Abstract:
:The authors conducted a randomized, double-blind, placebo-controlled, twofold crossover study in 16 patients with MS who presented with severe spasticity to investigate safety, tolerability, and efficacy of oral Delta(9)-Tetrahydrocannabinol (THC) and Cannabis sativa plant extract. Both drugs were safe, but adverse events were more common with plant-extract treatment. Compared with placebo, neither THC nor plant-extract treatment reduced spasticity. Both THC and plant-extract treatment worsened the participant's global impression.
journal_name
Neurologyjournal_title
Neurologyauthors
Killestein J,Hoogervorst EL,Reif M,Kalkers NF,Van Loenen AC,Staats PG,Gorter RW,Uitdehaag BM,Polman CHdoi
10.1212/wnl.58.9.1404subject
Has Abstractpub_date
2002-05-14 00:00:00pages
1404-7issue
9eissn
0028-3878issn
1526-632Xjournal_volume
58pub_type
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