagnostic sign and a potential lateralizing or localizing indicator. METHODS:We reviewed ...

journal_title：Neurology

authors： Geyer JD,Payne TA,Faught E,Drury I

更新日期：1999-03-10 00:00:00

abstract：:We report a longitudinal follow-up study on six patients with chronic manganese-induced parkinsonism following cessation of manganese exposure. Compared with the 1987 study, their parkinsonian symptoms showed a slow progression, particularly in gait disturbances such as freezing during turning and walking backward wit...

journal_title：Neurology

authors： Huang CC,Lu CS,Chu NS,Hochberg F,Lilienfeld D,Olanow W,Calne DB

更新日期：1993-08-01 00:00:00

abstract：:Because Hughlings Jackson directed that his personal documents be destroyed upon his death, none of his own clinical records are known. However, we have discovered several pages of notes in the Royal London Hospital Archive written in 1893 by Jackson to his House Physician at Queen Square concerning his proposals for ...

journal_title：Neurology

authors： Swash M,Evans J

更新日期：2006-08-22 00:00:00