Reversible alexia, mitochondrial myopathy, and lactic acidemia.

Abstract:

:A 11-year-old boy of short stature had recurrent right temporal pounding headaches of 7 months' duration, and progressive visual loss for 3 days. There was a left hemianopia, alexia without agraphia, and diffuse muscle weakness. Investigation established the presence of a mitochondrial myopathy with pyruvate and lactic acidemia and increased serum content of sarcoplasmic enzymes. On treatment with prednisone, the patient's strength and reading skill improved, symptoms resolved, and muscle enzymes returned to normal. Three attempts to reduce steroids resulted in accentuation of symptoms, seizures, weakness, regression of reading skills, and elevation of serum enzymes. The alexia was also reversible.

journal_name

Neurology

journal_title

Neurology

authors

Skoglund RR

doi

10.1212/wnl.29.5.717

subject

Has Abstract

pub_date

1979-05-01 00:00:00

pages

717-20

issue

5

eissn

0028-3878

issn

1526-632X

journal_volume

29

pub_type

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