Orthostatic hypotension in familial amyloid polyneuropathy: treatment with DL-threo-3,4-dihydroxyphenylserine.

abstract：OBJECTIVES:To assess the association of primary retinal inflammation, namely retinal periphlebitis (RP) and microcystic macular edema, with clinical, brain, and retinal imaging biomarkers of multiple sclerosis (MS) severity. METHODS:One hundred patients with MS underwent a neurologic and ophthalmic examination, MRI, a...

journal_title：Neurology

authors： Ortiz-Pérez S,Martínez-Lapiscina EH,Gabilondo I,Fraga-Pumar E,Martínez-Heras E,Saiz A,Sanchez-Dalmau B,Villoslada P

更新日期：2013-09-03 00:00:00

abstract：:We analyzed ictal features of psychogenic seizures using video-EEG recordings in 47 patients and reviewed the medical records to determine if patients received antiepileptic drug therapy and whether they were treated pharmacologically for status epilepticus. Unresponsive behavior in the absence of motor manifestations...

journal_title：Neurology

authors： Leis AA,Ross MA,Summers AK

更新日期：1992-01-01 00:00:00

abstract：:A 64-year-old man with diffuse atherosclerosis developed an organic mental syndrome, followed by hypothalamic symptoms. Autopsy showed an old large cystic infarct involving the left temporal lobe including the hippocampus, and atrophy of the ipsilateral fornix, mammillary body, hypothalamus, mammillothalamic tract, an...

journal_title：Neurology

authors： Torch WC,Hirano A,Solomon S

更新日期：1977-12-01 00:00:00

abstract：:A physically and intellectually normally developed boy had a resection of a lumbar myelomeningocele shortly after birth and a shunt was inserted for hydrocephalus. He died at age 12 years after a traffic accident. Autopsy disclosed a hyperplasia of the cerebellar vermis. An abnormal median-sagittal triangular fiber tr...

journal_title：Neurology

authors： Friede RL,Briner J

更新日期：1978-12-01 00:00:00

abstract：:We used a nested polymerase chain reaction assay to quantitate the number of viral copies in cells of CSF of eight patients with herpes simplex virus encephalitis (HSVE). The viral load was monitored in serial CSF samples during the course of disease and correlated to clinical symptoms, radiologic manifestations, effi...

journal_title：Neurology

authors： Wildemann B,Ehrhart K,Storch-Hagenlocher B,Meyding-Lamadé U,Steinvorth S,Hacke W,Haas J

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:Findings from a small clinical study suggested that statins may counteract the therapeutic effects of interferon beta (IFNbeta) in patients with relapsing-remitting multiple sclerosis (RRMS). METHODS:We conducted a post hoc analysis of data from the Safety and Efficacy of Natalizumab in Combination With IFN...

journal_title：Neurology

authors： Rudick RA,Pace A,Rani MR,Hyde R,Panzara M,Appachi S,Shrock J,Maurer SL,Calabresi PA,Confavreux C,Galetta SL,Lublin FD,Radue EW,Ransohoff RM

更新日期：2009-06-09 00:00:00

abstract：OBJECTIVE:To delineate the features of regional cerebral metabolic rate of glucose (CMRglc) in dementia with Lewy bodies (DLB). METHODS:We compared absolute CMRglc in 12 patients with a clinical diagnosis of DLB, 12 patients with a clinical diagnosis of Alzheimer's disease (AD), and 12 normal volunteers (NC), using 18...

journal_title：Neurology

authors： Ishii K,Imamura T,Sasaki M,Yamaji S,Sakamoto S,Kitagaki H,Hashimoto M,Hirono N,Shimomura T,Mori E

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Imaging determinations of the spatial extent of diffuse low-grade gliomas (DLGGs) are of paramount importance in evaluating the risk-to-benefit ratio of surgical resection. However, it is not clear how accurately preoperative conventional MRI can delineate DLGGs. METHODS:We report a retrospective histologic...

journal_title：Neurology

authors： Pallud J,Varlet P,Devaux B,Geha S,Badoual M,Deroulers C,Page P,Dezamis E,Daumas-Duport C,Roux FX

更新日期：2010-05-25 00:00:00

abstract：:The objective of this study was to use high-resolution MRI techniques to determine whether children with Down syndrome exhibit decreases in hippocampal and amygdala volumes similar to those demonstrated in recent studies of adults with this condition. When corrected for overall brain volumes, amygdala volumes did not ...

journal_title：Neurology

authors： Pinter JD,Brown WE,Eliez S,Schmitt JE,Capone GT,Reiss AL

更新日期：2001-04-10 00:00:00

abstract：:Sphingosine 1-phosphate receptors (S1PRs) are G protein-coupled receptors expressed by many cell types, including immune and neural cells. These receptors are promising targets for immunomodulatory and possibly neuromodulatory therapies. Fingolimod (FTY720) is a sphingosine analog that, when phosphorylated, becomes a ...

journal_title：Neurology

authors： Soliven B,Miron V,Chun J

更新日期：2011-02-22 00:00:00

abstract：:Migration from an area where MS is common to an area where it is rare (and vice versa) affects the risk of MS, provided migration occurs in childhood. A childhood infection might explain this effect. Therefore, the age pattern of infectious diseases in different regions was examined. A higher proportion of children sh...

journal_title：Neurology

authors： Alter M,Zhang ZX,Davanipour Z,Sobel E,Zibulewski J,Schwartz G,Friday G

更新日期：1986-10-01 00:00:00

abstract：:Twenty-two patients were analyzed 2 or more years after corpus callosum section (9 partial, 13 total). Forty-one percent had class 1 outcome (elimination of secondarily generalized and complex partial seizures), 32% had class 2 outcome (elimination of secondarily generalized seizures), and 27% had class 3 outcome (no ...

journal_title：Neurology

authors： Spencer SS,Spencer DD,Williamson PD,Sass K,Novelly RA,Mattson RH

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Inherited and de novo mutations in sodium channel genes underlie a variety of channelopathies. Mutations in SCN2A, encoding the brain sodium channel Na(V)1.2, have previously been reported to be associated with benign familial neonatal infantile seizures, febrile seizures plus, and intractable epilepsy of in...

journal_title：Neurology

authors： Liao Y,Anttonen AK,Liukkonen E,Gaily E,Maljevic S,Schubert S,Bellan-Koch A,Petrou S,Ahonen VE,Lerche H,Lehesjoki AE

更新日期：2010-10-19 00:00:00

abstract：OBJECTIVE:To determine whether there are distinct thalamic regions statistically associated with either contraversive or ipsiversive disturbance of verticality perception measured by subjective visual vertical (SVV). METHODS:We used modern statistical lesion behavior mapping on a sample of 37 stroke patients with isol...

journal_title：Neurology

authors： Baier B,Conrad J,Stephan T,Kirsch V,Vogt T,Wilting J,Müller-Forell W,Dieterich M

更新日期：2016-01-12 00:00:00

abstract：:This paper reviews the issue of hepatotoxicity with the use of the catechol-O-methly transferase (COMT) inhibitors tolcapone and entacapone. Neither drug caused hepatotoxicity in preclinical toxicity testing. However, in clinical trials of tolcapone, liver chemistry tests were elevated more than 3 times above the uppe...

journal_title：Neurology

authors： Watkins P

更新日期：2000-01-01 00:00:00

abstract：:Weight loss is common in Alzheimer's disease (AD), but its pathogenesis is poorly understood. It is unclear whether an elevated daily energy expenditure contributes to the weight loss. We tested the hypothesis that daily energy expenditure is higher in AD patients compared to healthy elderly. Thirty AD (73 +/- 8 years...

journal_title：Neurology

authors： Poehlman ET,Toth MJ,Goran MI,Carpenter WH,Newhouse P,Rosen CJ

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between temporal discrimination threshold (TDT) and "off" period gait freezing (OGF) in patients with fluctuating Parkinson disease (PD). METHODS:TDT values were measured at the dorsum of the toes in 11 control subjects and 22 patients with PD with a wearing-off phenomenon (16...

journal_title：Neurology

authors： Lee MS,Kim HS,Lyoo CH

更新日期：2005-02-22 00:00:00

abstract：OBJECTIVE:To assess the effect of usage of three different versions of Creutzfeldt-Jakob disease (CJD) diagnostic criteria on estimates of CJD incidence. METHODS:A total of 428 patients referred for suspected sporadic CJD between 1991 and 1997 were classified according to different criteria to be compared after analys...

journal_title：Neurology

authors： Brandel JP,Delasnerie-Lauprêtre N,Laplanche JL,Hauw JJ,Alpérovitch A

更新日期：2000-03-14 00:00:00

abstract：:Magnetization transfer imaging (MTI) is a magnetic resonance imaging (MRI) technique that is now used in multiple sclerosis (MS) studies, and is thought to have a higher pathological specificity than conventional T2-weighted imaging. This review outlines the correlations between magnetization transfer (MT) metrics and...

journal_title：Neurology

authors： Rovaris M,Horsfield MA,Filippi M

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Evidence linking APOE to myelin repair, neuronal plasticity, and cerebral inflammatory processes suggests that it may be relevant in multiple sclerosis (MS). The purpose of this study was to determine whether the epsilon4 allele of APOE is associated with cognitive deficits in patients with MS. METHOD:Using...

journal_title：Neurology

authors： Ghaffar O,Reis M,Pennell N,O'Connor P,Feinstein A

更新日期：2010-05-18 00:00:00

abstract：OBJECTIVE:To investigate whether the fornix and mamillary bodies, being part of the limbic system, are abnormal in patients with mesial temporal lobe epilepsy (MTLE). BACKGROUND:The limbic system comprises the hippocampal formation, fornix, mamillary bodies, thalamus, and other integrated structures. This system is im...

journal_title：Neurology

authors： Kuzniecky R,Bilir E,Gilliam F,Faught E,Martin R,Hugg J

更新日期：1999-08-11 00:00:00

abstract：:Charcot-Marie-Tooth disease type 1A (CMT1A) and hereditary neuropathy with liability to pressure palsies (HNPP) are inherited peripheral neuropathies. In most cases these disorders are caused by either the duplication (in CMT1A) or the deletion (in HNPP) of a 1.5-megabase DNA fragment on chromosome 17p11.2, which cont...

journal_title：Neurology

authors： Young P,Stögbauer F,Wiebusch H,Löfgren A,Timmerman V,Van Broeckhoven C,Ringelstein EB,Assmann G,Funke H

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Differentiating idiopathic late-onset cerebellar ataxia (ILOCA) from ataxia due to the cerebellar subtype of multiple-system atrophy (MSA-C) can be difficult in the early stages of the disease METHODS:The authors analyzed the levels of various CSF biomarkers in 27 patients with MSA-C and 18 patients with IL...

journal_title：Neurology

authors： Abdo WF,van de Warrenburg BP,Munneke M,van Geel WJ,Bloem BR,Kremer HP,Verbeek MM

更新日期：2006-08-08 00:00:00

abstract：:The authors compared the transcranial color-coded duplex pattern of the middle cerebral arteries (MCAs) before and after IV and combined IV-intra-arterial (IV-IA) thrombolysis in consecutive first-ever stroke patients. Patients receiving combined IV-IA thrombolysis showed greater improvement in flow signal and higher ...

journal_title：Neurology

authors： Perren F,Loulidi J,Graves R,Yilmaz H,Rüfenacht D,Landis T,Sztajzel R

更新日期：2006-07-25 00:00:00

abstract：BACKGROUND:The 1875 publications of Erb and Westphal brought widespread attention to the percussion of muscle stretch reflexes. Although the maneuver may have been observed before 1875, there is little concrete evidence of this. OBJECTIVES:To bring to light an early report of percussion eliciting the muscle stretch re...

journal_title：Neurology

authors： Louis ED

更新日期：2008-03-18 00:00:00

abstract：:We attempted to define the role of subtle changes in the normal-appearing white matter (NAWM) in the development of disability in multiple sclerosis (MS). Twenty-seven clinically definite MS patients with either relapsing-remitting or chronic-progressive courses and 10 sex- and age-matched controls entered the study. ...

journal_title：Neurology

authors： Filippi M,Campi A,Dousset V,Baratti C,Martinelli V,Canal N,Scotti G,Comi G

更新日期：1995-03-01 00:00:00

abstract：:We studied the effects of intravenous immunoglobulin (IVIg) in 12 patients with motor neuron syndromes associated with high titers of anti-GM1 antibodies. Five of the patients had conduction blocks. The study design was a double-blind, placebo-controlled, crossover trial with IVIg (0.4 g/kg body weight per day injecte...

journal_title：Neurology

authors： Azulay JP,Blin O,Pouget J,Boucraut J,Billé-Turc F,Carles G,Serratrice G

更新日期：1994-03-01 00:00:00

abstract：OBJECTIVE:Physician prediction of outcome in critically ill neurologic patients impacts treatment decisions and goals of care. In this observational study, we prospectively compared predictions by neurointensivists to patient outcomes at 6 months. METHODS:Consecutive neurologic patients requiring mechanical ventilatio...

journal_title：Neurology

authors： Finley Caulfield A,Gabler L,Lansberg MG,Eyngorn I,Mlynash M,Buckwalter MS,Venkatasubramanian C,Wijman CA

更新日期：2010-04-06 00:00:00

abstract：:Among 22 patients with human T-lymphotropic virus type I (HTLV-I)-associated chronic progressive myelopathy, agarose isoelectric focusing (AIF) revealed oligoclonal IgG bands in 21: in 3 in CSF only; in 11 in CSF and to some extent in serum; and in 7, identical patterns in CSF and serum. By immunoblot after AIF of CSF...

journal_title：Neurology

authors： Link H,Cruz M,Gessain A,Gout O,de Thé G,Kam-Hansen S

更新日期：1989-12-01 00:00:00

abstract：:Several controlled-release carbidopa/levodopa preparations have been formulated to achieve a more stable and extended antiparkinsonian action. The most effective is Sinemet CR (Sinemet CR4), with an erodible polymer matrix that retards release of levodopa. In 19 parkinsonians with prominent dose-by-dose fluctuations, ...

journal_title：Neurology

authors： LeWitt PA,Nelson MV,Berchou RC,Galloway MP,Kesaree N,Kareti D,Schlick P

更新日期：1989-11-01 00:00:00