Abstract:
:Prostaglandins B1 and B2 were topically applied to the pial vessels of mice and arteriolar constriction was observed. This constriction could be significantly increased if serotonin was added to B1, but not when norepinephrine was added. Response to B2 was not enhanced by the simultaneous addition of either serotonin or norepinephrine. Earlier work with prostaglandin F2alpha was replicated. F2alpha constricted pial arterioles and a significantly greater constriction was produced when norepinephrine was applied simultaneously with F2alpha. The data suggest that among the causes of cerebral vasospasm one should consider not only the action of singly agents, but also the combined effects of several agents that might be in contact with cerebral vessels.
journal_name
Neurologyjournal_title
Neurologyauthors
Rosenblum WIdoi
10.1212/wnl.25.12.1169subject
Has Abstractpub_date
1975-12-01 00:00:00pages
1169-71issue
12eissn
0028-3878issn
1526-632Xjournal_volume
25pub_type
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