Abstract:
OBJECTIVE:To quantify the isoprostane 8,12-iso-iPF2alpha-VI in brain tissues obtained from patients with AD, patients with frontotemporal dementia (FTD), and controls. BACKGROUND:Enhanced brain oxidative stress with secondary damage to cellular macromolecules may play a role in the pathogenesis of AD and FTD. The isoprostane 8,12-iso-iPF2alpha-VI is a specific and sensitive marker of in vivo lipid peroxidation and is increased in AD. METHODS:Levels of this isoprostane were determined by gas chromatography/negative ion chemical ionization mass spectrometry. RESULTS:Levels of 8,12-iso-iPF2alpha-VI were markedly elevated in both frontal and temporal cortex of AD brains compared to the corresponding areas of FTD and controls. No significant difference in brain 8,12-iso-iPF2alpha-VI levels for any regions considered was observed between FTD and controls. CONCLUSIONS:Lipid peroxidation is a feature of AD, but not FTD. The generation of 8,12-iso-iPF(2alpha)-VI in the brain is not a general or final common pathway of neurodegeneration, but may be relatively specific for disease processes in AD and not FTD.
journal_name
Neurologyjournal_title
Neurologyauthors
Yao Y,Zhukareva V,Sung S,Clark CM,Rokach J,Lee VM,Trojanowski JQ,Praticò Ddoi
10.1212/01.wnl.0000070185.02546.5dsubject
Has Abstractpub_date
2003-08-26 00:00:00pages
475-8issue
4eissn
0028-3878issn
1526-632Xjournal_volume
61pub_type
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